JP2016539639A - キッシング複合体を形成することができる核酸を含むキットオブパーツ及びその使用 - Google Patents

キッシング複合体を形成することができる核酸を含むキットオブパーツ及びその使用 Download PDF

Info

Publication number
JP2016539639A
JP2016539639A JP2016531034A JP2016531034A JP2016539639A JP 2016539639 A JP2016539639 A JP 2016539639A JP 2016531034 A JP2016531034 A JP 2016531034A JP 2016531034 A JP2016531034 A JP 2016531034A JP 2016539639 A JP2016539639 A JP 2016539639A
Authority
JP
Japan
Prior art keywords
nucleic acid
molecule
acid molecule
kit
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016531034A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016539639A5 (https=
Inventor
トゥルム，ジャン−ジャック
ドッス，エリック
デュラン，ギヨーム
ペイラン，エリック
ラヴレ，コリーヌ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of JP2016539639A publication Critical patent/JP2016539639A/ja
Publication of JP2016539639A5 publication Critical patent/JP2016539639A5/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • C12N2330/31—Libraries, arrays

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016531034A 2013-11-13 2014-11-13 キッシング複合体を形成することができる核酸を含むキットオブパーツ及びその使用 Pending JP2016539639A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13306546.6 2013-11-13
EP13306546 2013-11-13
PCT/EP2014/074548 WO2015071385A2 (en) 2013-11-13 2014-11-13 Kits-of-parts comprising nucleic acids able to form a kissing complex and their uses thereof

Publications (2)

Publication Number Publication Date
JP2016539639A true JP2016539639A (ja) 2016-12-22
JP2016539639A5 JP2016539639A5 (https=) 2017-10-26

Family

ID=49641698

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016531034A Pending JP2016539639A (ja) 2013-11-13 2014-11-13 キッシング複合体を形成することができる核酸を含むキットオブパーツ及びその使用

Country Status (5)

Country Link
US (1) US20160274095A1 (https=)
EP (1) EP3068882A2 (https=)
JP (1) JP2016539639A (https=)
CA (1) CA2937432A1 (https=)
WO (1) WO2015071385A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963706B2 (en) * 2015-03-09 2018-05-08 Base Pair Biotechnologies, Inc. Methods and compositions for backscattering interferometry
US11905559B2 (en) 2016-08-17 2024-02-20 Maumita Mandal Materials and methods for controlling gene expression
WO2023137559A1 (en) * 2022-01-21 2023-07-27 Neoventures Biotechnology Inc. A method for reproducible aptamer selection using closed sequence solution spaces

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
IE66597B1 (en) 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
EP0786469B1 (en) 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
DE4123673A1 (de) 1991-07-17 1993-01-21 Leybold Durferrit Gmbh Vorrichtung zum schalten einer hochstromzufuehrung
DE69326967T2 (de) 1992-01-17 2000-06-15 Lakowicz, Joseph R. Phasenmodulationsenergieübertragungsfluoroimmunassay
US6469158B1 (en) 1992-05-14 2002-10-22 Ribozyme Pharmaceuticals, Incorporated Synthesis, deprotection, analysis and purification of RNA and ribozymes
US6787305B1 (en) 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
US20020161219A1 (en) 2001-02-21 2002-10-31 Anastassia Kanavarioti Non-enzymatic large scale synthesis of RNA
US20050037394A1 (en) 2002-12-03 2005-02-17 Keefe Anthony D. Method for in vitro selection of 2'-substituted nucleic acids
JP2008512097A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
WO2008039254A2 (en) * 2006-06-02 2008-04-03 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rna nanoparticles and nanotubes
WO2010148085A1 (en) * 2009-06-16 2010-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rna nanoparticles and methods of use
US9297013B2 (en) * 2011-06-08 2016-03-29 University Of Cincinnati pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 322, JPN6018035501, 2004, pages 820 - 826, ISSN: 0004009922 *
BIOCHEMISTRY, vol. 48, no. 26, JPN6018035499, 2009, pages 6278 - 6284, ISSN: 0004009921 *

Also Published As

Publication number Publication date
WO2015071385A2 (en) 2015-05-21
CA2937432A1 (en) 2015-05-21
WO2015071385A3 (en) 2015-07-09
EP3068882A2 (en) 2016-09-21
US20160274095A1 (en) 2016-09-22

Similar Documents

Publication Publication Date Title
Hesselberth et al. In vitro selection of nucleic acids for diagnostic applications
AU2008275917B2 (en) Multiplexed analyses of test samples
Mascini et al. Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects
Thiviyanathan et al. Aptamers and the next generation of diagnostic reagents
US9404919B2 (en) Multiplexed analyses of test samples
Šmuc et al. Nucleic acid aptamers as high affinity ligands in biotechnology and biosensorics
JP4565787B2 (ja) 条件付きｓｅｌｅｘ
Jaffrey RNA-based fluorescent biosensors for detecting metabolites in vitro and in living cells
AU2014326975A2 (en) Multiaptamer target detection
NZ520745A (en) Signaling aptamers that transduce molecular recognition to a differential signal
CN101809164B (zh) 利用核酸酶-适配体复合物检测样品中靶核苷酸序列的方法
EP3995575A1 (en) Aptamer selection method and immunity analysis method using aptamer
US20250043290A1 (en) Rna sequences that induce fluorescence of small molecule fluorophores, molecular complexes, sensors, and methods of use thereof
JP2005517409A (ja) デオキシリボザイム
US9353404B2 (en) Capture based nucleic acid detection
JP2016539639A (ja) キッシング複合体を形成することができる核酸を含むキットオブパーツ及びその使用
US11231420B2 (en) Selection and optimization of aptamers to recognize ebola markers
WO2011061351A1 (en) Aptamers directed against the matrix protein-1 of type a influenza viruses and uses thereof
WO2012152711A1 (en) Methods for identifying aptamers
KR100828936B1 (ko) 단일가닥핵산 압타머와 금-나노입자를 이용한 생체분자분석방법
JP5783590B2 (ja) チログロブリン結合性アプタマー及びアプタマー多量体の作製方法
AU2017202493B2 (en) Multiplexed analyses of test samples
La Selection and characterization of an aptamer to a thiazole orange derivative for use in a fluorescence-based biosensor
JP2004531208A (ja) 情報伝達アプタマーのｉｎｖｉｔｒｏ選択
Toulmé et al. Aptamers: ligands for all reasons

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161007

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170912

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170912

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180911

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190402