JP2017019776A5 - - Google Patents
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- Publication number
- JP2017019776A5 JP2017019776A5 JP2016131781A JP2016131781A JP2017019776A5 JP 2017019776 A5 JP2017019776 A5 JP 2017019776A5 JP 2016131781 A JP2016131781 A JP 2016131781A JP 2016131781 A JP2016131781 A JP 2016131781A JP 2017019776 A5 JP2017019776 A5 JP 2017019776A5
- Authority
- JP
- Japan
- Prior art keywords
- brain
- proband
- synucleopathy
- abcc1 transporter
- drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004556 brain Anatomy 0.000 claims 8
- 101000969812 Homo sapiens Multidrug resistance-associated protein 1 Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229930182480 glucuronide Natural products 0.000 claims 1
- 150000008134 glucuronides Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000003688 hormone derivative Substances 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010044561 | 2010-09-07 | ||
| DE102010044561.4 | 2010-09-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527544A Division JP6084924B2 (ja) | 2010-09-07 | 2011-08-30 | β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017019776A JP2017019776A (ja) | 2017-01-26 |
| JP2017019776A5 true JP2017019776A5 (enExample) | 2017-03-23 |
| JP6426663B2 JP6426663B2 (ja) | 2018-11-21 |
Family
ID=44645670
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527544A Active JP6084924B2 (ja) | 2010-09-07 | 2011-08-30 | β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 |
| JP2016131781A Active JP6426663B2 (ja) | 2010-09-07 | 2016-07-01 | β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527544A Active JP6084924B2 (ja) | 2010-09-07 | 2011-08-30 | β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20130184268A1 (enExample) |
| EP (3) | EP2693216B1 (enExample) |
| JP (2) | JP6084924B2 (enExample) |
| CN (2) | CN106243060A (enExample) |
| BR (1) | BR112013005472A2 (enExample) |
| CA (2) | CA2870626C (enExample) |
| DE (2) | DE102010062810B4 (enExample) |
| DK (2) | DK2614060T3 (enExample) |
| ES (2) | ES2605705T3 (enExample) |
| MX (1) | MX357521B (enExample) |
| PL (2) | PL2614060T3 (enExample) |
| RU (2) | RU2016118021A (enExample) |
| WO (1) | WO2012031941A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3487505T3 (pl) | 2016-07-25 | 2023-10-09 | Wista Laboratories Ltd. | Podawanie i dawkowanie diaminofenotiazyn |
| BR112021000802A2 (pt) | 2018-07-26 | 2021-04-13 | Wista Laboratories Ltd. | Dosagem otimizada de diaminofenotiazinas em populações |
| WO2021188457A1 (en) * | 2020-03-16 | 2021-09-23 | Doublerainbow Biosciences Inc. | Etoposide glycosides, methods of making, and uses thereof as an anti-cancer drug |
| JP7897954B2 (ja) * | 2022-01-04 | 2026-07-30 | イムヌジェネティクス アーゲー | アルツハイマー型認知症の処置又は予防における使用のための特定の投与量のフェノチアジン化合物 |
| EP4605754A1 (en) * | 2022-10-18 | 2025-08-27 | Immungenetics AG | Identifying a subject suffering from alzheimer's dementia or being at risk of developing alzheimer's dementia |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH365379A (de) * | 1956-04-18 | 1962-11-15 | Sandoz Ag | Verfahren zur Herstellung von neuen, in 3-Stellung mit einer einwertigen Schwefelfunktion substituierten Phenothiazinen |
| BE568701A (enExample) * | 1957-06-18 | |||
| US3621097A (en) * | 1970-03-30 | 1971-11-16 | Jan Marcel Didier Aron Samuel | Method and compositions for treatment of mental illness |
| US4471116A (en) * | 1982-07-28 | 1984-09-11 | Hoffmann-La Roche Inc. | Substituted (10H-phenothiazin-10-L)-propyl-1-piperazines |
| US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
| WO1996004915A1 (en) * | 1994-08-08 | 1996-02-22 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes |
| DE4430091A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von N-substituierten Phenothiazinen |
| EP1470818B1 (en) * | 2003-04-25 | 2006-07-26 | Neuro3D | Use of piperazine phenothiazine derivatives in the manufacture of a medicament with neuroprotector and/or neurotrophic effects on cns and/or pns |
| DE102005014142B4 (de) * | 2005-03-23 | 2006-11-09 | Hennig Arzneimittel Gmbh & Co. Kg | Pelletförmige Retardzubereitung gegen Schwindel |
| WO2007062862A2 (en) * | 2005-12-02 | 2007-06-07 | Ludwig Maximilians Universität München | Use of calmodulin inhibitors for the treatment of neurodegenerative disorders |
| MY162313A (en) * | 2006-07-11 | 2017-05-31 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| JP5244810B2 (ja) * | 2006-11-10 | 2013-07-24 | カラ セラピューティクス インコーポレイテッド | 合成ペプチドアミド |
| GB0701970D0 (en) * | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
| TW200848063A (en) * | 2007-04-23 | 2008-12-16 | Combinatorx Inc | Methods and compositions for the treatment of neurodegenerative disorders |
| MX2010011880A (es) * | 2008-04-29 | 2011-05-25 | Pharnext | Nuevos enfoques terapeuticos para tratar la enfermedad del alzheimer y trastornos relacionados mediante una modulacion de la respuesta de estres celular. |
| NZ589307A (en) * | 2008-04-29 | 2012-04-27 | Pharnext | Compositions comprising baclogen or terbinafine for treating alzheimer disease and related disorders through a modulation of angiogenesis |
| WO2009133128A1 (en) * | 2008-04-29 | 2009-11-05 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
| US9399032B2 (en) * | 2009-05-14 | 2016-07-26 | The General Hospital Corporation | Methods and compositions for treating degenerative and ischemic disorders |
-
2010
- 2010-12-10 DE DE102010062810.7A patent/DE102010062810B4/de not_active Expired - Fee Related
-
2011
- 2011-08-30 DK DK11755294.3T patent/DK2614060T3/da active
- 2011-08-30 ES ES11755294.3T patent/ES2605705T3/es active Active
- 2011-08-30 JP JP2013527544A patent/JP6084924B2/ja active Active
- 2011-08-30 EP EP13190419.5A patent/EP2693216B1/de active Active
- 2011-08-30 CN CN201610631393.5A patent/CN106243060A/zh active Pending
- 2011-08-30 MX MX2013002612A patent/MX357521B/es active IP Right Grant
- 2011-08-30 WO PCT/EP2011/064893 patent/WO2012031941A2/de not_active Ceased
- 2011-08-30 EP EP11755294.3A patent/EP2614060B1/de active Active
- 2011-08-30 RU RU2016118021A patent/RU2016118021A/ru not_active Application Discontinuation
- 2011-08-30 EP EP16180106.3A patent/EP3097914A3/de not_active Withdrawn
- 2011-08-30 PL PL11755294T patent/PL2614060T3/pl unknown
- 2011-08-30 CA CA2870626A patent/CA2870626C/en active Active
- 2011-08-30 BR BR112013005472-7A patent/BR112013005472A2/pt not_active Application Discontinuation
- 2011-08-30 DE DE102011053114A patent/DE102011053114A1/de not_active Ceased
- 2011-08-30 CN CN201180053670.4A patent/CN103237802B/zh active Active
- 2011-08-30 US US13/821,515 patent/US20130184268A1/en not_active Abandoned
- 2011-08-30 ES ES13190419T patent/ES2701453T3/es active Active
- 2011-08-30 RU RU2013110018/04A patent/RU2587154C2/ru active
- 2011-08-30 DK DK13190419.5T patent/DK2693216T3/en active
- 2011-08-30 CA CA2811454A patent/CA2811454C/en active Active
- 2011-08-30 PL PL13190419T patent/PL2693216T3/pl unknown
-
2014
- 2014-09-29 US US14/499,918 patent/US9370523B2/en active Active
-
2015
- 2015-09-08 US US14/847,089 patent/US20150374711A1/en not_active Abandoned
-
2016
- 2016-07-01 JP JP2016131781A patent/JP6426663B2/ja active Active
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