JP2016540028A5 - - Google Patents
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- Publication number
- JP2016540028A5 JP2016540028A5 JP2016540559A JP2016540559A JP2016540028A5 JP 2016540028 A5 JP2016540028 A5 JP 2016540028A5 JP 2016540559 A JP2016540559 A JP 2016540559A JP 2016540559 A JP2016540559 A JP 2016540559A JP 2016540028 A5 JP2016540028 A5 JP 2016540028A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- methyl
- isoxazoline compound
- formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 methoxyethyl Chemical group 0.000 claims 76
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 230000009545 invasion Effects 0.000 claims 7
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 6
- 125000004970 halomethyl group Chemical group 0.000 claims 6
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 6
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 6
- 241000238421 Arthropoda Species 0.000 claims 5
- 230000003071 parasitic effect Effects 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 claims 3
- 229920005555 halobutyl Polymers 0.000 claims 3
- 125000004968 halobutyl group Chemical group 0.000 claims 3
- 125000004969 haloethyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 3
- 125000004673 propylcarbonyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 241001260012 Bursa Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000003651 drinking water Substances 0.000 claims 2
- 235000020188 drinking water Nutrition 0.000 claims 2
- 150000002547 isoxazolines Chemical class 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 241000272525 Anas platyrhynchos Species 0.000 claims 1
- 241000239290 Araneae Species 0.000 claims 1
- 241001480752 Argas persicus Species 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CC(C1)=NOC1(*)C(C=CC=C1)=C*1N Chemical compound CC(C1)=NOC1(*)C(C=CC=C1)=C*1N 0.000 description 32
- FUAKFJDWSVFGKO-UHFFFAOYSA-N CCC1=CSCN1C Chemical compound CCC1=CSCN1C FUAKFJDWSVFGKO-UHFFFAOYSA-N 0.000 description 3
- XNTFQMKXUFFUQO-UHFFFAOYSA-N C[n]1[n]ccc1CN Chemical compound C[n]1[n]ccc1CN XNTFQMKXUFFUQO-UHFFFAOYSA-N 0.000 description 3
- QYOJSNPPGRBNJR-UHFFFAOYSA-N NC(C1)CS1(=O)=O Chemical compound NC(C1)CS1(=O)=O QYOJSNPPGRBNJR-UHFFFAOYSA-N 0.000 description 3
- OZGWIFFWPCEUEE-UHFFFAOYSA-N NC(C1)CS1=O Chemical compound NC(C1)CS1=O OZGWIFFWPCEUEE-UHFFFAOYSA-N 0.000 description 3
- HRVLXTZHPZXHTR-UHFFFAOYSA-N NC1(CC1)c1ncccc1 Chemical compound NC1(CC1)c1ncccc1 HRVLXTZHPZXHTR-UHFFFAOYSA-N 0.000 description 3
- WOXFMYVTSLAQMO-UHFFFAOYSA-N NCc1ncccc1 Chemical compound NCc1ncccc1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 description 3
- FVLAYJRLBLHIPV-UHFFFAOYSA-N Nc1cncnc1 Chemical compound Nc1cncnc1 FVLAYJRLBLHIPV-UHFFFAOYSA-N 0.000 description 3
- BYOJPKDTSISMJH-UHFFFAOYSA-N CN(C12)C=CC1C(N)=CC=C2N Chemical compound CN(C12)C=CC1C(N)=CC=C2N BYOJPKDTSISMJH-UHFFFAOYSA-N 0.000 description 2
- WNGJNNOQQKMKGZ-UHFFFAOYSA-N NC(C1C=CSC11)=CC=C1N Chemical compound NC(C1C=CSC11)=CC=C1N WNGJNNOQQKMKGZ-UHFFFAOYSA-N 0.000 description 2
- JYFRBECAJLHOEK-UHFFFAOYSA-N Nc(cc1)c(cccn2)c2c1N Chemical compound Nc(cc1)c(cccn2)c2c1N JYFRBECAJLHOEK-UHFFFAOYSA-N 0.000 description 2
- UEYXZMIZYXYAJN-UHFFFAOYSA-N Nc(cc1)c(ccnc2)c2c1N Chemical compound Nc(cc1)c(ccnc2)c2c1N UEYXZMIZYXYAJN-UHFFFAOYSA-N 0.000 description 2
- CUYKNJBYIJFRCU-UHFFFAOYSA-N Nc1cnccc1 Chemical compound Nc1cnccc1 CUYKNJBYIJFRCU-UHFFFAOYSA-N 0.000 description 2
- JNDIQXKRAYWXBS-YFQKQBTRSA-N C/N=C\C=C(/C=C)\C(NCN)=O Chemical compound C/N=C\C=C(/C=C)\C(NCN)=O JNDIQXKRAYWXBS-YFQKQBTRSA-N 0.000 description 1
- NEAILCPAVYKJCC-UHFFFAOYSA-N CC1C=NC(C)=NC1 Chemical compound CC1C=NC(C)=NC1 NEAILCPAVYKJCC-UHFFFAOYSA-N 0.000 description 1
- VCPXZIUQCXEVCU-UHFFFAOYSA-N CCc1ncncc1 Chemical compound CCc1ncncc1 VCPXZIUQCXEVCU-UHFFFAOYSA-N 0.000 description 1
- BQXDVZQQCJHLMJ-UHFFFAOYSA-N CN(C12)N=CC1C(I)=CC=C2I Chemical compound CN(C12)N=CC1C(I)=CC=C2I BQXDVZQQCJHLMJ-UHFFFAOYSA-N 0.000 description 1
- DQPRHSRNQZVUIN-UHFFFAOYSA-N C[IH]c(nc1)nnc1N Chemical compound C[IH]c(nc1)nnc1N DQPRHSRNQZVUIN-UHFFFAOYSA-N 0.000 description 1
- KEJQIFXIIRLADN-UHFFFAOYSA-N NC(C1C=COC11)=CC=C1I Chemical compound NC(C1C=COC11)=CC=C1I KEJQIFXIIRLADN-UHFFFAOYSA-N 0.000 description 1
- KBHCMKXZLFVXRD-UHFFFAOYSA-N NC(NCC(F)(F)F)=O Chemical compound NC(NCC(F)(F)F)=O KBHCMKXZLFVXRD-UHFFFAOYSA-N 0.000 description 1
- PPFLLWDIBPUSJK-UHFFFAOYSA-N NCC(NCCC(F)(F)F)=O Chemical compound NCC(NCCC(F)(F)F)=O PPFLLWDIBPUSJK-UHFFFAOYSA-N 0.000 description 1
- HDOUGSFASVGDCS-UHFFFAOYSA-N NCc1cnccc1 Chemical compound NCc1cnccc1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
- FMCUPJKTGNBGEC-UHFFFAOYSA-N N[n]1cnnc1 Chemical compound N[n]1cnnc1 FMCUPJKTGNBGEC-UHFFFAOYSA-N 0.000 description 1
- NHAZGSRLKBTDBF-UHFFFAOYSA-N N[n]1ncnc1 Chemical compound N[n]1ncnc1 NHAZGSRLKBTDBF-UHFFFAOYSA-N 0.000 description 1
- OKBVMLGZPNDWJK-UHFFFAOYSA-N Nc(cc1)c(cccc2)c2c1N Chemical compound Nc(cc1)c(cccc2)c2c1N OKBVMLGZPNDWJK-UHFFFAOYSA-N 0.000 description 1
- ICSNLGPSRYBMBD-UHFFFAOYSA-N Nc1ncccc1 Chemical compound Nc1ncccc1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199007.9 | 2013-12-20 | ||
| EP13199007 | 2013-12-20 | ||
| PCT/EP2014/078636 WO2015091900A1 (en) | 2013-12-20 | 2014-12-19 | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016540028A JP2016540028A (ja) | 2016-12-22 |
| JP2016540028A5 true JP2016540028A5 (cg-RX-API-DMAC7.html) | 2018-01-25 |
| JP6506763B2 JP6506763B2 (ja) | 2019-04-24 |
Family
ID=49911279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540559A Active JP6506763B2 (ja) | 2013-12-20 | 2014-12-19 | 家禽類における節足動物侵襲の処置または予防のためのイソオキサゾリン誘導体の使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10272071B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3082806B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6506763B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110839641A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016014216B1 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2874054T3 (cg-RX-API-DMAC7.html) |
| HU (2) | HUE063842T2 (cg-RX-API-DMAC7.html) |
| MX (2) | MX376210B (cg-RX-API-DMAC7.html) |
| PL (2) | PL3082806T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3082806T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2688167C1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015091900A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10272071B2 (en) | 2013-12-20 | 2019-04-30 | Intervet Inc. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
| CN110327468B (zh) | 2013-12-20 | 2023-04-28 | 英特维特国际股份有限公司 | 异噁唑啉组合物及其在预防或治疗动物的寄生虫侵袭中的用途 |
| CN107750159B (zh) | 2015-06-23 | 2021-10-29 | 英特维特国际股份有限公司 | 用于消毒的饮用水的含有维生素的异噁唑啉溶液 |
| WO2018039508A1 (en) * | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| TWI834690B (zh) * | 2018-07-18 | 2024-03-11 | 美商富曼西公司 | 用於防治無脊椎動物害蟲之異噁唑啉化合物 |
| TW202012399A (zh) * | 2018-09-12 | 2020-04-01 | 美商富曼西公司 | 用於防制無脊椎動物害蟲之異口咢唑啉化合物 |
| WO2020201440A1 (en) * | 2019-04-03 | 2020-10-08 | Virbac | Low dose fluralaner compositions for protection against parasitic invertebrate pest |
| MX2022007309A (es) * | 2019-12-16 | 2022-07-12 | Intervet Int Bv | Composicion para control de piojos en aves de corral. |
| MX2022007455A (es) | 2019-12-18 | 2022-08-15 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como plaguicidas. |
| EP4185585A1 (en) | 2020-07-24 | 2023-05-31 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| EP4430947A1 (en) | 2023-03-17 | 2024-09-18 | Przedsiebiorstwo Wielobranzowe "Vet-Agro" Sp. Z O.O. | Therapeutic use of isoxazoline compounds, composition of isoxazoline compounds and kit for therapeutic use |
| US11903962B1 (en) * | 2023-05-07 | 2024-02-20 | Michael Farber | Isoxazoline complexes and compositions thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| WO2007053902A1 (en) | 2005-11-10 | 2007-05-18 | Bomac Animal Health Pty Limited | Method of treating parasites |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| CA2971008A1 (en) | 2007-06-27 | 2008-12-31 | E. I. Du Pont De Nemours And Company | Animal pest control method |
| TWI556741B (zh) * | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| AU2009270255B2 (en) * | 2008-07-09 | 2013-12-12 | Nissan Chemical Corporation | Process for production of isoxazoline-substituted benzoic acid amide compound |
| EP2364147A2 (en) | 2008-11-19 | 2011-09-14 | Merial Limited | Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection |
| CA2747060A1 (en) | 2008-12-18 | 2010-07-15 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
| AR074790A1 (es) | 2008-12-19 | 2011-02-09 | Novartis Ag | Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. |
| AR081843A1 (es) * | 2010-06-09 | 2012-10-24 | Syngenta Participations Ag | Mezclas pesticidas incluyendo derivados isoxazolina |
| EP2593592B1 (en) | 2010-07-15 | 2018-05-16 | Luxembourg Institute of Science and Technology (LIST) | Separation of master electrode and substrate in ecpr |
| HUE058290T2 (hu) * | 2010-12-27 | 2022-07-28 | Intervet Int Bv | Topikális lokalizált izoxazolin formuláció, amely tartalmaz glikofurolt |
| US9173870B2 (en) | 2010-12-27 | 2015-11-03 | Intervet Inc. | Topical localized isoxazoline formulation |
| MX2013009211A (es) * | 2011-02-10 | 2013-08-29 | Novartis Ag | Derivados de isoxazolina para controlar plagas de invertebrados. |
| WO2013026695A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| WO2013026931A1 (en) * | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
| SG11201400558YA (en) | 2011-09-12 | 2014-04-28 | Merial Ltd | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| CN103842346A (zh) * | 2011-10-03 | 2014-06-04 | 先正达参股股份有限公司 | 作为杀虫化合物的异噁唑啉衍生物 |
| DE102012200815B3 (de) | 2012-01-20 | 2013-01-10 | Dieter Kirsch | Inhalationsunterstützungsvorrichtung und Verfahren zur Inhalationsunterstützung |
| ES2633611T5 (es) * | 2012-04-04 | 2023-09-26 | Intervet Int Bv | Composiciones farmacéuticas orales sólidas de compuestos de isoxazolina |
| US10272071B2 (en) * | 2013-12-20 | 2019-04-30 | Intervet Inc. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
-
2014
- 2014-12-19 US US15/105,197 patent/US10272071B2/en active Active
- 2014-12-19 ES ES14816243T patent/ES2874054T3/es active Active
- 2014-12-19 BR BR112016014216-0A patent/BR112016014216B1/pt active IP Right Grant
- 2014-12-19 EP EP14816243.1A patent/EP3082806B1/en active Active
- 2014-12-19 PL PL14816243T patent/PL3082806T3/pl unknown
- 2014-12-19 PL PL21166872.8T patent/PL3878281T3/pl unknown
- 2014-12-19 WO PCT/EP2014/078636 patent/WO2015091900A1/en not_active Ceased
- 2014-12-19 HU HUE21166872A patent/HUE063842T2/hu unknown
- 2014-12-19 CN CN201911241170.8A patent/CN110839641A/zh active Pending
- 2014-12-19 HU HUE14816243A patent/HUE055444T2/hu unknown
- 2014-12-19 MX MX2016008119A patent/MX376210B/es active IP Right Grant
- 2014-12-19 PT PT148162431T patent/PT3082806T/pt unknown
- 2014-12-19 CN CN201480068597.1A patent/CN105979944A/zh active Pending
- 2014-12-19 JP JP2016540559A patent/JP6506763B2/ja active Active
- 2014-12-19 RU RU2016129272A patent/RU2688167C1/ru active
- 2014-12-19 ES ES21166872T patent/ES2950885T3/es active Active
- 2014-12-19 EP EP21166872.8A patent/EP3878281B1/en active Active
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2016
- 2016-06-17 MX MX2020010997A patent/MX2020010997A/es unknown
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2019
- 2019-03-05 US US16/293,024 patent/US10653675B2/en active Active
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2020
- 2020-04-15 US US16/849,487 patent/US11304934B2/en active Active
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2022
- 2022-03-08 US US17/653,950 patent/US12128032B2/en active Active