AP2016009080A0 - Compositions for the treatment of hypertension and/or fibrosis - Google Patents

Compositions for the treatment of hypertension and/or fibrosis

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Publication number
AP2016009080A0
AP2016009080A0 AP2016009080A AP2016009080A AP2016009080A0 AP 2016009080 A0 AP2016009080 A0 AP 2016009080A0 AP 2016009080 A AP2016009080 A AP 2016009080A AP 2016009080 A AP2016009080 A AP 2016009080A AP 2016009080 A0 AP2016009080 A0 AP 2016009080A0
Authority
AP
ARIPO
Prior art keywords
fibrosis
hypertension
compositions
treatment
Prior art date
Application number
AP2016009080A
Other languages
English (en)
Inventor
Karen Annette Duggan
Original Assignee
Vectus Biosystems Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013903572A external-priority patent/AU2013903572A0/en
Application filed by Vectus Biosystems Pty Ltd filed Critical Vectus Biosystems Pty Ltd
Publication of AP2016009080A0 publication Critical patent/AP2016009080A0/xx

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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
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PL3046901T3 (pl) * 2013-09-17 2018-03-30 Vectus Biosystems Limited Kompozycje do leczenia nadciśnienia i/lub zwłóknienia
RU2712624C9 (ru) * 2015-03-18 2020-04-28 Вектус Байосистемс Лимитед Композиции для лечения заболевания почек и/или печени
ES2766769T3 (es) * 2015-03-18 2020-06-15 Vectus Biosystems Ltd Composiciones para el tratamiento de la fibrosis y de las afecciones relacionadas con la fibrosis
NZ788858A (en) 2016-07-28 2024-07-26 Vectus Biosystems Ltd Compositions for the treatment of pulmonary fibrosis
US10906905B2 (en) 2016-10-14 2021-02-02 Jiangsu Hengrui Medicine Co., Ltd. Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
US11447488B2 (en) 2017-10-06 2022-09-20 Takeda Pharmaceutical Company Limited Heterocyclic compounds
JP2023526521A (ja) * 2020-05-21 2023-06-21 ステムシナジー セラピューティクス， インク． Ｎｏｔｃｈ阻害剤及びそれらの使用

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WO2002060875A1 (en) * 2001-01-31 2002-08-08 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
KR20040054729A (ko) * 2001-10-18 2004-06-25 브리스톨-마이어스 스큅 컴퍼니 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도
US20030162824A1 (en) * 2001-11-12 2003-08-28 Krul Elaine S. Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor
DE60312520T2 (de) * 2002-06-25 2007-11-22 Merck Frosst Canada Ltd., Kirkland 8-(biaryl)chinolin-pde4-inhibitoren
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
WO2005120545A1 (en) * 2004-06-11 2005-12-22 Vectus Biosystems Limited Compositions and methods for treatment of cardiovascular disease
RU2007109778A (ru) * 2004-08-17 2008-09-27 Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) Новые биароматические соединения, которые активируют рецепторы типа ppar, и их применение в косметических и фармацевтических композициях
TW200831080A (en) * 2006-12-15 2008-08-01 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
WO2009003921A1 (en) * 2007-07-04 2009-01-08 Neurosearch A/S Novel pyrazole derivatives useful as potassium channel modulators
TW201021797A (en) * 2008-12-04 2010-06-16 Nat Univ Tsing Hua 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists
CA2752190A1 (en) 2009-02-13 2010-08-19 Jerini Ag Small molecule bradykinin b1 receptor antagonists
AU2010251967B9 (en) * 2009-05-28 2014-04-03 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives

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IL244622A0 (en) 2016-04-21
EP3046902B1 (en) 2018-08-08
BR112016005606B1 (pt) 2020-09-15
EP3046902A1 (en) 2016-07-27
CN105683153B (zh) 2018-07-13
PH12016500495B1 (en) 2016-05-23
PH12016500495A1 (en) 2016-05-23
CN105683153A (zh) 2016-06-15
MY191337A (en) 2022-06-16
UA117254C2 (uk) 2018-07-10
EP3046902A4 (en) 2017-01-25
CA2924353A1 (en) 2015-03-26
SG11201601641VA (en) 2016-04-28
RU2016112053A (ru) 2017-10-23
JP2016531846A (ja) 2016-10-13
KR20160071384A (ko) 2016-06-21
CA2924353C (en) 2018-12-04
MX368011B (es) 2019-09-13
WO2015039172A1 (en) 2015-03-26
AU2014324075B2 (en) 2017-03-02
NZ717930A (en) 2018-12-21
US9630935B2 (en) 2017-04-25
RU2661878C2 (ru) 2018-07-20
KR101863708B1 (ko) 2018-06-01
US20160280671A1 (en) 2016-09-29
AU2014324075A1 (en) 2016-04-07
ES2694375T3 (es) 2018-12-20
DK3046902T3 (en) 2018-12-03
JP6293266B2 (ja) 2018-03-14

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