WO2018101793A3 - 아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물 - Google Patents
아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물 Download PDFInfo
- Publication number
- WO2018101793A3 WO2018101793A3 PCT/KR2017/014019 KR2017014019W WO2018101793A3 WO 2018101793 A3 WO2018101793 A3 WO 2018101793A3 KR 2017014019 W KR2017014019 W KR 2017014019W WO 2018101793 A3 WO2018101793 A3 WO 2018101793A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stereoisomer
- skin
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
Abstract
일 양상에 따른 아미드 유도체 화합물, 이의 입체이성질체, 유도체, 용매화물, 또는 이의 약학적으로 허용 가능한 염, 및 이의 용도를 제공한다. 이에 따르면, Sirt1의 발현을 증가시키는 효과가 우수하고, Sirt1의 활성화에 의한 피부 상처 치유 효과 및 피부 노화 억제 효과가 우수하므로, 피부 상처, 피부 노화 억제 또는 주름 개선용 약학 조성물로 유용하게 사용될 수 있다. 또한, 자외선 조사에 의해 유도된 피부 섬유아세포에서 MMP-1의 분비량 감소 및 프로콜라겐 타입 I의 분비량 증가, 및 Sirt1 분비량 및 활성 증가에 의해 항노화 또는 피부 주름을 개선하는데 유용하게 사용될 수 있다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20160162820 | 2016-12-01 | ||
KR10-2016-0162820 | 2016-12-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2018101793A2 WO2018101793A2 (ko) | 2018-06-07 |
WO2018101793A3 true WO2018101793A3 (ko) | 2018-07-19 |
WO2018101793A9 WO2018101793A9 (ko) | 2018-09-20 |
Family
ID=62242585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2017/014019 WO2018101793A2 (ko) | 2016-12-01 | 2017-12-01 | 아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101983788B1 (ko) |
WO (1) | WO2018101793A2 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220140124A (ko) | 2021-04-09 | 2022-10-18 | 전북대학교산학협력단 | 에피갈로카테킨 갈레이트를 포함하는 자외선에 의한 피부 손상 예방, 개선 또는 치료용 조성물 |
KR20220140125A (ko) | 2021-04-09 | 2022-10-18 | 전북대학교산학협력단 | 바이칼레인을 포함하는 자외선에 의한 피부 손상 예방 또는 개선용 조성물 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003049702A2 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ516873A (en) * | 2001-02-12 | 2003-11-28 | Warner Lambert Co | Compositions containing retinoids and erb inhibitors and their use in inhibiting retinoid skin damage |
WO2004014871A1 (en) * | 2002-08-08 | 2004-02-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
WO2008124000A2 (en) * | 2007-04-02 | 2008-10-16 | Ligand Pharmaceuticals Incorporated | Thiazole derivatives as androgen receptor modulator compounds |
EP2648735A4 (en) * | 2010-12-06 | 2014-07-30 | Univ British Columbia | GRANZYME B INHIBITOR COMPOSITIONS, METHODS AND USES FOR PROMOTING HEALING |
KR101612179B1 (ko) * | 2013-04-19 | 2016-04-12 | 영남대학교 산학협력단 | 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물 |
-
2017
- 2017-12-01 KR KR1020170164343A patent/KR101983788B1/ko active IP Right Grant
- 2017-12-01 WO PCT/KR2017/014019 patent/WO2018101793A2/ko active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003049702A2 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
Non-Patent Citations (9)
Title |
---|
DATABASE CAS [O] 1 April 2004 (2004-04-01), retrieved from STN Database accession no. 669701-60-4 * |
DATABASE CAS [O] 1 June 2016 (2016-06-01), retrieved from STN Database accession no. 1922572-11 -9 * |
DATABASE CAS [O] 1 October 2008 (2008-10-01), retrieved from STN Database accession no. 1056009-81-4 * |
DATABASE CAS [O] 11 June 2001 (2001-06-11), retrieved from STN Database accession no. 340258-25-5 * |
DATABASE CAS [O] 15 August 2006 (2006-08-15), retrieved from STN Database accession no. 901352-47-4 * |
DATABASE CAS [O] 2 July 2003 (2003-07-02), retrieved from STN Database accession no. 540795-31-1 * |
DATABASE CAS [O] 3 February 2009 (2009-02-03), retrieved from STN Database accession no. 1099967-41 -5 * |
DATABASE CAS [O] 3 June 2002 (2002-06-03), retrieved from STN Database accession no. 424809-05-2 * |
DATABASE CAS [O] 8 July 2003 (2003-07-08), retrieved from STN Database accession no. 544458-14-2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018101793A9 (ko) | 2018-09-20 |
KR20180062962A (ko) | 2018-06-11 |
KR101983788B1 (ko) | 2019-05-30 |
WO2018101793A2 (ko) | 2018-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2019004673A3 (ko) | 유산균 유래의 세포밖 베지클을 포함하는 항노화용 조성물 | |
ZA201701460B (en) | Gamma-diketones for treatment and prevention of aging skin and wrinkles | |
AR081790A1 (es) | Un metodo para mejorar el aspecto estetico de la piel, uso de tiliacora triandra en cosmeticos y composiciones, metodo para obtencion del extracto | |
BR112019007420A2 (pt) | composto, uso de um composto, composição cosmética ou farmacêutica, e, método cosmético não terapêutico de tratamento e/ou cuidado da pele, do cabelo, das unhas e/ou das membranas mucosas | |
WO2015031971A3 (en) | A composition comprising guacatonga extract and aroeira extract, use thereof for preventing and/or treating skin ageing | |
WO2017155232A3 (ko) | 발모 촉진 활성 및/또는 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도 | |
RU2016146372A (ru) | Комбинация гиалуроновой кислоты и сульфатированного полисахарида | |
WO2014111570A3 (en) | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one specific amide compound | |
WO2014043230A3 (en) | Formulations comprising idebenone, n-acetyl-s-farnesyl-l-cysteine and ergothioneine and uses thereof | |
WO2017164609A3 (ko) | 피부 재생 또는 상처 치료용 펩타이드 및 이의 용도 | |
IN2014DE01913A (ko) | ||
WO2016177908A3 (fr) | Procede de traitement des matieres keratiniques a partir de derives de c-glycosides amides, acides ou ester, et la composition cosmetique les contenant | |
WO2020046102A3 (es) | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular | |
WO2018101793A3 (ko) | 아미드 유도체 화합물, 이의 입체이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 피부 노화 억제, 주름 개선, 또는 피부 상처 치료용 약학적 또는 화장료 조성물 | |
MX2015009015A (es) | Composicion cosmetica o dermatologica que comprende una merocianina, un agente de filtro ultravioleta b (uvb) organico y un agente de filtro ultravioleta a (uva) organico adicional. | |
MX363850B (es) | Composicion cosmetica o dermatologica que comprende una merocianina, una fase aceitosa y un monoalcanol c1-c4. | |
RU2016148689A (ru) | Комбинация тетрапептида и эфира глицерина для лечения андрогенной алопеции | |
WO2014182610A3 (en) | Alpha adrenergic agonists for in the treatment of tissue trauma | |
WO2009106715A3 (fr) | Peptide derive d'une proteine de la famille des aquaporines | |
JP2015530376A5 (ko) | ||
WO2014111569A3 (en) | Anhydrous cosmetic or dermatological composition comprising a merocyanine and an oily phase | |
WO2019112238A3 (ko) | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피부 보습용 화장료 조성물 | |
SG11201909144VA (en) | Bacterial secretome for use in the treatment of skin lesions | |
WO2013087665A3 (en) | Composition comprising a carboxylated fructan for epidermis hydratation | |
EP3158989A3 (en) | Cosmetic skin treatment composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 17876308 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 17876308 Country of ref document: EP Kind code of ref document: A2 |