JP2016533190A5 - - Google Patents
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- Publication number
- JP2016533190A5 JP2016533190A5 JP2016544736A JP2016544736A JP2016533190A5 JP 2016533190 A5 JP2016533190 A5 JP 2016533190A5 JP 2016544736 A JP2016544736 A JP 2016544736A JP 2016544736 A JP2016544736 A JP 2016544736A JP 2016533190 A5 JP2016533190 A5 JP 2016533190A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- nucleotides
- stretch
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 54
- 125000003729 nucleotide group Chemical group 0.000 claims 54
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 102000039446 nucleic acids Human genes 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 238000012986 modification Methods 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 239000007908 nanoemulsion Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 101000978766 Homo sapiens Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000030279 gene silencing Effects 0.000 claims 1
- 102000045609 human NOTCH1 Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 230000001323 posttranslational effect Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13004722.8 | 2013-09-30 | ||
| EP13004722.8A EP2853595A1 (en) | 2013-09-30 | 2013-09-30 | NOTCH 1 specific siRNA molecules |
| PCT/EP2014/002655 WO2015043768A1 (en) | 2013-09-30 | 2014-09-30 | Notch 1 specific sirna molecule |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133268A Division JP7086039B2 (ja) | 2013-09-30 | 2019-07-19 | ＮＯＴＣＨ １特異的なｓｉＲＮＡ分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533190A JP2016533190A (ja) | 2016-10-27 |
| JP2016533190A5 true JP2016533190A5 (OSRAM) | 2017-11-09 |
| JP6561061B2 JP6561061B2 (ja) | 2019-08-14 |
Family
ID=49304652
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544736A Expired - Fee Related JP6561061B2 (ja) | 2013-09-30 | 2014-09-30 | ＮＯＴＣＨ １特異的なｓｉＲＮＡ分子 |
| JP2019133268A Active JP7086039B2 (ja) | 2013-09-30 | 2019-07-19 | ＮＯＴＣＨ １特異的なｓｉＲＮＡ分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133268A Active JP7086039B2 (ja) | 2013-09-30 | 2019-07-19 | ＮＯＴＣＨ １特異的なｓｉＲＮＡ分子 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9896690B2 (OSRAM) |
| EP (2) | EP2853595A1 (OSRAM) |
| JP (2) | JP6561061B2 (OSRAM) |
| CN (2) | CN105814202B (OSRAM) |
| AU (1) | AU2014327809B2 (OSRAM) |
| CA (1) | CA2924788A1 (OSRAM) |
| DK (1) | DK3052625T3 (OSRAM) |
| HR (1) | HRP20211525T1 (OSRAM) |
| HU (1) | HUE056609T2 (OSRAM) |
| IL (1) | IL244661B (OSRAM) |
| LT (1) | LT3052625T (OSRAM) |
| MX (1) | MX377713B (OSRAM) |
| RU (1) | RU2651493C2 (OSRAM) |
| SG (2) | SG11201602437VA (OSRAM) |
| SI (1) | SI3052625T1 (OSRAM) |
| WO (1) | WO2015043768A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2853595A1 (en) * | 2013-09-30 | 2015-04-01 | Soluventis GmbH | NOTCH 1 specific siRNA molecules |
| CN115151644B (zh) * | 2019-12-27 | 2024-06-21 | 国立大学法人神户大学 | 癌基因治疗药 |
| CN112626068B (zh) * | 2020-12-21 | 2021-12-03 | 徐州医科大学 | 一种靶向Notch1基因的LncRNA及其应用 |
| CN116790603B (zh) * | 2023-08-18 | 2023-10-31 | 成都中科奥格生物科技有限公司 | 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| DK0618925T4 (da) | 1991-12-24 | 2012-07-09 | Isis Pharmaceuticals Inc | Antisense-oligonukleotider |
| CA2140343A1 (en) | 1992-07-17 | 1994-02-03 | Sean M. Sullivan | Method and reagent for treatment of animal diseases |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US6001311A (en) | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| EP1071753A2 (en) | 1998-04-20 | 2001-01-31 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
| ATE408699T1 (de) | 1999-03-10 | 2008-10-15 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| DK1527176T4 (en) | 2002-08-05 | 2017-07-03 | Silence Therapeutics Gmbh | ADDITIONAL NEW FORMS OF INTERFERRING RNA MOLECULES |
| KR101356935B1 (ko) | 2004-05-05 | 2014-01-28 | 사일런스 테라퓨틱스 아게 | 지질, 지질 복합체 및 이들의 용도 |
| JP2011510647A (ja) * | 2008-01-29 | 2011-04-07 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ | 遺伝子発現の転写後抑制を相乗的に生じさせることができる方法および組成物 |
| EP2250265A1 (en) * | 2008-03-12 | 2010-11-17 | Intradigm Corporation | Compositions comprising notch1 sirna and methods of use thereof |
| EP2123256A1 (en) * | 2008-05-19 | 2009-11-25 | Ruhr-Universität Bochum | Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer |
| NZ597504A (en) * | 2009-06-15 | 2013-10-25 | Alnylam Pharmaceuticals Inc | Lipid formulated dsrna targeting the pcsk9 gene |
| AU2012289865A1 (en) * | 2011-08-03 | 2014-02-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide compounds for treating hearing and balance disorders |
| EP2802657B1 (en) * | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| EP2853595A1 (en) * | 2013-09-30 | 2015-04-01 | Soluventis GmbH | NOTCH 1 specific siRNA molecules |
-
2013
- 2013-09-30 EP EP13004722.8A patent/EP2853595A1/en not_active Withdrawn
-
2014
- 2014-09-30 HR HRP20211525TT patent/HRP20211525T1/hr unknown
- 2014-09-30 US US15/026,084 patent/US9896690B2/en active Active
- 2014-09-30 SI SI201431913T patent/SI3052625T1/sl unknown
- 2014-09-30 EP EP14777525.8A patent/EP3052625B1/en active Active
- 2014-09-30 WO PCT/EP2014/002655 patent/WO2015043768A1/en not_active Ceased
- 2014-09-30 HU HUE14777525A patent/HUE056609T2/hu unknown
- 2014-09-30 RU RU2016116931A patent/RU2651493C2/ru active
- 2014-09-30 AU AU2014327809A patent/AU2014327809B2/en not_active Ceased
- 2014-09-30 SG SG11201602437VA patent/SG11201602437VA/en unknown
- 2014-09-30 DK DK14777525.8T patent/DK3052625T3/da active
- 2014-09-30 MX MX2016004142A patent/MX377713B/es active IP Right Grant
- 2014-09-30 CN CN201480061599.8A patent/CN105814202B/zh not_active Expired - Fee Related
- 2014-09-30 LT LTEPPCT/EP2014/002655T patent/LT3052625T/lt unknown
- 2014-09-30 SG SG10201802593WA patent/SG10201802593WA/en unknown
- 2014-09-30 CA CA2924788A patent/CA2924788A1/en active Pending
- 2014-09-30 JP JP2016544736A patent/JP6561061B2/ja not_active Expired - Fee Related
- 2014-09-30 CN CN202010081100.7A patent/CN111197046A/zh active Pending
-
2016
- 2016-03-20 IL IL244661A patent/IL244661B/en unknown
-
2018
- 2018-02-01 US US15/886,386 patent/US10669548B2/en not_active Expired - Fee Related
-
2019
- 2019-07-19 JP JP2019133268A patent/JP7086039B2/ja active Active
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