JP2016531846A5 - - Google Patents
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- Publication number
- JP2016531846A5 JP2016531846A5 JP2016515427A JP2016515427A JP2016531846A5 JP 2016531846 A5 JP2016531846 A5 JP 2016531846A5 JP 2016515427 A JP2016515427 A JP 2016515427A JP 2016515427 A JP2016515427 A JP 2016515427A JP 2016531846 A5 JP2016531846 A5 JP 2016531846A5
- Authority
- JP
- Japan
- Prior art keywords
- stereoisomer
- acceptable salt
- pharmaceutically acceptable
- fibrosis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 206010016654 Fibrosis Diseases 0.000 claims 10
- 230000004761 fibrosis Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010020772 Hypertension Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 206010065918 Prehypertension Diseases 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 201000002793 renal fibrosis Diseases 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- -1 hydroxy, amino Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013903571 | 2013-09-17 | ||
| AU2013903571A AU2013903571A0 (en) | 2013-09-17 | Compositions for the treatment of hypertension and/or fibrosis | |
| AU2013903572 | 2013-09-17 | ||
| AU2013903572A AU2013903572A0 (en) | 2013-09-17 | Compositions for the treatment of hypertension and/or fibrosis | |
| PCT/AU2014/000922 WO2015039172A1 (en) | 2013-09-17 | 2014-09-17 | Compositions for the treatment of hypertension and/or fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531846A JP2016531846A (ja) | 2016-10-13 |
| JP2016531846A5 true JP2016531846A5 (enExample) | 2017-10-05 |
| JP6293266B2 JP6293266B2 (ja) | 2018-03-14 |
Family
ID=52687997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515427A Active JP6293266B2 (ja) | 2013-09-17 | 2014-09-17 | 高血圧及び／又は線維症の処置用組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9630935B2 (enExample) |
| EP (1) | EP3046902B1 (enExample) |
| JP (1) | JP6293266B2 (enExample) |
| KR (1) | KR101863708B1 (enExample) |
| CN (1) | CN105683153B (enExample) |
| AP (1) | AP2016009080A0 (enExample) |
| AU (1) | AU2014324075B2 (enExample) |
| BR (1) | BR112016005606B1 (enExample) |
| CA (1) | CA2924353C (enExample) |
| DK (1) | DK3046902T3 (enExample) |
| ES (1) | ES2694375T3 (enExample) |
| IL (1) | IL244622A0 (enExample) |
| MX (1) | MX368011B (enExample) |
| MY (1) | MY191337A (enExample) |
| NZ (1) | NZ717930A (enExample) |
| PH (1) | PH12016500495B1 (enExample) |
| RU (1) | RU2661878C2 (enExample) |
| SG (1) | SG11201601641VA (enExample) |
| UA (1) | UA117254C2 (enExample) |
| WO (1) | WO2015039172A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY172557A (en) * | 2013-09-17 | 2019-12-02 | Vectus Biosystems Ltd | Compositions for the treatment of hypertension and/or fibrosis |
| JP6734294B2 (ja) * | 2015-03-18 | 2020-08-05 | ヴェクタス バイオシステムズ リミテッド | 線維症及び線維症に関連する状態の処置のための組成物 |
| RU2712624C9 (ru) * | 2015-03-18 | 2020-04-28 | Вектус Байосистемс Лимитед | Композиции для лечения заболевания почек и/или печени |
| CA3030309C (en) | 2016-07-28 | 2023-06-20 | Vectus Biosystems Limited | Compositions for the treatment of pulmonary fibrosis |
| WO2018068759A1 (zh) | 2016-10-14 | 2018-04-19 | 江苏恒瑞医药股份有限公司 | 五元杂芳环并桥环类衍生物、其制备方法及其在医药上的应用 |
| EP3693360B1 (en) | 2017-10-06 | 2023-12-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| EP4153575A4 (en) * | 2020-05-21 | 2024-07-17 | StemSynergy Therapeutics, Inc. | Notch inhibitors and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1355884A1 (en) * | 2001-01-31 | 2003-10-29 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| HRP20040343A2 (en) * | 2001-10-18 | 2005-08-31 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| US20030162824A1 (en) * | 2001-11-12 | 2003-08-28 | Krul Elaine S. | Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor |
| ES2282667T3 (es) * | 2002-06-25 | 2007-10-16 | Merck Frosst Canada Ltd. | Inhibidores de pde4 8-(biaril)quinolinas. |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| KR101638308B1 (ko) * | 2004-06-11 | 2016-07-08 | 벡투스 바이오시스템즈 리미티드 | 심혈관 질환의 치료를 위한 조성물 및 방법 |
| WO2006018325A1 (en) * | 2004-08-17 | 2006-02-23 | Galderma Research & Development, S.N.C. | Novel biaromatic compounds which activate receptors of ppar type and their use in cosmetic or pharmaceutical compositions |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| JP2010531841A (ja) * | 2007-07-04 | 2010-09-30 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤として有用な新規なピラゾール誘導体 |
| TW201021797A (en) * | 2008-12-04 | 2010-06-16 | Nat Univ Tsing Hua | 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists |
| WO2010091876A2 (en) * | 2009-02-13 | 2010-08-19 | Jerini Ag | Small molecule bradykinin b1 receptor antagonists |
| MX2011012628A (es) * | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados amino-propionicos sustituidos como inhibidores de neprilisina. |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
-
2014
- 2014-09-17 AU AU2014324075A patent/AU2014324075B2/en active Active
- 2014-09-17 RU RU2016112053A patent/RU2661878C2/ru active
- 2014-09-17 AP AP2016009080A patent/AP2016009080A0/xx unknown
- 2014-09-17 US US15/022,264 patent/US9630935B2/en active Active
- 2014-09-17 JP JP2016515427A patent/JP6293266B2/ja active Active
- 2014-09-17 CA CA2924353A patent/CA2924353C/en active Active
- 2014-09-17 DK DK14845828.4T patent/DK3046902T3/en active
- 2014-09-17 BR BR112016005606-0A patent/BR112016005606B1/pt active IP Right Grant
- 2014-09-17 EP EP14845828.4A patent/EP3046902B1/en active Active
- 2014-09-17 ES ES14845828.4T patent/ES2694375T3/es active Active
- 2014-09-17 WO PCT/AU2014/000922 patent/WO2015039172A1/en not_active Ceased
- 2014-09-17 SG SG11201601641VA patent/SG11201601641VA/en unknown
- 2014-09-17 NZ NZ717930A patent/NZ717930A/en unknown
- 2014-09-17 MY MYPI2016000481A patent/MY191337A/en unknown
- 2014-09-17 UA UAA201602269A patent/UA117254C2/uk unknown
- 2014-09-17 KR KR1020167009836A patent/KR101863708B1/ko active Active
- 2014-09-17 CN CN201480050947.1A patent/CN105683153B/zh active Active
- 2014-09-17 MX MX2016003372A patent/MX368011B/es active IP Right Grant
-
2016
- 2016-03-14 PH PH12016500495A patent/PH12016500495B1/en unknown
- 2016-03-16 IL IL244622A patent/IL244622A0/en active IP Right Grant
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