JP2017122120A5 - - Google Patents
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- Publication number
- JP2017122120A5 JP2017122120A5 JP2017067243A JP2017067243A JP2017122120A5 JP 2017122120 A5 JP2017122120 A5 JP 2017122120A5 JP 2017067243 A JP2017067243 A JP 2017067243A JP 2017067243 A JP2017067243 A JP 2017067243A JP 2017122120 A5 JP2017122120 A5 JP 2017122120A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- muc1
- antigen
- yeast
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 22
- 102100034256 Mucin-1 Human genes 0.000 claims 22
- 238000009169 immunotherapy Methods 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 230000001024 immunotherapeutic effect Effects 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 11
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 6
- 102000037865 fusion proteins Human genes 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000002519 immonomodulatory effect Effects 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000003092 anti-cytokine Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000011220 combination immunotherapy Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229940126586 small molecule drug Drugs 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524407P | 2011-08-17 | 2011-08-17 | |
| US61/524,407 | 2011-08-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526241A Division JP6122007B2 (ja) | 2011-08-17 | 2012-08-17 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018040308A Division JP6571822B2 (ja) | 2011-08-17 | 2018-03-07 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017122120A JP2017122120A (ja) | 2017-07-13 |
| JP2017122120A5 true JP2017122120A5 (cg-RX-API-DMAC7.html) | 2018-01-11 |
| JP6306238B2 JP6306238B2 (ja) | 2018-04-04 |
Family
ID=47715495
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526241A Active JP6122007B2 (ja) | 2011-08-17 | 2012-08-17 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2017067243A Active JP6306238B2 (ja) | 2011-08-17 | 2017-03-30 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2018040308A Active JP6571822B2 (ja) | 2011-08-17 | 2018-03-07 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2019145946A Pending JP2019194261A (ja) | 2011-08-17 | 2019-08-08 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526241A Active JP6122007B2 (ja) | 2011-08-17 | 2012-08-17 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018040308A Active JP6571822B2 (ja) | 2011-08-17 | 2018-03-07 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2019145946A Pending JP2019194261A (ja) | 2011-08-17 | 2019-08-08 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9533031B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2744918A4 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6122007B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102049928B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN109010809A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2012296425B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014003477B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2844500C (cg-RX-API-DMAC7.html) |
| IL (2) | IL230863B (cg-RX-API-DMAC7.html) |
| MX (1) | MX352892B (cg-RX-API-DMAC7.html) |
| RU (2) | RU2017143985A (cg-RX-API-DMAC7.html) |
| SG (1) | SG10201607663YA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013025972A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (40)
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| WO2009006479A2 (en) | 2007-07-02 | 2009-01-08 | Etubics Corporation | Methods and compositions for producing an adenovirus vector for use with multiple vaccinations |
| WO2012083302A2 (en) | 2010-12-17 | 2012-06-21 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| CN103476426B (zh) | 2011-02-12 | 2021-08-10 | 全球免疫股份有限公司 | 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂 |
| RU2690180C2 (ru) | 2011-03-17 | 2019-05-31 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей с brachyury |
| SG10201605265TA (en) | 2011-06-14 | 2016-08-30 | Globeimmune Inc | Yeast-Based Compositions and Methods for the Treatment or Prevention of Hepatitis Delta Virus Infection |
| BR112014003477B1 (pt) | 2011-08-17 | 2021-11-03 | Globeimmune, Inc. | Composição imunoterapêutica de muc1 de levedura |
| AU2013206896B2 (en) * | 2012-01-03 | 2017-05-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Native and agonist CTL epitopes of the MUC1 tumor antigen |
| AU2013281221B2 (en) | 2012-06-26 | 2018-05-17 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| WO2014031178A1 (en) | 2012-08-24 | 2014-02-27 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| WO2014186047A1 (en) | 2013-03-19 | 2014-11-20 | Globeimmune, Inc. | Yeast-based immunotherapy for chordoma |
| TWI728239B (zh) | 2013-03-26 | 2021-05-21 | 美商環球免疫公司 | 治療或預防人類免疫缺乏病毒感染之組合物及方法 |
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| WO2015157639A1 (en) | 2014-04-11 | 2015-10-15 | Globeimmune, Inc. | Yeast-based immunotherapy and type i interferon sensitivity |
| EP3236995A4 (en) | 2014-12-23 | 2018-07-18 | University of Maryland, Baltimore | Muc1 decoy peptides for treatment and prevention of bacterial infections |
| EP3242940B1 (en) * | 2015-01-09 | 2023-03-29 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| US10695417B2 (en) | 2015-01-09 | 2020-06-30 | Etubics Corporation | Human adenovirus serotype 5 vectors containing E1 and E2B deletions encoding the ebola virus glycoprotein |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| JP6858128B2 (ja) | 2015-02-18 | 2021-04-14 | エンリヴェックス セラピューティクス リミテッド | 癌治療のための免疫療法とサイトカイン制御療法との組み合わせ |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| US10857181B2 (en) | 2015-04-21 | 2020-12-08 | Enlivex Therapeutics Ltd | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| JP6789283B2 (ja) | 2015-08-03 | 2020-11-25 | グローブイミューン，インコーポレイテッド | 改変酵母−ブラキュリー免疫療法組成物 |
| WO2017096247A1 (en) * | 2015-12-04 | 2017-06-08 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different mhc molecules |
| EP3400009A2 (en) | 2016-01-05 | 2018-11-14 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| CA2954892A1 (en) | 2016-01-19 | 2017-07-19 | Pfizer Inc. | Immunogens derived from tumor-associated antigens or nucleic acid molecules encoding the immunogens |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11154597B2 (en) | 2016-03-24 | 2021-10-26 | Nantcell, Inc. | Sequence arrangements and sequences for neoepitope presentation |
| SG11201909882SA (en) | 2017-04-24 | 2019-11-28 | Nantcell Inc | Targeted neoepitope vectors and methods therefor |
| WO2019222073A1 (en) | 2018-05-15 | 2019-11-21 | Globeimmune, Inc. | Lysates of recombinant yeast for inducing cellular immune responses |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| WO2021212100A1 (en) * | 2020-04-17 | 2021-10-21 | The Trustees Of Columbia University In The City Of New York | Methods, compositions and uses thereof for reversing sacropenia |
| CN113185485B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的半合成方法 |
| CN113214210B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的制备方法 |
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| RU2690180C2 (ru) | 2011-03-17 | 2019-05-31 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей с brachyury |
| SG10201605265TA (en) | 2011-06-14 | 2016-08-30 | Globeimmune Inc | Yeast-Based Compositions and Methods for the Treatment or Prevention of Hepatitis Delta Virus Infection |
| BR112014003477B1 (pt) | 2011-08-17 | 2021-11-03 | Globeimmune, Inc. | Composição imunoterapêutica de muc1 de levedura |
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2012
- 2012-08-17 BR BR112014003477-0A patent/BR112014003477B1/pt active IP Right Grant
- 2012-08-17 AU AU2012296425A patent/AU2012296425B2/en active Active
- 2012-08-17 WO PCT/US2012/051299 patent/WO2013025972A1/en not_active Ceased
- 2012-08-17 EP EP12824638.6A patent/EP2744918A4/en active Pending
- 2012-08-17 CN CN201810735110.0A patent/CN109010809A/zh active Pending
- 2012-08-17 CN CN201280051154.2A patent/CN104024429B/zh active Active
- 2012-08-17 SG SG10201607663YA patent/SG10201607663YA/en unknown
- 2012-08-17 MX MX2014001717A patent/MX352892B/es active IP Right Grant
- 2012-08-17 RU RU2017143985A patent/RU2017143985A/ru not_active Application Discontinuation
- 2012-08-17 CN CN202210208007.7A patent/CN114617958B/zh active Active
- 2012-08-17 RU RU2014109741A patent/RU2642300C2/ru active
- 2012-08-17 KR KR1020147006872A patent/KR102049928B1/ko active Active
- 2012-08-17 CA CA2844500A patent/CA2844500C/en active Active
- 2012-08-17 JP JP2014526241A patent/JP6122007B2/ja active Active
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2013
- 2013-03-14 US US13/803,757 patent/US9533031B2/en active Active
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2014
- 2014-02-06 IL IL230863A patent/IL230863B/en active IP Right Grant
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2016
- 2016-11-22 US US15/358,797 patent/US10188714B2/en active Active
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2017
- 2017-03-30 JP JP2017067243A patent/JP6306238B2/ja active Active
- 2017-10-18 AU AU2017248462A patent/AU2017248462B2/en active Active
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2018
- 2018-02-14 IL IL257533A patent/IL257533B/en active IP Right Grant
- 2018-03-07 JP JP2018040308A patent/JP6571822B2/ja active Active
- 2018-12-06 US US16/211,492 patent/US11065318B2/en active Active
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2019
- 2019-08-08 JP JP2019145946A patent/JP2019194261A/ja active Pending
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2020
- 2020-01-08 AU AU2020200137A patent/AU2020200137B2/en active Active