JP2017169739A - バルーンカテーテルおよびその製造方法並びに処置方法 - Google Patents
バルーンカテーテルおよびその製造方法並びに処置方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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Abstract
【解決手段】独立した長軸を有して延在する水不溶性薬剤の結晶である複数の長尺体42がバルーン30の外表面に設けられるバルーンカテーテル10であって、バルーン30の外表面に複数の凹部35が設けられ、少なくとも2つの長尺体42が凹部35から当該凹部35よりもバルーン30の径方向外側へ延在する。
【選択図】図4
Description
20 カテーテル本体、
21 外管、
22 内管、
30 バルーン、
35 凹部、
40 コート層、
41 基材、
42 長尺体、
45 基部、
50 バルーンコーティング装置、
94 ディスペンシングチューブ。
Claims (7)
- 独立した長軸を有して延在する水不溶性薬剤の結晶である複数の長尺体がバルーンの外表面に設けられるバルーンカテーテルであって、
前記バルーンの外表面に複数の凹部が設けられ、
少なくとも2つの前記長尺体が前記凹部から当該凹部よりも前記バルーンの径方向外側へ延在するバルーンカテーテル。 - 前記長尺体は、少なくとも先端側が中空である請求項1に記載のバルーンカテーテル。
- 前記長尺体は、長軸と直交する断面が多角形である請求項1または2に記載のバルーンカテーテル。
- 前記凹部は、内径が500μm以下である請求項1〜3のいずれか1項に記載のバルーンカテーテル。
- 前記水不溶性薬剤は、ラパマイシン、パクリタキセル、ドセタキセル、またはエベロリムスである請求項1〜4のいずれか1項に記載のバルーンコーティング方法。
- 独立した長軸を有して延在する水不溶性薬剤の結晶である複数の長尺体がバルーンの外表面に設けられるバルーンカテーテルの製造方法であって、
薬剤、有機溶媒および水を含むコーティング溶液を、凹部が複数設けられているバルーンの外表面に供給するステップと、
有機溶媒を揮発させることで前記凹部から当該凹部よりも前記バルーンの径方向外側まで前記水不溶性薬剤の結晶を成長させて少なくとも2つの前記長尺体を形成するステップと、を有するバルーンカテーテルの製造方法。 - 請求項1に記載のバルーンカテーテルを使用して生体管腔内の病変部に薬剤を送達する処置方法であって、
前記バルーンを生体管腔内に挿入して病変部へ到達させるステップと、
前記バルーンを拡張させて前記長尺体を生体組織に接触させるステップと、
前記バルーンを収縮させて生体管腔から抜去するステップと、を有する処置方法。
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