AU2014314053C1 - Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics - Google Patents

Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics Download PDF

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Publication number
AU2014314053C1
AU2014314053C1 AU2014314053A AU2014314053A AU2014314053C1 AU 2014314053 C1 AU2014314053 C1 AU 2014314053C1 AU 2014314053 A AU2014314053 A AU 2014314053A AU 2014314053 A AU2014314053 A AU 2014314053A AU 2014314053 C1 AU2014314053 C1 AU 2014314053C1
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Prior art keywords
dose
functional fragment
seq
neutralizing antibody
amino acid
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AU2014314053A
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AU2014314053B2 (en
AU2014314053A1 (en
Inventor
Malin CARLSSON
Margit STAUM KALTOFT
Thomas Wagner
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of AU2014314053A1 publication Critical patent/AU2014314053A1/en
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Priority to AU2020203917A priority Critical patent/AU2020203917A1/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: TAKEDA GMBH
Priority to AU2023210647A priority patent/AU2023210647A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2014314053A 2013-08-30 2014-09-01 Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics Active AU2014314053C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020203917A AU2020203917A1 (en) 2013-08-30 2020-06-12 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics
AU2023210647A AU2023210647A1 (en) 2013-08-30 2023-08-04 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361871904P 2013-08-30 2013-08-30
US201361871900P 2013-08-30 2013-08-30
US61/871,904 2013-08-30
US61/871,900 2013-08-30
PCT/EP2014/068489 WO2015028657A1 (en) 2013-08-30 2014-09-01 Antibodies neutralizing gm-csf for use in the treatment of rheumatoid arthritis or as analgesics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203917A Division AU2020203917A1 (en) 2013-08-30 2020-06-12 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics

Publications (3)

Publication Number Publication Date
AU2014314053A1 AU2014314053A1 (en) 2016-02-11
AU2014314053B2 AU2014314053B2 (en) 2020-03-12
AU2014314053C1 true AU2014314053C1 (en) 2023-11-02

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2014314053A Active AU2014314053C1 (en) 2013-08-30 2014-09-01 Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
AU2020203917A Abandoned AU2020203917A1 (en) 2013-08-30 2020-06-12 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics
AU2023210647A Pending AU2023210647A1 (en) 2013-08-30 2023-08-04 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2020203917A Abandoned AU2020203917A1 (en) 2013-08-30 2020-06-12 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics
AU2023210647A Pending AU2023210647A1 (en) 2013-08-30 2023-08-04 Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics

Country Status (12)

Country Link
US (2) US10745475B2 (enExample)
EP (2) EP3039039B1 (enExample)
JP (4) JP2016536327A (enExample)
KR (3) KR20240090993A (enExample)
CN (2) CN105705518A (enExample)
AU (3) AU2014314053C1 (enExample)
BR (1) BR112016003293A8 (enExample)
CA (1) CA2922251C (enExample)
ES (1) ES2860480T3 (enExample)
MX (2) MX385854B (enExample)
RU (1) RU2714919C2 (enExample)
WO (1) WO2015028657A1 (enExample)

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EP4066836A1 (en) 2014-08-18 2022-10-05 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
JP7256116B2 (ja) 2016-09-19 2023-04-11 アイ－エムエービー バイオファーマ （ハンジョウ） カンパニー リミテッド 抗ｇｍ－ｃｓｆ抗体およびその使用
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Also Published As

Publication number Publication date
CN118178647A (zh) 2024-06-14
MX2016002177A (es) 2016-06-28
ES2860480T3 (es) 2021-10-05
KR20220045064A (ko) 2022-04-12
JP2016536327A (ja) 2016-11-24
AU2014314053B2 (en) 2020-03-12
US10745475B2 (en) 2020-08-18
JP2020109108A (ja) 2020-07-16
CA2922251A1 (en) 2015-03-05
KR20160044035A (ko) 2016-04-22
KR20240090993A (ko) 2024-06-21
MX2021010472A (es) 2021-10-01
US11795216B2 (en) 2023-10-24
BR112016003293A8 (pt) 2022-08-16
JP2022105160A (ja) 2022-07-12
RU2016109944A (ru) 2017-10-06
MX385854B (es) 2025-03-18
EP3889178A1 (en) 2021-10-06
AU2023210647A1 (en) 2023-10-12
CA2922251C (en) 2023-10-17
AU2014314053A1 (en) 2016-02-11
EP3039039B1 (en) 2021-03-10
US20210171620A1 (en) 2021-06-10
AU2020203917A1 (en) 2020-07-02
US20160355584A1 (en) 2016-12-08
WO2015028657A1 (en) 2015-03-05
CN105705518A (zh) 2016-06-22
RU2016109944A3 (enExample) 2018-07-09
BR112016003293A2 (pt) 2017-11-21
JP2024123249A (ja) 2024-09-10
RU2714919C2 (ru) 2020-02-21
EP3039039A1 (en) 2016-07-06

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DA2 Applications for amendment section 104

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