JP2016539997A - 長時間作用型ケトプロフェン組成物 - Google Patents
長時間作用型ケトプロフェン組成物 Download PDFInfo
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- JP2016539997A JP2016539997A JP2016538550A JP2016538550A JP2016539997A JP 2016539997 A JP2016539997 A JP 2016539997A JP 2016538550 A JP2016538550 A JP 2016538550A JP 2016538550 A JP2016538550 A JP 2016538550A JP 2016539997 A JP2016539997 A JP 2016539997A
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- Prior art keywords
- ketoprofen
- veterinary
- triglyceride
- long
- ester
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Abstract
Description
は、熱、疼痛、及び/または炎症の治療において有用であるとして長い間認識されているNSAIDである(すなわち、解熱剤及び鎮痛剤)。鎮痛剤として、ケトプロフェンは、インドメタシン、メロキシカム、フルニキシンメグルミン、及びフェニルブタゾンなど、他の利用可能な高効力NSAID化合物と少なくとも同じくらい有効である。解熱剤として、ケトプロフェンは、メロキシカムよりも強力である。
本明細書に記載及び特許請求される本発明の目的で、以下の用語及び語句は、以下の通り定義される。
測定可能な数値変数に関連して使用される場合、「約」は、変数の指示値、及び指示値の実験誤差以内(例えば、平均の95%信頼区間内)または指示値の10パーセント以内のどちらか大きい範囲にある変数の全ての値を指す。
ケトプロフェンエステルは、本明細書に記載されるプロセス及び方法に従って調製され得る。あるいは、メチルエステルは、以下のスキームに従って調製され得る。
ケトプロフェン(50g)を室温でメタノール(200mL)に添加し、溶解するまで撹拌した。溶液を約5〜10℃まで冷却した。HClガスを溶液に通過させて、反応生成量の約23gの増加をもたらした。溶液を撹拌しながら室温まで温めた。次いで、溶液を約0〜5℃まで冷却した。約0〜20℃の反応温度を維持しながら、冷水(200mL)を滴下添加した。次いで、溶液を約30分間室温で撹拌した。固体を濾過し、水で洗浄した。固体を約40℃において真空下で乾燥させて、約52gのケトプロフェンメチルエステル(98.6%)を得た。
組成物1
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組成物8
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組成物10
組成物11
組成物12
組成物13
組成物14
ブタ肺胞マクロファージを使用した適格な初代細胞アッセイを用いて、ブタCOX−1及びCOX−2酵素に対して、多くのNSAIDのインビトロ活性を評価した。NSAIDは、フルニキシンメグルミン(Banamine−S(登録商標))、メロキシカム(Metacam(登録商標))、ケトプロフェン(Ketofen(登録商標)、注射可能)、ケトプロフェンS−エナンチオマー、ケトプロフェン(ラセミ)、カルプロフェン、及びケトプロフェンプロドラッグ(式1及び式3)を含んだ。肺胞マクロファージを、種々の量の阻害剤の存在下で、リポ多糖(LPS)で処理して、トロンボキサンB2(TXB2)及び/またはプロスタグランジンE2(PGE2)を生成した。細胞上清を21〜24時間のインキュベーション後に採取し、ELISAによって定量化されるまで−80℃で冷凍した。TXB2をCOX−1阻害に対するアッセイ読み出しとして使用した。PGE2をCOX−2阻害に対するアッセイ読み出しとして使用した。各薬物を3つの異なる日における3つの異なる実験で試験した(最低でも)。COX−1またはCOX−2の阻害の百分率を、それぞれ観察されたTXB2またはPGE2濃度の平均に基づき、各薬物濃度に対して計算した。平均%阻害曲線(%阻害対薬物濃度)を非線形回帰によって解析して、COX−2 IC50効力の順位で列挙される個々のIC50及びIC90値を得た。ブタCOX酵素に対するラセミケトプロフェンのIC50値(表1)は、ヒトに関して報告された値と同様である。表1に示されるように、ケトプロフェン(ラセミ化合物)は、フルニキシンよりもわずかに強力であり、両方が、典型的なCOX−2基準、メロキシカムよりも約5倍強力である、ケトプロフェンメチルエステルよりも1桁強力である。
表1.種々のNSAIDに対するブタCOX−1及びCOX−2のIC50及びIC90効力(μM)
表2.ケトプロフェン(Ketofen(登録商標)、注射可能)及び式1に対するウシCOX−1及びCOX−2のIC50及びIC90効力(μM)
表3.ケトプロフェンまたはそのエステルの静脈内及び筋肉内投与後のブタにおける正規化された平均ケトプロフェンAUC
表4.ケトプロフェンメチルエステルの単回の筋肉内投与後のブタにおけるケトプロフェンの平均薬物動態パラメータ
表5.ケトプロフェンメチルエステルの単回の筋肉内投与後のブタにおけるケトプロフェンの平均薬物動態パラメータ
表6.ケトプロフェンメチルエステルの単回筋肉内投与後のブタにおけるケトプロフェンの平均薬物動態パラメータ
表7.ケトプロフェンメチルエステルの単回筋肉内投与後のブタにおけるケトプロフェンの平均薬物動態パラメータ
表8.ケトプロフェンメチルエステルの単回の筋肉内投与後のウシにおけるケトプロフェンの平均薬物動態パラメータ
表9.Neoprofen(登録商標)の単回の筋肉内注射後のケトプロフェンの平均薬物動態パラメータ
Claims (15)
- a)ケトプロフェンエステルプロドラッグと、
b)少なくとも1つの獣医学的に許容できるトリグリセリドと、
c)任意に少なくとも1つの保存料と、
d)任意に少なくとも1つの追加の獣医学的に許容できる賦形剤と、を含む、獣医用長時間作用型組成物。 - 前記ケトプロフェンエステルプロドラッグは、メチルエステル、エチルエステル、ニコチンアミドエステル、ベンジルエステル、ポリエチレングリコールエステル、プロピレングリコールモノエステル、プロピレングリコールジエステル、プロピレングリコールモノエステル及びプロピレングリコールジエステルの混合物、ならびにこれらの混合物からなる群から選択される、請求項1に記載の前記獣医用長時間作用型組成物。
- 前記ケトプロフェンエステルプロドラッグは、前記ケトプロフェンメチルエステルプロドラッグである、請求項2に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるトリグリセリドは、カプリル酸/カプリン酸トリグリセリド、ジカプリル酸/ジカプリン酸プロピレングリコール、カプリル酸/カプリン酸/リノール酸トリグリセリド、グリセロールトリアセテート、ヒマシ油、綿実油、ゴマ油、及びこれらの混合物からなる群から選択される、請求項1〜3のいずれか1項に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるトリグリセリドは、カプリル酸/カプリン酸トリグリセリドである、請求項4に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるトリグリセリドは、ジカプリル酸/ジカプリン酸プロピレングリコールトリグリセリドである、請求項4に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるトリグリセリドは、グリセロールトリアセテート、ヒマシ油、綿実油、及びこれらの混合物からなる群から選択される、請求項4に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるカプリル酸/カプリン酸トリグリセリドは、ミグリオール812である、請求項5に記載の前記獣医用長時間作用型組成物。
- 前記獣医学的に許容できるジカプリル酸/ジカプリン酸プロピレングリコールトリグリセリドは、ミグリオール840である、請求項6に記載の前記獣医用長時間作用型組成物。
- 少なくとも1つの保存料をさらに含む、請求項1〜9のいずれか1項に記載の前記獣医用長時間作用型組成物。
- 少なくとも1つの獣医学的に許容できる賦形剤をさらに含む、請求項1〜10のいずれか1項に記載の前記獣医用長時間作用型組成物。
- 熱、疼痛、及び/または炎症に関して動物を治療する方法であって、
a)ケトプロフェンエステルプロドラッグと、
b)少なくとも1つの獣医学的に許容できるトリグリセリドと、
c)任意に少なくとも1つの保存料と、
d)任意に少なくとも1つの獣医学的に許容できる賦形剤と、を含む、獣医用長時間作用型組成物を、治療を必要としている前記動物に投与することを含む、前記方法。 - 前記ケトプロフェンエステルプロドラッグは、式1の化合物であり、前記少なくとも1つの獣医学的に許容できるトリグリセリドは、カプリル酸/カプリン酸トリグリセリド、ジカプリル酸/ジカプリン酸プロピレングリコール、カプリル酸/カプリン酸/リノール酸トリグリセリド、グリセロールトリアセテート、ヒマシ油、綿実油、ゴマ油、及びこれらの混合物からなる群から選択され、前記組成物は、少なくとも1つの保存料をさらに含む、請求項12に記載の前記方法。
- 治療を必要としている動物に注射によって前記組成物を投与することによる、前記動物における熱、疼痛、及び/または炎症の前記治療のための、請求項1に記載の長時間作用型組成物の使用。
- 前記注射は、筋肉内注射または皮下注射である、請求項14に記載の前記使用。
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US9714403B2 (en) | 2014-06-19 | 2017-07-25 | E I Du Pont De Nemours And Company | Compositions containing one or more poly alpha-1,3-glucan ether compounds |
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