CN105683153B - 用于治疗高血压和/或纤维化的组合物 - Google Patents

用于治疗高血压和/或纤维化的组合物 Download PDF

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CN105683153B
CN105683153B CN201480050947.1A CN201480050947A CN105683153B CN 105683153 B CN105683153 B CN 105683153B CN 201480050947 A CN201480050947 A CN 201480050947A CN 105683153 B CN105683153 B CN 105683153B
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fibrosis
compound
nmr
pharmaceutically acceptable
amino
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CN105683153A (zh
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凯伦·安妮特·达根
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Vectus Biosystems Pty Ltd
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1518542A (zh) * 2001-01-31 2004-08-04 �Ʒ� 用作pde4同工酶的抑制剂的烟酰胺联芳基衍生物
CN1630709A (zh) * 2001-10-18 2005-06-22 百时美施贵宝公司 人胰高血糖素样多肽－1模拟物和它们在治疗糖尿病和相关状况中的应用
WO2006018325A1 (en) * 2004-08-17 2006-02-23 Galderma Research & Development, S.N.C. Novel biaromatic compounds which activate receptors of ppar type and their use in cosmetic or pharmaceutical compositions
CN102574801A (zh) * 2009-05-28 2012-07-11 诺瓦提斯公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030162824A1 (en) * 2001-11-12 2003-08-28 Krul Elaine S. Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor
WO2004000814A1 (en) 2002-06-25 2003-12-31 Merck Frosst Canada & Co. 8-(biaryl) quinoline pde4 inhibitors
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
EP1768689B1 (en) * 2004-06-11 2014-08-20 Vectus Biosystems Limited Compositions and methods for treatment of cardiovascular disease
TW200831080A (en) * 2006-12-15 2008-08-01 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
WO2009003921A1 (en) * 2007-07-04 2009-01-08 Neurosearch A/S Novel pyrazole derivatives useful as potassium channel modulators
TW201021797A (en) * 2008-12-04 2010-06-16 Nat Univ Tsing Hua 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists
CA2752190A1 (en) 2009-02-13 2010-08-19 Jerini Ag Small molecule bradykinin b1 receptor antagonists
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1518542A (zh) * 2001-01-31 2004-08-04 �Ʒ� 用作pde4同工酶的抑制剂的烟酰胺联芳基衍生物
CN1630709A (zh) * 2001-10-18 2005-06-22 百时美施贵宝公司 人胰高血糖素样多肽－1模拟物和它们在治疗糖尿病和相关状况中的应用
WO2006018325A1 (en) * 2004-08-17 2006-02-23 Galderma Research & Development, S.N.C. Novel biaromatic compounds which activate receptors of ppar type and their use in cosmetic or pharmaceutical compositions
CN102574801A (zh) * 2009-05-28 2012-07-11 诺瓦提斯公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A Modular Synthesis of Teraryl-Based a-Helix Mimetics, Part 1: Synthesis of Core Fragments with Two ElectronACHTUNGTRENUNGicACHTUNGTRENUNGally Differentiated Leaving Groups;Rolf Breinbauer 等;《Chem. Eur. J.》;20130104;第19卷;第2442-2449页 *

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