JP2016527306A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016527306A5 JP2016527306A5 JP2016532791A JP2016532791A JP2016527306A5 JP 2016527306 A5 JP2016527306 A5 JP 2016527306A5 JP 2016532791 A JP2016532791 A JP 2016532791A JP 2016532791 A JP2016532791 A JP 2016532791A JP 2016527306 A5 JP2016527306 A5 JP 2016527306A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- composition
- skin
- group
- fabac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 5
- 229930195729 fatty acid Natural products 0.000 claims 5
- 239000000194 fatty acid Substances 0.000 claims 5
- 230000032683 aging Effects 0.000 claims 4
- 239000000839 emulsion Substances 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 2
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
- 239000003613 bile acid Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 235000021357 Behenic acid Nutrition 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 206010051246 Photodermatosis Diseases 0.000 claims 1
- 206010040799 Skin atrophy Diseases 0.000 claims 1
- 206010040867 Skin hypertrophy Diseases 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 208000031439 Striae Distensae Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229940114079 arachidonic acid Drugs 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- 229940116226 behenic acid Drugs 0.000 claims 1
- 239000003858 bile acid conjugate Substances 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229960001091 chenodeoxycholic acid Drugs 0.000 claims 1
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000002845 discoloration Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 239000007908 nanoemulsion Substances 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 229960002969 oleic acid Drugs 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229940098695 palmitic acid Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 230000008845 photoaging Effects 0.000 claims 1
- 230000019612 pigmentation Effects 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000007665 sagging Methods 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims 1
- 229960001661 ursodiol Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL227890A IL227890A0 (en) | 2013-08-08 | 2013-08-08 | Antiaging compounds containing bile acid and fatty acid conjugates |
| IL227890 | 2013-08-08 | ||
| PCT/IL2014/050717 WO2015019358A1 (en) | 2013-08-08 | 2014-08-07 | Anti-aging compositions comprising bile acid-fatty acid conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016527306A JP2016527306A (ja) | 2016-09-08 |
| JP2016527306A5 true JP2016527306A5 (https=) | 2017-09-14 |
Family
ID=50022996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532791A Pending JP2016527306A (ja) | 2013-08-08 | 2014-08-07 | 胆汁酸−脂肪酸抱合体を含む抗老化組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160175223A1 (https=) |
| EP (1) | EP3030221A4 (https=) |
| JP (1) | JP2016527306A (https=) |
| CN (1) | CN105611910A (https=) |
| AU (1) | AU2014304078A1 (https=) |
| CA (1) | CA2920456A1 (https=) |
| HK (1) | HK1224198A1 (https=) |
| IL (2) | IL227890A0 (https=) |
| WO (1) | WO2015019358A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015019359A1 (en) * | 2013-08-08 | 2015-02-12 | Galderm Therapeutics Ltd. | Anti-acne compositions comprising bile acid-fatty acid conjugates |
| WO2016199137A1 (en) | 2015-06-10 | 2016-12-15 | Galmed Research And Development Ltd. | Low dose compositions of aramchol salts |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| WO2016127102A2 (en) | 2015-02-06 | 2016-08-11 | Ernesto Abel-Santos | Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| CN109503693B (zh) * | 2018-12-12 | 2021-04-06 | 合肥工业大学 | 一种利用胆酸为原料合成Aramchol的工艺 |
| JP2021100925A (ja) * | 2019-10-31 | 2021-07-08 | 共栄化学工業株式会社 | 皮膚外用剤 |
| WO2023287261A1 (ko) * | 2021-07-16 | 2023-01-19 | 주식회사 스카이테라퓨틱스 | 담즙산 또는 담즙산 염의 분자 회합체를 포함하는 화장료 조성물 |
| WO2023039159A2 (en) * | 2021-09-09 | 2023-03-16 | Abel Santos Ernesto | Inhibitors of c. difficile spore germination |
| WO2024012317A1 (zh) * | 2022-07-14 | 2024-01-18 | 爱医谷(苏州)生物科技有限公司 | 一种用于抵抗衰老的组合物及其用途或方法 |
| CN116236490A (zh) * | 2023-02-14 | 2023-06-09 | 四川大学 | 脱氧胆酸的用途及药物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115313A (en) * | 1974-10-08 | 1978-09-19 | Irving Lyon | Bile acid emulsions |
| IL142650A (en) * | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
| US6019992A (en) * | 1998-12-04 | 2000-02-01 | Chesebrough-Pond's Usa Co. | Cosmetic skin care compositions containing 4-chromanone |
| US8975246B2 (en) * | 2001-04-17 | 2015-03-10 | Galmed Research And Development Ltd. | Bile acid or bile salt fatty acid conjugates |
| US20060127468A1 (en) * | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| ES2296463B1 (es) * | 2005-07-13 | 2009-02-16 | Universidade De Santiago Compostela | Nuevos amidoderivados de acidos billares funcionalizados en la posicion 3 del anillo a. procedimientos para su obtencion y aplicaciones. |
| GB0722077D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
| CN101969915B (zh) * | 2008-03-11 | 2014-07-09 | 株式会社资生堂 | 皮肤美白方法以及皮肤斑形成抑制和/或除去因子的筛选方法 |
| US8937194B2 (en) * | 2008-12-31 | 2015-01-20 | Nitromega Corp. | Topical compositions containing nitro fatty acids |
| US20120157419A1 (en) * | 2009-02-02 | 2012-06-21 | Tuvia Gilat | Methods and compositions for treating alzheimer's disease |
| WO2015019359A1 (en) * | 2013-08-08 | 2015-02-12 | Galderm Therapeutics Ltd. | Anti-acne compositions comprising bile acid-fatty acid conjugates |
| HUE045209T2 (hu) * | 2013-12-04 | 2019-12-30 | Galmed Res & Development Ltd | Aramchol-sók |
-
2013
- 2013-08-08 IL IL227890A patent/IL227890A0/en unknown
-
2014
- 2014-08-07 CA CA2920456A patent/CA2920456A1/en not_active Abandoned
- 2014-08-07 CN CN201480055618.6A patent/CN105611910A/zh active Pending
- 2014-08-07 EP EP14834924.4A patent/EP3030221A4/en not_active Withdrawn
- 2014-08-07 US US14/910,477 patent/US20160175223A1/en not_active Abandoned
- 2014-08-07 AU AU2014304078A patent/AU2014304078A1/en not_active Abandoned
- 2014-08-07 JP JP2016532791A patent/JP2016527306A/ja active Pending
- 2014-08-07 HK HK16112516.2A patent/HK1224198A1/zh unknown
- 2014-08-07 WO PCT/IL2014/050717 patent/WO2015019358A1/en not_active Ceased
-
2016
- 2016-02-04 IL IL243964A patent/IL243964A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016527306A5 (https=) | ||
| JP2016527307A5 (https=) | ||
| MX2021008981A (es) | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar. | |
| HRP20201184T1 (hr) | Spojevi alkilamida i njihove uporabe | |
| WO2017132432A8 (en) | Benzimidazole derivatives as modulators of ror-gamma | |
| CO6640250A2 (es) | Formulación tópica que comprende (r)-3-ciclopentil-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo o una sal farmaceúticamente aceptable del mismo y una emulsión de aceite en agua | |
| CR20170563A (es) | Compuestos de benzoxacepina oxazolidinona y métodos de uso. | |
| AR067183A1 (es) | Composiciones terapeuticas y metodos, usos y equipos | |
| JP6412513B2 (ja) | 毛髪処理の方法 | |
| WO2009082819A8 (en) | Novel lupane derivatives | |
| WO2009082818A8 (en) | Novel c-21-keto lupane derivatives preparation and use thereof | |
| WO2018201167A3 (en) | Propionic acid derivatives and methods of use thereof | |
| JP2016540825A5 (https=) | ||
| HK1217495A1 (zh) | 治疗活性的作为17β-羟基类固醇脱氢酶抑制剂的17-氮取代雌三烯噻唑衍生物 | |
| EP3831839A3 (en) | C-3 and c-17 modified triterpenoids as hiv-1 inhibitors | |
| MA40149A1 (fr) | Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial | |
| ZA201908404B (en) | 15.beta.-[3-propanamido]-substituted estra-1,3,5(10)-trien-17-one compounds and their 17-oximes for use in inhibition of 17.beta.-hydroxysteroid dehydrogenases | |
| WO2014111570A3 (en) | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one specific amide compound | |
| WO2014111564A3 (en) | Cosmetic or dermatological composition comprising a merocyanine, an oily phase and a c1-c4 monoalkanol | |
| NO20075758L (no) | Polymorfer av 3-0-(3',3'-dimetylsuccinyl) betulin syre di-N-metyl-D-glukamin | |
| MX358169B (es) | Composicion cosmetica o dermatologica que comprende una merocianina y un agente de filtro ultravioleta (uv) de benzotriazol, lipofilo y/o un compuesto de bis-resorcinil-triazina . | |
| MX2020007062A (es) | Composiciones farmacéuticas para la piel tópicas que contienen cerdulatinib y usos de estas. | |
| RU2010106614A (ru) | Применение по меньшей мере одного производного оксима холест-4-ен-3-она в качестве антиоксиданта | |
| BR112014033088A2 (pt) | composição para prevenção ou tratamento de colite compreendendo s-alil-l-cisteína como ingrediente ativo, e preparação médica compreendendo a mesma | |
| WO2018101793A3 (ko) | 아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물 |