JP2016537010A5 - - Google Patents
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- Publication number
- JP2016537010A5 JP2016537010A5 JP2016540920A JP2016540920A JP2016537010A5 JP 2016537010 A5 JP2016537010 A5 JP 2016537010A5 JP 2016540920 A JP2016540920 A JP 2016540920A JP 2016540920 A JP2016540920 A JP 2016540920A JP 2016537010 A5 JP2016537010 A5 JP 2016537010A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- luminal
- breast cancer
- biological sample
- subtype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010006187 Breast cancer Diseases 0.000 claims 22
- 239000012472 biological sample Substances 0.000 claims 22
- 208000026310 Breast neoplasm Diseases 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 230000004083 survival effect Effects 0.000 claims 16
- 230000014509 gene expression Effects 0.000 claims 13
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 11
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 11
- 208000026535 luminal A breast carcinoma Diseases 0.000 claims 11
- 208000026534 luminal B breast carcinoma Diseases 0.000 claims 11
- 238000003556 assay Methods 0.000 claims 8
- 230000035755 proliferation Effects 0.000 claims 8
- 230000005855 radiation Effects 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- KIAPWMKFHIKQOZ-UHFFFAOYSA-N 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester Chemical compound COC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(F)C=C1 KIAPWMKFHIKQOZ-UHFFFAOYSA-N 0.000 claims 2
- 102100033393 Anillin Human genes 0.000 claims 2
- 108700020472 CDC20 Proteins 0.000 claims 2
- 101150023302 Cdc20 gene Proteins 0.000 claims 2
- 102100027047 Cell division control protein 6 homolog Human genes 0.000 claims 2
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 claims 2
- 102100023344 Centromere protein F Human genes 0.000 claims 2
- 101710092479 Centrosomal protein of 55 kDa Proteins 0.000 claims 2
- 102100031219 Centrosomal protein of 55 kDa Human genes 0.000 claims 2
- 102100038595 Estrogen receptor Human genes 0.000 claims 2
- 102100029075 Exonuclease 1 Human genes 0.000 claims 2
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 claims 2
- 101000732632 Homo sapiens Anillin Proteins 0.000 claims 2
- 101000914465 Homo sapiens Cell division control protein 6 homolog Proteins 0.000 claims 2
- 101000907941 Homo sapiens Centromere protein F Proteins 0.000 claims 2
- 101000918264 Homo sapiens Exonuclease 1 Proteins 0.000 claims 2
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 claims 2
- 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 claims 2
- 101001112162 Homo sapiens Kinetochore protein NDC80 homolog Proteins 0.000 claims 2
- 101000590482 Homo sapiens Kinetochore protein Nuf2 Proteins 0.000 claims 2
- 101000721146 Homo sapiens Origin recognition complex subunit 6 Proteins 0.000 claims 2
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 claims 2
- 101000575639 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 Proteins 0.000 claims 2
- 101001087372 Homo sapiens Securin Proteins 0.000 claims 2
- 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 claims 2
- 101000807354 Homo sapiens Ubiquitin-conjugating enzyme E2 C Proteins 0.000 claims 2
- 101000837581 Homo sapiens Ubiquitin-conjugating enzyme E2 T Proteins 0.000 claims 2
- 102100023424 Kinesin-like protein KIF2C Human genes 0.000 claims 2
- 102100023890 Kinetochore protein NDC80 homolog Human genes 0.000 claims 2
- 102100032431 Kinetochore protein Nuf2 Human genes 0.000 claims 2
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 claims 2
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 claims 2
- 102100025201 Origin recognition complex subunit 6 Human genes 0.000 claims 2
- 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 claims 2
- 102100026006 Ribonucleoside-diphosphate reductase subunit M2 Human genes 0.000 claims 2
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 claims 2
- 102100033004 Securin Human genes 0.000 claims 2
- 102100038618 Thymidylate synthase Human genes 0.000 claims 2
- 102100037256 Ubiquitin-conjugating enzyme E2 C Human genes 0.000 claims 2
- 102100028705 Ubiquitin-conjugating enzyme E2 T Human genes 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 108091012583 BCL2 Proteins 0.000 claims 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 102100036167 CXXC-type zinc finger protein 5 Human genes 0.000 claims 1
- 101001030219 Drosophila melanogaster Unconventional myosin ID Proteins 0.000 claims 1
- 102100021084 Forkhead box protein C1 Human genes 0.000 claims 1
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 1
- 101000884385 Homo sapiens Arylamine N-acetyltransferase 1 Proteins 0.000 claims 1
- 101000947154 Homo sapiens CXXC-type zinc finger protein 5 Proteins 0.000 claims 1
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 claims 1
- 101001034811 Homo sapiens Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 claims 1
- 101000818310 Homo sapiens Forkhead box protein C1 Proteins 0.000 claims 1
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 1
- 101000973510 Homo sapiens Melanoma-derived growth regulatory protein Proteins 0.000 claims 1
- 101001055386 Homo sapiens Melanophilin Proteins 0.000 claims 1
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 1
- 101000857740 Homo sapiens Probable G-protein coupled receptor 160 Proteins 0.000 claims 1
- 101000639975 Homo sapiens Sodium-dependent noradrenaline transporter Proteins 0.000 claims 1
- 102100022185 Melanoma-derived growth regulatory protein Human genes 0.000 claims 1
- 102100026158 Melanophilin Human genes 0.000 claims 1
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 1
- 101100366602 Oryza sativa subsp. japonica SRFP1 gene Proteins 0.000 claims 1
- 102100025346 Probable G-protein coupled receptor 160 Human genes 0.000 claims 1
- 102100033929 Sodium-dependent noradrenaline transporter Human genes 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000019 nipple aspirate fluid Anatomy 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361875373P | 2013-09-09 | 2013-09-09 | |
| US61/875,373 | 2013-09-09 | ||
| US201461990948P | 2014-05-09 | 2014-05-09 | |
| US61/990,948 | 2014-05-09 | ||
| PCT/US2014/054760 WO2015035377A1 (en) | 2013-09-09 | 2014-09-09 | Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537010A JP2016537010A (ja) | 2016-12-01 |
| JP2016537010A5 true JP2016537010A5 (enExample) | 2017-09-14 |
Family
ID=51688397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540920A Pending JP2016537010A (ja) | 2013-09-09 | 2014-09-09 | 予後を予測するための方法及びキット、並びに、放射線照射療法を用いた乳癌の治療方法及びキット |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150072021A1 (enExample) |
| EP (1) | EP3044332A1 (enExample) |
| JP (1) | JP2016537010A (enExample) |
| AU (1) | AU2014317843A1 (enExample) |
| CA (1) | CA2923166A1 (enExample) |
| IL (1) | IL244421A0 (enExample) |
| WO (1) | WO2015035377A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030198972A1 (en) | 2001-12-21 | 2003-10-23 | Erlander Mark G. | Grading of breast cancer |
| JP5740302B2 (ja) | 2008-05-30 | 2015-06-24 | ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル | 乳癌の予後を予測するための遺伝子発現プロフィール |
| EP3223947B1 (en) | 2014-11-24 | 2019-10-30 | Nanostring Technologies, Inc. | Methods and apparatuses for gene purification and imaging |
| CA2969163A1 (en) * | 2014-12-09 | 2016-06-16 | King's College London | Breast cancer treatment with taxane therapy |
| US11530448B2 (en) | 2015-11-13 | 2022-12-20 | Biotheranostics, Inc. | Integration of tumor characteristics with breast cancer index |
| PT3423105T (pt) | 2016-03-02 | 2021-07-19 | Eisai R&D Man Co Ltd | Conjugados de anticorpo-fármaco à base de eribulina e métodos de utilização |
| CN107574243B (zh) * | 2016-06-30 | 2021-06-29 | 博奥生物集团有限公司 | 分子标志物、内参基因及其应用、检测试剂盒以及检测模型的构建方法 |
| CN108456730B (zh) * | 2018-02-27 | 2021-01-05 | 海门善准生物科技有限公司 | 一种复发风险基因群作为标志物在制备评估乳腺癌分子分型内远处复发风险的产品中的应用 |
| WO2020206359A1 (en) * | 2019-04-04 | 2020-10-08 | University Of Utah Research Foundation | Multigene assay to assess risk of recurrence of cancer |
| KR102414754B1 (ko) * | 2019-10-10 | 2022-06-30 | 주식회사 종근당 | 직장암 항암화학방사선 치료 반응 예측용 바이오마커 |
| TW202129008A (zh) * | 2019-11-05 | 2021-08-01 | 香港商行動基因（智財）有限公司 | 檢測異檸檬酸脫氫酶突變的套組及方法 |
| EP3945136A1 (en) * | 2020-07-28 | 2022-02-02 | Hospital Clínic de Barcelona | In vitro method for the prognosis of patients suffering from her2-positive breast cancer |
| CN113278700B (zh) * | 2021-06-04 | 2022-08-09 | 浙江省肿瘤医院 | 一种用于乳腺癌分型及预后预测的引物组及试剂盒 |
| KR20240081508A (ko) | 2022-11-17 | 2024-06-10 | 인제대학교 산학협력단 | Dna 메틸화 변화를 통한 방사선치료 반응성 예측용 바이오마커 조성물 및 이의 용도 |
| CN116622885B (zh) * | 2023-05-23 | 2025-01-10 | 福建省农业科学院果树研究所 | 一种用于不同桃花色鉴定的分子标记方法及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| DE69217497T2 (de) | 1991-09-18 | 1997-06-12 | Affymax Tech Nv | Verfahren zur synthese der verschiedenen sammlungen von oligomeren |
| EP0916396B1 (en) | 1991-11-22 | 2005-04-13 | Affymetrix, Inc. (a Delaware Corporation) | Combinatorial strategies for polymer synthesis |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| ATE291097T1 (de) | 1997-10-31 | 2005-04-15 | Affymetrix Inc A Delaware Corp | Expressionsprofile in adulten und fötalen organen |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US20080032293A1 (en) | 2004-07-15 | 2008-02-07 | The University Of North Carolina At Chapel Hill | Housekeeping Genes And Methods For Identifying Same |
| EP1954708A4 (en) | 2005-11-23 | 2009-05-13 | Univ Utah Res Found | Methods and compositions involving intrinsic genes |
| CA2640385C (en) | 2005-12-23 | 2014-07-15 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| WO2007076132A2 (en) | 2005-12-23 | 2007-07-05 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| WO2007084992A2 (en) * | 2006-01-19 | 2007-07-26 | The University Of Chicago | Prognosis and therapy predictive markers and methods of use |
| WO2008124847A2 (en) | 2007-04-10 | 2008-10-16 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
| CN102395682B (zh) * | 2007-09-06 | 2015-09-30 | 生物治疗诊断股份有限公司 | 肿瘤分级和癌症预后 |
| JP2010539890A (ja) * | 2007-09-14 | 2010-12-24 | ユニヴァーシティ オブ サウス フロリダ | 放射線治療の応答を予測するための遺伝子シグネチャー |
| JP5740302B2 (ja) | 2008-05-30 | 2015-06-24 | ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル | 乳癌の予後を予測するための遺伝子発現プロフィール |
| EP2331704B1 (en) | 2008-08-14 | 2016-11-30 | Nanostring Technologies, Inc | Stable nanoreporters |
| US9181588B2 (en) * | 2011-11-30 | 2015-11-10 | The University Of Utah Research Foundation | Methods of treating breast cancer with taxane therapy |
| WO2013177245A2 (en) * | 2012-05-22 | 2013-11-28 | Nanostring Technologies, Inc. | Nano46 genes and methods to predict breast cancer outcome |
-
2014
- 2014-09-09 JP JP2016540920A patent/JP2016537010A/ja active Pending
- 2014-09-09 CA CA2923166A patent/CA2923166A1/en not_active Abandoned
- 2014-09-09 EP EP14781977.5A patent/EP3044332A1/en not_active Withdrawn
- 2014-09-09 AU AU2014317843A patent/AU2014317843A1/en not_active Abandoned
- 2014-09-09 WO PCT/US2014/054760 patent/WO2015035377A1/en not_active Ceased
- 2014-09-09 US US14/480,942 patent/US20150072021A1/en not_active Abandoned
-
2016
- 2016-03-03 IL IL244421A patent/IL244421A0/en unknown
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