JP2017057223A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017057223A5 JP2017057223A5 JP2016252909A JP2016252909A JP2017057223A5 JP 2017057223 A5 JP2017057223 A5 JP 2017057223A5 JP 2016252909 A JP2016252909 A JP 2016252909A JP 2016252909 A JP2016252909 A JP 2016252909A JP 2017057223 A5 JP2017057223 A5 JP 2017057223A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- suspension formulation
- formoterol fumarate
- fluticasone propionate
- cromolyn sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 21
- 239000003380 propellant Substances 0.000 claims 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 19
- 229960000265 cromoglicic acid Drugs 0.000 claims 16
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 16
- 239000000725 suspension Substances 0.000 claims 15
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 14
- 239000008249 pharmaceutical aerosol Substances 0.000 claims 14
- 229960000289 fluticasone propionate Drugs 0.000 claims 13
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 13
- 238000000034 method Methods 0.000 claims 9
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229960000193 formoterol fumarate Drugs 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000000080 wetting agent Substances 0.000 claims 6
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical group FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 3
- 239000007971 pharmaceutical suspension Substances 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 230000007774 longterm Effects 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0918149.6A GB0918149D0 (en) | 2009-10-16 | 2009-10-16 | Improved medicinal aerosol formulation |
| GB0918149.6 | 2009-10-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015036045A Division JP2015129162A (ja) | 2009-10-16 | 2015-02-26 | 改善された医薬エアゾール製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142684A Division JP7203701B2 (ja) | 2009-10-16 | 2019-08-02 | 改善された医薬エアゾール製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017057223A JP2017057223A (ja) | 2017-03-23 |
| JP2017057223A5 true JP2017057223A5 (https=) | 2017-08-03 |
| JP6568511B2 JP6568511B2 (ja) | 2019-08-28 |
Family
ID=41462450
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533650A Pending JP2013507430A (ja) | 2009-10-16 | 2010-10-15 | 改善された医薬エアゾール製剤 |
| JP2015036045A Pending JP2015129162A (ja) | 2009-10-16 | 2015-02-26 | 改善された医薬エアゾール製剤 |
| JP2016252909A Active JP6568511B2 (ja) | 2009-10-16 | 2016-12-27 | 改善された医薬エアゾール製剤 |
| JP2019142684A Active JP7203701B2 (ja) | 2009-10-16 | 2019-08-02 | 改善された医薬エアゾール製剤 |
| JP2022209895A Pending JP2023026517A (ja) | 2009-10-16 | 2022-12-27 | 改善された医薬エアゾール製剤 |
| JP2025127827A Pending JP2025148616A (ja) | 2009-10-16 | 2025-07-31 | 改善された医薬エアゾール製剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533650A Pending JP2013507430A (ja) | 2009-10-16 | 2010-10-15 | 改善された医薬エアゾール製剤 |
| JP2015036045A Pending JP2015129162A (ja) | 2009-10-16 | 2015-02-26 | 改善された医薬エアゾール製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142684A Active JP7203701B2 (ja) | 2009-10-16 | 2019-08-02 | 改善された医薬エアゾール製剤 |
| JP2022209895A Pending JP2023026517A (ja) | 2009-10-16 | 2022-12-27 | 改善された医薬エアゾール製剤 |
| JP2025127827A Pending JP2025148616A (ja) | 2009-10-16 | 2025-07-31 | 改善された医薬エアゾール製剤 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20120282189A1 (https=) |
| EP (3) | EP2488158B1 (https=) |
| JP (6) | JP2013507430A (https=) |
| CN (1) | CN102665675B (https=) |
| AU (1) | AU2010305698C9 (https=) |
| BR (1) | BR112012008983A2 (https=) |
| CA (1) | CA2776359C (https=) |
| CL (1) | CL2012000947A1 (https=) |
| CY (1) | CY1116109T1 (https=) |
| DK (2) | DK2488158T3 (https=) |
| ES (2) | ES2973882T3 (https=) |
| FI (1) | FI2881108T3 (https=) |
| GB (1) | GB0918149D0 (https=) |
| HR (2) | HRP20240402T1 (https=) |
| HU (1) | HUE065583T2 (https=) |
| IL (1) | IL219161B (https=) |
| LT (1) | LT2881108T (https=) |
| MX (1) | MX2012004337A (https=) |
| NZ (1) | NZ599901A (https=) |
| PL (2) | PL2881108T3 (https=) |
| PT (2) | PT2881108T (https=) |
| RS (2) | RS53883B1 (https=) |
| SI (2) | SI2881108T1 (https=) |
| SM (2) | SMT202400119T1 (https=) |
| WO (1) | WO2011045432A1 (https=) |
| ZA (1) | ZA201202452B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ528640A (en) * | 2001-03-30 | 2004-06-25 | Jagotec Ag | Medical aerosol formulations |
| GB0323684D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| GB0918149D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
| TWI495466B (zh) * | 2010-09-23 | 2015-08-11 | Intech Biopharm Ltd | 用於氣喘之吸入性複方組合物 |
| GB201515310D0 (en) * | 2015-08-27 | 2015-10-14 | Jagotec Ag | Pharmaceutical composition |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2503962A1 (de) | 1975-01-31 | 1976-08-05 | Thomae Gmbh Dr K | Spruehbare mittel in suspensionsform zur anwendung auf der haut |
| FR2420972A1 (fr) | 1978-03-31 | 1979-10-26 | Roussel Uclaf | Application du peroxyde de thenoyle a titre de medicament |
| JPS5529524A (en) | 1978-08-21 | 1980-03-01 | Toyo Aerosol Kogyo Kk | Powdery aerosol composition |
| DE2914181C2 (de) | 1979-04-07 | 1982-06-16 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren und Vorrichtung zum Trocknen temperaturempfindlicher Güter der Pharma- und Nahrungsmittelindustrie |
| JPS6135815A (ja) | 1984-07-28 | 1986-02-20 | Sanshin Seisakusho:Kk | 上部集液式加圧ろ過機に於ける機体内液の脱液方法及び同装置 |
| FR2666962B1 (fr) | 1990-09-26 | 1996-06-14 | Oreal | Composition antifongique sous forme de spray sec. |
| SE9101090D0 (sv) | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| SE9302777D0 (sv) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| US5874063A (en) | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
| EP0617610B1 (en) * | 1991-12-18 | 1997-03-19 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
| DE4321288A1 (de) | 1993-06-26 | 1995-01-05 | Solvay Fluor & Derivate | Zusammensetzungen mit chlorfreien, gegebenenfalls wasserstoffhaltigen Fluorkohlenwasserstoffen |
| US6596260B1 (en) | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| DK0731688T3 (da) | 1993-12-02 | 2003-06-23 | Abbott Lab | Aerosol-lægemiddelformuleringer til anvendelse med CFC-frie drivmidler |
| MX9707864A (es) | 1995-04-14 | 1997-11-29 | Glaxo Wellcome Inc | Inhalador de dosis medida por salmeterol. |
| JP3707107B2 (ja) | 1995-09-18 | 2005-10-19 | 鈴木油脂工業株式会社 | 薬剤分散液及びその製造方法 |
| US6054488A (en) | 1996-06-11 | 2000-04-25 | 3M Innovative Properties Company | Medicinal aerosol formulations of formoterol |
| US6361938B1 (en) | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| AU725625B2 (en) | 1997-01-30 | 2000-10-19 | Alpenstock Holdings Limited | A composition |
| AU718967B2 (en) | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
| US6086376A (en) | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
| US6451285B2 (en) | 1998-06-19 | 2002-09-17 | Baker Norton Pharmaceuticals, Inc. | Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant |
| JP4570251B2 (ja) | 1998-07-24 | 2010-10-27 | ヤゴテック アーゲー | 医薬用エーロゾル製剤 |
| CN1150890C (zh) | 1998-08-04 | 2004-05-26 | 杰格研究股份公司 | 药用气溶胶制剂 |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| AU756852B2 (en) | 1998-11-13 | 2003-01-23 | Jagotec Ag | Dry powder for inhalation |
| US7074388B2 (en) * | 1998-12-10 | 2006-07-11 | Kos Life Science, Inc. | Water stabilized medicinal aerosol formulation |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| AU2879100A (en) | 1999-02-12 | 2000-08-29 | Miles A. Libbey Iii | Formulation and system for intra-oral delivery of pharmaceutical agents |
| GB9903759D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| GB9904919D0 (en) | 1999-03-03 | 1999-04-28 | Novartis Ag | Organic compounds |
| GB0012260D0 (en) | 2000-05-19 | 2000-07-12 | Astrazeneca Ab | Novel composition |
| GB0012261D0 (en) | 2000-05-19 | 2000-07-12 | Astrazeneca Ab | Novel process |
| JP5392880B2 (ja) | 2000-05-22 | 2014-01-22 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| AU2001247123A1 (en) * | 2000-07-19 | 2002-02-05 | Aeropharm Technology, Inc. | A medicinal aerosol formulation |
| AU2001278115A1 (en) | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
| CA2425035A1 (en) | 2000-10-09 | 2002-04-18 | 3M Innovative Properties Company | Medicinal aerosol formulations |
| NZ528640A (en) * | 2001-03-30 | 2004-06-25 | Jagotec Ag | Medical aerosol formulations |
| US6455028B1 (en) | 2001-04-23 | 2002-09-24 | Pharmascience | Ipratropium formulation for pulmonary inhalation |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| TWI324934B (en) | 2001-08-28 | 2010-05-21 | Schering Corp | Pharmaceutical compositions for the treatment of asthma |
| GB0201400D0 (en) | 2002-01-22 | 2002-03-13 | Glaxo Group Ltd | Novel apparatus and process |
| EP3384931B1 (en) | 2002-03-01 | 2019-07-24 | Chiesi Farmaceutici S.p.A. | Formoterol superfine formulation |
| GB0207899D0 (en) | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and cielesonide aerosol formulations |
| US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| EP2322243A1 (en) * | 2002-08-29 | 2011-05-18 | Cipla Ltd. | Pharmaceutical products and compositions comprising formoterol, ciclesonide and tiotropium |
| US20060193610A1 (en) | 2003-07-12 | 2006-08-31 | Jong-Hun Han | Aromatic emitting apparatus for using cigarjack |
| EA200600598A1 (ru) | 2003-09-19 | 2006-08-25 | Пенвест Фармасьютикалз Ко. | Лекарственные формы замедленного высвобождения |
| GB0323685D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| GB0323684D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| EP1811981B1 (en) * | 2004-10-12 | 2008-08-13 | Merck Generics (UK) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
| GB0918149D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
| GB0918150D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved formulations |
| JP2015036045A (ja) * | 2013-08-12 | 2015-02-23 | 株式会社泉技研 | 骨質改善のための超音波音響システム及び超音波音響機器の作動方法 |
-
2009
- 2009-10-16 GB GBGB0918149.6A patent/GB0918149D0/en not_active Ceased
-
2010
- 2010-10-15 WO PCT/EP2010/065573 patent/WO2011045432A1/en not_active Ceased
- 2010-10-15 BR BR112012008983A patent/BR112012008983A2/pt not_active Application Discontinuation
- 2010-10-15 SI SI201032141T patent/SI2881108T1/sl unknown
- 2010-10-15 LT LTEP14199881.5T patent/LT2881108T/lt unknown
- 2010-10-15 DK DK10768922T patent/DK2488158T3/en active
- 2010-10-15 EP EP10768922.6A patent/EP2488158B1/en not_active Revoked
- 2010-10-15 PL PL14199881.5T patent/PL2881108T3/pl unknown
- 2010-10-15 DK DK14199881.5T patent/DK2881108T3/da active
- 2010-10-15 NZ NZ599901A patent/NZ599901A/xx unknown
- 2010-10-15 CN CN201080046310.7A patent/CN102665675B/zh active Active
- 2010-10-15 PT PT141998815T patent/PT2881108T/pt unknown
- 2010-10-15 SM SM20240119T patent/SMT202400119T1/it unknown
- 2010-10-15 ES ES14199881T patent/ES2973882T3/es active Active
- 2010-10-15 AU AU2010305698A patent/AU2010305698C9/en active Active
- 2010-10-15 RS RS20150160A patent/RS53883B1/sr unknown
- 2010-10-15 EP EP23219752.5A patent/EP4327807A3/en active Pending
- 2010-10-15 PL PL10768922T patent/PL2488158T3/pl unknown
- 2010-10-15 JP JP2012533650A patent/JP2013507430A/ja active Pending
- 2010-10-15 CA CA2776359A patent/CA2776359C/en active Active
- 2010-10-15 US US13/503,245 patent/US20120282189A1/en not_active Abandoned
- 2010-10-15 RS RS20240366A patent/RS65391B1/sr unknown
- 2010-10-15 FI FIEP14199881.5T patent/FI2881108T3/fi active
- 2010-10-15 MX MX2012004337A patent/MX2012004337A/es active IP Right Grant
- 2010-10-15 HR HRP20240402TT patent/HRP20240402T1/hr unknown
- 2010-10-15 HU HUE14199881A patent/HUE065583T2/hu unknown
- 2010-10-15 PT PT10768922T patent/PT2488158E/pt unknown
- 2010-10-15 SI SI201030889T patent/SI2488158T1/sl unknown
- 2010-10-15 EP EP14199881.5A patent/EP2881108B1/en active Active
- 2010-10-15 HR HRP20150174TT patent/HRP20150174T1/hr unknown
- 2010-10-15 ES ES10768922.6T patent/ES2533372T3/es active Active
-
2012
- 2012-04-04 ZA ZA2012/02452A patent/ZA201202452B/en unknown
- 2012-04-13 CL CL2012000947A patent/CL2012000947A1/es unknown
- 2012-04-15 IL IL219161A patent/IL219161B/en active IP Right Grant
-
2014
- 2014-05-16 US US14/279,751 patent/US20140314684A1/en not_active Abandoned
-
2015
- 2015-02-26 JP JP2015036045A patent/JP2015129162A/ja active Pending
- 2015-03-06 SM SM201500052T patent/SMT201500052B/xx unknown
- 2015-03-13 CY CY20151100253T patent/CY1116109T1/el unknown
-
2016
- 2016-09-14 US US15/265,467 patent/US10471077B2/en active Active
- 2016-12-27 JP JP2016252909A patent/JP6568511B2/ja active Active
-
2019
- 2019-08-02 JP JP2019142684A patent/JP7203701B2/ja active Active
-
2022
- 2022-12-27 JP JP2022209895A patent/JP2023026517A/ja active Pending
-
2025
- 2025-07-31 JP JP2025127827A patent/JP2025148616A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017057223A5 (https=) | ||
| AR130239A2 (es) | Método para reducir la cantidad del producto de degradación dp3 durante la vida de estante de una composición farmacéutica en solución para aerosol y uso de una lata de aerosol asociada | |
| US20150250713A1 (en) | Pharmaceutical Composition | |
| JP2017019845A5 (https=) | ||
| JP2019182878A5 (https=) | ||
| AU2012216890A1 (en) | Combination of glycopyrrolate and a beta2 -agonist | |
| JP2019500340A5 (https=) | ||
| JPH04327527A (ja) | 医薬エアロゾール配合物 | |
| JP2012528792A5 (https=) | ||
| RU2013104401A (ru) | Фармацевтический препарат, содержащий ингибитор фосфодиэстеразы | |
| SI3096737T1 (en) | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination | |
| JP2019528316A5 (https=) | ||
| CA2814445A1 (en) | Pharmaceutical composition | |
| JP2016534142A5 (https=) | ||
| RU2010108640A (ru) | Новая комбинация терапевтических агентов | |
| FI3500241T3 (fi) | Yhdistelmähoito copd:lle | |
| AR123674A2 (es) | Composición farmacéutica en aerosol de formoterol y dipropionato de beclometasona | |
| JOP20200314A1 (ar) | تركيبات صيدلانية مستقرة لأجهزة إستنشاق جرعات مضغوطة معايرة الجرعة | |
| JP2013507430A5 (https=) | ||
| DE03754425T1 (de) | Anwendungen die in Bezug stehen mit durch Wasser stabilisierte medizinische Aerosolformulierungen | |
| MY191712A (en) | Composition comprising at least one dry powder obtained by spray drying to increase the stability of the formulation | |
| HRP20150174T1 (hr) | Poboljšane medicinske aerosolne formulacije | |
| US20130104881A1 (en) | Stabilized Metered Dose Inhaler | |
| US9402854B2 (en) | Pharmaceutical composition | |
| JP2013519695A5 (https=) |