JP2016535600A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016535600A5 JP2016535600A5 JP2016549646A JP2016549646A JP2016535600A5 JP 2016535600 A5 JP2016535600 A5 JP 2016535600A5 JP 2016549646 A JP2016549646 A JP 2016549646A JP 2016549646 A JP2016549646 A JP 2016549646A JP 2016535600 A5 JP2016535600 A5 JP 2016535600A5
- Authority
- JP
- Japan
- Prior art keywords
- cpp
- therapeutic agent
- molecule
- drug
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 27
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 27
- 239000003814 drug Substances 0.000 claims 23
- 229940124597 therapeutic agent Drugs 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000012528 membrane Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 239000002924 silencing RNA Substances 0.000 claims 2
- 150000003384 small molecules Chemical group 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000013000 chemical inhibitor Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1318954.3A GB201318954D0 (en) | 2013-10-28 | 2013-10-28 | Cell transport |
| GB1318954.3 | 2013-10-28 | ||
| PCT/GB2014/053037 WO2015063452A2 (en) | 2013-10-28 | 2014-10-09 | Cell transport |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535600A JP2016535600A (ja) | 2016-11-17 |
| JP2016535600A5 true JP2016535600A5 (OSRAM) | 2017-11-09 |
| JP6576355B2 JP6576355B2 (ja) | 2019-09-18 |
Family
ID=49767211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549646A Active JP6576355B2 (ja) | 2013-10-28 | 2014-10-09 | 細胞輸送 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9913914B2 (OSRAM) |
| EP (1) | EP3062822B1 (OSRAM) |
| JP (1) | JP6576355B2 (OSRAM) |
| CA (1) | CA2928773A1 (OSRAM) |
| GB (1) | GB201318954D0 (OSRAM) |
| WO (1) | WO2015063452A2 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018301804B2 (en) | 2017-07-10 | 2024-07-25 | Sri International | Molecular guide system peptides and uses thereof |
| US12195768B2 (en) | 2018-07-13 | 2025-01-14 | The Trustees Of Princeton University | System and method for modulating stress granule assembly |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523359A (en) * | 1995-01-13 | 1996-06-04 | Exxon Chemical Patents Inc. | Functionalized polymer and methods to obtain functionalized polymer |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| CA2350919A1 (en) | 1998-11-13 | 2000-05-25 | Cyclacel Limited | Antennapedia homeodomain helix 3 derived translocation vectors |
| US7091026B2 (en) | 2001-02-16 | 2006-08-15 | University Of Iowa Research Foundation | Artificial endonuclease |
| GB0229151D0 (en) * | 2002-12-13 | 2003-01-15 | St Georges Entpr Ltd | Product and method |
| US20050112064A1 (en) | 2003-08-12 | 2005-05-26 | Sonya Franklin | DNA-dependent MRI contrast agents |
| JP5295785B2 (ja) * | 2006-02-20 | 2013-09-18 | エファ・ユニバーシティ・インダストリー・コラボレイション・ファウンデイション | 細胞膜透過性ペプチド |
| WO2007109908A1 (en) * | 2006-03-29 | 2007-10-04 | The University Of British Columbia | Therapeutic yb-1 phosphorylation decoys |
| WO2012023284A1 (en) | 2010-08-20 | 2012-02-23 | Oncotherapy Science, Inc. | Lhx4 as a target gene for cancer therapy and diagnosis |
| WO2012170431A2 (en) | 2011-06-06 | 2012-12-13 | Bluebird Bio, Inc. | Improved geneswitch systems |
-
2013
- 2013-10-28 GB GBGB1318954.3A patent/GB201318954D0/en not_active Ceased
-
2014
- 2014-10-09 CA CA2928773A patent/CA2928773A1/en active Pending
- 2014-10-09 WO PCT/GB2014/053037 patent/WO2015063452A2/en not_active Ceased
- 2014-10-09 EP EP14784358.5A patent/EP3062822B1/en active Active
- 2014-10-09 JP JP2016549646A patent/JP6576355B2/ja active Active
- 2014-10-09 US US15/032,668 patent/US9913914B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2751128B1 (en) | Cell-penetrating peptides having a central hydrophobic domain | |
| JP2023071853A (ja) | 核酸および／またはタンパク質ペイロード送達のための組成物および方法 | |
| Hu et al. | Inhibiting gene expression with peptide nucleic acid (PNA)− peptide conjugates that target chromosomal DNA | |
| CN115521374B (zh) | 条件活性多肽 | |
| JP5726299B2 (ja) | 細胞透過性ペプチドおよびその使用 | |
| AU2019216781B2 (en) | Nanoparticle-hydrogel composite for nucleic acid molecule delivery | |
| Kozhikhova et al. | A novel peptide dendrimer LTP efficiently facilitates transfection of mammalian cells | |
| Zhang et al. | Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery | |
| JP2006517790A (ja) | ポリペプチド−核酸複合体の細胞の送達および活性化 | |
| CN105829336A (zh) | α-螺旋细胞穿透肽多聚体、其产生方法及其用途 | |
| CN103172701B (zh) | 一种新型穿膜肽及其应用 | |
| CN106255699A (zh) | 细胞穿透肽和使用其输送生物活性物质的方法 | |
| Soudah et al. | AntimiR-155 cyclic peptide–PNA conjugate: synthesis, cellular uptake, and biological activity | |
| JP2024012517A (ja) | がん治療用ペプチドサポリン複合体 | |
| JP2022502347A (ja) | 細胞透過性ペプチド | |
| O'Donovan et al. | Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy | |
| Peng et al. | Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate | |
| JP2016535600A5 (OSRAM) | ||
| JP2019118307A (ja) | 細胞膜透過ペプチド、構築物、及び、カーゴ分子を細胞内に輸送する方法 | |
| JP2017137256A (ja) | 細胞膜透過性を有するペプチド、構築物、及び、カーゴ分子を細胞内に輸送する方法 | |
| US20250129355A1 (en) | Programmable nuclease-peptidase compositions | |
| JP6373762B2 (ja) | ターゲット分子細胞内導入用ペプチド | |
| WO2022218997A1 (en) | Novel universal vaccine presenting system | |
| HK1194389A (en) | Cell-penetrating peptides having a central hydrophobic domain | |
| HK1194389B (en) | Cell-penetrating peptides having a central hydrophobic domain |