JP2016527213A5 - - Google Patents
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- Publication number
- JP2016527213A5 JP2016527213A5 JP2016522965A JP2016522965A JP2016527213A5 JP 2016527213 A5 JP2016527213 A5 JP 2016527213A5 JP 2016522965 A JP2016522965 A JP 2016522965A JP 2016522965 A JP2016522965 A JP 2016522965A JP 2016527213 A5 JP2016527213 A5 JP 2016527213A5
- Authority
- JP
- Japan
- Prior art keywords
- dheaa
- acetoxyandrosta
- dien
- crude
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 14
- NCMZQTLCXHGLOK-ZKHIMWLXSA-N prasterone acetate Chemical compound C([C@@H]12)C[C@]3(C)C(=O)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)C)C1 NCMZQTLCXHGLOK-ZKHIMWLXSA-N 0.000 claims 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical group CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 claims 4
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004103 abiraterone acetate Drugs 0.000 claims 2
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 150000002576 ketones Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 241000876466 Varanus bengalensis Species 0.000 claims 1
- MCIVSCZCJRGEJR-ZKHIMWLXSA-N [(3s,8r,9s,10r,13s,14s)-10,13-dimethyl-17-(trifluoromethylsulfonyloxy)-2,3,4,7,8,9,11,12,14,15-decahydro-1h-cyclopenta[a]phenanthren-3-yl] acetate Chemical compound C([C@@H]12)C[C@]3(C)C(OS(=O)(=O)C(F)(F)F)=CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)C)C1 MCIVSCZCJRGEJR-ZKHIMWLXSA-N 0.000 claims 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
- 238000011097 chromatography purification Methods 0.000 claims 1
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2133/MUM/2013 | 2013-06-24 | ||
| PCT/IN2014/000420 WO2014207762A1 (en) | 2013-06-24 | 2014-06-24 | Process for preparation of abiraterone acetate |
| IN2133MU2013 IN2013MU02133A (enExample) | 2013-06-24 | 2014-06-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016527213A JP2016527213A (ja) | 2016-09-08 |
| JP2016527213A5 true JP2016527213A5 (enExample) | 2017-08-24 |
Family
ID=52141189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522965A Pending JP2016527213A (ja) | 2013-06-24 | 2014-06-24 | アビラテロン酢酸エステルの製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160176915A1 (enExample) |
| EP (1) | EP3013844A4 (enExample) |
| JP (1) | JP2016527213A (enExample) |
| IN (1) | IN2013MU02133A (enExample) |
| WO (1) | WO2014207762A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108948120A (zh) * | 2018-07-07 | 2018-12-07 | 张正光 | 一种醋酸阿比特龙中间体的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69327096T2 (de) * | 1992-03-31 | 2000-06-21 | Btg International Ltd., London | 17-substituierte steroide, verwendbar bei behandlung von krebs |
| JP5199667B2 (ja) * | 2004-08-24 | 2013-05-15 | ビーティージー・インターナショナル・リミテッド | 中間体としての１７−ｏ−ビニル−トリフレートの調製のための方法 |
| GB0418900D0 (en) * | 2004-08-24 | 2004-09-29 | Btg Int Ltd | Novel salt forms |
| WO2014071983A1 (en) * | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making the 17-triflate intermediate of abiraterone-3-acetate |
| CA2890589A1 (en) * | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making abiraterone-3-acetate |
| US9650410B2 (en) * | 2013-07-29 | 2017-05-16 | Industriale Chimica S.R.L. | Process for the preparation of abiraterone and abiraterone acetate |
| WO2015014686A1 (en) * | 2013-07-29 | 2015-02-05 | Industriale Chimica S.R.L. | Process for the preparation of abiraterone or abiraterone acetate |
-
2014
- 2014-06-24 EP EP14816900.6A patent/EP3013844A4/en not_active Withdrawn
- 2014-06-24 WO PCT/IN2014/000420 patent/WO2014207762A1/en not_active Ceased
- 2014-06-24 JP JP2016522965A patent/JP2016527213A/ja active Pending
- 2014-06-24 US US14/392,210 patent/US20160176915A1/en not_active Abandoned
- 2014-06-24 IN IN2133MU2013 patent/IN2013MU02133A/en unknown
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