JP2016530216A5 - - Google Patents
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- Publication number
- JP2016530216A5 JP2016530216A5 JP2016516187A JP2016516187A JP2016530216A5 JP 2016530216 A5 JP2016530216 A5 JP 2016530216A5 JP 2016516187 A JP2016516187 A JP 2016516187A JP 2016516187 A JP2016516187 A JP 2016516187A JP 2016530216 A5 JP2016530216 A5 JP 2016530216A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- buffer
- antibody
- pka
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 39
- 239000000872 buffer Substances 0.000 claims 35
- 239000007853 buffer solution Substances 0.000 claims 34
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 18
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 15
- 150000001412 amines Chemical group 0.000 claims 13
- 238000006386 neutralization reaction Methods 0.000 claims 13
- 238000002955 isolation Methods 0.000 claims 10
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 9
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 9
- OWXMKDGYPWMGEB-UHFFFAOYSA-N HEPPS Chemical compound OCCN1CCN(CCCS(O)(=O)=O)CC1 OWXMKDGYPWMGEB-UHFFFAOYSA-N 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 8
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 claims 6
- NUFBIAUZAMHTSP-UHFFFAOYSA-N 3-(n-morpholino)-2-hydroxypropanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CN1CCOCC1 NUFBIAUZAMHTSP-UHFFFAOYSA-N 0.000 claims 6
- XNPKNHHFCKSMRV-UHFFFAOYSA-N 4-(cyclohexylamino)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCNC1CCCCC1 XNPKNHHFCKSMRV-UHFFFAOYSA-N 0.000 claims 6
- PJWWRFATQTVXHA-UHFFFAOYSA-N Cyclohexylaminopropanesulfonic acid Chemical compound OS(=O)(=O)CCCNC1CCCCC1 PJWWRFATQTVXHA-UHFFFAOYSA-N 0.000 claims 6
- 239000007995 HEPES buffer Substances 0.000 claims 6
- 239000007993 MOPS buffer Substances 0.000 claims 6
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 6
- SEQKRHFRPICQDD-UHFFFAOYSA-N N-tris(hydroxymethyl)methylglycine Chemical compound OCC(CO)(CO)[NH2+]CC([O-])=O SEQKRHFRPICQDD-UHFFFAOYSA-N 0.000 claims 6
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 6
- 229960003237 betaine Drugs 0.000 claims 6
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 6
- 239000007790 solid phase Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- INEWUCPYEUEQTN-UHFFFAOYSA-N 3-(cyclohexylamino)-2-hydroxy-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CNC1CCCCC1 INEWUCPYEUEQTN-UHFFFAOYSA-N 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- 230000003472 neutralizing effect Effects 0.000 claims 4
- SXGZJKUKBWWHRA-UHFFFAOYSA-N 2-(N-morpholiniumyl)ethanesulfonate Chemical compound [O-]S(=O)(=O)CC[NH+]1CCOCC1 SXGZJKUKBWWHRA-UHFFFAOYSA-N 0.000 claims 3
- LOJNFONOHINEFI-UHFFFAOYSA-N 4-[4-(2-hydroxyethyl)piperazin-1-yl]butane-1-sulfonic acid Chemical compound OCCN1CCN(CCCCS(O)(=O)=O)CC1 LOJNFONOHINEFI-UHFFFAOYSA-N 0.000 claims 3
- NZUUXQSBKZPFKK-UHFFFAOYSA-N 4-piperazin-1-ylmorpholine Chemical compound C1CNCCN1N1CCOCC1 NZUUXQSBKZPFKK-UHFFFAOYSA-N 0.000 claims 3
- 239000007996 HEPPS buffer Substances 0.000 claims 3
- GIZQLVPDAOBAFN-UHFFFAOYSA-N HEPPSO Chemical compound OCCN1CCN(CC(O)CS(O)(=O)=O)CC1 GIZQLVPDAOBAFN-UHFFFAOYSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 108010077895 Sarcosine Proteins 0.000 claims 3
- UZMAPBJVXOGOFT-UHFFFAOYSA-N Syringetin Natural products COC1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UZMAPBJVXOGOFT-UHFFFAOYSA-N 0.000 claims 3
- 239000007997 Tricine buffer Substances 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 229940000635 beta-alanine Drugs 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 230000021615 conjugation Effects 0.000 claims 3
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 claims 3
- 108700003601 dimethylglycine Proteins 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 3
- 150000003335 secondary amines Chemical class 0.000 claims 3
- YCLWMUYXEGEIGD-UHFFFAOYSA-M sodium;2-hydroxy-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonate Chemical compound [Na+].OCCN1CCN(CC(O)CS([O-])(=O)=O)CC1 YCLWMUYXEGEIGD-UHFFFAOYSA-M 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 150000003512 tertiary amines Chemical class 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- -1 cyclohexylamino Chemical group 0.000 claims 2
- 238000001212 derivatisation Methods 0.000 claims 2
- 102000034287 fluorescent proteins Human genes 0.000 claims 2
- 108091006047 fluorescent proteins Proteins 0.000 claims 2
- AGVKXDPPPSLISR-UHFFFAOYSA-N n-ethylcyclohexanamine Chemical class CCNC1CCCCC1 AGVKXDPPPSLISR-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000001294 propane Substances 0.000 claims 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims 1
- 238000006177 thiolation reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1309759.7A GB2516808A (en) | 2013-05-31 | 2013-05-31 | Antibody composition and buffer system therefor |
| GB1309759.7 | 2013-05-31 | ||
| PCT/EP2014/061281 WO2014191560A1 (en) | 2013-05-31 | 2014-05-30 | Antibody composition and buffer system therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019163553A Division JP2020007343A (ja) | 2013-05-31 | 2019-09-09 | 抗体組成物及びそのための緩衝系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016530216A JP2016530216A (ja) | 2016-09-29 |
| JP2016530216A5 true JP2016530216A5 (enExample) | 2017-07-06 |
Family
ID=48805557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516187A Pending JP2016530216A (ja) | 2013-05-31 | 2014-05-30 | 抗体組成物及びそのための緩衝系 |
| JP2019163553A Pending JP2020007343A (ja) | 2013-05-31 | 2019-09-09 | 抗体組成物及びそのための緩衝系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019163553A Pending JP2020007343A (ja) | 2013-05-31 | 2019-09-09 | 抗体組成物及びそのための緩衝系 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11046753B2 (enExample) |
| EP (1) | EP3003385B1 (enExample) |
| JP (2) | JP2016530216A (enExample) |
| CN (1) | CN105592860B (enExample) |
| AU (1) | AU2014273034B2 (enExample) |
| DK (1) | DK3003385T3 (enExample) |
| ES (1) | ES2762501T3 (enExample) |
| GB (2) | GB2516808A (enExample) |
| WO (1) | WO2014191560A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS65120B1 (sr) * | 2015-11-25 | 2024-02-29 | Immunogen Inc | Farmaceutske formulacije i postupci za njihovu upotrebu |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| CN111896752A (zh) * | 2020-08-11 | 2020-11-06 | 上海捷门生物技术有限公司 | 一种适用于多种poct类仪器的c-反应蛋白试剂盒 |
| CN113671188A (zh) * | 2021-08-10 | 2021-11-19 | 江南大学 | 一种检测贝类食品中河豚毒素的时间分辨免疫定量试纸条 |
| EP4218562A1 (en) | 2022-01-28 | 2023-08-02 | Charité - Universitätsmedizin Berlin | Real-time breath antigen detection system and method thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0516873A1 (en) | 1991-06-06 | 1992-12-09 | THE STATE of ISRAEL Atomic Energy Commission Soreq Nuclear Research Center | A method and kit for protein labelling with 99 mTC |
| DK0988861T3 (da) * | 1998-08-17 | 2004-04-19 | Pfizer Prod Inc | Stabiliserede proteinpræparater |
| ES2407468T3 (es) * | 2005-04-18 | 2013-06-12 | Yeda Research And Development Company Limited | Formulaciones de anticuerpos anti-hepatitis B (HBV) estabilizadas |
| CA2618068C (en) | 2005-08-05 | 2016-02-16 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
| US8492129B2 (en) * | 2005-12-12 | 2013-07-23 | Innova Biosciences, Ltd. | Production of conjugates |
| JP5231810B2 (ja) * | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| EP2129401B8 (en) * | 2006-12-21 | 2020-01-15 | Amgen Inc. | Stable buffered formulations containing polypeptides |
| DK2318838T3 (da) | 2008-07-16 | 2013-10-14 | Radiometer Medical Aps | Fast fase med høj kapacitet |
| JP2011241206A (ja) | 2010-04-23 | 2011-12-01 | Arkray Inc | 標識抗体の安定化方法 |
| EP2583973B1 (en) | 2010-06-21 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Method for purifying protein using amino acid |
| US8877892B2 (en) * | 2011-03-15 | 2014-11-04 | Innova Biosciences Limited | Conjugation reactions |
| HRP20180028T4 (hr) | 2011-03-16 | 2020-10-02 | F. Hoffmann - La Roche Ag | Kromatografija izmjene iona s poboljšanom selektivnošću za odvajanje polipeptidnih monomera, agregata i fragmenata modulacijom pokretne faze |
| KR20120128440A (ko) | 2011-05-17 | 2012-11-27 | 삼성전자주식회사 | 표적 물질 검출용 키트 및 이를 이용한 표적 물질 검출 방법 |
-
2013
- 2013-05-31 GB GB1309759.7A patent/GB2516808A/en not_active Withdrawn
-
2014
- 2014-05-30 GB GB1522774.7A patent/GB2530217A/en not_active Withdrawn
- 2014-05-30 CN CN201480043061.4A patent/CN105592860B/zh active Active
- 2014-05-30 US US14/894,828 patent/US11046753B2/en active Active
- 2014-05-30 AU AU2014273034A patent/AU2014273034B2/en active Active
- 2014-05-30 EP EP14730479.4A patent/EP3003385B1/en active Active
- 2014-05-30 DK DK14730479.4T patent/DK3003385T3/da active
- 2014-05-30 JP JP2016516187A patent/JP2016530216A/ja active Pending
- 2014-05-30 ES ES14730479T patent/ES2762501T3/es active Active
- 2014-05-30 WO PCT/EP2014/061281 patent/WO2014191560A1/en not_active Ceased
-
2019
- 2019-09-09 JP JP2019163553A patent/JP2020007343A/ja active Pending
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