JP2017132814A5 - - Google Patents
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- JP2017132814A5 JP2017132814A5 JP2017095022A JP2017095022A JP2017132814A5 JP 2017132814 A5 JP2017132814 A5 JP 2017132814A5 JP 2017095022 A JP2017095022 A JP 2017095022A JP 2017095022 A JP2017095022 A JP 2017095022A JP 2017132814 A5 JP2017132814 A5 JP 2017132814A5
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- JP
- Japan
- Prior art keywords
- group
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- alkoxy
- halogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- -1 cyano, hydroxy Chemical group 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 16
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 8
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 6
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 6
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 6
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 6
- 125000004103 aminoalkyl group Chemical group 0.000 claims 6
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 6
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000004971 nitroalkyl group Chemical group 0.000 claims 6
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- 208000009901 Polycystic Kidney Disease Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10254108P | 2008-10-03 | 2008-10-03 | |
US61/102,541 | 2008-10-03 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015075248A Division JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018028160A Division JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017132814A JP2017132814A (ja) | 2017-08-03 |
JP2017132814A5 true JP2017132814A5 (US07846941-20101207-C00217.png) | 2017-09-14 |
JP6297194B2 JP6297194B2 (ja) | 2018-03-20 |
Family
ID=41402426
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011530057A Withdrawn JP2012504608A (ja) | 2008-10-03 | 2009-10-02 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011530057A Withdrawn JP2012504608A (ja) | 2008-10-03 | 2009-10-02 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Country Status (10)
Families Citing this family (17)
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JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
PL2032134T3 (pl) | 2006-05-09 | 2015-11-30 | Genzyme Corp | Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów |
EP2594564B1 (en) * | 2007-05-31 | 2016-09-28 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
RU2517345C9 (ru) * | 2007-10-05 | 2014-08-20 | Гензим Корпорейшн | Способ лечения поликистозных заболеваний почек с помощью производных церамида |
CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
KR101687039B1 (ko) | 2008-10-03 | 2016-12-15 | 젠자임 코포레이션 | 2-아실아미노프로판올형 글루코실세라미드 합성효소 억제제 |
US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
CN102702010B (zh) * | 2012-05-23 | 2014-09-17 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
AU2014321397C1 (en) * | 2013-09-20 | 2019-08-01 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
CA2954030A1 (en) * | 2014-07-03 | 2016-01-07 | Dr. Reddy's Laboratories Limited | Amorphous form of eliglustat hemitartarate |
JP6749923B2 (ja) * | 2015-02-02 | 2020-09-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | グルコシルセラミドシンターゼ阻害剤及びそれを使用した治療方法 |
WO2016145153A1 (en) * | 2015-03-11 | 2016-09-15 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
MX2018006250A (es) | 2015-11-18 | 2018-09-05 | Genzyme Corp | Biomarcador de enfermedad poliquistica renal y usos del mismo. |
KR20180124971A (ko) | 2016-03-25 | 2018-11-21 | 젠자임 코포레이션 | 단백질병증의 바이오마커 및 이의 용도 |
WO2017204319A1 (ja) * | 2016-05-27 | 2017-11-30 | 公益財団法人野口研究所 | グルコシルセラミド合成酵素阻害剤 |
WO2019126776A1 (en) | 2017-12-21 | 2019-06-27 | Lysosomal Therapeutics Inc. | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
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RU2517345C9 (ru) | 2007-10-05 | 2014-08-20 | Гензим Корпорейшн | Способ лечения поликистозных заболеваний почек с помощью производных церамида |
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2009
- 2009-10-02 KR KR1020117010056A patent/KR101687039B1/ko active IP Right Grant
- 2009-10-02 CA CA2738768A patent/CA2738768C/en not_active Expired - Fee Related
- 2009-10-02 US US13/122,135 patent/US8309593B2/en not_active Expired - Fee Related
- 2009-10-02 MX MX2011003517A patent/MX2011003517A/es active IP Right Grant
- 2009-10-02 EP EP09741487.4A patent/EP2349255B1/en not_active Not-in-force
- 2009-10-02 CN CN201710483611.XA patent/CN107935983A/zh active Pending
- 2009-10-02 RU RU2011117028/15A patent/RU2578947C2/ru not_active IP Right Cessation
- 2009-10-02 JP JP2011530057A patent/JP2012504608A/ja not_active Withdrawn
- 2009-10-02 EP EP16162074.5A patent/EP3078373A1/en not_active Withdrawn
- 2009-10-02 CN CN200980147488.8A patent/CN102271678B/zh not_active Expired - Fee Related
- 2009-10-02 WO PCT/US2009/005435 patent/WO2010039256A1/en active Application Filing
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2011
- 2011-03-27 IL IL211946A patent/IL211946A/en not_active IP Right Cessation
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2012
- 2012-08-27 US US13/595,251 patent/US9272996B2/en not_active Expired - Fee Related
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2015
- 2015-04-01 JP JP2015075248A patent/JP6175465B2/ja not_active Expired - Fee Related
- 2015-05-03 IL IL238583A patent/IL238583B/en not_active IP Right Cessation
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2016
- 2016-01-21 US US15/003,207 patent/US9744153B2/en not_active Expired - Fee Related
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2017
- 2017-05-11 JP JP2017095022A patent/JP6297194B2/ja not_active Expired - Fee Related
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2018
- 2018-02-20 JP JP2018028160A patent/JP2018087232A/ja active Pending