JP2017002083A5 - - Google Patents
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- JP2017002083A5 JP2017002083A5 JP2016196955A JP2016196955A JP2017002083A5 JP 2017002083 A5 JP2017002083 A5 JP 2017002083A5 JP 2016196955 A JP2016196955 A JP 2016196955A JP 2016196955 A JP2016196955 A JP 2016196955A JP 2017002083 A5 JP2017002083 A5 JP 2017002083A5
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- 239000000203 mixture Substances 0.000 claims 62
- 210000004204 Blood Vessels Anatomy 0.000 claims 16
- 239000002105 nanoparticle Substances 0.000 claims 15
- 102100001249 ALB Human genes 0.000 claims 9
- 101710027066 ALB Proteins 0.000 claims 9
- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 9
- 229940050528 albumin Drugs 0.000 claims 9
- 238000002347 injection Methods 0.000 claims 9
- 239000007924 injection Substances 0.000 claims 9
- 229960002930 sirolimus Drugs 0.000 claims 9
- 210000001367 Arteries Anatomy 0.000 claims 6
- 230000002792 vascular Effects 0.000 claims 6
- 206010016654 Fibrosis Diseases 0.000 claims 5
- 230000004761 fibrosis Effects 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 238000007634 remodeling Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000265 Leukocytes Anatomy 0.000 claims 2
- 210000001147 Pulmonary Artery Anatomy 0.000 claims 2
- 230000001737 promoting Effects 0.000 claims 2
- 206010002383 Angina pectoris Diseases 0.000 claims 1
- 206010003119 Arrhythmia Diseases 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 210000001627 Cerebral Arteries Anatomy 0.000 claims 1
- 210000004351 Coronary Vessels Anatomy 0.000 claims 1
- 210000002414 Leg Anatomy 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 206010062585 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 210000002254 Renal Artery Anatomy 0.000 claims 1
- 210000003462 Veins Anatomy 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 201000006233 congestive heart failure Diseases 0.000 claims 1
- 201000002818 limb ischemia Diseases 0.000 claims 1
- 230000002093 peripheral Effects 0.000 claims 1
Claims (37)
- 血管におけるネガティブリモデリングを阻害する必要のある個体において血管におけるネガティブリモデリングを阻害するための組成物であって、ラパマイシンおよびアルブミンを含むナノ粒子の有効量を含み、該組成物は、血管壁内への注射によって該個体に投与されることを特徴とする、組成物。
- 血管における血管線維症を阻害する必要のある個体において血管における血管線維症を阻害するための組成物であって、ラパマイシンおよびアルブミンを含むナノ粒子の有効量を含み、該組成物は、血管壁内への注射によって該個体に投与されることを特徴とする、組成物。
- 前記血管線維症が中膜血管線維症または外膜線維症である、請求項２に記載の組成物。
- 血管におけるポジティブリモデリングを促進する必要のある個体において血管におけるポジティブリモデリングを促進するための組成物であって、ラパマイシンおよびアルブミンを含むナノ粒子の有効量を含み、該組成物は、血管壁内への注射によって該個体に投与されることを特徴とする、組成物。
- 血管における外膜血管を低減する必要のある個体において血管における外膜血管を低減するための組成物であって、ラパマイシンおよびアルブミンを含むナノ粒子の有効量を含み、該組成物は、血管壁内への注射によって該個体に投与されることを特徴とする、組成物。
- 血管における外膜の白血球を低減する必要のある個体において血管における外膜の白血球を低減するための組成物であって、ラパマイシンおよびアルブミンを含むナノ粒子の有効量を含み、該組成物は、血管壁内への注射によって該個体に投与されることを特徴とする、組成物。
- 前記血管が動脈である、請求項１から６のいずれか一項に記載の組成物。
- 前記動脈が冠動脈または末梢動脈である、請求項７に記載の組成物。
- 前記動脈が、腎動脈、脳動脈、肺動脈、および脚の動脈からなる群から選択される、請求項７に記載の組成物。
- 前記動脈が肺動脈である、請求項９に記載の組成物。
- 前記血管が静脈である、請求項１から６のいずれか一項に記載の組成物。
- 前記組成物が、約０．００１ｍｇ〜約１００ｍｇの用量で投与されることを特徴とする、請求項１から１１のいずれか一項に記載の組成物。
- 前記組成物が、約０．０５ｍｇ〜約５ｍｇの用量で投与されることを特徴とする、請求項１２に記載の組成物。
- 前記組成物の注射量が、約０．０１ｍｌ〜約５０ｍｌであることを特徴とする、請求項１から１３のいずれか一項に記載の組成物。
- 前記組成物の前記注射量が、約０．５ｍｌ〜約５ｍｌであることを特徴とする、請求項１４に記載の組成物。
- 前記組成物が、針付きカテーテルを通して注射されることを特徴とする、請求項１から１５のいずれか一項に記載の組成物。
- 前記組成物が、少なくとも年１回投与されることを特徴とする、請求項１から１６のいずれか一項に記載の組成物。
- 前記組成物が、疾患部位の遠位または近位に注射されることを特徴とする、請求項１から１７のいずれか一項に記載の組成物。
- 前記組成物が、疾患部位から少なくとも約２ｃｍ離れた場所に注射されることを特徴とする、請求項１から１７のいずれか一項に記載の組成物。
- 前記組成物が、疾患部位に、または疾患部位に隣接して注射されることを特徴とする、請求項１から１７のいずれか一項に記載の組成物。
- 前記個体が、狭心症、心筋梗塞、うっ血性心不全、心不整脈、末梢動脈疾患、跛行、または慢性肢虚血のうちのいずれか１つを有する、請求項１から２０のいずれか一項に記載の組成物。
- アルブミンおよびラパマイシンを含むナノ粒子を含む、血管に送達するための組成物であって、有効量の該組成物が、血管壁内への注射によって個体に投与されることを特徴とする、組成物。
- 前記組成物が、針付きカテーテルを介して注射されることを特徴とする、請求項２２に記載の組成物。
- 前記組成物中の前記ナノ粒子が、約２００ｎｍ以下のアベレージ直径を有する、請求項１から２３のいずれか一項に記載の組成物。
- 前記組成物中の前記ナノ粒子が、約１００ｎｍ以下のアベレージ直径を有する、請求項２４に記載の組成物。
- 前記組成物中の前記ナノ粒子が、約７０ｎｍ以上のアベレージ直径を有する、請求項２５に記載の組成物。
- 前記ナノ粒子中の前記ラパマイシンが、アルブミンで被覆されている、請求項１から２６のいずれか一項に記載の組成物。
- 前記個体がヒトである、請求項１から２７のいずれか一項に記載の組成物。
- 前記組成物が血管介入手順中に使用されることを特徴とする、請求項１から２８のいずれか一項に記載の組成物。
- 前記組成物が血管介入手順後に使用されることを特徴とする、請求項１から２８のいずれか一項に記載の組成物。
- 前記介入手順が、血管形成術、ステント留置術、またはアテローム切除術である、請求項２９または３０に記載の組成物。
- 針付きカテーテルであって、該針が、ラパマイシンおよびアルブミンを含むナノ粒子を含む組成物を含有し、該組成物が、血管壁内への注射によって投与されることを特徴とする、カテーテル。
- 前記組成物中の前記ナノ粒子が、約２００ｎｍ以下のアベレージ直径を有する、請求項３２に記載のカテーテル。
- 前記組成物中の前記ナノ粒子が、約１００ｎｍ以下のアベレージ直径を有する、請求項３３に記載のカテーテル。
- 前記組成物中の前記ナノ粒子が、約７０ｎｍ以上のアベレージ直径を有する、請求項３４に記載のカテーテル。
- 前記ナノ粒子が、アルブミンで被覆された前記ラパマイシンを含む、請求項３２から３５のいずれか一項に記載のカテーテル。
- 前記針が展開可能である、請求項３２から３６のいずれか一項に記載のカテーテル。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161518084P | 2011-04-28 | 2011-04-28 | |
| US61/518,084 | 2011-04-28 | ||
| US201161557851P | 2011-11-09 | 2011-11-09 | |
| US61/557,851 | 2011-11-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508146A Division JP6038123B2 (ja) | 2011-04-28 | 2012-04-27 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157942A Division JP6427641B2 (ja) | 2011-04-28 | 2017-08-18 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017002083A JP2017002083A (ja) | 2017-01-05 |
| JP2017002083A5 true JP2017002083A5 (ja) | 2017-02-16 |
| JP6196719B2 JP6196719B2 (ja) | 2017-09-13 |
Family
ID=47072793
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508146A Active JP6038123B2 (ja) | 2011-04-28 | 2012-04-27 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| JP2016196955A Active JP6196719B2 (ja) | 2011-04-28 | 2016-10-05 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| JP2017157942A Active JP6427641B2 (ja) | 2011-04-28 | 2017-08-18 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| JP2018203038A Pending JP2019011378A (ja) | 2011-04-28 | 2018-10-29 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508146A Active JP6038123B2 (ja) | 2011-04-28 | 2012-04-27 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157942A Active JP6427641B2 (ja) | 2011-04-28 | 2017-08-18 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| JP2018203038A Pending JP2019011378A (ja) | 2011-04-28 | 2018-10-29 | ナノ粒子組成物の脈管内送達およびそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9061014B2 (ja) |
| EP (1) | EP2701731B1 (ja) |
| JP (4) | JP6038123B2 (ja) |
| KR (3) | KR101970342B1 (ja) |
| CN (3) | CN103648521A (ja) |
| AU (2) | AU2012249371B2 (ja) |
| BR (1) | BR112013027674A2 (ja) |
| CA (2) | CA3063641A1 (ja) |
| ES (1) | ES2819204T3 (ja) |
| IL (2) | IL229041B (ja) |
| MX (1) | MX354216B (ja) |
| SG (2) | SG194623A1 (ja) |
| WO (1) | WO2012149451A1 (ja) |
| ZA (1) | ZA201307875B (ja) |
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