JP2016533373A5 - - Google Patents

Info

Publication number

JP2016533373A5

JP2016533373A5 JP2016524100A JP2016524100A JP2016533373A5 JP 2016533373 A5 JP2016533373 A5 JP 2016533373A5 JP 2016524100 A JP2016524100 A JP 2016524100A JP 2016524100 A JP2016524100 A JP 2016524100A JP 2016533373 A5 JP2016533373 A5 JP 2016533373A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

tumor

pancreatic cancer

pharmaceutically acceptable

Prior art date

2014-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 13
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 13
• 201000002528 pancreatic cancer Diseases 0.000 claims description 13
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 13
• 150000001875 compounds Chemical class 0.000 claims description 9
• 150000003839 salts Chemical class 0.000 claims description 9
• 206010028980 Neoplasm Diseases 0.000 claims description 8
• 239000002246 antineoplastic agent Substances 0.000 claims description 6
• 229940041181 antineoplastic drug Drugs 0.000 claims description 6
• 206010021143 Hypoxia Diseases 0.000 claims description 4
• 206010052399 Neuroendocrine tumour Diseases 0.000 claims description 4
• 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 claims description 4
• 102400000015 Vasoactive intestinal peptide Human genes 0.000 claims description 4
• 208000009956 adenocarcinoma Diseases 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 201000000052 gastrinoma Diseases 0.000 claims description 4
• 230000001146 hypoxic effect Effects 0.000 claims description 4
• VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 claims description 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
• 208000016065 neuroendocrine neoplasm Diseases 0.000 claims description 4
• 201000011519 neuroendocrine tumor Diseases 0.000 claims description 4
• 239000007787 solid Substances 0.000 claims description 4
• 229940124597 therapeutic agent Drugs 0.000 claims description 4
• 208000007569 Giant Cell Tumors Diseases 0.000 claims description 2
• 206010018404 Glucagonoma Diseases 0.000 claims description 2
• 208000009164 Islet Cell Adenoma Diseases 0.000 claims description 2
• 208000009311 VIPoma Diseases 0.000 claims description 2
• 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims description 2
• 208000006336 acinar cell carcinoma Diseases 0.000 claims description 2
• 201000008395 adenosquamous carcinoma Diseases 0.000 claims description 2
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
• 229960004316 cisplatin Drugs 0.000 claims description 2
• 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 claims description 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
• 229960005277 gemcitabine Drugs 0.000 claims description 2
• 206010022498 insulinoma Diseases 0.000 claims description 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
• 208000010492 mucinous cystadenocarcinoma Diseases 0.000 claims description 2
• 208000022669 mucinous neoplasm Diseases 0.000 claims description 2
• 208000029522 neoplastic syndrome Diseases 0.000 claims description 2
• 201000011116 pancreatic cholera Diseases 0.000 claims description 2
• 208000021255 pancreatic insulinoma Diseases 0.000 claims description 2
• 201000010341 pancreatic somatostatinoma Diseases 0.000 claims description 2
• 208000002820 pancreatoblastoma Diseases 0.000 claims description 2
• 208000004548 serous cystadenocarcinoma Diseases 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 241000283080 Proboscidea <mammal> Species 0.000 claims 1
• 0 *[C@]1O[C@@](*)CN(Cc2ccc(C=C[C@@]3NNc4c3ccc([C@](C3)[C@]3(c3cc(*)ccc3N3*=I)C3=O)c4)cc2)C1 Chemical compound *[C@]1O[C@@](*)CN(Cc2ccc(C=C[C@@]3NNc4c3ccc([C@](C3)[C@]3(c3cc(*)ccc3N3*=I)C3=O)c4)cc2)C1 0.000 description 5
• JOCNOQUWDPPPRY-LYWAIKEGSA-N C[C@H]1O[C@@H](C)CN(Cc2ccc(/C=C/c3n[nH]c4cc([C@H](C5)[C@]5(c5ccccc5N5)C5=O)ccc34)cc2)C1 Chemical compound C[C@H]1O[C@@H](C)CN(Cc2ccc(/C=C/c3n[nH]c4cc([C@H](C5)[C@]5(c5ccccc5N5)C5=O)ccc34)cc2)C1 JOCNOQUWDPPPRY-LYWAIKEGSA-N 0.000 description 2