JP2016536327A5 - - Google Patents
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- JP2016536327A5 JP2016536327A5 JP2016537322A JP2016537322A JP2016536327A5 JP 2016536327 A5 JP2016536327 A5 JP 2016536327A5 JP 2016537322 A JP2016537322 A JP 2016537322A JP 2016537322 A JP2016537322 A JP 2016537322A JP 2016536327 A5 JP2016536327 A5 JP 2016536327A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- functional fragment
- neutralizing antibody
- days
- csf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003472 neutralizing effect Effects 0.000 claims 59
- 239000012634 fragment Substances 0.000 claims 52
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 29
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 29
- 241000288906 Primates Species 0.000 claims 28
- 208000027866 inflammatory disease Diseases 0.000 claims 21
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 19
- 229960000485 methotrexate Drugs 0.000 claims 19
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 201000008482 osteoarthritis Diseases 0.000 claims 12
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 11
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 9
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 9
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 208000002193 Pain Diseases 0.000 claims 6
- 230000003432 anti-folate effect Effects 0.000 claims 6
- 229940127074 antifolate Drugs 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000009266 disease activity Effects 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000004052 folic acid antagonist Substances 0.000 claims 6
- 229960000074 biopharmaceutical Drugs 0.000 claims 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 230000004968 inflammatory condition Effects 0.000 claims 3
- 208000004235 neutropenia Diseases 0.000 claims 3
- 230000003442 weekly effect Effects 0.000 claims 3
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 2
- 206010033661 Pancytopenia Diseases 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 2
- 208000024389 cytopenia Diseases 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004171 hydroxychloroquine Drugs 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 2
- 229960000681 leflunomide Drugs 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 2
- 229960001940 sulfasalazine Drugs 0.000 claims 2
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 206010065553 Bone marrow failure Diseases 0.000 claims 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims 1
- 206010071602 Genetic polymorphism Diseases 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000587058 Homo sapiens Methylenetetrahydrofolate reductase Proteins 0.000 claims 1
- 108010007666 IMP cyclohydrolase Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 1
- 102100029684 Methylenetetrahydrofolate reductase Human genes 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 108010045040 Phosphoribosylaminoimidazolecarboxamide formyltransferase Proteins 0.000 claims 1
- 101150006379 Rfc1 gene Proteins 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 229940121359 adenosine receptor antagonist Drugs 0.000 claims 1
- 230000003092 anti-cytokine Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000008191 folinic acid Nutrition 0.000 claims 1
- 239000011672 folinic acid Substances 0.000 claims 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- 229960001691 leucovorin Drugs 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 230000001185 psoriatic effect Effects 0.000 claims 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361871904P | 2013-08-30 | 2013-08-30 | |
| US201361871900P | 2013-08-30 | 2013-08-30 | |
| US61/871,900 | 2013-08-30 | ||
| US61/871,904 | 2013-08-30 | ||
| PCT/EP2014/068489 WO2015028657A1 (en) | 2013-08-30 | 2014-09-01 | Antibodies neutralizing gm-csf for use in the treatment of rheumatoid arthritis or as analgesics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042267A Division JP2020109108A (ja) | 2013-08-30 | 2020-03-11 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ−ｃｓｆ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016536327A JP2016536327A (ja) | 2016-11-24 |
| JP2016536327A5 true JP2016536327A5 (enExample) | 2017-10-12 |
Family
ID=51454704
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537322A Pending JP2016536327A (ja) | 2013-08-30 | 2014-09-01 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ−ｃｓｆ |
| JP2020042267A Pending JP2020109108A (ja) | 2013-08-30 | 2020-03-11 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ−ｃｓｆ |
| JP2022076303A Pending JP2022105160A (ja) | 2013-08-30 | 2022-05-02 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ－ｃｓｆ |
| JP2024103720A Pending JP2024123249A (ja) | 2013-08-30 | 2024-06-27 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ－ｃｓｆ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020042267A Pending JP2020109108A (ja) | 2013-08-30 | 2020-03-11 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ−ｃｓｆ |
| JP2022076303A Pending JP2022105160A (ja) | 2013-08-30 | 2022-05-02 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ－ｃｓｆ |
| JP2024103720A Pending JP2024123249A (ja) | 2013-08-30 | 2024-06-27 | 関節リウマチの治療における、又は、鎮痛剤としての使用のための抗体中和ｇｍ－ｃｓｆ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10745475B2 (enExample) |
| EP (2) | EP3039039B1 (enExample) |
| JP (4) | JP2016536327A (enExample) |
| KR (3) | KR20240090993A (enExample) |
| CN (2) | CN105705518A (enExample) |
| AU (3) | AU2014314053C1 (enExample) |
| BR (1) | BR112016003293A8 (enExample) |
| CA (1) | CA2922251C (enExample) |
| ES (1) | ES2860480T3 (enExample) |
| MX (2) | MX385854B (enExample) |
| RU (1) | RU2714919C2 (enExample) |
| WO (1) | WO2015028657A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2572975T3 (es) | 2003-05-15 | 2016-06-03 | Ampio Pharmaceuticals, Inc. | Tratamiento de enfermedades mediadas por los linfocitos T |
| BR112014007675A2 (pt) | 2011-10-10 | 2017-04-18 | Ampio Pharmaceuticals Inc | tratamento de doença articular degenerativa |
| EP3183240A4 (en) | 2014-08-18 | 2018-06-27 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| HK1246669A1 (zh) | 2015-06-22 | 2018-09-14 | Ampio Pharmaceuticals, Inc. | 人血清白蛋白低分子量组分在疾病治疗中的应用 |
| CN107840885B (zh) * | 2016-09-19 | 2020-11-10 | 天境生物科技(上海)有限公司 | Gm-csf抗体及其用途 |
| NZ750976A (en) | 2016-09-19 | 2023-01-27 | I Mab Biopharma Hangzhou Co Ltd | Anti-gm-csf antibodies and uses thereof |
| SG11201906852XA (en) | 2017-02-01 | 2019-08-27 | Univ Yale | Treatment of diuretic resistance |
| SG11202006157VA (en) | 2018-01-05 | 2020-07-29 | Corvidia Therapeutics Inc | Methods for treating il-6 mediated inflammation without immunosuppression |
| EP3765630B1 (en) * | 2018-03-14 | 2024-08-28 | Indiana University Research And Technology Corporation | Precision medicine for pain: diagnostic biomarkers, pharmacogenomics, and repurposed drugs |
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-
2014
- 2014-09-01 US US14/913,578 patent/US10745475B2/en active Active
- 2014-09-01 KR KR1020247017478A patent/KR20240090993A/ko active Pending
- 2014-09-01 MX MX2016002177A patent/MX385854B/es unknown
- 2014-09-01 EP EP14758384.3A patent/EP3039039B1/en active Active
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