JP2016527311A - メチロールアルカンの改良された製造 - Google Patents
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- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
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- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4314—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/43195—Wires or coils
- B01F25/431951—Spirally-shaped baffle
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- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
- B01F25/431972—Mounted on an axial support member, e.g. a rod or bar
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00058—Temperature measurement
- B01J2219/0006—Temperature measurement of the heat exchange medium
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00094—Jackets
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00191—Control algorithm
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00222—Control algorithm taking actions
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00761—Details of the reactor
- B01J2219/00763—Baffles
- B01J2219/00765—Baffles attached to the reactor wall
- B01J2219/0077—Baffles attached to the reactor wall inclined
- B01J2219/00772—Baffles attached to the reactor wall inclined in a helix
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00761—Details of the reactor
- B01J2219/00763—Baffles
- B01J2219/00765—Baffles attached to the reactor wall
- B01J2219/00777—Baffles attached to the reactor wall horizontal
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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Abstract
Description
によって規定される。
ホルムアルデヒド水溶液濃度(ホルムアルデヒドの重量%):10%〜50%;
総ホルムアルデヒド/反応物質アルデヒドのモル比:3.01:1〜10:1;
総無機塩基/反応物質アルデヒドのモル比:1:1〜2:1、好ましくは1:1〜1.5:1。
DE−1154080は、一連の撹拌反応器を用いるアルカリ性縮合による三価及び多価アルコールの連続製造方法に関する。実施例1を参照。
Claims (15)
- (a)ホルムアルデヒドを含む流れを、複数の逐次反応段階を有する管状反応システムに供給し;
(b)C2以上の縮合性のアルデヒド及び場合によっては塩基を、ホルムアルデヒドを含む流れに加え、ここでC2以上の縮合性のアルデヒド又は塩基の少なくとも1つを複数の逐次供給点においてホルムアルデヒドを含む流れに加えて生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なるC2以上の縮合性のアルデヒド又は塩基を漸次供給し;そして
(c)C2以上の縮合性のアルデヒド及びホルムアルデヒドをメチロールアルカンに転化させる;
ことを含む、多段階プロセスでホルムアルデヒド及びC2以上の縮合性のアルデヒドからメチロールアルカンを製造する方法。 - C2以上の縮合性のアルデヒドを複数の逐次供給点においてホルムアルデヒドを含む流れに加えて生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なるC2以上の縮合性のアルデヒドを漸次供給する、請求項1に記載の方法。
- メチロールアルカンがトリメチロールプロパンであり、C2以上の縮合性のアルデヒドがn−ブチルアルデヒドである、請求項1に記載の方法。
- メチロールアルカンがネオペンチルグリコールであり、C2以上の縮合性のアルデヒドがイソブチルアルデヒドである、請求項1に記載の方法。
- 塩基を複数の逐次供給点においてホルムアルデヒドを含む流れに加えて生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なる塩基を漸次供給する、請求項1に記載の方法。
- 塩基が、水酸化カリウム、水酸化カルシウム、及び水酸化ナトリウムから選択される無機塩基である、請求項5に記載の方法。
- 管状反応システムが少なくとも3つの段階を有する、請求項1に記載の方法。
- C2以上の縮合性のアルデヒド及び無機塩基を複数の逐次供給点においてホルムアルデヒドを含む流れに加えて生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なるC2以上の縮合性のアルデヒド及び無機塩基を漸次供給することを含む、請求項1に記載の方法。
- 無機塩基が、水酸化カリウム、水酸化カルシウム、及び水酸化ナトリウムから選択される、請求項8に記載の方法。
- C2以上の縮合性のアルデヒドを複数の逐次供給点において無機塩基と一定割合で加えて生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なるC2以上の縮合性のアルデヒドを漸次供給する、請求項8に記載の方法。
- C2以上の縮合性のアルデヒド及び無機塩基を、上流の供給点において、下流の供給点において供給する量と比べてより多い量で供給する、請求項10に記載の方法。
- 無機塩基を、下流の供給点において、上流の供給点において供給する量と比べてより多い量で供給して生成流を与え、後期段階において、初期段階における無機塩基のレベルと比べてより高いレベルの無機塩基をこれに供給する、請求項8に記載の方法。
- 生成流の温度を30℃〜75℃の間に維持する、請求項1に記載の方法。
- (a)複数の反応管を含む複数の逐次反応器段階を有する管状反応システム;
(b)ホルムアルデヒドを含む流れを管状反応システムに供給するように構成されている反応システム入口;及び
(c)C2以上の縮合性のアルデヒド又は塩基の少なくとも1つを複数の逐次供給点においてホルムアルデヒドを含む流れに供給して生成流を与え、生成流を逐次反応段階を通して前進させながら、これに更なるC2以上の縮合性のアルデヒド又は塩基を漸次供給するように構成されている複数の供給口;
を含む、C2以上の縮合性のアルデヒドのメチロール誘導体を製造するための多段階管状反応システム。 - 反応システムが、C2以上の縮合性のアルデヒド及び塩基の両方を反応システムの逐次段階に供給して、生成流を逐次反応段階を通して前進させながら、生成流に更なるC2以上の縮合性のアルデヒド及び塩基を漸次供給するように構成されている、請求項14に記載のC2以上の縮合性のアルデヒドのメチロール誘導体を製造するための多段階管状反応システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361862574P | 2013-08-06 | 2013-08-06 | |
US61/862,574 | 2013-08-06 | ||
PCT/US2014/047738 WO2015020796A1 (en) | 2013-08-06 | 2014-07-23 | Improved manufacture of methylolalkanes |
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JP2019071149A Division JP6762395B2 (ja) | 2013-08-06 | 2019-04-03 | メチロールアルカンの改良された製造 |
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JP2016527311A true JP2016527311A (ja) | 2016-09-08 |
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JP2016533314A Pending JP2016527311A (ja) | 2013-08-06 | 2014-07-23 | メチロールアルカンの改良された製造 |
JP2019071149A Active JP6762395B2 (ja) | 2013-08-06 | 2019-04-03 | メチロールアルカンの改良された製造 |
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JP2019071149A Active JP6762395B2 (ja) | 2013-08-06 | 2019-04-03 | メチロールアルカンの改良された製造 |
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Country | Link |
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US (1) | US9394218B2 (ja) |
EP (1) | EP3030540B1 (ja) |
JP (2) | JP2016527311A (ja) |
KR (1) | KR102283433B1 (ja) |
CN (1) | CN105431402B (ja) |
ES (1) | ES2671557T3 (ja) |
WO (1) | WO2015020796A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019533725A (ja) * | 2016-10-25 | 2019-11-21 | オクセア・ゲゼルシャフト・ミト・べシュレンクテル・ハフツング | 無機塩基の存在下でポリオールを併産する方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3030541B1 (en) | 2013-08-06 | 2017-05-17 | Oxea Bishop LLC | Manufacture of methylolalkanes with augmented heat transfer and improved temperature control |
CN109485544B (zh) * | 2017-09-11 | 2021-12-14 | 中国科学院大连化学物理研究所 | 一种连续制备三羟甲基丙烷的方法 |
JP7343191B2 (ja) * | 2019-01-17 | 2023-09-12 | 日本分光株式会社 | 液体クロマトグラフィー用スタティックミキサー |
CN110878005B (zh) * | 2019-12-09 | 2022-05-03 | 赤峰瑞阳化工有限公司 | 一种三羟甲基丙烷和双三羟甲基丙烷连续缩合工艺 |
Citations (3)
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DE1154080B (de) * | 1959-06-04 | 1963-09-12 | Bayer Ag | Verfahren zur kontinuierlichen Herstellung von drei- und mehrwertigen Alkoholen durch alkalische Kondensation |
JPS6191144A (ja) * | 1984-10-08 | 1986-05-09 | Mitsubishi Gas Chem Co Inc | ネオペンチルグリコ−ルの製造法 |
JP2011132230A (ja) * | 2009-12-24 | 2011-07-07 | Oxea Bishop Llc | トリメチロールプロパンの色の向上法 |
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US3183274A (en) * | 1956-10-09 | 1965-05-11 | Celanese Corp | Trimethylolpropane |
US5603835A (en) | 1994-01-19 | 1997-02-18 | Hoechst Celanese Corporation | Trimethylolpropane color improvement |
DE19653093A1 (de) * | 1996-12-20 | 1998-06-25 | Basf Ag | Verfahren zur Herstellung von Polyalkoholen |
US5948943A (en) | 1997-10-16 | 1999-09-07 | Celanese International Corporation | Process improvement to produce low color trimethylolpropane |
DE10234016A1 (de) * | 2002-07-26 | 2004-02-05 | Basf Ag | Verfahren zur Ausbeuteerhöhung bei der Herstellung von mehrwertigen Alkoholen durch Spaltung acetalhaltiger Nebenprodukte |
KR100837523B1 (ko) | 2006-03-07 | 2008-06-12 | 주식회사 엘지화학 | 트리메틸올프로판의 제조방법 |
EP2281794B1 (de) * | 2009-08-07 | 2015-10-14 | LANXESS Deutschland GmbH | Verfahren zur Farbzahlverbesserung von Trimethylolpropan |
EP2457648A1 (en) * | 2010-11-29 | 2012-05-30 | Yellow Diesel B.V. | Production of fatty acid alkyl esters |
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2014
- 2014-07-23 JP JP2016533314A patent/JP2016527311A/ja active Pending
- 2014-07-23 CN CN201480042917.6A patent/CN105431402B/zh active Active
- 2014-07-23 US US14/903,619 patent/US9394218B2/en active Active
- 2014-07-23 EP EP14750854.3A patent/EP3030540B1/en active Active
- 2014-07-23 ES ES14750854.3T patent/ES2671557T3/es active Active
- 2014-07-23 WO PCT/US2014/047738 patent/WO2015020796A1/en active Application Filing
- 2014-07-23 KR KR1020167003226A patent/KR102283433B1/ko active IP Right Grant
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2019
- 2019-04-03 JP JP2019071149A patent/JP6762395B2/ja active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1154080B (de) * | 1959-06-04 | 1963-09-12 | Bayer Ag | Verfahren zur kontinuierlichen Herstellung von drei- und mehrwertigen Alkoholen durch alkalische Kondensation |
JPS6191144A (ja) * | 1984-10-08 | 1986-05-09 | Mitsubishi Gas Chem Co Inc | ネオペンチルグリコ−ルの製造法 |
JP2011132230A (ja) * | 2009-12-24 | 2011-07-07 | Oxea Bishop Llc | トリメチロールプロパンの色の向上法 |
Non-Patent Citations (1)
Title |
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化学工学便覧, vol. 改訂六版, JPN6018028808, 2001, pages 186 - 189 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019533725A (ja) * | 2016-10-25 | 2019-11-21 | オクセア・ゲゼルシャフト・ミト・べシュレンクテル・ハフツング | 無機塩基の存在下でポリオールを併産する方法 |
Also Published As
Publication number | Publication date |
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EP3030540A1 (en) | 2016-06-15 |
CN105431402B (zh) | 2018-01-02 |
KR102283433B1 (ko) | 2021-07-30 |
JP6762395B2 (ja) | 2020-09-30 |
KR20160040564A (ko) | 2016-04-14 |
CN105431402A (zh) | 2016-03-23 |
ES2671557T3 (es) | 2018-06-07 |
WO2015020796A1 (en) | 2015-02-12 |
EP3030540B1 (en) | 2018-04-11 |
JP2019142894A (ja) | 2019-08-29 |
US20160145179A1 (en) | 2016-05-26 |
US9394218B2 (en) | 2016-07-19 |
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