JP2016527213A - アビラテロン酢酸エステルの製造方法 - Google Patents

アビラテロン酢酸エステルの製造方法 Download PDF

Info

Publication number
JP2016527213A
JP2016527213A JP2016522965A JP2016522965A JP2016527213A JP 2016527213 A JP2016527213 A JP 2016527213A JP 2016522965 A JP2016522965 A JP 2016522965A JP 2016522965 A JP2016522965 A JP 2016522965A JP 2016527213 A JP2016527213 A JP 2016527213A
Authority
JP
Japan
Prior art keywords
dheaa
improvement
acetoxyandrosta
crude
yltrifluoromethanesulfonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016522965A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016527213A5 (enExample
Inventor
トヘンナトイ ラジャマンナル
トヘンナトイ ラジャマンナル
ブドフデブ レハニ ラジェエブ
ブドフデブ レハニ ラジェエブ
ビノドブハイ パテル ニスチャルクマル
ビノドブハイ パテル ニスチャルクマル
ラジェニカント カンサラ リテシュクマル
ラジェニカント カンサラ リテシュクマル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Ltd
Original Assignee
Sun Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd filed Critical Sun Pharmaceutical Industries Ltd
Publication of JP2016527213A publication Critical patent/JP2016527213A/ja
Publication of JP2016527213A5 publication Critical patent/JP2016527213A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2016522965A 2013-06-24 2014-06-24 アビラテロン酢酸エステルの製造方法 Pending JP2016527213A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2133/MUM/2013 2013-06-24
IN2133MU2013 IN2013MU02133A (enExample) 2013-06-24 2014-06-24
PCT/IN2014/000420 WO2014207762A1 (en) 2013-06-24 2014-06-24 Process for preparation of abiraterone acetate

Publications (2)

Publication Number Publication Date
JP2016527213A true JP2016527213A (ja) 2016-09-08
JP2016527213A5 JP2016527213A5 (enExample) 2017-08-24

Family

ID=52141189

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016522965A Pending JP2016527213A (ja) 2013-06-24 2014-06-24 アビラテロン酢酸エステルの製造方法

Country Status (5)

Country Link
US (1) US20160176915A1 (enExample)
EP (1) EP3013844A4 (enExample)
JP (1) JP2016527213A (enExample)
IN (1) IN2013MU02133A (enExample)
WO (1) WO2014207762A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108948120A (zh) * 2018-07-07 2018-12-07 张正光 一种醋酸阿比特龙中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505377A (ja) * 1992-03-31 1995-06-15 ブリテイツシユ・テクノロジー・グループ・リミテツド 癌治療に有用な１７位置換ステロイド
JP2008510781A (ja) * 2004-08-24 2008-04-10 ビーティージー・インターナショナル・リミテッド 中間体としての１７−ｏ−ビニル−トリフレートの調製のための方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms
WO2014071983A1 (en) * 2012-11-09 2014-05-15 Synthon Bv Process for making the 17-triflate intermediate of abiraterone-3-acetate
CA2890589A1 (en) * 2012-11-09 2014-05-15 Synthon Bv Process for making abiraterone-3-acetate
EP3027638B1 (en) * 2013-07-29 2017-12-27 Industriale Chimica S.R.L. Process for the preparation of abiraterone and abiraterone acetate
EP2890705B1 (en) * 2013-07-29 2016-04-13 Industriale Chimica S.R.L. Process for the preparation of abiraterone or abiraterone acetate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505377A (ja) * 1992-03-31 1995-06-15 ブリテイツシユ・テクノロジー・グループ・リミテツド 癌治療に有用な１７位置換ステロイド
JP2008510781A (ja) * 2004-08-24 2008-04-10 ビーティージー・インターナショナル・リミテッド 中間体としての１７−ｏ−ビニル−トリフレートの調製のための方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 13, JPN6018015004, 1995, pages 2463 - 2471, ISSN: 0003920869 *

Also Published As

Publication number Publication date
EP3013844A4 (en) 2017-03-01
WO2014207762A1 (en) 2014-12-31
IN2013MU02133A (enExample) 2015-06-05
US20160176915A1 (en) 2016-06-23
EP3013844A1 (en) 2016-05-04

Similar Documents

Publication Publication Date Title
US5532391A (en) Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US6046185A (en) 6,7-oxygenated steroids and uses related thereto
EP2766381B1 (en) Process for preparing 17-substituted steroids
JPS5854160B2 (ja) １α，３β−ジヒドロキシステロイド−５−エンまたはその誘導体の製造方法
EP0312867B1 (en) Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them
CN101652142A (zh) 盐皮质激素受体拮抗剂
TWI280133B (en) Process for preparing C-7 substituted steroids
US4310467A (en) Process and intermediates for the synthesis of vitamin D3 metabolites
ES2951323A2 (es) Proceso para preparar (3alfa,5alfa)-3-hidroxi-3-metil-pregnan-20-ona (ganaxolona)
KR20100131018A (ko) 에플레레논의 제조를 위한 신규 중간체
JPS6323895A (ja) 新規な６−もしくは７−メチレンアンドロスタ−１，４−ジエン−３，１７−ジオン誘導体およびその製造方法
FR2569408A1 (fr) Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
JP2015500857A (ja) １６−置換型−１７−ケトステロイド類のアルキニル化方法
JPS62158300A (ja) １０β−アルキニルエストレン誘導体およびそれらの製造法
AU582789B2 (en) Vitamin d derivatives and methods for preparing same
JP2016527213A (ja) アビラテロン酢酸エステルの製造方法
US5712263A (en) Steroid derivatives
KR870001937B1 (ko) 7위에 치환된 3-케토 △₄또는 △₁,₄스테로이드 유도체의 제조방법
JP4015206B2 (ja) メドロゲストンの製造
JP3300359B2 (ja) １７−ハロゲノ−４−アザアンドロステン誘導体およびその製造方法
US2895970A (en) Bisnorallo-7-cholenaldehydes
EP1070082B1 (de) Verfahren zur herstellung von 4,4-dimethyl-5 alpha-cholesta-8,14,24-trien-3 beta-ol und zwischenprodukte im verfahren (i)
TWI570131B (zh) 製備１７－經取代類固醇之方法
JP3228486B2 (ja) ヒドロキシケトン誘導体およびその製造方法
EP2215104B1 (de) 11.beta.-fluoro-3-acetoxyestra-3,5-dien-17-on und verfahren zu seiner herstellung

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170622

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170714

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180501

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20181120