TWI807636B - Manufacturing method of PTP sheet - Google Patents

Abstract

The present invention provides a method of manufacturing a PTP sheet capable of more reliably preventing the occurrence of obstacles to understanding the contents of an information section due to the cloudiness of the bottom wall. The manufacturing process of a PTP sheet includes the process of forming the bag part (2) for accommodating a tablet (5) in a container film. An information portion (5j) is provided in an information imparting region (5k) on a surface (5b) of a tablet (5). In the forming process of the pocket (2), the bottom wall (2b) of the pocket (2) has a peripheral region (b1) and a central region (b2), and the pocket (2) is formed such that the distance from the center of the surface (5b) of the tablet (5) to the center of the pocket (2) in plan view is Δc (mm) in such a way that the tablet (5) moves to the maximum toward the side wall of the pocket (2). The distance Δc satisfies Δc≦rc-(φRp/2) when the diameter of the information imparting region (5k) is φRp (mm) and the radius of the central region is rc (mm).

Description

Manufacturing method of PTP sheet

The present invention relates to a method for producing a PTP sheet containing a tablet in a pocket.

A PTP (blister pack) sheet is known as a blister sheet generally employed in the fields of pharmaceuticals, foods, and the like. The PTP sheet includes a container film having a pocket for storing tablets, and a cover film attached to the container film so as to seal the opening side of the pocket.

A general tablet is circular in plan view, and its outer surface consists of a curved surface, a flat surface, a back surface, and side surfaces sandwiched between these surfaces. In addition, there is known a tablet in which an information portion consisting of characters, symbols, etc. such as a product name and a product number is provided on the surface (the surface disposed on the bottom wall side of the bag portion) by printing, engraving, or the like. In addition, as tablets, orally disintegrating tablets configured to dissolve rapidly with saliva or a small amount of water may be used.

The above-mentioned PTP sheet is produced through, for example, a bag portion forming process, a filling process, a mounting process, a punching process, and the like. In the bag portion forming step, the bag portion is formed on the strip-shaped container film. In the filling process, the tablet is filled in the pocket. In the mounting step, the covering film is mounted on the container film so as to close the pocket. In the punching process, the strip-shaped PTP film on which two films are mounted is punched out into sheet units. PTP sheet can be obtained by punching PTP film.

In addition, there is a problem that the surface of the tablet rubs against the bottom wall of the bag due to impact and vibration applied to the PTP sheet during product transportation or when the user carries it. If the surface of the tablet rubs against the bottom wall, the components of the tablet adhere to the bottom wall, and when the container film is made of a transparent or translucent material, cloudiness occurs on the bottom wall. When such cloudiness occurs, there is a problem that it is difficult to accurately grasp the contents of the information section provided on the tablet. In particular, when the tablet is an orally disintegrating tablet, the components of the tablet tend to adhere to the bottom wall, and cloudiness of the bottom wall is more likely to occur.

Therefore, in recent years, a technology has been proposed for the purpose of suppressing cloudiness of the bottom wall even when shock and vibration are applied to the PTP sheet by setting the radius of curvature of the surface of the tablet and the radius of curvature of the bottom wall in a predetermined relationship (for example, refer to Patent Document 1, etc.). More specifically, in this technique, clouding of the bottom wall can be prevented by setting the radius of curvature of the bottom wall (top surface portion of Patent Document 1) along at least one direction to be equal to or less than the radius of curvature of the surface of the tablet (information display portion of Patent Document 1) along at least one direction. [Prior Art Literature] [Patent Document]

Patent Document 1: Japanese Patent Laid-Open No. 2017-178352

[Problem to be solved by the invention]

However, in the technique described above, when the radius of curvature of the bottom wall is set to be the same as that of the surface of the tablet, the entire surface of the tablet comes into surface contact with the inner surface of the bottom wall. Therefore, there is a risk of clouding the entire area of the bottom wall portion and hindering the understanding of the contents of the information section.

In contrast, as shown in FIG. 17 (in FIG. 17 , the upper side shows a cross-sectional view of the bag portion 2, etc., and the lower side shows a bottom view of the inner surface of the bottom wall portion 2, etc.), if the radius of curvature of the bottom wall portion 2b of the bag portion 2 is smaller than the radius of curvature of the surface 5b of the tablet 5, only the outer peripheral portion (periphery portion) of the surface 5b of the tablet 5 is in contact with the inner surface of the bottom wall portion 2b. Therefore, it is possible to prevent the occurrence of cloudiness in the entire area of the bottom wall.

However, even in the case of the above configuration, when the tablet 5 moves inside the bag portion 2 (for example, moves as shown by a chain line of two dots), the tablet 5 rubs against the peripheral edge region b1 (in FIG. 17 , a region with a thick line in a cross-sectional view, and a region with a scatter pattern in a plan view) on the inner surface of the bottom wall portion 2b. Therefore, there is a problem of cloudiness in the peripheral region b1, and if the peripheral region b1 overlaps with the information part 5j provided on the tablet 5, there is still a problem in understanding the content of the information part 5j.

The present invention was made in view of the above circumstances, and an object of the present invention is to provide a method of manufacturing a PTP sheet that can more reliably prevent the occurrence of obstacles to understanding the content of the information section due to the cloudiness of the bottom wall. [Means to solve the problem]

Hereinafter, each means suitable for solving the above objects will be described item by item. In addition, a specific function and effect is added after the corresponding means as necessary.

Means 1. A method for manufacturing a PTP sheet, the PTP sheet has: a container film forming a pocket for receiving the tablet; and a covering film attached to the container film in such a manner as to plug the opening of the bag portion; The tablet accommodated in the pocket is an orally disintegrating tablet that is circular in plan view and has a predetermined information portion formed on at least the surface, and The above pocket has: The bottom wall, which is circular when viewed from above, is opposite to the above-mentioned surface of the tablet to be accommodated, and is in a curved shape protruding outward; a cylindrical side wall portion connected to the outermost peripheral portion of the bottom wall portion; The manufacturing method of the PTP tablet is characterized in that the above-mentioned information part is provided in an information-imparting area on the above-mentioned surface of the tablet, and the information-imparting area is divided by a circle centered on the center of the surface when the tablet is viewed from above; The manufacture method of this PTP sheet comprises: A pocket portion forming step of forming the pocket portion on the strip-shaped container film; The filling process is to fill the tablet provided with the above-mentioned information part into the above-mentioned bag part, In the pocket portion forming step, the following requirements (1) and (2) are satisfied, and the pocket portion is formed such that the distance from the center of the surface of the tablet to the center of the pocket portion in plan view is Δc (mm) when the tablet accommodated in the pocket portion moves to the maximum toward the side wall portion; In the above-mentioned filling process, the tablet provided with the above-mentioned information part is filled in the above-mentioned bag part; The distance Δc satisfies the following necessary condition (3): (1) The depth of the pocket is not larger than the diameter of the surface of the tablet; (2) The inner surface of the bottom wall portion on the side of the tablet accommodated in the pocket has a peripheral region and a central region, the peripheral region is a region that may come into contact with the surface of the tablet accommodated in the pocket, and has a circular ring shape in plan view, and the central region is a region separated from the surface of the tablet, surrounded by the peripheral region, and circular in plan view; (3) When φRp (mm) is the diameter of the information-applied region and rc (mm) is the radius of the central region in plan view, Δc≦rc-(φRp/2).

According to the above means 1, in the pocket forming step, pockets satisfying Δc≦rc-(φRp/2) are formed. That is, in the formed pocket, the maximum movement distance (distance Δc) of the tablet from the state where the central axis of the pocket coincides with the central axis of the tablet is equal to or less than the distance (rc-(φRp/2)) from the outer edge of the information imparting region to the outer edge of the central region in the state where both central axes coincide. Therefore, even when the tablet (information imparting region) moves to the maximum (distance Δc) from the state where both central axes coincide, the information imparting region can be prevented from protruding from the central region in plan view. Thus, even if the tablet moves to the maximum extent in the pocket, the information-applied area does not overlap with the peripheral area where cloudiness may occur, and the entire information-apply area overlaps with the central area where cloudiness is less likely to occur. Therefore, even if the peripheral area becomes cloudy, the information part can be recognized through the clear central area. As a result, it is possible to more reliably prevent the occurrence of obstacles in grasping the content of the information department due to cloudiness.

In addition, in the obtained PTP sheet, the contact of the information imparting region with respect to the bottom wall can be more reliably prevented. Thereby, it is possible to effectively suppress the loss of the information portion caused by the contact with the bottom wall portion.

Means 2. The method for producing a PTP sheet according to Means 1, wherein Δc=rc-(φRp/2) is satisfied.

According to the above means 2, the maximum distance Δc can be ensured under the condition that the information imparted area does not overlap with the peripheral area. Therefore, in a state where the central axis of the pocket coincides with the central axis of the tablet, a large distance from the side wall of the pocket to the tablet can be ensured. Accordingly, in the filling step, the filling of the tablet into the pocket can be performed more easily and more reliably.

Means 3. A method for manufacturing a PTP sheet, the PTP sheet comprising: a container film, the container film is formed with a pocket for containing the tablet; a covering film attached to the container film in such a manner as to plug the opening of the bag portion; The tablet accommodated in the pocket is an orally disintegrating tablet that is circular in plan view and has a predetermined information portion formed on at least the surface, and The above pocket has: The bottom wall, which is circular when viewed from above, is opposite to the above-mentioned surface of the tablet to be accommodated, and is in a curved shape protruding outward; a cylindrical side wall portion connected to the outermost peripheral portion of the bottom wall portion, The manufacturing method of this PTP sheet is characterized in that the above-mentioned bag part satisfies the following necessary conditions (1) and (2); The manufacture method of this PTP sheet comprises: The manufacturing process of the information part, the above-mentioned information part is provided on at least the above-mentioned surface of the tablet; and Filling process, filling the tablet provided with the above-mentioned information part into the above-mentioned bag part; In the manufacturing process of the above-mentioned information portion, the above-mentioned information portion is provided in an information-imparting area on the above-mentioned surface of the tablet, and the information-imparting area is divided by a circle having a diameter φRp (mm) centered on the center of the surface when the tablet is viewed from above; In the above-mentioned filling process, the tablet provided with the above-mentioned information part in the above-mentioned information part forming process is filled in the above-mentioned bag part; The diameter φRp satisfies the following necessary condition (3): (1) The depth of the pocket is not larger than the diameter of the surface of the tablet; (2) The inner surface of the bottom wall portion on the side of the tablet accommodated in the pocket has a peripheral region and a central region, the peripheral region is a region that may come into contact with the surface of the tablet accommodated in the pocket, and has a circular ring shape in plan view, and the central region is a region separated from the surface of the tablet, surrounded by the peripheral region, and circular in plan view; (3) In the case where the tablet moves to the side of the side wall to the maximum extent in the pocket, the distance from the center of the surface of the tablet to the center of the pocket in plan view is Δc (mm), and the radius of the central region in plan view is rc (mm), φRp≤(rc-Δc)×2.

According to the above means 3, in the information part production process, the information part is provided so as to satisfy φRp≤(rc-Δc)×2. Here, (rc-Δc)×2 corresponds to the diameter of an imaginary circle passing through a position separated by a distance Δc from the outer edge of the central region toward the center side of the central region. Furthermore, the virtual circle does not protrude beyond the central region even when it moves by a distance Δc in a plan view.

Therefore, by satisfying φRp≦(rc−Δc)×2, the information provision region can be set to a region that coincides with the above-mentioned virtual circle or a region located inside the virtual circle. Thus, even if the tablet moves to the maximum (distance Δc) in the pocket, the information-applied area does not overlap with the peripheral area where cloudiness may occur, and the entire information-added area overlaps with the central area where cloudiness is less likely to occur. Therefore, even if cloudiness occurs in the peripheral area, the information section can be recognized through the clear central area. As a result, it is possible to more reliably prevent the occurrence of obstacles in grasping the content of the information department due to cloudiness.

In addition, in the obtained PTP sheet, the contact between the information imparting region and the bottom wall can be more reliably prevented. Thereby, it is possible to effectively suppress the loss of the information portion caused by the contact with the bottom wall portion.

Means 4. The method for producing a PTP sheet according to means 3, wherein φRp=(rc-Δc)×2 is satisfied.

According to the above means 4, the diameter φRp can be ensured to the maximum under the condition that the information imparting area does not overlap with the peripheral area. Therefore, the visibility of the information section can be sufficiently ensured, and the information section can have a larger amount of information.

Means 5. The method of manufacturing a PTP sheet according to any one of means 1 to 4, which includes an information position determination step of performing a pass/fail judgment on whether the information portion is placed in the information imparting area after the information portion production step.

According to the above means 5, in the information position judging step, a pass/fail judgment is performed on whether or not an information unit is installed in the information providing area. Then, the tablet whose information part may overlap with cloudiness, and the PTP sheet containing this tablet can be discharged as a defective product. Thereby, in the manufactured PTP sheet, the effect of the said means 1 etc. can be exhibited more reliably.

[Mode for Carrying Out the Invention]

Hereinafter, one embodiment will be described with reference to the drawings. First, the configuration of the PTP slice will be described. As shown in FIGS. 1 and 3 , the PTP sheet 1 has a container film 3 having a plurality of pockets 2 and a cover film 4 attached to the container film 3 so as to close the pockets 2 .

The container film 3 is formed through a transparent or translucent thermoplastic resin material made of, for example, PP (polypropylene), PVC (polyvinyl chloride), and has light transmission. That is, the container film 3 can recognize the inside of the bag part 2 from the outside. In addition, the container film 3 is formed to extend outward from the opening-side end of the bag portion 2 , and has a flat flange portion 3 a to which the cover film 4 is attached.

The covering film 4 is made of, for example, an opaque material (such as aluminum foil) on the surface of which a sealant made of PP resin or the like is provided. In addition, the material of each film 3, 4 is not limited to this, The material of each film 3, 4 can also be changed suitably.

The PTP sheet 1 is manufactured by punching a strip-shaped PTP film 6 (see FIG. 2 ) formed of a strip-shaped container film 3 and a strip-shaped cover film 4 into a sheet, and is formed in a substantially rectangular shape in plan view.

In the PTP sheet 1 , a pocket line composed of five pocket portions 2 arranged in the long side direction forms two rows in the short side direction. That is, a total of 10 pockets 2 are formed. One tablet 5 is accommodated in each bag portion 2 . In addition, a more detailed configuration of the PTP sheet 1 will be described later.

Next, the schematic structure of the PTP packaging machine 10 for manufacturing the said PTP sheet 1 is demonstrated.

As shown in FIG. 7 , on the most upstream side of the PTP packaging machine 10 , the raw material roll of the strip-shaped container film 3 is wound in a roll shape. The pull-out end side of the container film 3 wound in a roll shape is guided by guide rollers 12 and 13 . The container film 3 is hanged on the intermittent conveying roller 14 on the downstream side of the guide rollers 12 and 13 . The intermittent conveying roller 14 is connected to a motor that rotates intermittently, and conveys the container film 3 intermittently.

Between the guide roller 13 and the intermittent conveyance roller 14, along the conveyance path of the container film 3, a heating device 15 and a pocket portion forming device 16 are provided in this order.

The heating device 15 preheats the container film 3 immediately upstream of the pocket forming device 16 . The pocket forming device 16 forms a plurality of pockets 2 at predetermined positions on the container film 3 that has been heated by the heating device 15 and is in a relatively soft state. The formation of the bag portion 2 is performed at intervals during the operation of conveying the container film 3 by the intermittent conveying rollers 14 . In addition, the more detailed structure of the pocket part forming apparatus 16 is demonstrated later.

The container film 3 sent out from the intermittent conveyance roll 14 is hung on the guide roll 17, the tension roll 18, and the film support roll 20 in this order. Since the film support roller 20 is connected to a motor that rotates at a constant speed, the container film 3 is conveyed continuously at a constant speed. The tension roller 18 is in a state of stretching the container film 3 to the tensioned side through the elastic force, preventing the container film 3 from slack due to the difference in the conveying action of the intermittent conveying roller 14 and the film support roller 20, and keeping the container film 3 in a tensioned state all the time.

Between the guide roller 19 and the film support roller 20 , along the conveyance path of the container film 3 , a print filling device 21 and an inspection device 22 are arranged in this order.

The printing filling device 21 provides an information portion 5 j described later on the tablet 5 and fills the tablet 5 provided with the information portion 5 j in the bag portion 2 . The print filling device 21 will be described in detail later.

The inspection device 22 conducts inspections mainly related to defective tablets, such as whether the tablets 5 are reliably filled in the pockets 2 , whether there is an abnormality in the tablets 5 , and whether foreign matter is mixed into the pockets 2 .

On the other hand, the raw material roll of the coating film 4 formed in the shape of a belt is wound in a roll shape on the most upstream side. The drawn end of the coating film 4 wound in a roll is guided to the heat roller 25 side through the guide roller 24 .

The heating roll 25 can be pressure-contacted to the above-mentioned film backup roll 20 so that the container film 3 and the coating film 4 are fed between the two rolls 20 and 25 . In addition, the two films 3 and 4 are passed between the two rollers 20 and 25 in a heat-compression bonded state, whereby the cover film 4 is attached to the container film 3 and the bag portion 2 is plugged with the cover film 4 . Thereby, the strip-shaped PTP film 6 in which the tablet 5 is accommodated in each bag part 2 is obtained.

The PTP film 6 sent out from the film support roll 20 is wound around the tension roll 27 and the intermittent feed roll 28 in this order. Since the intermittent conveyance roller 28 is connected to the intermittently rotating motor, the PTP film 6 is conveyed intermittently. The tension roller 27 is in a state of stretching the PTP film 6 to the tensioned side through the elastic force, and prevents the PTP film 6 from loosening due to the difference in the conveying action of the above-mentioned film support roller 20 and the intermittent conveying roller 28, and keeps the PTP film 6 in a tensioned state all the time.

The PTP film 6 sent out from the intermittent feed roll 28 is wound around the tension roll 31 and the intermittent feed roll 32 in this order. Since the intermittently conveying roller 32 is connected to the intermittently rotating motor, the PTP film 6 is conveyed intermittently. The tension roller 31 is in a state of stretching the PTP film 6 to the side tensioned by elastic force, and prevents the PTP film 6 from loosening between the intermittent conveying rollers 28 and 32 .

Between the intermittent conveyance roller 28 and the tension roller 31, along the conveyance path of the PTP film 6, the slit forming apparatus 33 and the marking apparatus 34 are arrange|positioned in this order. The slit forming device 33 has a function of forming a slit for cutting at a predetermined position of the PTP film 6 . The marking device 34 has a function of providing a marking on a predetermined position (for example, a label portion) of the PTP film 6 . In addition, in FIG. 1, illustration of a slit and a marking is abbreviate|omitted.

The PTP film 6 sent out from the intermittent feed roll 32 is wound on the tension roll 35 and the continuous feed roll 36 sequentially on the downstream side. Between the intermittent conveyance roller 32 and the tension roller 35 , along the conveyance path of the PTP film 6 , a sheet punching device 37 is provided. The sheet punching device 37 cuts (punches) the outer edge of the PTP film 6 into one PTP sheet. Thereby, PTP sheet 1 was obtained.

The obtained PTP sheet 1 is transported by the conveyor 39 and temporarily stored in the finished product hopper 40 . However, when the inspection device 22 judges that it is defective, the judged PTP sheet 1 is not sent to the finished product hopper 40, but is discharged separately by the defective sheet discharge mechanism not shown in the figure.

A cutting device 41 is arranged on the downstream side of the continuous conveyance roller 36 . The unnecessary film portion 42 remaining in a strip shape after being punched out by the sheet punching device 37 is guided by the tension roller 35 and the continuous feed roller 36 , and then guided to the cutting device 41 . The cutting device 41 cuts the unnecessary film portion 42 into a predetermined size. Unnecessary film parts 42 (scrap) after cutting are stored in the hopper 43 for waste, and are disposed of separately.

Next, a more detailed configuration of the PTP sheet 1 will be described with reference to FIGS. 3 to 6 . 3 is a cross-sectional view of the bag portion 2 and the like in a state where the center axis Lt of the tablet 5 coincides with the center axis Lp of the bag portion 2 . FIG. 4 is a plan view (bottom view) of the tablet 5 . FIG. 5 is a cross-sectional view of the bag portion 2 and the like for showing the radius of curvature CRp and the like. 6 is a diagram for explaining the peripheral area b1 and the central area b2, etc., showing a cross-sectional view of the bag portion 2, etc., and a bottom view of the inner surface of the bottom wall portion 2b viewed along the central axis Lp. First, the tablet 5 accommodated in the pocket part 2 is demonstrated.

Tablet 5 is an orally disintegrating tablet configured to rapidly dissolve through saliva or a small amount of water. The tablet 5 has a circular shape in plan view, that is, a circular shape when viewed in the direction of the central axis Lt.

In addition, the tablet 5 constitutes an outer surface through the side surface 5a, the surface 5b and the back surface 5c sandwiching the side surface 5a. The side surface 5a has a cylindrical shape having a constant outer diameter along the central axis Lt direction. On the other hand, each of the front surface 5b and the back surface 5c has a curved surface shape protruding outward, and is continuous with the end of the side surface 5a. In this embodiment, each shape of the surface 5b and the back surface 5c is the same, however, the surface 5b refers to the surface provided in the bottom wall part 2b side of the bag part 2 mentioned later.

In addition, the diameter φt (mm) of the surface 5 b of the tablet 5 is equal to or greater than the depth Dp (mm) of the pocket portion 2 . In addition, in the present embodiment, the diameter φt is set to be twice or more the depth Dp. In other words, assuming that Dp≦φt/2 is satisfied, the depth Dp is sufficiently smaller than the diameter φt. However, of course, the depth Dp is set larger than the maximum thickness of the tablet 5 (the distance between the surface 5b and the back surface 5c on the central axis Lt). In addition, the diameter φt is usually set to 5 to 15 mm.

In addition, the outline of the surface 5 b of the tablet 5 in any cross section including the central axis Lt of the tablet 5 has a constant radius of curvature CRt (mm). That is, the surface 5b of the tablet 5 has a spherical shape with a constant radius of curvature CRt (mm) (however, recesses such as dividing lines and engravings are ignored). In this embodiment, the radius of curvature CRt is equal to or larger than the diameter φt, and the center of the surface 5b is in a state in which it does not protrude excessively from the outermost peripheral portion of the surface 5b along the central axis Lt direction. On the other hand, the radius of curvature CRt is, for example, set to be equal to or smaller than diameter φt×5, and the corner portion from the surface 5b to the side surface 5a has a sufficiently large obtuse angle. Thereby, even if the tablet 5 is a relatively brittle orally disintegrating tablet, it is possible to suppress the above-mentioned corner portion from being chipped.

Furthermore, on the surface 5b and the back surface 5c of the tablet 5, an information portion 5j is formed, and the information portion 5 is inkjet printed with characters, symbols, numbers, graphics, etc. representing product information related to the tablet 5. The product information of tablet 5 includes "product name", "content", "dosage form", "manufacturer" and "lot number". The information portion 5j is a portion on the tablet 5 on which characters, numerals, etc. are printed, and is formed by the printing and filling device 21 described above in the present embodiment. In addition, the respective information parts 5j on the front surface 5b and the back surface 5c may have the same content or different content.

In addition, at least the information part 5j in the surface 5b is provided in the information provision area 5k. The information imparting area 5k is an area demarcated by a circle with a diameter φRp (mm) centered on the center of the tablet 5 when the tablet 5 is viewed from above (a circle indicated by a chain line of two dots in FIG. 4 ) on the surface 5b of the tablet 5. In this embodiment, a certain range of the surface 5b of the tablet 5 is set as the information provision area 5k. In addition, in order to sufficiently secure the area of the information imparting region 5k, it is preferable to satisfy φRp≥φt/4, more preferably to satisfy φRp≥φt/3.

Next, the pocket part 2 which accommodates the tablet 5 is demonstrated. The bag portion 2 includes a cylindrical side wall portion 2a protruding from the flange portion 3a and a bottom wall portion 2b connected to an end portion of the side wall portion 2a and having a substantially circular shape in plan view.

The side wall portion 2 a has a substantially constant inner diameter along the central axis Lp direction of the bag portion 2 , and the inner diameter of the side wall portion 2 a is larger than the diameter φt of the surface 5 b of the tablet 5 . Thereby, in the state where the tablet 5 is placed inside the bag portion 2 so that the two central axes Lp and Lt overlap, the entire inner surface of the side wall portion 2a is separated from the entire area of the side surface 5a of the tablet 5, and an annular gap in plan view is formed between the inner surface of the side wall portion 2a and the side surface 5a. Thereby, when a load is applied to the side wall portion 2a, the tablet 5 can be moved so as to be released from the load, and breakage of the tablet 5 can be more reliably prevented.

In addition, the side wall part 2a may have a tapered shape whose inner diameter gradually decreases toward the bottom wall part 2b side. Even in this case, the state where the tablet 5 is placed in the bag portion 2 so that the two central axes Lp, Lt overlap, is preferably a state where the entire inner surface of the side wall portion 2a is separated from the entire side surface 5a of the tablet 5.

The bottom wall portion 2b has a curved shape that protrudes outward. In addition, the outline of the inner surface of the bottom wall portion 2b (the surface on the side of the tablet 5 housed in the bag portion 2 ) in any cross section including the central axis Lp has a constant radius of curvature CRp (mm). That is, the inner surface of the bottom wall portion 2b is formed in a spherical shape having a constant curvature radius CRp (mm).

Furthermore, the radius of curvature CRp is smaller than the radius of curvature CRt of the surface 5 b of the tablet 5 . In addition, by adjusting the relative shape of the pocket portion 2 to the shape of the tablet 5 while setting the radius of curvature CRp in this way, the inner surface of the bottom wall portion 2b has a peripheral region b1 and a central region b2 (see FIG. 6 ). In addition, in the cross-sectional view of FIG. 6 , the tablet 5 moving while changing its posture inside the bag portion 2 is shown by a two-dot chain line.

The peripheral area b1 is an area likely to come into contact with the surface 5b of the tablet 5 accommodated in the pocket 2, and is an annular area in plan view (that is, an annular area when viewed in the direction of the central axis Lp). Therefore, cloudiness due to adhesion of components of the tablet 5 may occur in the peripheral region b1. In the bottom view of Fig. 6, there is a scatter pattern in the peripheral region b1. In the present embodiment, the peripheral region b1 is a region extending to the outer edge of the bottom wall portion 2b. However, depending on the shape of the pocket portion 2 relative to the shape of the tablet 5, the peripheral region b1 may not reach the outer edge of the bottom wall portion 2b.

The central region b2 is a region away from the surface 5b of the tablet 5, and is a circular region in plan view surrounded by the peripheral region b1. Since the central region b2 is basically a region that is unlikely to come into contact with the tablet 5, cloudiness hardly occurs in the central region b2. Therefore, the central region b2 functions as a so-called window when checking the tablet 5 in the pocket portion 2 .

In addition, the radius of the central region b2 in a planar view is rc (mm). The radius rc varies according to the relative shape of the pocket 2 to the shape of the tablet 5 . For example, the larger the difference between the curvature radius CRp of the bottom wall portion 2b and the curvature radius CRt of the surface 5b, the larger the radius rc is. On the other hand, the radius rc tends to be smaller as the distance between the side wall portion 2 a and the side surface 5 a in a state where the two central axes Lp and Lt overlap is larger. In this embodiment, in order to secure a sufficiently wide central region b2, rc≧φp×0.2 is satisfied when the diameter of the outermost edge of the inner surface of the bottom wall portion 2b is φp (mm). The diameter φp varies according to the diameter φt of the tablet 5, and is, for example, 6 to 20 mm.

In addition, in terms of easier confirmation of the tablet 5 through the central region b2, the larger the radius rc, the better. Therefore, it is more preferable to satisfy rc≧φp×0.25, and it is still more preferable to satisfy rc≧φp×0.3.

In addition, the bag portion 2 is configured such that the distance from the center of the surface 5b in plan view to the center of the bag portion 2 (central axis Lp) is Δc (mm) when the stored tablet 5 moves to the maximum toward the side wall portion 2a side. Regarding the distance Δc, 0<Δc≦rc-(φRp/2) is satisfied, and in particular, in the present embodiment, Δc=rc-(φRp/2) is satisfied.

The distance Δc varies depending on the relative shape of the pocket portion 2 to the shape of the tablet 5 such as the size of the gap formed between the side wall portion 2 a and the side portion 5 a. In this embodiment, Δc≧0.2 is satisfied in consideration of the ease of filling the bag portion 2 with the tablet 5 .

In addition, the larger the distance Δc is, the easier it is to fill the pocket portion 2 with the tablets 5 , and high-speed filling of the tablet 5 into the pocket portion 2 becomes possible. Therefore, it is more preferable to configure so that Δc≧0.5 can be satisfied.

However, in order to provide the central region b2, it is necessary to satisfy Δc<rc. In addition, since the smaller Δc is, the larger the radius rc of the central region b2 can be. Therefore, it is preferable to satisfy Δc≤φp×0.15, more preferably to satisfy Δc≤φp×0.10.

Next, the pocket forming device 16 will be described. In addition, in the present embodiment, when a certain range of the surface 5b is set as the information imparting area 5k, the pocket forming device 16 forms the pocket 2 in a shape matching the information imparting area 5k.

As shown in FIG. 8 , the bag portion forming device 16 includes a lower mold 161 and an upper mold 162 which are fixedly provided. The upper mold 162 can move up and down and can sandwich the container film 3 between the upper mold 161 and the lower mold 161 .

A plurality of holes 161 a are formed in the lower die 161 . In addition, at a position corresponding to the hole 161a, a plug 163 functioning as a mold for forming the bag portion 2 is provided.

The plug 163 is movable up and down, and can be inserted into the hole 161a. The plug 163 forms the bag portion 2 by pushing up the container film 3 . Regarding the shape of the plug 163, the inner surface of the bottom wall portion 2b has a peripheral area b1 and a central area b2 due to the relationship with the tablet 5 to be accommodated, and can form a pocket portion 2 satisfying Δc≤rc-(φRp/2) (in this embodiment, Δc=rc-(φRp/2)). In addition, the plug 163 can be replaced according to a change of the tablet 5 accommodated in the bag part 2, etc. FIG.

On the other hand, a hole 162 a is formed in a portion of the upper mold 162 vertically above the hole 161 a. Furthermore, predetermined air may be supplied to the hole 162a from an air supply device not shown in the figure.

The bag portion forming device 16 configured as described above forms the bag portion 2 as follows. That is, when the upper die 162 set at a predetermined initial position moves downward, the two dies 161, 162 pinch the periphery of the part to be formed of the bag portion 2 of the temporarily stopped container film 3 as shown in FIG. 9 . In addition, the plug 163 arranged at a predetermined initial position moves upward, is inserted through the hole 162a, and temporarily stops at a predetermined position.

Then, as shown in FIG. 10 , the container film 3 is temporarily deformed on the side (lower side) opposite to the protruding side (upper side) of the bag portion 2 by supplying air to the hole 162 a. At this time, the permeable container film 3 is in contact with the upper surface of the plug 163 to limit the amount of deformation of the container film 3 .

Next, as shown in FIG. 11 , by restarting the upward movement of the plug 163 , the upper surface of the plug 163 is protruded from the inner side toward the outer side of the container film 3 . Thereby, the container film 3 is squeezed and deformed through the plug 163 . In addition, the bag portion 2 is formed by stopping the plug 163 at a predetermined position. The pocket portion 2 formed has a depth Dp equal to or less than the diameter φt of the surface 5b due to the relationship with the tablet 5 to be accommodated, and the inner surface of the bottom wall portion 2b has a peripheral region b1 and a central region b2. In addition, the formed pocket 2 satisfies Δc≦rc-(φRp/2) (in this embodiment, Δc=rc-(φRp/2)) in relation to the stored tablet 5 .

In addition, the supply of air to the hole 162a is continued until the plug 163 presses and deforms the container film 3 and stops. Thereby, the container film 3 is more reliably adhered to the plug 163, and the bag portion 2 satisfying Δc≦rc-(φRp/2) and the like can be more reliably formed in relation to the stored tablet 5 .

In addition, after the bag portion 2 is formed, by moving the plug 163 downward and moving the upper mold 162 upward, the waiter is returned to the initial position. In the present embodiment, the step of forming the bag portion 2 by the bag portion forming device 16 corresponds to the “pocket portion forming step”.

Next, the print filling device 21 will be described. As shown in FIG. 12 , the printing and filling device 21 includes a storage unit 211 , a supply chute 212 , a first rotating cylinder 213 a , a second rotating cylinder 213 b , and a third rotating cylinder 213 c sequentially from the upstream side along the supply path of the tablet 5 . The printing filling device 21 has a first camera 214 and a first printing device 215 corresponding to the first rotating drum 213a, a second camera 216 and a second printing device 217 corresponding to the second rotating drum 213b, and an inspection camera 218 corresponding to the third rotating drum 213c. In addition, each mechanism unit (supply chute 212 , rotary cylinders 213 a , 213 b , 213 c , cameras 214 , 216 , 218 , printing devices 215 , 217 ) of the printing filling device 21 is controlled and driven by the control device 219 .

The storage unit 211 is configured to store a plurality of tablets 5 , and supplies the stored tablets 5 to the supply chute 212 sequentially. On the tablet 5 stored in the storage part 211, the information part 5j is not provided.

The supply chute 212 has a cylindrical shape and stores the tablets 5 in a line in the vertical direction. The supply chutes 212 are provided in the same number (five in the present embodiment) as the number of rows of the bag portions 2 arranged in the longitudinal direction of the container film 3 . A shutter 212 a capable of opening and closing is provided at the lower opening of the supply chute 212 , and the tablets 5 are supplied toward the first rotating drum 213 a by opening and closing the shutter 212 a.

Each of the rotating drums 213a, 213b, and 213c has the same configuration, and conveys the tablet 5 downstream by rotating while absorbing the tablet 5 . A plurality of adsorption parts 213d are provided on the outer peripheries of the respective rotary cylinders 213a, 213b, and 213c. The adsorption units 213d are arranged in the circumferential direction of the rotary cylinders 213a, 213b, and 213c, and the rows of the adsorption units 213d arranged in the circumferential direction are provided in the same number as the number of rows of the pockets 2 (five rows in this embodiment). In addition, negative pressure can be supplied to the suction part 213d, and the tablet 5 can be suctioned through the suction part 213d supplied with the negative pressure. On the other hand, by stopping the supply of negative pressure to the adsorption unit 213d, the adsorption of the tablet 5 by the adsorption unit 213d can be released.

The first rotating drum 213a, the second rotating drum 213b, and the third rotating drum 213c are arranged in this order from upstream to downstream. The tablet 5 is transferred from the first rotating drum 213a to the second rotating drum 213b, and then transferred from the second rotating drum 213b to the third rotating drum 213c. The delivery of the tablet 5 is carried out by releasing the suction of the tablet 5 through the rotary drums 213a, 213b on the upstream side, and by suctioning the tablet 5 through the rotary drums 213b, 213c on the downstream side.

In addition, when the rotary drums 213a, 213b, and 213c adsorb the tablet 5, they adsorb the surface 5b or the back surface 5c. In this embodiment, the 1st rotating cylinder 213a and the 3rd rotating cylinder 213c adsorb the back surface 5c, and the 2nd rotating cylinder 213b adsorbs the surface 5b. However, since there is no difference between the front and back of the tablet 5 supplied from the storage unit 211, it can be said that the surface sucked by the first rotating drum 213a and the third rotating drum 213c becomes the rear face 5c, and the surface sucked by the second rotating drum 213b becomes the front face 5b. Among the surface 5b and the back surface 5c, the non-adsorbed surface is in a state of being exposed on the outer peripheries of the rotary cylinders 213a, 213b, and 213c.

In addition, the third rotating drum 213c releases the suction of the tablet 5 vertically below the rotating shaft. Thereby, the tablet 5 is filled in the bag part 2 . The step of filling the tablet 5 by the third rotary drum 213c corresponds to the "filling step".

The cameras 214, 216, and 218 are constituted by, for example, CCD cameras, CMOS cameras, etc., and take pictures of the conveyed tablets 5 . The imaging range of each camera 214, 216, 218 is a range capable of imaging five tablets 5 (adsorption part 213d) arranged in the axial direction of each rotary drum 213a, 213b, 213c at one time.

The first camera 214 is located upstream of the first printing device 215, and captures images of the surface 5b of the tablet 5 to obtain image data of the surface 5b. This image data is used to specify the printing range of the tablet 5 of the first printing device 215 .

The second camera 216 is located upstream of the second printing unit 217, and takes an image of the back surface 5c of the tablet 5 to obtain image data of the back surface 5c. This image data is used to specify the printing range of the tablet 5 by the second printing device 217 .

The inspection camera 218 is located downstream of the first printing unit 215, and images the surface 5b of the tablet 5 to obtain image data of the surface 5b. This image data is used for inspection of the information portion 5j printed on the surface 5b. The image data acquired by each camera 214 , 216 , 218 are fed into a control device 219 .

Each of the printing devices 215 and 217 is a known tablet printing device capable of non-contact printing on the tablet 5 using a predetermined inkjet method (for example, piezoelectric or thermal) printing head. Each of the printing devices 215 and 217 includes five print heads (not shown) corresponding to the five suction units 213d (tablets 5 ) arranged in the axial direction of the rotary cylinders 213a and 213b. Each print head has a plurality of nozzles (not shown). Next, information such as characters and symbols are printed on the tablet 5 by ejecting droplets of the edible ink from the nozzles. Nozzles for ejecting ink are selected by the control unit 219 .

The first printing unit 215 is arranged at a position lateral to the first rotary drum 213a. The first printing device 215 ejects ink toward the surface 5b of the tablet 5 conveyed through the first rotary drum 213a, and prints on the surface 5b in a non-contact manner. Thereby, the information portion 5j is formed on the surface 5b of the tablet 5 .

On the other hand, the printing device 217 is arranged at a position lateral to the second rotary drum 213b. The second printing device 217 ejects ink toward the back surface 5c of the tablet 5 conveyed by the second rotary drum 213b, and prints on the back surface 5c in a non-contact manner. Thereby, the information part 5j is formed in the back surface 5c of the tablet 5. As shown in FIG.

The control device 219 has a CPU as an arithmetic unit, a ROM for storing various programs, a RAM for temporarily storing various data, a storage medium (for example, a hard disk, etc.) for long-term storage of information, and the like. Printed data (data related to printed content) for forming the information part 5j, data related to the information provision area 5k (for example, data required for specifying the information provision area 5k), inspection data for inspection of the information part 5j, etc. are stored in advance in the storage medium.

The control device 219 controls the first printing device 215 so as to print the information part 5j in the information provision area 5k of the surface 5b based on the data related to the above information provision area 5k, the image data obtained by the first camera 214, and the like. Specifically, the control device 219 uses the image data obtained by the first camera 214 and the data related to the information-added area 5k to specify the information-added area 5k on the tablet 5 to be printed. Then, the control device 219 selects nozzles for ejecting ink using the specified information-imparted area 5k and printing data. On top of this, the control device 219 ejects ink from the selected nozzles to the tablet 5 to be printed at a predetermined printing timing. Thereby, the information part 5j can be formed in the information provision area 5k of the surface 5b. In this embodiment, the process of providing the information part 5j in the information provision area 5k on the surface 5b by the 1st printing apparatus 215 corresponds to "information part preparation process".

In addition, the control device 219 controls the second printing device 217 so that the information portion 5j is printed in a predetermined print target area of the back surface 5c based on the image data obtained by the second camera 216 and the like. In addition, regarding the information portion 5j formed on the back surface 5c, there is no limitation that it is formed in the information imparting region 5k. Therefore, the printing target area of the information part 5j of the back surface 5c can be made wider than the information provision area 5k.

Furthermore, the control device 219 performs a pass/fail judgment on whether or not the information part 5j on the surface 5b is provided in the information providing area 5k based on the above-mentioned inspection data and the image data obtained by the inspection camera 218 . Specifically, the control device 219 specifies the center of the surface 5b of the tablet 5 from the image data obtained by the inspection camera 218, and specifies an area located at a certain distance or less from the center as the information-added area 5k. Then, the control device 219 judges whether or not the information part 5j is provided in the information providing area 5k by determining whether or not the entirety of the information part 5j is contained in the specified information providing area 5k. In the present embodiment, the process of performing the pass/fail judgment on whether or not the information part 5j is provided in the information providing area 5k by the control device 219 corresponds to the "information position judgment process".

In addition, when the defective judgment is set by the control device 219, the PTP tablet 1 containing the tablet 5 judged to be defective is discharged by the above-mentioned defective tablet discharge mechanism.

As described above, according to the present embodiment, in the step of forming the pocket 2 , the pocket 2 satisfying Δc≦rc-(φRp/2) is formed. That is, as shown in FIG. 13 and FIG. 14 , in the formed pocket 2, the maximum moving distance (distance Δc) of the tablet 5 from the state where the two central axes Lp, Lt are aligned is equal to or less than the distance (rc-(φRp/2)) from the outer edge of the information imparting region 5k in the state where the two central axes Lp, Lt are aligned to the outer edge of the central region b2. In addition, in FIG. 13 and FIG. 14 , the upper side shows a bottom view of the bottom wall portion 2b and the like when the two central axes Lp and Lt are aligned, and the lower side shows a bottom view of the bottom wall portion 2b when the tablet 5 is moved by a distance Δc. In addition, in FIG. 13 , Δc=rc-(φRp/2), and in FIG. 14 , Δc<rc-(φRp/2).

Therefore, even if the tablet 5 (information imparting area 5k) is set to move to the maximum (distance Δc) from the state where the two central axes Lp and Lt coincide, the information imparting area 5k does not come out of the central area b2 when viewed from above. Thereby, even when the tablet 5 moves to the maximum inside the bag portion 2, the information imparting region 5k does not overlap the peripheral region b1 where cloudiness may occur, and the entire information imparting region 5k overlaps the central region b2 where cloudiness is unlikely to occur. Therefore, even when cloudiness occurs in the peripheral region b1, the information portion 5j can be confirmed through the clear central region b2. As a result, it is possible to more reliably prevent the occurrence of obstacles in grasping the contents of the information section 5j due to cloudiness.

Furthermore, by satisfying Δc=rc-(φRp/2), the maximum distance Δc can be ensured under the condition that the information-applied region 5k does not overlap with the peripheral region b1. Therefore, a large distance from the side wall portion 2 a of the bag portion 2 to the tablet 5 can be ensured in a state where the two central axes Lp, Lt coincide. Thereby, in the process of filling the bag part 2 with the tablet 5, filling the bag part 2 with the tablet 5 can be performed more easily and more reliably.

In addition, in the obtained PTP sheet 1, it is possible to more reliably prevent the contact of the information portion 5j with the bottom wall portion 2b. Thereby, the loss of the information part 5j accompanying the contact with the bottom wall part 2b can be suppressed effectively.

In addition, in this embodiment, the pass/fail judgment regarding whether or not the information part 5j is provided in the information provision area 5k is performed. Therefore, the information part 5j can discharge the tablet 5 overlapped with cloudiness, and the PTP sheet 1 containing this tablet 5 as a defective product. Thereby, in the manufactured PTP sheet 1, it is possible to more reliably prevent the occurrence of hindrance in grasping the contents of the information portion 5j due to cloudiness.

In addition, it is not limited to the description content of the said embodiment, For example, you may implement as follows. Of course, other application examples and modified examples not shown below are also possible.

(a) In the above embodiment, the information adding area 5k is determined in advance, and the bag portion 2 corresponding to the information adding area 5k is formed in the pocket portion 2 forming step.

On the other hand, it can also be constructed in such a way that the shape of the bag portion 2 is determined in advance, and the information portion 5j is provided inside the information imparting region 5k corresponding to the shape of the bag portion 2 and the tablet 5 to be accommodated in the manufacturing process of the information portion 5j.

For example, the pocket portion 2 is predetermined, the depth Dp of the pocket portion 2 is equal to or less than the diameter φt of the surface 5b, and the inner surface of the bottom wall portion 2b has a peripheral region b1 that can be in contact with the tablet 5 and a central region b2 that is not in contact with the tablet 5. Thereby, the radius rc and the distance Δc of the central region b2 are determined. On this basis, in the manufacturing process of the information portion 5j, the first printing device 215 is controlled so that the information portion 5j is formed in the information imparting region 5k defined by a circle having a diameter φRp (mm) centered on the center of the surface 5b of the surface 5b of the tablet 5 and satisfying φRp≤(rc-Δc)/2. Thereby, the information part 5j can be provided in the information provision area 5k.

Here, as shown in FIG. 15 , (rc-Δc)×2 corresponds to the diameter of a virtual circle VC passing through a position separated by a distance Δc from the outer edge of the central region b2 toward the center side of the central region b2. This virtual circle VC does not appear outside the central region b2 even when it moves by a distance Δc in plan view. In addition, in FIG. 15 , a bottom view of the bottom wall portion 2b and the like when the central axes Lt and Lp are aligned are shown on the upper side, and a bottom view of the bottom wall portion 2b and the like when the tablet 5 and the virtual circle VC are moved by a distance Δc is shown on the lower side.

Therefore, by satisfying φRp≦(rc−Δc)×2, the information adding region 5k becomes a region that coincides with the virtual circle VC or is located inside the virtual circle VC. In addition, in FIG. 15, the information provision area 5k is set as the area located inside the virtual circle VC, and this information provision area 5k is hatched.

By setting the information-applied area 5k as described above, even when the tablet 5 moves to the maximum (distance Δc) inside the pocket 2, the information-applied area 5k does not overlap with the peripheral area b1 where cloudiness may occur, and the entire information-added area 5k overlaps with the central area b2 where cloudiness is unlikely to occur. As a result, similar to the above-described embodiment, it is possible to more reliably prevent the occurrence of hindrance in understanding the contents of the information section 5j due to cloudiness.

In addition, similarly to the above-mentioned embodiment, in the obtained PTP sheet 1, the loss of the information part 5j accompanying the contact with the bottom wall part 2b can be effectively suppressed.

In addition, regarding the diameter φRp, it is more preferable to configure so that φRp=(rc-Δc)/2 is satisfied. With such a configuration, the diameter φRp can be ensured to the maximum under the condition that the information imparting region 5k does not overlap with the peripheral region b1. Therefore, the visibility of the information section 5j can be sufficiently ensured, and the information section 5j can have a larger amount of information.

In addition, in order to secure the area of the information imparting region 5k, it is preferable to set the shapes of the bag portion 2 and the tablet 5 so as to satisfy φRp≥φt/4 (more preferably φRp≥φt/3).

(b) In the above-mentioned embodiment, the pass/fail judgment as to whether the information portion 5j is provided inside the information imparting area 5k is performed based on the image data of the tablet 5 before being filled in the pocket portion 2 . On the other hand, the above-mentioned pass/fail judgment may be performed based on the image data of the tablet 5 filled in the bag portion 2 . For example, the tablet 5 may be imaged through the bottom wall portion 2b of the bag portion 2, and the pass/fail determination may be performed based on the image data obtained through the image capture.

(c) In the above-mentioned embodiment, the front surface 5b and the back surface 5c of the tablet 5 each have a curved shape protruding outward, but the front surface 5b and the back surface 5c may also be flat surfaces. That is, the tablet 5 may be a flat ingot in which the surface 5b and the back surface 5c are parallel.

(d) In the above embodiment, the bag portion forming device 16 is configured to form the bag portion 2 by pressing the plug 163 against the container film 3 after temporarily deforming the container film 3 with air. That is, the pocket forming device 16 forms the pocket 2 using a so-called air-assisted plug molding method.

On the other hand, the bag portion forming device may have a mold for forming a molding recess having a shape corresponding to the bottom wall portion 2b, and the bag portion 2 may be formed by bringing the container film 3 into contact with the mold through air control or the like. In addition, the bag portion forming apparatus may form the bag portion 2 by merely abutting the plug against the container film without performing the step of deforming the container film 3 with air.

(e) In the above embodiment, when forming the information part 5j on the tablet 5, the inkjet printing devices 215 and 217 are used, however, printing devices other than the inkjet method may be used. For example, as a printing device, a device that performs printing by directly contacting the tablet 5 , a device that performs printing by irradiating the tablet 5 with a laser, or the like may be used.

In addition, the information part 5j may be formed by methods other than printing. For example, the information part can also be formed by imprinting in the tablet press process (process of manufacturing tablet 5).

(f) In the above-mentioned embodiment, the PTP packaging machine 10 is provided with the printing and filling device 21 , and has a function of forming the information portion 5 j on the tablet 5 . On the other hand, the PTP packaging machine 10 does not need to have the function of forming the information portion 5 j on the tablet 5 . Here, it can also be configured in such a way that instead of the printing filling device 21, a filling device having a function of filling the tablet 5 into the bag part 2 is provided, and the tablet 5 having the information portion 5j formed in advance in the information imparting area 5k is supplied to the filling device.

(g) In the above-mentioned embodiment, the filling of the bag portion 2 with the tablet 5 is carried out through the cartridge capable of absorbing the tablet 5 , but it may also be carried out through another filling device. For example, a filling device or the like may be used. The filling device includes a cylindrical chute for accommodating the tablets 5 in a row, and a shutter (not shown in the drawings) capable of opening and closing the outlet of the chute. By opening the shutter at a predetermined timing, the tablets 5 are filled in the bag portion 2.

(h) In the above-mentioned embodiment, by adjusting the size relationship between the radius of curvature CRp of the bottom wall portion 2b and the radius of curvature CRt of the surface 5b, etc., the inner surface of the bottom wall portion 2b is configured such that the peripheral region b1 that may be in contact with the tablet 5 and the central region b2 away from the tablet 5 are provided. On the other hand, it is also possible to form a configuration in which the peripheral region b1 and the central region b2 are provided on the inner surface of the bottom wall portion 2b by a method other than the above.

For example, as shown in FIG. 16, it may also be configured in such a manner that a bulging portion 2c that bulges outward and is separated from the surface 5b of the tablet 5 is provided at the central portion of the bottom wall portion 2b, whereby a peripheral region b1 and a central region b2 are provided on the inner surface of the bottom wall portion 2b.

(i) The structure of the produced PTP sheet can also be changed suitably within the range which does not deviate from the summary of this invention. For example, the arrangement and number of pockets 2 in one PTP sheet unit are not limited to the above-mentioned embodiments.

In addition, in the above-mentioned embodiment, the PTP film 6 has a structure in which the number of pockets 2 corresponding to one sheet is arranged along the width direction thereof, but, for example, a structure in which the number of pockets 2 corresponding to a plurality of sheets is arranged in the width direction thereof may also be used.

In addition, in the above-mentioned embodiment, the information part 5j was provided on the front surface 5b and the back surface 5c, but it may be provided only on the front surface 5b.

1:PTP film

2: Pocket

2a: side wall

2b: Bottom wall

3: container film

4: Cover the mask

5: Tablet

5b: Surface (of tablet)

5j: Department of Information

5k: information endowment area

b1: peripheral area

b2: central area

Δc: distance from the center of the surface of the tablet to the center of the pocket

rc: the radius of the central area when looking down

φRp: The diameter of the information endowed area

Lp: Central axis of pocket

Lt: Central axis of the tablet

Fig. 1 is the perspective view that represents PTP sheet; Figure 2 is a perspective view showing a PTP film; 3 is a partially enlarged cross-sectional view of a PTP sheet used to indicate the diameter of the surface of the tablet, etc.; 4 is a partially enlarged cross-sectional view of a PTP sheet for showing the radius of curvature of the surface of the tablet, etc.; Fig. 5 is a plan view of the tablet when viewed from the surface side; FIG. 6 is a diagram for explaining a peripheral area, a central area, and the like; Fig. 7 is a schematic diagram showing a schematic configuration of a PTP packaging machine; Fig. 8 is a schematic diagram of a pocket forming device; Fig. 9 is a diagram showing a process of clamping a container film by a lower mold and an upper mold in a bag forming process; Fig. 10 is a diagram showing a process of deforming a container film by air in a process of forming a bag portion; Fig. 11 is a diagram showing a step of deforming a container film by using a plug in a bag portion forming step; Fig. 12 is a schematic diagram showing a schematic configuration of a printing and filling device; 13 is a diagram for explaining the effect of forming a pocket portion satisfying Δc=rc-(φRp/2); 14 is a diagram for explaining the effect of forming a pocket portion satisfying Δc<rc-(φRp/2); FIG. 15 is a diagram for explaining the effect of setting an information part in an information imparting area satisfying φRp≤(rc-Δc)×2; Fig. 16 is a cross-sectional view of a pocket and the like in another embodiment; Fig. 17 is a diagram for explaining the prior art.

2: Pocket

2b: Bottom wall

5: Tablet

5b: Surface (of tablet)

5j: Department of Information

5k: information endowment area

b1: peripheral area

b2: central area

Δc: Distance from the center of the surface of the tablet to the center of the pocket (distance from the outer edge of the information-imparting area 5k in the state where the two central axes Lp, Lt coincide to the outer edge of the central area b2)

rc: the radius of the central area when looking down

Lt: Central axis of the tablet

Lp: Central axis of pocket

φRp: The diameter of the information endowed area

Claims (5)

A method for manufacturing a PTP sheet, the PTP sheet has: a container film forming a pocket for receiving the tablet; and a covering film attached to the container film so as to close the opening of the bag portion, The tablet accommodated in the pocket portion is an orally disintegrating tablet that is circular in plan view and has a predetermined information portion formed on at least the surface, and, The above pocket has: a bottom wall portion, which is circular in plan view, is opposite to the above-mentioned surface of the tablet to be accommodated, and is in a curved shape protruding outward; and a cylindrical side wall portion connected to the outermost peripheral portion of the bottom wall portion; The manufacturing method of the PTP tablet is characterized in that the above-mentioned information portion is provided in an information-imparting area on the above-mentioned surface of the tablet, and the information-imparting area is divided by a circle centered on the center of the surface when the tablet is viewed from above; The manufacture method of this PTP sheet comprises: a pocket portion forming step of forming the pocket portion on the strip-shaped container film; and Filling process, filling the tablet provided with the above-mentioned information part into the above-mentioned bag part; In the pocket portion forming step, the following requirements (1) and (2) are satisfied, and the pocket portion is formed such that the distance from the center of the surface of the tablet to the center of the pocket portion in plan view is Δc (mm) when the tablet accommodated in the pocket portion moves to the maximum toward the side wall portion; In the above-mentioned filling process, the tablet provided with the above-mentioned information part is filled in the above-mentioned bag part; The distance Δc satisfies the following necessary condition (3); (1) The depth of the pocket is not larger than the diameter of the surface of the tablet; (2) The inner surface of the bottom wall portion on the side of the tablet accommodated in the pocket has a peripheral region and a central region, the peripheral region is a region that may come into contact with the surface of the tablet accommodated in the pocket, and is circular in plan view, and the central region is a region separated from the surface of the tablet, surrounded by the peripheral region, and circular in plan view; (3) When φRp (mm) is the diameter of the information-applied region and rc (mm) is the radius of the central region in plan view, Δc≦rc-(φRp/2). The method of manufacturing a PTP sheet according to claim 1, wherein Δc=rc-(φRp/2) is satisfied. A method for manufacturing a PTP sheet, the PTP sheet has: a container film forming a pocket for receiving the tablet; and a covering film attached to the container film so as to close the opening of the pocket; The tablet accommodated in the pocket portion is an orally disintegrating tablet that is circular in plan view and has a predetermined information portion formed on at least the surface thereof, and The above pocket has: a bottom wall portion, which is circular in plan view, is opposite to the above-mentioned surface of the tablet to be accommodated, and is in a curved shape protruding outward; and a cylindrical side wall portion connected to the outermost peripheral portion of the bottom wall portion; The manufacturing method of this PTP sheet is characterized in that the above-mentioned bag part satisfies the following necessary conditions (1) and (2); The manufacture method of this PTP sheet comprises: The manufacturing process of the information part, setting the above-mentioned information part on at least the above-mentioned surface of the tablet; and Filling process, filling the tablet provided with the above-mentioned information part into the above-mentioned bag part; In the manufacturing process of the above-mentioned information portion, the above-mentioned information portion is provided in an information-imparting area on the above-mentioned surface of the tablet, and the information-imparting area is divided by a circle having a diameter φRp (mm) centered on the center of the surface when the tablet is viewed from above; In the above-mentioned filling process, the tablet provided with the above-mentioned information part in the above-mentioned information part forming process is filled in the above-mentioned bag part; The diameter φRp satisfies the following necessary condition (3): (1) The depth of the pocket is not larger than the diameter of the surface of the tablet; (2) The inner surface of the bottom wall portion on the side of the tablet accommodated in the pocket has a peripheral region and a central region. The peripheral region is a region that may come into contact with the surface of the tablet accommodated in the pocket and is circular in plan view. The central region is a region separated from the surface of the tablet and is surrounded by the peripheral region and is circular in plan view; (3) When the tablet in the pocket moves to the side of the side wall to the maximum extent, the distance from the center of the surface of the tablet to the center of the pocket in plan view is Δc (mm), and the radius of the central region in plan view is rc (mm), and φRp≤(rc-Δc)×2. The method for manufacturing a PTP sheet according to claim 3, wherein φRp=(rc-Δc)×2 is satisfied. The manufacturing method of the PTP sheet according to any one of claims 1 to 4, which includes an information position determination process, the information position determination process is after the above-mentioned information part production process, and whether the above-mentioned information part is provided in the above-mentioned information imparting area is judged whether it is acceptable or not.

Images