JP2016536314A - ヒトのがんを治療するための特異的抗ｃｄ３８抗体 - Google Patents

ヒトのがんを治療するための特異的抗ｃｄ３８抗体 Download PDF

Info

Publication number
JP2016536314A
JP2016536314A JP2016527374A JP2016527374A JP2016536314A JP 2016536314 A JP2016536314 A JP 2016536314A JP 2016527374 A JP2016527374 A JP 2016527374A JP 2016527374 A JP2016527374 A JP 2016527374A JP 2016536314 A JP2016536314 A JP 2016536314A
Authority
JP
Japan
Prior art keywords
antibody
pharmaceutical composition
administered
human subject
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016527374A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016536314A5 (OSRAM
Inventor
アントワーヌ・デランド
クシシュトフ・ジェイ・グゥゼグォゼウスキー
マリー−ロール・オズゥ
ブレイク・トムキンソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JP2016536314A publication Critical patent/JP2016536314A/ja
Publication of JP2016536314A5 publication Critical patent/JP2016536314A5/ja
Priority to JP2019000024A priority Critical patent/JP6914283B2/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016527374A 2013-10-31 2014-10-31 ヒトのがんを治療するための特異的抗ｃｄ３８抗体 Pending JP2016536314A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019000024A JP6914283B2 (ja) 2013-10-31 2019-01-04 ヒトのがんを治療するための特異的抗ｃｄ３８抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361898309P 2013-10-31 2013-10-31
US61/898,309 2013-10-31
EP14306220 2014-07-31
EP14306220.6 2014-07-31
PCT/US2014/063380 WO2015066450A1 (en) 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019000024A Division JP6914283B2 (ja) 2013-10-31 2019-01-04 ヒトのがんを治療するための特異的抗ｃｄ３８抗体

Publications (2)

Publication Number Publication Date
JP2016536314A true JP2016536314A (ja) 2016-11-24
JP2016536314A5 JP2016536314A5 (OSRAM) 2017-12-07

Family

ID=51266255

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016527374A Pending JP2016536314A (ja) 2013-10-31 2014-10-31 ヒトのがんを治療するための特異的抗ｃｄ３８抗体
JP2023085105A Pending JP2023109927A (ja) 2013-10-31 2023-05-24 ヒトのがんを治療するための特異的抗ｃｄ３８抗体
JP2025077126A Pending JP2025139586A (ja) 2013-10-31 2025-05-07 ヒトのがんを治療するための特異的抗ｃｄ３８抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023085105A Pending JP2023109927A (ja) 2013-10-31 2023-05-24 ヒトのがんを治療するための特異的抗ｃｄ３８抗体
JP2025077126A Pending JP2025139586A (ja) 2013-10-31 2025-05-07 ヒトのがんを治療するための特異的抗ｃｄ３８抗体

Country Status (20)

Country Link
US (2) US20150118251A1 (OSRAM)
EP (2) EP3805266A1 (OSRAM)
JP (3) JP2016536314A (OSRAM)
KR (1) KR20160077155A (OSRAM)
CN (1) CN106103481A (OSRAM)
AU (1) AU2014342103B2 (OSRAM)
BR (1) BR112016009403A2 (OSRAM)
CA (1) CA2927099A1 (OSRAM)
CR (1) CR20160186A (OSRAM)
EA (1) EA035098B1 (OSRAM)
IL (1) IL245196B (OSRAM)
MA (2) MA39070A1 (OSRAM)
MX (1) MX373301B (OSRAM)
NZ (1) NZ719784A (OSRAM)
PL (1) PL3063173T3 (OSRAM)
PT (1) PT3063173T (OSRAM)
SG (2) SG10201803288RA (OSRAM)
TN (1) TN2016000142A1 (OSRAM)
TW (1) TW201522378A (OSRAM)
WO (1) WO2015066450A1 (OSRAM)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019031444A1 (ja) * 2017-08-07 2019-02-14 国立大学法人九州大学 細胞集団における特異的結合物質の占有率を測定する方法
JP2021519295A (ja) * 2018-03-28 2021-08-10 武田薬品工業株式会社 抗ｃｄ３８抗体の皮下投薬
JP2023505219A (ja) * 2019-12-06 2023-02-08 サノフィ－アベンティス・ユー・エス・エルエルシー 再発性および／または不応性の多発性骨髄腫の処置のためのイサツキシマブの使用
US12209138B2 (en) 2010-12-30 2025-01-28 Takeda Pharmaceutical Company Limited Anti-CD38 antibodies
US12371506B2 (en) 2018-01-12 2025-07-29 Takeda Pharmaceutical Company Limited Subcutaneous administration of anti-CD38 antibodies
US12391765B2 (en) 2016-07-15 2025-08-19 Takeda Pharmaceutical Company Limited Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112170C2 (uk) 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
US10342869B2 (en) * 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
CN120860201A (zh) * 2013-03-13 2025-10-31 赛诺菲-安万特美国有限责任公司 包含抗cd38抗体和卡非佐米的组合物
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
BR112017004614A2 (pt) 2014-09-09 2018-02-27 Janssen Biotech, Inc. terapias de combinação com anticorpos anti-cd38
EA202092609A1 (ru) 2014-12-04 2021-10-29 Янссен Байотек, Инк. Антитела к cd38 для лечения острого миелолейкоза
RU2723047C2 (ru) * 2015-05-13 2020-06-08 МорфоСис АГ Средство для лечения множественной миеломы (ММ)
CN108136218B (zh) * 2015-05-20 2022-12-13 詹森生物科技公司 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体
CN107849096B (zh) 2015-05-30 2022-05-24 分子模板公司 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子
WO2016201337A1 (en) * 2015-06-12 2016-12-15 Immungene, Inc. Engineered antibody-interferon fusion molecules for the treatment of glucose-regulated protein 94 (grp94) expressing cancers
NZ777133A (en) 2015-06-22 2025-05-02 Janssen Biotech Inc Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
RS61651B1 (sr) * 2015-11-03 2021-04-29 Janssen Biotech Inc Potkožne formulacije anti-cd38 antitela i njihova upotreba
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
AU2017226960B2 (en) 2016-03-04 2024-03-21 Morphosys Ag Clinical assessment of M-protein response in multiple myeloma
WO2017223111A1 (en) 2016-06-21 2017-12-28 Teneobio, Inc. Cd3 binding antibodies
MY200988A (en) 2016-09-14 2024-01-27 Teneobio Inc CD3 Binding Antibodies
EP3559035A1 (en) 2016-12-21 2019-10-30 TeneoBio, Inc. Anti-bcma heavy chain-only antibodies
CN118146370A (zh) 2017-06-20 2024-06-07 特纳奥尼股份有限公司 仅有重链的抗bcma抗体
CA3067584A1 (en) 2017-06-20 2018-12-27 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
RU2020112490A (ru) * 2017-09-13 2021-10-13 Тенеобио, Инк. Антитела из тяжелых цепей, связывающиеся с эктоферментами
JP2021502961A (ja) 2017-10-31 2021-02-04 ヤンセン バイオテツク，インコーポレーテツド 高リスク多発性骨髄腫の治療方法
AU2018362014A1 (en) 2017-11-03 2020-05-28 Sorrento Therapeutics, Inc. CD38-directed chimeric antigen receptor constructs
BR112021000065A2 (pt) * 2018-07-10 2021-04-06 Sanofi Terapias de combinação contra câncer direcionando cd38 e tgf-beta
MX2021007047A (es) 2018-12-14 2021-10-26 Morphosys Ag Formulaciones de anticuerpos.
EP3941489A4 (en) * 2019-03-21 2022-12-28 Gamida-Cell Ltd. EXTENDED NK CELL FRACTIONS SUITABLE FOR POLYTHERAPY TRANSPLANTATION
EA202192736A1 (ru) 2019-04-05 2022-01-27 Тенеобио, Инк. Антитела, содержащие только тяжелые цепи, которые связываются с псма
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
PH12021553145A1 (en) 2019-06-14 2022-07-25 Teneobio Inc Multispecific heavy chain antibodies binding to cd22 and cd3
CN112876563B (zh) * 2019-11-29 2022-08-16 康诺亚生物医药科技（成都）有限公司 药物组合物及其制备方法和应用
AU2020397170A1 (en) 2019-12-05 2022-07-21 Sanofi-Aventis U.S. Llc Formulations of anti-CD38 antibodies for subcutaneous administration
JP7720871B2 (ja) 2020-06-23 2025-08-08 ジアンスー カニョン ファーマシューティカル カンパニー リミテッド 抗ｃｄ３８抗体及びその使用
US20240018248A1 (en) 2020-12-02 2024-01-18 Vib Vzw An ltbr agonist in combination therapy against cancer
WO2024094660A1 (en) * 2022-10-31 2024-05-10 Genmab A/S Cd38 antibodies and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076663A1 (en) * 2010-12-10 2012-06-14 Sanofi Antitumor combinations containing antibodies recognizing specifically cd38 and bortezomib

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
ATE356869T1 (de) 1990-01-12 2007-04-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
ATE390933T1 (de) 1995-04-27 2008-04-15 Amgen Fremont Inc Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP2314625B1 (en) 1996-12-03 2014-05-07 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
SI0970126T1 (en) 1997-04-14 2001-08-31 Micromet Ag Novel method for the production of antihuman antigen receptors and uses thereof
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
CN1976950B (zh) * 2004-02-06 2012-08-29 莫佛塞斯公司 抗cd38人抗体及其用途
MX2007011064A (es) * 2005-03-23 2008-02-19 Genmab As Anticuerpos contra cd38 para tratamiento de mieloma multiple.
TW200745162A (en) * 2005-05-24 2007-12-16 Morphosys Ag Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38
NZ576122A (en) * 2006-09-26 2012-09-28 Genmab As Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2191842A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine
EP2191843A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide
EP2191840A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
EP2191841A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine
JOP20210044A1 (ar) * 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
WO2013059885A2 (en) * 2011-10-28 2013-05-02 Cephalon Australia Pty Ltd Polypeptide constructs and uses thereof
US10342869B2 (en) * 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
CN120860201A (zh) * 2013-03-13 2025-10-31 赛诺菲-安万特美国有限责任公司 包含抗cd38抗体和卡非佐米的组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076663A1 (en) * 2010-12-10 2012-06-14 Sanofi Antitumor combinations containing antibodies recognizing specifically cd38 and bortezomib

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ＥＸＰＥＲＴ ＲＥＶＩＥＷ ＯＦ ＡＮＴＩＣＡＮＣＥＲ ＴＨＥＲＡＰＹ, vol. 13, no. 9, JPN6018024977, September 2013 (2013-09-01), pages 1081 - 1088, ISSN: 0004004221 *
ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＯＮＣＯＬＯＧＹ, vol. 30, no. 16, JPN6018024978, 2012, pages 1960 - 1965, ISSN: 0004004222 *
ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＯＮＣＯＬＯＧＹ, vol. Ｖｏｌ．３０，Ｎｏ．１５ Ｓｕｐｐｌ．, JPN6018024975, 2012, pages 8019, ISSN: 0004004219 *
ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＯＮＣＯＬＯＧＹ, vol. Ｖｏｌ．３１，Ｎｏ．１５ Ｓｕｐｐｌ．, JPN6018024976, May 2013 (2013-05-01), pages 8512, ISSN: 0004004220 *
RICHARDSON P: "DARATUMUMAB. ANTI-CD38 MONOCLONAL ANTIBODY, TREATMENT OF MULTIPLE MYELOMA", DRUGS OF THE FUTURE, vol. VOL:38, NR:8, JPN5017000874, August 2013 (2013-08-01), ES, pages 545 - 554, ISSN: 0003829581 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12209138B2 (en) 2010-12-30 2025-01-28 Takeda Pharmaceutical Company Limited Anti-CD38 antibodies
US12391765B2 (en) 2016-07-15 2025-08-19 Takeda Pharmaceutical Company Limited Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies
WO2019031444A1 (ja) * 2017-08-07 2019-02-14 国立大学法人九州大学 細胞集団における特異的結合物質の占有率を測定する方法
JPWO2019031444A1 (ja) * 2017-08-07 2020-08-27 国立大学法人九州大学 細胞集団における特異的結合物質の占有率を測定する方法
US12371506B2 (en) 2018-01-12 2025-07-29 Takeda Pharmaceutical Company Limited Subcutaneous administration of anti-CD38 antibodies
JP2021519295A (ja) * 2018-03-28 2021-08-10 武田薬品工業株式会社 抗ｃｄ３８抗体の皮下投薬
JP2024045121A (ja) * 2018-03-28 2024-04-02 武田薬品工業株式会社 抗ｃｄ３８抗体の皮下投薬
JP7526099B2 (ja) 2018-03-28 2024-07-31 武田薬品工業株式会社 抗ｃｄ３８抗体の皮下投薬
JP2023505219A (ja) * 2019-12-06 2023-02-08 サノフィ－アベンティス・ユー・エス・エルエルシー 再発性および／または不応性の多発性骨髄腫の処置のためのイサツキシマブの使用
JP7704751B2 (ja) 2019-12-06 2025-07-08 サノフィ－アベンティス・ユー・エス・エルエルシー 再発性および／または不応性の多発性骨髄腫の処置のためのイサツキシマブの使用

Also Published As

Publication number Publication date
JP2023109927A (ja) 2023-08-08
MA39070A1 (fr) 2017-11-30
CR20160186A (es) 2016-06-13
EP3805266A1 (en) 2021-04-14
EP3063173A1 (en) 2016-09-07
CA2927099A1 (en) 2015-05-07
JP2025139586A (ja) 2025-09-26
IL245196A0 (en) 2016-06-30
AU2014342103A1 (en) 2016-05-26
SG11201603088RA (en) 2016-05-30
TW201522378A (zh) 2015-06-16
EA201690905A1 (ru) 2016-08-31
EP3063173B1 (en) 2020-07-29
AU2014342103B2 (en) 2020-06-04
MA44560B2 (fr) 2021-01-29
TN2016000142A1 (en) 2017-10-06
NZ719784A (en) 2022-02-25
MX2016005666A (es) 2016-07-14
MA44560B1 (fr) 2020-06-30
MA44560A1 (fr) 2019-09-30
MX373301B (es) 2020-04-24
SG10201803288RA (en) 2018-05-30
IL245196B (en) 2021-04-29
BR112016009403A2 (pt) 2017-09-19
WO2015066450A1 (en) 2015-05-07
US20180022814A1 (en) 2018-01-25
KR20160077155A (ko) 2016-07-01
EA035098B1 (ru) 2020-04-27
CN106103481A (zh) 2016-11-09
PT3063173T (pt) 2020-10-20
US20150118251A1 (en) 2015-04-30
PL3063173T3 (pl) 2021-01-11

Similar Documents

Publication Publication Date Title
JP2023109927A (ja) ヒトのがんを治療するための特異的抗ｃｄ３８抗体
US12121579B2 (en) Antibodies specific to human t-cell immunoglobulin and ITIM domain (TIGIT)
US20230235060A1 (en) Neutralization of inhibitory pathways in lymphocytes
JP6914283B2 (ja) ヒトのがんを治療するための特異的抗ｃｄ３８抗体
EP3092252B1 (en) Antibody targeting cell surface deposited complement protein c3d and use thereof
EP4292611A1 (en) Anti-cd112r antibody and use thereof
US12173081B2 (en) CD19/CD38 multispecific antibodies
TW201916890A (zh) 抗ｐｄ－１抗體和抗ｌａｇ－３抗體聯合在製備治療腫瘤的藥物中的用途
US20240270840A1 (en) Antibodies against cd112r and uses thereof
TW202345895A (zh) 在用於治療瀰漫性大型ｂ細胞淋巴瘤之組合療法中針對ｃｄ３和ｃｄ２０之雙特異性抗體
CN113368232B (zh) 多特异性抗原结合蛋白及其应用
HK1223116B (en) Specific anti-cd38 antibodies for treating human cancers
JP2024517985A (ja) 抗－ＣＤ３００ｃモノクローナル抗体及びその癌の予防または治療用バイオマーカー

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A525

Effective date: 20160615

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171030

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171030

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180928

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190326