PH12016500495B1 - Compositions for the treatment of hypertension and/or fibrosis - Google Patents

Compositions for the treatment of hypertension and/or fibrosis Download PDF

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Publication number
PH12016500495B1
PH12016500495B1 PH12016500495A PH12016500495A PH12016500495B1 PH 12016500495 B1 PH12016500495 B1 PH 12016500495B1 PH 12016500495 A PH12016500495 A PH 12016500495A PH 12016500495 A PH12016500495 A PH 12016500495A PH 12016500495 B1 PH12016500495 B1 PH 12016500495B1
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Philippines
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fibrosis
compound
mmol
nmr
pharmaceutically acceptable
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PH12016500495A
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PH12016500495A1 (en
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Karen Annette Duggan
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Vectus Biosystems Ltd
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Priority claimed from AU2013903571A external-priority patent/AU2013903571A0/en
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Publication of PH12016500495A1 publication Critical patent/PH12016500495A1/en
Publication of PH12016500495B1 publication Critical patent/PH12016500495B1/en

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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Thiazole And Isothizaole Compounds (AREA)
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BR112019001510B1 (pt) * 2016-07-28 2022-11-08 Vectus Biosystems Limited Composto, e, uso de um composto para manufatura de um medicamento para tratar profilática ou terapeuticamente fibrose pulmonar, ou uma enfermidade relacionada em um indivíduo com fibrose pulmonar ou em risco de desenvolver fibrose pulmonar
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WO2009003921A1 (en) * 2007-07-04 2009-01-08 Neurosearch A/S Novel pyrazole derivatives useful as potassium channel modulators
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MX2016003372A (es) 2016-10-21
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US9630935B2 (en) 2017-04-25
US20160280671A1 (en) 2016-09-29
PH12016500495A1 (en) 2016-05-23
AP2016009080A0 (en) 2016-03-31
DK3046902T3 (en) 2018-12-03
IL244622A0 (en) 2016-04-21
EP3046902B1 (en) 2018-08-08
AU2014324075A1 (en) 2016-04-07
EP3046902A4 (en) 2017-01-25
JP6293266B2 (ja) 2018-03-14
RU2016112053A (ru) 2017-10-23
MX368011B (es) 2019-09-13
MY191337A (en) 2022-06-16
NZ717930A (en) 2018-12-21
KR20160071384A (ko) 2016-06-21
WO2015039172A1 (en) 2015-03-26
CA2924353C (en) 2018-12-04
ES2694375T3 (es) 2018-12-20
CA2924353A1 (en) 2015-03-26
BR112016005606B1 (pt) 2020-09-15
UA117254C2 (uk) 2018-07-10
SG11201601641VA (en) 2016-04-28
AU2014324075B2 (en) 2017-03-02
CN105683153A (zh) 2016-06-15
CN105683153B (zh) 2018-07-13
JP2016531846A (ja) 2016-10-13
KR101863708B1 (ko) 2018-06-01

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