JP2016525143A5 - - Google Patents
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- Publication number
- JP2016525143A5 JP2016525143A5 JP2016528592A JP2016528592A JP2016525143A5 JP 2016525143 A5 JP2016525143 A5 JP 2016525143A5 JP 2016528592 A JP2016528592 A JP 2016528592A JP 2016528592 A JP2016528592 A JP 2016528592A JP 2016525143 A5 JP2016525143 A5 JP 2016525143A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- compartment
- polyoxyethylene
- nanoparticle
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 fatty acid ester Chemical class 0.000 claims description 34
- 239000002105 nanoparticle Substances 0.000 claims description 28
- 150000002632 lipids Chemical class 0.000 claims description 25
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 19
- 239000000194 fatty acid Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 150000003904 phospholipids Chemical class 0.000 claims description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 claims description 6
- 150000005215 alkyl ethers Chemical class 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 150000005690 diesters Chemical class 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 2
- 239000001194 polyoxyethylene (40) stearate Substances 0.000 claims description 2
- 235000011185 polyoxyethylene (40) stearate Nutrition 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 229920002675 Polyoxyl Polymers 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 8
- 239000012530 fluid Substances 0.000 description 6
- 229960003511 macrogol Drugs 0.000 description 5
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 4
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 229960001285 quercetin Drugs 0.000 description 4
- 235000005875 quercetin Nutrition 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- VIBDJEWPNNCFQO-UHFFFAOYSA-N ethane-1,1,2-triol Chemical group OCC(O)O VIBDJEWPNNCFQO-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000047703 Nonion Species 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000000604 cryogenic transmission electron microscopy Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1357363 | 2013-07-25 | ||
| FR1357363A FR3008900B1 (fr) | 2013-07-25 | 2013-07-25 | Nanoparticules lipidiques multicompartimentees |
| PCT/FR2014/051922 WO2015011419A1 (fr) | 2013-07-25 | 2014-07-24 | Nanoparticules lipidiques multicompartimentées |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525143A JP2016525143A (ja) | 2016-08-22 |
| JP2016525143A5 true JP2016525143A5 (enExample) | 2017-08-10 |
| JP6489556B2 JP6489556B2 (ja) | 2019-03-27 |
Family
ID=49378477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528592A Active JP6489556B2 (ja) | 2013-07-25 | 2014-07-24 | マルチコンパートメント脂質ナノ粒子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9757337B2 (enExample) |
| EP (1) | EP3024566B1 (enExample) |
| JP (1) | JP6489556B2 (enExample) |
| CN (1) | CN105408015B (enExample) |
| CA (1) | CA2914551C (enExample) |
| FR (1) | FR3008900B1 (enExample) |
| WO (1) | WO2015011419A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017183635A (ja) * | 2016-03-31 | 2017-10-05 | ソニー株式会社 | 半導体装置、半導体装置の製造方法、集積基板、及び、電子機器 |
| WO2020223813A1 (en) * | 2019-05-07 | 2020-11-12 | University Health Network | Nanoemulsion with porphyrin shell |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06183953A (ja) * | 1991-06-24 | 1994-07-05 | Nippon Oil & Fats Co Ltd | 混合脂質膜小胞 |
| US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5853755A (en) * | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| WO1995013796A1 (en) * | 1993-11-16 | 1995-05-26 | Depotech Corporation | Vesicles with controlled release of actives |
| US5993850A (en) * | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| ATE514676T1 (de) * | 1999-11-24 | 2011-07-15 | Sugen Inc | Ionisierbare indolinon derivate und deren verwendung als ptk liganden |
| FR2805761B1 (fr) | 2000-03-02 | 2002-08-30 | Mainelab | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
| FR2857263B1 (fr) * | 2003-07-09 | 2005-09-09 | Sanofi Synthelabo | Nouvelle composition pharmaceutique solide comprenant de l'amisulpride |
| ES2617063T3 (es) * | 2007-03-30 | 2017-06-15 | Xisle Pharma Ventures Trust | Composición de vesículas lipídicas bifásicas y método para tratar la displasia de cuello uterino por suministro intravaginal |
| EP2172263A4 (en) * | 2007-07-02 | 2015-08-05 | Nisshin Oillio Group Ltd | E / H / E EMULSION COMPOSITION |
| EP2039352A1 (en) * | 2007-09-18 | 2009-03-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules |
| CN100558459C (zh) * | 2007-12-14 | 2009-11-11 | 天津理工大学 | 以脂质体作为微聚合器制备聚合物微球 |
| CN101366697A (zh) * | 2008-08-14 | 2009-02-18 | 沈阳万爱普利德医药科技有限公司 | 一种新的包含紫杉醇类物质的注射用纳米脂质载体及其制备方法 |
-
2013
- 2013-07-25 FR FR1357363A patent/FR3008900B1/fr not_active Expired - Fee Related
-
2014
- 2014-07-24 CN CN201480041825.6A patent/CN105408015B/zh active Active
- 2014-07-24 US US14/907,249 patent/US9757337B2/en active Active
- 2014-07-24 WO PCT/FR2014/051922 patent/WO2015011419A1/fr not_active Ceased
- 2014-07-24 CA CA2914551A patent/CA2914551C/fr active Active
- 2014-07-24 JP JP2016528592A patent/JP6489556B2/ja active Active
- 2014-07-24 EP EP14750579.6A patent/EP3024566B1/fr active Active
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