JP6266883B2 - Method for manufacturing PTP package - Google Patents

Description

  The present invention relates to a PTP package used for packaging pharmaceutical products such as tablets, and a method for producing the same, and further relates to a packaging sheet used as a lid for the PTP package.

  For packaging pharmaceutical products such as tablets and capsules, a PTP package (press-through pack) 10 as shown in FIG. 5 is often used. For example, as shown in FIG. 6, the PTP package 10 stores the medicines 13 individually in the storage recesses 12 of the storage sheet 11 made of vinyl chloride, and is covered with a lid material 14 made of aluminum foil or the like.

For example, as shown in FIG. 7, the lid member 14 is formed with an overprint (OP) layer 17 that protects printing on one surface or both surfaces of a base material 15 made of aluminum foil or the like, and protects the printing or the like. A heat seal layer 18 that can be adhered to the storage sheet 11 is formed on the back side. This print 16 displays invariant information such as product name, price, efficacy and effect, and variable information such as date of manufacture, lot number, and expiration date. In some cases, the information is displayed as a one-dimensional code (bar code) or a two-dimensional code including the information.
As such a PTP package, for example, a white colored layer and a base layer are provided on an aluminum foil to eliminate difficulty in reading a one-dimensional code due to reflection of the aluminum foil (Patent Document 1 below). reference).

JP 2008-174302 A

  Since invariant information such as product name, price, efficacy and effect does not change frequently, it may be printed on the base material 15 such as aluminum foil in advance, but the production date, expiration date, etc. are variable. If the information is printed on the base material in advance, there is a possibility that the planned number may be wasted if it cannot be manufactured. In addition, since variable information such as a lot number is individually attached to a product, it is less likely to be printed after packaging the medicine.

  When the lid 14 is heat-sealed to the storage sheet 11 in the PTP package 10, a grid-like or grid-like heat sealer is used, and a grid-like or grid-like narrow groove 19 is formed on the surface of the lid 14. Engraving is often done. This is to prevent the lid member 14 and the like from being broken. Therefore, when printing is performed on the overprint (OP) layer 17 after packaging, as shown in FIG. 8, the ink of the print 20 may flow into the narrow groove 19 and the print 20 may become hazy. When a one-dimensional code or a two-dimensional code is printed, it cannot be read by a reader, and information may not be deciphered.

  Then, the objective of this invention is providing the PTP package which can perform clear printing on the cover material surface after packaging.

The method for producing a PTP package according to the present invention is a method for producing a PTP package comprising a storage sheet having a storage recess for storing storage items, and a lid member that adheres to the storage sheet and covers the storage recess. The cover material has an overprint layer made of a coating agent on the front surface side of the base material, and has a heat seal layer that can be adhered to the storage sheet on the back surface side, and heat-seal the cover material to the storage sheet. After bonding, at least a part of the surface of the overprint layer is subjected to a rough surface treatment so that the wettability is 40 dynes to 60 dynes, and printing is performed thereon, or a storage recess for storing stored items And a cover material that is bonded to the storage sheet and covers the storage recess, wherein the cover material is an overcoat made of a coating agent on the surface side of the substrate. With print layer It has a heat seal layer that can be adhered to the storage sheet on the back side, and a rough surface treatment is applied to at least a part of the surface of the overprint layer to make the wet property 40 dynes to 60 dynes, and the heat seal layer side is used as the storage sheet. After heat-sealing and bonding, printing is performed on a portion subjected to a rough surface treatment.

The stored item is preferably a pharmaceutical product. Further, the rough surface treatment was carried out by corona treatment or plasma treatment, and the substrate is preferably an aluminum foil.
In the printing, at least one of a one-dimensional code, a two-dimensional code, a manufacturing date, and a lot number can be printed.

The method for producing a PTP package according to the present invention is such that the surface of the lid material has an appropriate roughness by applying a rough surface treatment to the overprint layer on the surface of the lid material, and printing on the surface. Is difficult to flow, and can be printed with a clear appearance. Even when a one-dimensional code or a two-dimensional code is printed, it can be reliably read by a reader.

It is a perspective view from the storage sheet side which shows an example of the PTP package manufactured with the manufacturing method of the PTP package of one Embodiment of this invention. It is a top view from the lid | cover material side of the PTP package of FIG. It is the expanded sectional view which showed typically the cover material of the PTP package of FIG. In the PTP package of FIG. 1, it is the partial expanded sectional view which showed typically the cover material surface part before printing. It is the schematic perspective view which showed an example of the conventional PTP package. It is a schematic sectional drawing of the PTP package of FIG. It is the expanded sectional view which showed typically the cover material of the PTP package of FIG. It is the elements on larger scale which showed typically the cover material surface part of the PTP package of Drawing 5.

Hereinafter, the manufacturing method of the PTP package of one Embodiment of this invention is demonstrated.

As shown in FIG. 1, the PTP package 1 manufactured by the method for manufacturing a PTP package of one embodiment of the present invention includes a storage sheet 2 having a storage recess 3 and a lid member 4.

As the storage sheet 2, a storage sheet conventionally used for PTP packaging can be used, and the size, material, and the like are not particularly limited.
The storage sheet 2 can be manufactured by forming the storage recess 3 by thermoforming or the like on a resin sheet made of, for example, vinyl chloride resin, polypropylene resin, polyethylene terephthalate resin, or the like. The thickness of the resin sheet is not particularly limited, but is 150 μm to 600 μm, preferably 200 μm to 400 μm, more preferably 250 μm to 300 μm.

The lid member 4 can be a lid member that has been conventionally used for PTP packaging.
In this embodiment, as shown in FIG. 3, a heat seal layer 6 that can be bonded to the storage sheet 2 is formed on one side of the substrate 5, and an overprint (OP) layer 7 is formed on the other side.
As the base material 5, for example, an aluminum foil or an aluminum foil laminate can be used.
As the aluminum foil, for example, a hard or soft aluminum foil having a thickness of about 10 to 30 μm can be used. Aluminum foil has a glossy surface (mirror surface) on one side and a matte surface (matte surface) on the other side, a glossy surface (mirror surface) on both sides, and glossy on both sides. There are types that have a vanishing surface (matte surface), but any of them may be used.
As the aluminum foil laminate product, for example, one obtained by laminating a synthetic resin sheet such as polystyrene or polyethylene terephthalate on one side or both sides of an aluminum foil can be used.
As shown in FIG. 2 or FIG. 3, printing 5 a may be applied to one side or both sides of the substrate 5. The printing 5a can be performed by a conventional method. For example, it can be printed by gravure printing or the like. The print 5a can display, for example, a product name, price, dose, efficacy / effect, and the like. In the present embodiment, the print 5a is displayed as “A 10 mg” as shown in FIG.

The heat seal layer 6 is a layer for welding the lid material 4 to the storage sheet 2 and can be formed of a material conventionally used for a heat seal layer of a PTP package.
The heat seal layer 6 can be formed, for example, by applying a gravure coat or the like using a resin coating agent mainly composed of a mixture of the same resin as the storage sheet 2.
The overprint (OP) layer 7 is a layer for covering the surface of the lid 4 and protecting the print 5a on the base material 5 and has been conventionally used for an overprint layer of a PTP package. Can be formed.
The overprint (OP) layer 7 can be formed, for example, by applying an OP coating agent made of a transparent resin such as nitrocellulose-based, acrylic-based, or epoxy-based by gravure coating. The thickness of the overprint (OP) layer 7 is not particularly limited, but is preferably 0.5 μm to 3.0 μm. The overprint (OP) layer 7 may contain 3 to 5% by mass of a matting agent such as silicon oxide.

On the surface of the lid 4 (overprint layer 7), as shown in FIG. 2, grid-like or lattice-like narrow grooves 8 formed at the time of heat sealing are engraved. This is for preventing the lid member 4 from being broken. For example, the narrow grooves 8 are formed at an angle of 40 ° to 50 °, a pitch of 0.5 mm to 1.0 mm, and a depth of 0.1 mm to 1 mm. Is done.
Moreover, as shown in FIG. 2, printing 9 is given to the surface of the lid | cover material 4 (overprint layer 7). This printing 9 is performed after the surface of the lid 4 (overprint layer 7) is roughened.
As shown in FIG. 4, the rough surface treatment is a treatment for appropriately roughening the surface of the lid 4 (overprint layer 7), and can be performed by, for example, corona treatment or plasma treatment. Corona treatment and plasma treatment can be performed using a commercially available corona treatment apparatus or plasma treatment apparatus. More specifically, a low frequency corona treatment device “Multidyne”, a high frequency corona treatment device “Polydyne”, a plasma beam type high frequency corona treatment device “Plasma Dyne”, etc. manufactured by Navitas Corporation can be used. .

  The rough surface treatment is carried out so that the wetting characteristic is 40 dynes to 60 dynes, preferably 45 dynes to 55 dynes, more preferably 48 dynes to 50 dynes, according to a determination method using a wetting reagent based on JISK6768.

  The rough surface treatment can be performed on the entire surface or a part of the surface of the lid member 4 (overprint layer 7). When it is applied to a part, it is preferably applied to the periphery of the print 9. The rough surface treatment can be applied in advance after the lid member 4 is bonded to the storage sheet 2 or on the packaging sheet that becomes the lid member 4.

  Although the printing 9 is not particularly limited, it is possible to print invariant information such as product name, price, dose, efficacy and effect, and variable information such as manufacturing date, lot number, and expiration date. It can also be printed as a one-dimensional code or two-dimensional code including variable information. In particular, it is preferable to print a one-dimensional code or a two-dimensional code including variable information such as manufacturing date and lot number, which is individual product information. More specifically, it is preferable to print GS1 (old RSS code), GS1-RSS limited composite symbol CC-A, GS1-RSS14 stack composite symbol CC-A, etc., which are barcodes for pharmaceuticals.

  The printing 9 can be performed by a conventional printing method, for example, ink jet printing, gravure printing, or the like. The ink is not particularly limited, but it is preferable to use a UV curable type.

Hereinafter, an example of the manufacturing method of the PTP package 1 is shown.
The PTP packaging body 1 may be the storage sheet 2 and the lid material 4 that have been conventionally used in PTP packaging bodies, and can be manufactured using a conventionally known PTP packaging machine.
For example, a stored item such as a medicine is stored in the storage recess 3 of the storage sheet 2, and the lid 4 is heat-sealed and bonded to the storage sheet 2, and then the entire surface or one surface of the lid 4 (overprint layer 7). The PTP package 1 can be manufactured by subjecting the surface to a rough surface treatment such as corona treatment and printing 9 thereon.

  Further, the entire surface or a part of the surface of the overprint layer 7 of the packaging sheet used as the lid member 4 may be subjected to rough surface treatment such as corona treatment. In this case, the packaging sheet is cut into the shape of a lid on the storage sheet 2 containing the stored items such as pharmaceuticals, and bonded by heat sealing, and then the surface 9 is subjected to printing 9, and PTP packaging is performed. The body 1 can be manufactured.

In the PTP package 1, the surface of the lid 4 (overprint layer 7) is roughened and printed 9 thereon, so that the ink of the print 9 is held on the surface and hardly flows into the narrow groove 8. A clear print 9 can be applied. When printing 9 of a one-dimensional code or a two-dimensional code, it can be reliably read by a reader.
In the present embodiment, the lid member 4 includes the base material 5, the heat seal layer 6, and the overprint layer 7. However, in the present invention, the lid member 4 may include other layers besides this. Good.

The test results using the PTP package are shown below.
(test)
As a storage sheet, a trade name “Vinyl foil C for PTP” (manufactured by Taketomo Co., Ltd.) made of hard vinyl chloride was used.
As a cover material, an OP agent mainly composed of nitrocellulose is applied to a surface of 20 μm thick aluminum foil as a base material to form a 2 μm thick overprint layer, and a heat sealant (DIC graphics) is formed on the back surface. Co., Ltd.) was applied to a thickness of 4 μm to form a heat seal layer.

These were heat-sealed and adhered by a PTP packaging machine (“FBP-M1 type” manufactured by CKD Corporation) to produce 10 PTP packaging bodies.
First, in this state, the wetting characteristics of the surface of the lid member were measured based on JISK6768. These wetting characteristics were 30-35 dynes.

Bar codes were printed on the surface of the lid material by inkjet printing on five of the produced PTP packages. In this printing, a pharmaceutical barcode GS1 was printed. The ink used was a UV curable ink.
When this printing was visually observed, there was a thing in which the ink flowed into the narrow groove and was blurred. Further, when information was read by a bar code reader, two of them could not be read.

  Next, a corona treatment was performed on the surface of the remaining five of the produced PTP packages. The corona treatment was performed using a low frequency corona treatment apparatus “Multidyne” (manufactured by Navitas).

The surface wetting characteristics of these lid materials were measured based on JISK6768. These wetting characteristics were 40-50 dynes.
Bar codes were printed on these lid materials by inkjet printing. In this printing, a pharmaceutical barcode GS1 was printed. The ink used was a UV curable ink.
When this print was visually observed, no problem was found. Moreover, when the information was read with a bar code reader, it was possible to read all.

  The configuration aspect of the above embodiment is not intended to limit the present invention, but can be changed as long as the technical purpose is common, and the present invention includes such a change.

1 PTP package 2 Storage sheet 3 Storage recess 4 Cover material 5 Base material 5a Printing 6 Heat seal layer 7 Overprint (OP) layer 8 Narrow groove 9 Printing

Claims (5)

A method for producing a PTP package comprising: a storage sheet having a storage recess for storing storage; and a lid member that adheres to the storage sheet and covers the storage recess,
The lid material has an overprint layer formed by applying a coating agent on the front surface side of the base material, and has a heat seal layer that can be adhered to the storage sheet on the back surface side,
After the lid material is heat-sealed and adhered to the storage sheet, at least a part of the surface of the overprint layer is subjected to a rough surface treatment so that the wetting property is 40 dynes to 60 dynes, and printing is performed thereon. Production method. A method for producing a PTP package comprising: a storage sheet having a storage recess for storing storage; and a lid member that adheres to the storage sheet and covers the storage recess,
The lid material has an overprint layer formed by applying a coating agent on the front surface side of the base material, and has a heat seal layer that can be adhered to the storage sheet on the back surface side ,
At least a part of the surface of the overprint layer is subjected to a rough surface treatment so that the wettability is 40 dynes to 60 dynes, the heat seal layer side is heat sealed to the storage sheet and bonded, and then the surface is subjected to the rough surface treatment A method for producing a PTP package for printing. The method for producing a PTP package according to claim 1 or 2, wherein the stored item is a pharmaceutical product. The method for producing a PTP package according to claim 3, wherein the rough surface treatment is a corona treatment or a plasma treatment, and the base material is an aluminum foil. The printing, one-dimensional code, the two-dimensional code, date of manufacture, at least one method for producing a PTP package according to claim 4 of the lot number.

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