JP2016526564A5 - - Google Patents
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- JP2016526564A5 JP2016526564A5 JP2016524767A JP2016524767A JP2016526564A5 JP 2016526564 A5 JP2016526564 A5 JP 2016526564A5 JP 2016524767 A JP2016524767 A JP 2016524767A JP 2016524767 A JP2016524767 A JP 2016524767A JP 2016526564 A5 JP2016526564 A5 JP 2016526564A5
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- Prior art keywords
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- Prior art date
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- 239000012634 fragment Substances 0.000 claims 30
- -1 monosaccharide disulfide Chemical class 0.000 claims 27
- 125000006239 protecting group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 18
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 17
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 15
- 238000006243 chemical reaction Methods 0.000 claims 13
- 150000001720 carbohydrates Chemical class 0.000 claims 11
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 239000003638 chemical reducing agent Substances 0.000 claims 8
- 238000003786 synthesis reaction Methods 0.000 claims 8
- 229940125782 compound 2 Drugs 0.000 claims 7
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 6
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 6
- 238000003776 cleavage reaction Methods 0.000 claims 6
- 150000002016 disaccharides Chemical class 0.000 claims 6
- 230000007017 scission Effects 0.000 claims 6
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 claims 5
- 229940126214 compound 3 Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 4
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 4
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- LJOOWESTVASNOG-UFJKPHDISA-N [(1s,3r,4ar,7s,8s,8as)-3-hydroxy-8-[2-[(4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2s)-2-methylbutanoate Chemical compound C([C@H]1[C@@H](C)C=C[C@H]2C[C@@H](O)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)CC1C[C@@H](O)CC(=O)O1 LJOOWESTVASNOG-UFJKPHDISA-N 0.000 claims 4
- XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 claims 4
- KGNDCEVUMONOKF-UGPLYTSKSA-N benzyl n-[(2r)-1-[(2s,4r)-2-[[(2s)-6-amino-1-(1,3-benzoxazol-2-yl)-1,1-dihydroxyhexan-2-yl]carbamoyl]-4-[(4-methylphenyl)methoxy]pyrrolidin-1-yl]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1CO[C@H]1CN(C(=O)[C@@H](CCC=2C=CC=CC=2)NC(=O)OCC=2C=CC=CC=2)[C@H](C(=O)N[C@@H](CCCCN)C(O)(O)C=2OC3=CC=CC=C3N=2)C1 KGNDCEVUMONOKF-UGPLYTSKSA-N 0.000 claims 4
- 229940125797 compound 12 Drugs 0.000 claims 4
- 229940126142 compound 16 Drugs 0.000 claims 4
- 229940125810 compound 20 Drugs 0.000 claims 4
- 229940125833 compound 23 Drugs 0.000 claims 4
- 229940125961 compound 24 Drugs 0.000 claims 4
- 229940127204 compound 29 Drugs 0.000 claims 4
- 238000010511 deprotection reaction Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 claims 4
- 150000002772 monosaccharides Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- ABJSOROVZZKJGI-OCYUSGCXSA-N (1r,2r,4r)-2-(4-bromophenyl)-n-[(4-chlorophenyl)-(2-fluoropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide Chemical compound C1=NC(F)=CC(C(NC(=O)[C@H]2[C@@H](C[C@@H](CC2)N2CCOCC2)C=2C=CC(Br)=CC=2)C=2C=CC(Cl)=CC=2)=C1 ABJSOROVZZKJGI-OCYUSGCXSA-N 0.000 claims 3
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 3
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 3
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims 3
- TVTJUIAKQFIXCE-HUKYDQBMSA-N 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynyl-1H-purine-6,8-dione Chemical compound NC=1NC(C=2N(C(N(C=2N=1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)=O)CC#C)=O TVTJUIAKQFIXCE-HUKYDQBMSA-N 0.000 claims 3
- NPRYCHLHHVWLQZ-TURQNECASA-N 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynylpurin-8-one Chemical compound NC1=NC=C2N(C(N(C2=N1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)=O)CC#C NPRYCHLHHVWLQZ-TURQNECASA-N 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 3
- 229940126543 compound 14 Drugs 0.000 claims 3
- 229940125758 compound 15 Drugs 0.000 claims 3
- 229940125851 compound 27 Drugs 0.000 claims 3
- 239000000543 intermediate Substances 0.000 claims 3
- 239000003880 polar aprotic solvent Substances 0.000 claims 3
- 150000004043 trisaccharides Chemical class 0.000 claims 3
- STBLNCCBQMHSRC-BATDWUPUSA-N (2s)-n-[(3s,4s)-5-acetyl-7-cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)N(C(C)=O)C2=CC(C#N)=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 STBLNCCBQMHSRC-BATDWUPUSA-N 0.000 claims 2
- KQZLRWGGWXJPOS-NLFPWZOASA-N 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile Chemical compound ClC1=C(C=CC(=C1)Cl)[C@@H](C)N1N=C(C=2C1=NC(=CN=2)C1=CC[C@@H]([C@@H](C1)C)N1[C@@H](CCC1)CO)C#N KQZLRWGGWXJPOS-NLFPWZOASA-N 0.000 claims 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 229940126639 Compound 33 Drugs 0.000 claims 2
- UDCDOJQOXWCCSD-UHFFFAOYSA-N N,N-dimethyl-N'-p-tolylsulfamide Chemical compound CN(C)S(=O)(=O)NC1=CC=C(C)C=C1 UDCDOJQOXWCCSD-UHFFFAOYSA-N 0.000 claims 2
- 229930182473 O-glycoside Natural products 0.000 claims 2
- PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229940125877 compound 31 Drugs 0.000 claims 2
- 229940125878 compound 36 Drugs 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 239000012454 non-polar solvent Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 239000003586 protic polar solvent Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical compound C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- SMNRFWMNPDABKZ-WVALLCKVSA-N [[(2R,3S,4R,5S)-5-(2,6-dioxo-3H-pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)C2C=CC(=O)NC2=O)[C@H](O)[C@@H](F)[C@@H]1O SMNRFWMNPDABKZ-WVALLCKVSA-N 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 201000005547 chronic conjunctivitis Diseases 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 229940125807 compound 37 Drugs 0.000 claims 1
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 238000010324 immunological assay Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 0 CC(*1)OC(C)[C@](*)C1OC Chemical compound CC(*1)OC(C)[C@](*)C1OC 0.000 description 5
- ADUUKKFZJMALKO-BQHSNLCNSA-N CC(C(C([C@H]1O)OC)O)OC1C(O)=O Chemical compound CC(C(C([C@H]1O)OC)O)OC1C(O)=O ADUUKKFZJMALKO-BQHSNLCNSA-N 0.000 description 1
- IOSZEGRLKFATDL-VHJXUHCKSA-N CC(C(C([C@H]1OC)[O-])O)OC1C(O)=O Chemical compound CC(C(C([C@H]1OC)[O-])O)OC1C(O)=O IOSZEGRLKFATDL-VHJXUHCKSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13175447 | 2013-07-07 | ||
| EP13175447.5 | 2013-07-07 | ||
| EP13183826.0A EP2845860A1 (en) | 2013-09-10 | 2013-09-10 | Synthetic vaccines against Streptococcus pneumoniae |
| EP13183826.0 | 2013-09-10 | ||
| EP13196568.3 | 2013-12-10 | ||
| EP13196568 | 2013-12-10 | ||
| PCT/EP2014/064407 WO2015004041A1 (en) | 2013-07-07 | 2014-07-07 | Synthetic vaccines against streptococcus pneumoniae type 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526564A JP2016526564A (ja) | 2016-09-05 |
| JP2016526564A5 true JP2016526564A5 (OSRAM) | 2018-04-26 |
| JP6416249B2 JP6416249B2 (ja) | 2018-10-31 |
Family
ID=51257468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524767A Active JP6416249B2 (ja) | 2013-07-07 | 2014-07-07 | ストレプトコッカス ニューモニエ１型に対する合成ワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10328141B2 (OSRAM) |
| EP (1) | EP3019513B1 (OSRAM) |
| JP (1) | JP6416249B2 (OSRAM) |
| KR (1) | KR102250099B1 (OSRAM) |
| CN (1) | CN105492454B (OSRAM) |
| AU (1) | AU2014289342B2 (OSRAM) |
| BR (1) | BR112016000210A2 (OSRAM) |
| CA (1) | CA2917365A1 (OSRAM) |
| HK (1) | HK1224300A1 (OSRAM) |
| IL (1) | IL243452B (OSRAM) |
| MX (1) | MX2016000099A (OSRAM) |
| RU (1) | RU2016103771A (OSRAM) |
| SG (1) | SG11201600042YA (OSRAM) |
| WO (1) | WO2015004041A1 (OSRAM) |
| ZA (1) | ZA201600136B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US10188718B2 (en) * | 2014-12-12 | 2019-01-29 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccines against Streptococcus pneumoniae serotype 4 |
| EP3292131B1 (en) * | 2016-04-14 | 2019-05-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Improved preparation of vaccines against streptococcus pneumoniae type 3 |
| WO2019018253A1 (en) | 2017-07-17 | 2019-01-24 | 3M Innovative Properties Company | BEND LIMIT FILM |
| EP3894431A2 (en) | 2018-12-12 | 2021-10-20 | GlaxoSmithKline Biologicals SA | Modified carrier proteins for o-linked glycosylation |
| PE20251701A1 (es) | 2022-11-22 | 2025-07-02 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos |
| WO2025057078A1 (en) | 2023-09-14 | 2025-03-20 | Pfizer Inc. | Adjuvanted immunogenic compositions comprising conjugated pneumococcal capsular saccharide antigens and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| KR100898845B1 (ko) * | 2000-06-29 | 2009-05-21 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 다가 백신 조성물 |
| CA2545276C (en) * | 2003-11-05 | 2016-05-31 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer |
| US8062641B2 (en) * | 2005-05-06 | 2011-11-22 | Novartis Ag | Immunogens for meningitidis-A vaccines |
| WO2011133227A2 (en) * | 2010-04-23 | 2011-10-27 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for staphyloccocus vaccine |
| WO2011137181A1 (en) * | 2010-04-27 | 2011-11-03 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for moraxella vaccine |
-
2014
- 2014-07-07 KR KR1020167003282A patent/KR102250099B1/ko active Active
- 2014-07-07 US US14/903,118 patent/US10328141B2/en active Active
- 2014-07-07 MX MX2016000099A patent/MX2016000099A/es unknown
- 2014-07-07 SG SG11201600042YA patent/SG11201600042YA/en unknown
- 2014-07-07 RU RU2016103771A patent/RU2016103771A/ru not_active Application Discontinuation
- 2014-07-07 JP JP2016524767A patent/JP6416249B2/ja active Active
- 2014-07-07 CN CN201480046993.4A patent/CN105492454B/zh active Active
- 2014-07-07 BR BR112016000210A patent/BR112016000210A2/pt not_active Application Discontinuation
- 2014-07-07 HK HK16112653.5A patent/HK1224300A1/zh unknown
- 2014-07-07 AU AU2014289342A patent/AU2014289342B2/en active Active
- 2014-07-07 EP EP14744787.4A patent/EP3019513B1/en active Active
- 2014-07-07 CA CA2917365A patent/CA2917365A1/en not_active Abandoned
- 2014-07-07 WO PCT/EP2014/064407 patent/WO2015004041A1/en not_active Ceased
-
2016
- 2016-01-03 IL IL243452A patent/IL243452B/en active IP Right Grant
- 2016-01-07 ZA ZA2016/00136A patent/ZA201600136B/en unknown
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