JP2017002092A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017002092A5 JP2017002092A5 JP2016202730A JP2016202730A JP2017002092A5 JP 2017002092 A5 JP2017002092 A5 JP 2017002092A5 JP 2016202730 A JP2016202730 A JP 2016202730A JP 2016202730 A JP2016202730 A JP 2016202730A JP 2017002092 A5 JP2017002092 A5 JP 2017002092A5
- Authority
- JP
- Japan
- Prior art keywords
- starch
- pharmaceutically acceptable
- acceptable salt
- calcium
- canagliflozin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 67
- 229920002678 cellulose Polymers 0.000 claims 38
- 239000001913 cellulose Substances 0.000 claims 38
- 235000010980 cellulose Nutrition 0.000 claims 38
- 238000002360 preparation method Methods 0.000 claims 38
- 239000007787 solid Substances 0.000 claims 37
- 229960001713 canagliflozin Drugs 0.000 claims 36
- VHOFTEAWFCUTOS-TUGBYPPCSA-N canagliflozin hydrate Chemical compound O.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1.CC1=CC=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C=C1CC(S1)=CC=C1C1=CC=C(F)C=C1 VHOFTEAWFCUTOS-TUGBYPPCSA-N 0.000 claims 36
- 229920002472 Starch Polymers 0.000 claims 33
- 229930006000 Sucrose Natural products 0.000 claims 33
- 239000005720 sucrose Substances 0.000 claims 33
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 32
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 32
- 229920000881 Modified starch Polymers 0.000 claims 32
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 32
- 239000001506 calcium phosphate Substances 0.000 claims 32
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 32
- 239000008101 lactose Substances 0.000 claims 32
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 30
- -1 dextrate Polymers 0.000 claims 22
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 17
- 235000019698 starch Nutrition 0.000 claims 17
- 239000008107 starch Substances 0.000 claims 17
- 229920002261 Corn starch Polymers 0.000 claims 16
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 16
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 16
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 16
- 229920001353 Dextrin Polymers 0.000 claims 16
- 239000004375 Dextrin Substances 0.000 claims 16
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 16
- 239000004386 Erythritol Substances 0.000 claims 16
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 16
- 229930091371 Fructose Natural products 0.000 claims 16
- 239000005715 Fructose Substances 0.000 claims 16
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 16
- 229920002774 Maltodextrin Polymers 0.000 claims 16
- 239000005913 Maltodextrin Substances 0.000 claims 16
- 229930195725 Mannitol Natural products 0.000 claims 16
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 16
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 16
- 239000001354 calcium citrate Substances 0.000 claims 16
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 16
- 235000011010 calcium phosphates Nutrition 0.000 claims 16
- 238000007906 compression Methods 0.000 claims 16
- 230000006835 compression Effects 0.000 claims 16
- 239000008120 corn starch Substances 0.000 claims 16
- 235000019425 dextrin Nutrition 0.000 claims 16
- 239000008121 dextrose Substances 0.000 claims 16
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 16
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 16
- 229940038472 dicalcium phosphate Drugs 0.000 claims 16
- 235000019414 erythritol Nutrition 0.000 claims 16
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 16
- 229940009714 erythritol Drugs 0.000 claims 16
- 239000000845 maltitol Substances 0.000 claims 16
- 235000010449 maltitol Nutrition 0.000 claims 16
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 16
- 229940035436 maltitol Drugs 0.000 claims 16
- 229940035034 maltodextrin Drugs 0.000 claims 16
- 239000000594 mannitol Substances 0.000 claims 16
- 235000010355 mannitol Nutrition 0.000 claims 16
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 16
- 229920001592 potato starch Polymers 0.000 claims 16
- 229940116317 potato starch Drugs 0.000 claims 16
- 229940100486 rice starch Drugs 0.000 claims 16
- 239000000600 sorbitol Substances 0.000 claims 16
- 235000010356 sorbitol Nutrition 0.000 claims 16
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 16
- 235000013337 tricalcium citrate Nutrition 0.000 claims 16
- 229940100445 wheat starch Drugs 0.000 claims 16
- 239000002023 wood Substances 0.000 claims 16
- 239000000811 xylitol Substances 0.000 claims 16
- 235000010447 xylitol Nutrition 0.000 claims 16
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 16
- 229960002675 xylitol Drugs 0.000 claims 16
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 15
- XFWJKVMFIVXPKK-UHFFFAOYSA-N calcium;oxido(oxo)alumane Chemical compound [Ca+2].[O-][Al]=O.[O-][Al]=O XFWJKVMFIVXPKK-UHFFFAOYSA-N 0.000 claims 13
- 239000008187 granular material Substances 0.000 claims 7
- WGRQANOPCQRCME-PMACEKPBSA-N teneligliptin Chemical compound O=C([C@H]1NC[C@H](C1)N1CCN(CC1)C1=CC(=NN1C=1C=CC=CC=1)C)N1CCSC1 WGRQANOPCQRCME-PMACEKPBSA-N 0.000 claims 7
- 229950000034 teneligliptin Drugs 0.000 claims 7
- 244000215068 Acacia senegal Species 0.000 claims 6
- 229920000084 Gum arabic Polymers 0.000 claims 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 6
- 235000010489 acacia gum Nutrition 0.000 claims 6
- 239000000205 acacia gum Substances 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
- 239000008247 solid mixture Substances 0.000 claims 6
- 238000005469 granulation Methods 0.000 claims 4
- 230000003179 granulation Effects 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 235000012241 calcium silicate Nutrition 0.000 claims 3
- 229910052918 calcium silicate Inorganic materials 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003086 colorant Substances 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 239000003205 fragrance Substances 0.000 claims 2
- 238000009775 high-speed stirring Methods 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229960005069 calcium Drugs 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- FYHXNYLLNIKZMR-UHFFFAOYSA-N calcium;carbonic acid Chemical compound [Ca].OC(O)=O FYHXNYLLNIKZMR-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 1
- 229960005168 croscarmellose Drugs 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000004503 fine granule Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 claims 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014262702 | 2014-12-25 | ||
| JP2014262702 | 2014-12-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546861A Division JP6027710B1 (ja) | 2014-12-25 | 2015-12-24 | 糖尿病治療用固形製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017002092A JP2017002092A (ja) | 2017-01-05 |
| JP2017002092A5 true JP2017002092A5 (enExample) | 2019-01-31 |
| JP6639368B2 JP6639368B2 (ja) | 2020-02-05 |
Family
ID=56150656
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546861A Active JP6027710B1 (ja) | 2014-12-25 | 2015-12-24 | 糖尿病治療用固形製剤 |
| JP2016202730A Active JP6639368B2 (ja) | 2014-12-25 | 2016-10-14 | 糖尿病治療用固形製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546861A Active JP6027710B1 (ja) | 2014-12-25 | 2015-12-24 | 糖尿病治療用固形製剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JP6027710B1 (enExample) |
| WO (1) | WO2016104643A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA039402B1 (ru) * | 2017-02-03 | 2022-01-24 | Гленмарк Фармасьтикалз Лимитед | Оксалаты тенелиглиптина и их сольваты, промежуточные соединения, способ получения и их маркеры |
| JPWO2020209350A1 (enExample) * | 2019-04-12 | 2020-10-15 | ||
| AU2020394498A1 (en) | 2019-11-28 | 2022-06-09 | Boehringer Ingelheim Vetmedica Gmbh | Use of SGLT-2 inhibitors in the drying-off of non-human mammals |
| WO2024053680A1 (ja) * | 2022-09-07 | 2024-03-14 | 田辺三菱製薬株式会社 | 口腔内崩壊錠 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101646420B (zh) * | 2007-02-01 | 2012-11-07 | 武田药品工业株式会社 | 包含阿格列汀和吡格列酮的固体制剂 |
| CL2008003653A1 (es) * | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
| UY32427A (es) * | 2009-02-13 | 2010-09-30 | Boheringer Ingelheim Internat Gmbh | Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma |
| WO2011074660A1 (ja) * | 2009-12-18 | 2011-06-23 | 田辺三菱製薬株式会社 | 溶出安定性製剤 |
| EP2568971B1 (en) * | 2010-05-11 | 2020-10-14 | Mitsubishi Tanabe Pharma Corporation | Canagliflozin containing tablets |
-
2015
- 2015-12-24 JP JP2016546861A patent/JP6027710B1/ja active Active
- 2015-12-24 WO PCT/JP2015/086097 patent/WO2016104643A1/ja not_active Ceased
-
2016
- 2016-10-14 JP JP2016202730A patent/JP6639368B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2455195T3 (es) | Comprimido que se disgrega en la cavidad oral | |
| JP5399749B2 (ja) | プロトンポンプ阻害剤を含有する被覆微粒子 | |
| JP2021001192A5 (enExample) | ||
| RU2485947C2 (ru) | Фармацевтические композиции энтакапона, леводопы и карбидопы с улучшенной биодоступностью | |
| TWI526210B (zh) | Oral pharmaceutical composition | |
| JP2017002092A5 (enExample) | ||
| US20100183730A1 (en) | High dose composition of ursodeoxycholic acid | |
| JP5174909B2 (ja) | 活性成分のコーティング膜が保護される口腔内崩壊剤形を製造するための組成物 | |
| JPWO2004078171A1 (ja) | 吸水性アミノ酸含有錠剤 | |
| JP6164346B2 (ja) | 口腔内崩壊錠の製造方法 | |
| JP6393549B2 (ja) | ビタミンｂ１２含有組成物 | |
| JP5572321B2 (ja) | 被覆微粒子含有口腔内崩壊錠 | |
| JP2013237651A (ja) | ピタバスタチンの口腔内崩壊錠 | |
| JP2005139085A (ja) | 顆粒 | |
| JP2018145095A (ja) | エルロチニブ塩酸塩含有医薬組成物 | |
| JP2005298373A (ja) | 吸水性アミノ酸含有糖衣錠剤 | |
| TW201716063A (zh) | 維生素c和鋅之穩定組合物錠劑 | |
| JP5828280B2 (ja) | 錠剤及びその製造方法 | |
| JP7023600B2 (ja) | シロドシン含有医薬組成物とその製造方法 | |
| JP6601844B2 (ja) | 光安定性に優れたミルタザピン含有医薬製剤 | |
| CN105555316A (zh) | 通过二阶段的湿式制粒工序制备的崩解性颗粒组合物及含有该组合物的口腔内崩解片剂 | |
| JP6198329B2 (ja) | 積層錠及びその製造方法 | |
| JP7480983B2 (ja) | レベチラセタム含有製剤 | |
| JP6986244B2 (ja) | レボセチリジン固形製剤 | |
| RU2286143C1 (ru) | Муколитическая фармацевтическая композиция |