JP2016525545A5 - - Google Patents

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Publication number
JP2016525545A5
JP2016525545A5 JP2016529759A JP2016529759A JP2016525545A5 JP 2016525545 A5 JP2016525545 A5 JP 2016525545A5 JP 2016529759 A JP2016529759 A JP 2016529759A JP 2016529759 A JP2016529759 A JP 2016529759A JP 2016525545 A5 JP2016525545 A5 JP 2016525545A5
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JP
Japan
Prior art keywords
fusion antibody
acid sequence
amino acid
seq
heavy chain
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JP2016529759A
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English (en)
Japanese (ja)
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JP6692293B2 (ja
JP2016525545A (ja
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Priority claimed from PCT/US2014/038660 external-priority patent/WO2015012944A1/en
Publication of JP2016525545A publication Critical patent/JP2016525545A/ja
Publication of JP2016525545A5 publication Critical patent/JP2016525545A5/ja
Priority to JP2020072208A priority Critical patent/JP6914392B2/ja
Application granted granted Critical
Publication of JP6692293B2 publication Critical patent/JP6692293B2/ja
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JP2016529759A 2013-07-22 2014-05-19 Ｃｎｓにおける酵素活性を増大するための方法および組成物 Active JP6692293B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020072208A JP6914392B2 (ja) 2013-07-22 2020-04-14 Ｃｎｓにおける酵素活性を増大するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361857140P 2013-07-22 2013-07-22
US61/857,140 2013-07-22
PCT/US2014/038660 WO2015012944A1 (en) 2013-07-22 2014-05-19 Methods and compositions for increasing enzyme activity in the cns

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020072208A Division JP6914392B2 (ja) 2013-07-22 2020-04-14 Ｃｎｓにおける酵素活性を増大するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2016525545A JP2016525545A (ja) 2016-08-25
JP2016525545A5 true JP2016525545A5 (https=) 2017-06-29
JP6692293B2 JP6692293B2 (ja) 2020-05-13

Family

ID=51023055

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016529759A Active JP6692293B2 (ja) 2013-07-22 2014-05-19 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2020072208A Active JP6914392B2 (ja) 2013-07-22 2020-04-14 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2021115534A Pending JP2021180658A (ja) 2013-07-22 2021-07-13 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2023153971A Pending JP2024012225A (ja) 2013-07-22 2023-09-20 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2024230169A Pending JP2025041923A (ja) 2013-07-22 2024-12-26 Ｃｎｓにおける酵素活性を増大するための方法および組成物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2020072208A Active JP6914392B2 (ja) 2013-07-22 2020-04-14 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2021115534A Pending JP2021180658A (ja) 2013-07-22 2021-07-13 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2023153971A Pending JP2024012225A (ja) 2013-07-22 2023-09-20 Ｃｎｓにおける酵素活性を増大するための方法および組成物
JP2024230169A Pending JP2025041923A (ja) 2013-07-22 2024-12-26 Ｃｎｓにおける酵素活性を増大するための方法および組成物

Country Status (6)

Country Link
US (3) US20150023956A1 (https=)
EP (2) EP3730516A1 (https=)
JP (5) JP6692293B2 (https=)
AU (2) AU2014293626A1 (https=)
CA (1) CA2918579C (https=)
WO (1) WO2015012944A1 (https=)

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US8759297B2 (en) 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
AU2008282496B2 (en) 2007-07-27 2013-04-04 Armagen Technologies, Inc. Methods and compositions for increasing alpha-iduronidase activity in the CNS
CA2748889A1 (en) 2009-03-18 2010-09-23 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins
EP2485761B1 (en) 2009-10-09 2019-02-27 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
AU2012346448B2 (en) 2011-12-02 2017-09-14 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US10538589B2 (en) * 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
JP2019515677A (ja) 2016-04-26 2019-06-13 アール．ピー．シェーラー テクノロジーズ エルエルシー 抗体複合体ならびにそれを作製および使用する方法
CR20200129A (es) 2017-10-02 2020-08-22 Denali Therapeutics Inc Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas
AU2019317460A1 (en) * 2018-08-07 2021-03-18 Armagen, Inc. Methods and compositions for increasing the activity in the CNS of hexosaminidase a, acid sphingomyelinase, and palmitoyl-protein thioesterase 1
EP4229192A1 (en) 2020-10-14 2023-08-23 Denali Therapeutics Inc. Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
CN119497630A (zh) * 2022-05-04 2025-02-21 免疫新炉有限公司 包含glp-1、免疫球蛋白fc和igf-1的融合蛋白及其用途
WO2023240220A1 (en) * 2022-06-09 2023-12-14 The University Of North Carolina At Chapel Hill Aav-sgsh vectors for treatment of mucopolysaccharidosis iiia

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US5182107A (en) * 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
TW279133B (https=) 1990-12-13 1996-06-21 Elan Med Tech
US6060069A (en) 1991-05-20 2000-05-09 Dura Pharmaceuticals, Inc. Pulmonary delivery of pharmaceuticals
US6195608B1 (en) 1993-05-28 2001-02-27 Lucent Technologies Inc. Acoustic highway monitor
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5656284A (en) 1995-04-24 1997-08-12 Balkin; Michael S. Oral transmucosal delivery tablet and method of making it
CN1137680C (zh) 1995-09-19 2004-02-11 藤泽药品工业株式会社 气雾剂组合物
WO1998054213A2 (en) * 1997-05-30 1998-12-03 Amgen Inc. Neurotrophic factor receptors
US6016800A (en) 1997-10-24 2000-01-25 Century; Theodore J. Intrapulmonary aerosolizer
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6284262B1 (en) 1999-01-26 2001-09-04 Virgil A. Place Compact dosage unit for buccal administration of a pharmacologically active agent
US20050142141A1 (en) * 2002-11-27 2005-06-30 Pardridge William M. Delivery of enzymes to the brain
US7388079B2 (en) 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
CA2515708A1 (en) * 2003-02-11 2004-08-26 Transkaryotic Therapies, Inc. Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies
AU2003286870A1 (en) * 2003-06-05 2005-01-04 Salk Institute For Biological Studies Targeting polypeptides to the central nervous system
EP2485761B1 (en) * 2009-10-09 2019-02-27 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
JP6073783B2 (ja) * 2010-06-25 2017-02-01 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ヘパランｎ−スルファターゼのｃｎｓ送達のための方法および組成物
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AU2012346448B2 (en) * 2011-12-02 2017-09-14 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
EP2854834A4 (en) * 2012-05-30 2016-05-18 Biostrategies LC PLANT LENSES AS CARRIER CORRESPONDING AGENTS IN ANIMAL AND HUMAN CELLS

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