JP2016532703A5 - - Google Patents
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- JP2016532703A5 JP2016532703A5 JP2016536405A JP2016536405A JP2016532703A5 JP 2016532703 A5 JP2016532703 A5 JP 2016532703A5 JP 2016536405 A JP2016536405 A JP 2016536405A JP 2016536405 A JP2016536405 A JP 2016536405A JP 2016532703 A5 JP2016532703 A5 JP 2016532703A5
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- Prior art keywords
- seq
- antibody
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- binding fragment
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims description 82
- 102000036639 antigens Human genes 0.000 claims description 82
- 108091007433 antigens Proteins 0.000 claims description 82
- 239000012634 fragment Substances 0.000 claims description 82
- 239000000611 antibody drug conjugate Substances 0.000 claims description 39
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 39
- 108010002519 Prolactin Receptors Proteins 0.000 claims description 32
- 102100029000 Prolactin receptor Human genes 0.000 claims description 32
- 210000004027 cell Anatomy 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 11
- 229940127089 cytotoxic agent Drugs 0.000 claims description 11
- 239000002254 cytotoxic agent Substances 0.000 claims description 10
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 10
- 101100409237 Homo sapiens PRLR gene Proteins 0.000 claims description 9
- 108010057464 Prolactin Proteins 0.000 claims description 9
- 102000003946 Prolactin Human genes 0.000 claims description 9
- 230000001404 mediated effect Effects 0.000 claims description 9
- 229940097325 prolactin Drugs 0.000 claims description 9
- 210000004881 tumor cell Anatomy 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 230000011664 signaling Effects 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 230000004614 tumor growth Effects 0.000 claims description 5
- 206010061968 Gastric neoplasm Diseases 0.000 claims description 2
- 101001123448 Homo sapiens Prolactin receptor Proteins 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010029098 Neoplasm skin Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 208000037841 lung tumor Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000023958 prostate neoplasm Diseases 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims 4
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 23
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 229940124597 therapeutic agent Drugs 0.000 description 6
- 108010057085 cytokine receptors Proteins 0.000 description 4
- 102000003675 cytokine receptors Human genes 0.000 description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 4
- 108010044540 auristatin Proteins 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 102100034608 Angiopoietin-2 Human genes 0.000 description 1
- 102000016989 Ciliary Neurotrophic Factor Receptor Human genes 0.000 description 1
- 108010000063 Ciliary Neurotrophic Factor Receptor Proteins 0.000 description 1
- 102100028471 Eosinophil peroxidase Human genes 0.000 description 1
- 108010054017 Granulocyte Colony-Stimulating Factor Receptors Proteins 0.000 description 1
- 102100039622 Granulocyte colony-stimulating factor receptor Human genes 0.000 description 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 description 1
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 description 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 description 1
- 102100026244 Interleukin-9 receptor Human genes 0.000 description 1
- 102100031775 Leptin receptor Human genes 0.000 description 1
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 description 1
- 101710142062 Leukemia inhibitory factor receptor Proteins 0.000 description 1
- 108090000630 Oncostatin M Proteins 0.000 description 1
- 102100031942 Oncostatin-M Human genes 0.000 description 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 description 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 1
- 101710148465 Platelet-derived growth factor receptor alpha Proteins 0.000 description 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 108040006873 interleukin-11 receptor activity proteins Proteins 0.000 description 1
- 108040003610 interleukin-12 receptor activity proteins Proteins 0.000 description 1
- 108040003607 interleukin-13 receptor activity proteins Proteins 0.000 description 1
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 description 1
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 description 1
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 1
- 108040006856 interleukin-3 receptor activity proteins Proteins 0.000 description 1
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 description 1
- 108040006859 interleukin-5 receptor activity proteins Proteins 0.000 description 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 description 1
- 108040006861 interleukin-7 receptor activity proteins Proteins 0.000 description 1
- 108040006862 interleukin-9 receptor activity proteins Proteins 0.000 description 1
- 108010019813 leptin receptors Proteins 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868185P | 2013-08-21 | 2013-08-21 | |
| US61/868,185 | 2013-08-21 | ||
| US201462012440P | 2014-06-16 | 2014-06-16 | |
| US62/012,440 | 2014-06-16 | ||
| US201462026088P | 2014-07-18 | 2014-07-18 | |
| US62/026,088 | 2014-07-18 | ||
| PCT/US2014/051831 WO2015026907A1 (en) | 2013-08-21 | 2014-08-20 | Anti-prlr antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019175762A Division JP2020023511A (ja) | 2013-08-21 | 2019-09-26 | 抗ｐｒｌｒ抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016532703A JP2016532703A (ja) | 2016-10-20 |
| JP2016532703A5 true JP2016532703A5 (enExample) | 2017-10-05 |
| JP6621412B2 JP6621412B2 (ja) | 2019-12-18 |
Family
ID=51494506
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536405A Active JP6621412B2 (ja) | 2013-08-21 | 2014-08-20 | 抗ｐｒｌｒ抗体及びその使用 |
| JP2019175762A Pending JP2020023511A (ja) | 2013-08-21 | 2019-09-26 | 抗ｐｒｌｒ抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019175762A Pending JP2020023511A (ja) | 2013-08-21 | 2019-09-26 | 抗ｐｒｌｒ抗体及びその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9302015B2 (enExample) |
| EP (1) | EP3036257B1 (enExample) |
| JP (2) | JP6621412B2 (enExample) |
| KR (1) | KR102343315B1 (enExample) |
| CN (1) | CN105793286B (enExample) |
| AU (1) | AU2014308920B2 (enExample) |
| CA (1) | CA2920369C (enExample) |
| CL (1) | CL2016000376A1 (enExample) |
| EA (1) | EA201600190A1 (enExample) |
| IL (1) | IL243974B (enExample) |
| MX (1) | MX370787B (enExample) |
| MY (1) | MY179851A (enExample) |
| NZ (1) | NZ716612A (enExample) |
| PH (1) | PH12016500349B1 (enExample) |
| SG (1) | SG11201601211TA (enExample) |
| TW (1) | TWI641620B (enExample) |
| UY (1) | UY35712A (enExample) |
| WO (1) | WO2015026907A1 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2661023C (en) * | 2006-08-18 | 2017-08-15 | Novartis Ag | Prlr-specific antibody and uses thereof |
| SG10201704846VA (en) | 2012-03-14 | 2017-07-28 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| DK2935331T3 (en) | 2012-12-24 | 2018-06-06 | Abbvie Inc | PROLACTIN RECEPTOR BINDING PROTEINS AND APPLICATIONS THEREOF |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| WO2015187596A2 (en) | 2014-06-02 | 2015-12-10 | Regeneron Pharmaceuticals, Inc. | Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses |
| CA2978340C (en) | 2015-03-27 | 2024-05-28 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
| JP6993958B2 (ja) | 2015-07-06 | 2022-02-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 多重特異性抗原結合分子およびその使用 |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
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| CN105785607A (zh) * | 2016-03-31 | 2016-07-20 | 京东方科技集团股份有限公司 | 显示基板、点灯设备及点灯测试探针对位检测方法 |
| WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| WO2018002902A1 (en) | 2016-07-01 | 2018-01-04 | Glaxosmithkline Intellectual Property (No.2) Limited | Antibody-drug conjugates and therapeutic methods using the same |
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| MX2019006131A (es) * | 2016-11-29 | 2019-08-21 | Regeneron Pharma | Metodos para tratar cancer de mama positivo para prlr. |
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