JP2016532457A5 - - Google Patents
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- Publication number
- JP2016532457A5 JP2016532457A5 JP2016547976A JP2016547976A JP2016532457A5 JP 2016532457 A5 JP2016532457 A5 JP 2016532457A5 JP 2016547976 A JP2016547976 A JP 2016547976A JP 2016547976 A JP2016547976 A JP 2016547976A JP 2016532457 A5 JP2016532457 A5 JP 2016532457A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell culture
- cell
- interest
- metabolic shift
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims description 113
- 238000000034 method Methods 0.000 claims description 37
- 238000004113 cell culture Methods 0.000 claims description 36
- 230000002503 metabolic effect Effects 0.000 claims description 19
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 18
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 241001529936 Murinae Species 0.000 claims description 6
- 238000012258 culturing Methods 0.000 claims description 6
- 102000025171 antigen binding proteins Human genes 0.000 claims description 4
- 108091000831 antigen binding proteins Proteins 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 4
- 102000037865 fusion proteins Human genes 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000007523 nucleic acids Chemical group 0.000 claims description 4
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 3
- 210000004408 hybridoma Anatomy 0.000 claims description 3
- 210000003125 jurkat cell Anatomy 0.000 claims description 3
- 210000004698 lymphocyte Anatomy 0.000 claims description 3
- 230000002207 retinal effect Effects 0.000 claims description 3
- 210000003501 vero cell Anatomy 0.000 claims description 3
- 230000005526 G1 to G0 transition Effects 0.000 claims description 2
- 239000006143 cell culture medium Substances 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020024484A JP6967620B2 (ja) | 2013-10-11 | 2020-02-17 | 代謝が最適化された細胞培養 |
| JP2021173755A JP7377243B2 (ja) | 2013-10-11 | 2021-10-25 | 代謝が最適化された細胞培養 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889815P | 2013-10-11 | 2013-10-11 | |
| US61/889,815 | 2013-10-11 | ||
| PCT/US2014/059993 WO2015054554A1 (en) | 2013-10-11 | 2014-10-10 | Metabolically optimized cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024484A Division JP6967620B2 (ja) | 2013-10-11 | 2020-02-17 | 代謝が最適化された細胞培養 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016532457A JP2016532457A (ja) | 2016-10-20 |
| JP2016532457A5 true JP2016532457A5 (cg-RX-API-DMAC7.html) | 2017-11-09 |
| JP6663854B2 JP6663854B2 (ja) | 2020-03-13 |
Family
ID=52813657
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547976A Active JP6663854B2 (ja) | 2013-10-11 | 2014-10-10 | 代謝が最適化された細胞培養 |
| JP2020024484A Active JP6967620B2 (ja) | 2013-10-11 | 2020-02-17 | 代謝が最適化された細胞培養 |
| JP2021173755A Active JP7377243B2 (ja) | 2013-10-11 | 2021-10-25 | 代謝が最適化された細胞培養 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024484A Active JP6967620B2 (ja) | 2013-10-11 | 2020-02-17 | 代謝が最適化された細胞培養 |
| JP2021173755A Active JP7377243B2 (ja) | 2013-10-11 | 2021-10-25 | 代謝が最適化された細胞培養 |
Country Status (17)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160244726A1 (en) * | 2013-10-11 | 2016-08-25 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| EA201991976A1 (ru) | 2013-10-11 | 2020-04-02 | Регенерон Фармасьютикалз, Инк. | Метаболически оптимизированная клеточная культура |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| JP7260018B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260020B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260011B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7310945B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7272480B2 (ja) * | 2017-04-27 | 2023-05-12 | 株式会社三洋物産 | 遊技機 |
| JP7260012B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260021B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7310952B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7260009B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7310947B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7260013B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| CN111344558A (zh) | 2017-10-06 | 2020-06-26 | 龙沙有限公司 | 使用拉曼光谱法自动控制细胞培养 |
| EA202090740A1 (ru) | 2017-10-16 | 2020-07-07 | Ридженерон Фармасьютикалз, Инк. | Перфузионный биореактор и связанные с ним способы применения |
| CN111406112A (zh) * | 2017-11-30 | 2020-07-10 | 豪夫迈·罗氏有限公司 | 用于培养哺乳动物细胞的工艺 |
| JP2021519073A (ja) * | 2018-03-29 | 2021-08-10 | ジェネンテック， インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
| GB201810772D0 (en) * | 2018-06-29 | 2018-08-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| JP7231355B2 (ja) * | 2018-08-22 | 2023-03-01 | 日機装株式会社 | 細胞培養方法および細胞培養装置 |
| KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
| JP2020151559A (ja) * | 2020-06-24 | 2020-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2020151560A (ja) * | 2020-06-24 | 2020-09-24 | 株式会社三洋物産 | 遊技機 |
| EP3985097A1 (en) * | 2020-10-14 | 2022-04-20 | Sartorius Stedim Biotech GmbH | A method and system for configuring and/or setup of a downstream process for processing a biomass |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
| US6165741A (en) | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
| US5972650A (en) | 1997-06-26 | 1999-10-26 | Brigham And Women's Hospital | Tetracycline repressor regulated mammalian cell transcription and viral replication switch |
| EP1392859B1 (en) | 2001-01-16 | 2006-05-10 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| US6953692B2 (en) * | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| CA2417689C (en) | 2002-03-05 | 2006-05-09 | F. Hoffmann-La Roche Ag | Improved methods for growing mammalian cells in vitro |
| US7039770B1 (en) | 2002-03-05 | 2006-05-02 | Juniper Networks, Inc. | Low latency request dispatcher |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| WO2004104186A1 (en) | 2003-05-15 | 2004-12-02 | Wyeth | Restricted glucose feed for animal cell culture |
| US7531327B2 (en) * | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| TWI364458B (en) * | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
| WO2007056062A2 (en) * | 2005-11-02 | 2007-05-18 | Wyeth | Methods for adapting mammalian cells |
| EA016609B1 (ru) | 2005-11-28 | 2012-06-29 | Генмаб А/С | Рекомбинантные моновалентные антитела и способы их получения |
| US7575890B2 (en) | 2006-01-18 | 2009-08-18 | Oxygen Enterprises, Ltd. | Method for rapid detection and evaluation of cultured cell growth |
| MX2009004519A (es) | 2006-11-03 | 2009-05-12 | Wyeth Corp | Sustancias que inhiben la glucolisis en un cultivo de celulas. |
| EP2150617B1 (en) | 2007-06-04 | 2014-10-22 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| UA106047C2 (uk) * | 2008-06-13 | 2014-07-25 | Сентокор Орто Байотек Інк. | Спосіб отримання високої щільності життєздатних клітин в культурі клітин ссавців |
| US8470552B2 (en) | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| BR112012027282B1 (pt) * | 2010-04-26 | 2020-09-29 | Novartis Ag | Meio de cultura de células aperfeiçoado e processo para a produção de um polipeptídeo recombinante |
| BR112012030197A2 (pt) * | 2010-05-28 | 2015-09-29 | Genentech Inc | diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase. |
| TWI637057B (zh) | 2012-11-09 | 2018-10-01 | 拜爾沙納有限公司 | 具交替生物反應器用途之不連續進料批次製程 |
| US20150353542A1 (en) * | 2013-01-14 | 2015-12-10 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| EA201991976A1 (ru) | 2013-10-11 | 2020-04-02 | Регенерон Фармасьютикалз, Инк. | Метаболически оптимизированная клеточная культура |
-
2014
- 2014-10-10 EA EA201991976A patent/EA201991976A1/ru unknown
- 2014-10-10 EP EP14851841.8A patent/EP3055409B1/en not_active Revoked
- 2014-10-10 SG SG11201601681QA patent/SG11201601681QA/en unknown
- 2014-10-10 CN CN201480055499.4A patent/CN105637085A/zh active Pending
- 2014-10-10 HU HUE18161278A patent/HUE051049T2/hu unknown
- 2014-10-10 ES ES14851841.8T patent/ES2678945T3/es active Active
- 2014-10-10 SG SG10201800772TA patent/SG10201800772TA/en unknown
- 2014-10-10 CA CA2926049A patent/CA2926049C/en active Active
- 2014-10-10 DK DK18161278.9T patent/DK3351620T3/da active
- 2014-10-10 KR KR1020167009163A patent/KR102243980B1/ko active Active
- 2014-10-10 AU AU2014331776A patent/AU2014331776B2/en active Active
- 2014-10-10 MX MX2020011334A patent/MX384960B/es unknown
- 2014-10-10 EP EP18161278.9A patent/EP3351620B1/en not_active Revoked
- 2014-10-10 KR KR1020227003381A patent/KR102510238B1/ko active Active
- 2014-10-10 ES ES18161278T patent/ES2833471T3/es active Active
- 2014-10-10 JP JP2016547976A patent/JP6663854B2/ja active Active
- 2014-10-10 KR KR1020237008467A patent/KR102610425B1/ko active Active
- 2014-10-10 PL PL18161278T patent/PL3351620T3/pl unknown
- 2014-10-10 EP EP20193898.2A patent/EP3812453A1/en active Pending
- 2014-10-10 CN CN202210497778.2A patent/CN114717196A/zh active Pending
- 2014-10-10 HU HUE14851841A patent/HUE039551T2/hu unknown
- 2014-10-10 KR KR1020217011547A patent/KR102358807B1/ko active Active
- 2014-10-10 WO PCT/US2014/059993 patent/WO2015054554A1/en not_active Ceased
- 2014-10-10 DK DK14851841.8T patent/DK3055409T3/en active
- 2014-10-10 EA EA201690600A patent/EA033783B1/ru active IP Right Revival
- 2014-10-10 PL PL14851841T patent/PL3055409T3/pl unknown
- 2014-10-10 MX MX2016004564A patent/MX376623B/es active IP Right Grant
- 2014-10-10 US US15/028,521 patent/US20160244725A1/en not_active Abandoned
-
2016
- 2016-03-04 ZA ZA2016/01550A patent/ZA201601550B/en unknown
- 2016-03-08 IL IL244511A patent/IL244511A0/en unknown
-
2018
- 2018-11-06 IL IL262833A patent/IL262833A/en unknown
-
2020
- 2020-02-17 JP JP2020024484A patent/JP6967620B2/ja active Active
- 2020-08-04 US US16/984,531 patent/US20210087535A1/en active Pending
-
2021
- 2021-01-14 AU AU2021200193A patent/AU2021200193B2/en active Active
- 2021-10-25 JP JP2021173755A patent/JP7377243B2/ja active Active
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