JP2016524915A5 - - Google Patents

Download PDF

Info

Publication number
JP2016524915A5
JP2016524915A5 JP2016527046A JP2016527046A JP2016524915A5 JP 2016524915 A5 JP2016524915 A5 JP 2016524915A5 JP 2016527046 A JP2016527046 A JP 2016527046A JP 2016527046 A JP2016527046 A JP 2016527046A JP 2016524915 A5 JP2016524915 A5 JP 2016524915A5
Authority
JP
Japan
Prior art keywords
virus
codon optimized
wild type
optimized
gene segments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2016527046A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016524915A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/046731 external-priority patent/WO2015009743A1/en
Publication of JP2016524915A publication Critical patent/JP2016524915A/ja
Publication of JP2016524915A5 publication Critical patent/JP2016524915A5/ja
Priority to JP2019171818A priority Critical patent/JP7627544B2/ja
Withdrawn legal-status Critical Current

Links

Images

JP2016527046A 2013-07-15 2014-07-15 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス Withdrawn JP2016524915A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019171818A JP7627544B2 (ja) 2013-07-15 2019-09-20 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846460P 2013-07-15 2013-07-15
US61/846,460 2013-07-15
PCT/US2014/046731 WO2015009743A1 (en) 2013-07-15 2014-07-15 High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019171818A Division JP7627544B2 (ja) 2013-07-15 2019-09-20 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Publications (2)

Publication Number Publication Date
JP2016524915A JP2016524915A (ja) 2016-08-22
JP2016524915A5 true JP2016524915A5 (enExample) 2017-03-30

Family

ID=51257635

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016527046A Withdrawn JP2016524915A (ja) 2013-07-15 2014-07-15 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2019171818A Active JP7627544B2 (ja) 2013-07-15 2019-09-20 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2022016436A Active JP7691380B2 (ja) 2013-07-15 2022-02-04 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2024050083A Pending JP2024091645A (ja) 2013-07-15 2024-03-26 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019171818A Active JP7627544B2 (ja) 2013-07-15 2019-09-20 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2022016436A Active JP7691380B2 (ja) 2013-07-15 2022-02-04 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2024050083A Pending JP2024091645A (ja) 2013-07-15 2024-03-26 Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Country Status (5)

Country Link
US (2) US9950057B2 (enExample)
EP (1) EP3022296B1 (enExample)
JP (4) JP2016524915A (enExample)
AU (2) AU2014290203B2 (enExample)
WO (1) WO2015009743A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
WO2011056591A1 (en) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
WO2017143236A1 (en) * 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development
US11896661B2 (en) 2017-04-27 2024-02-13 Mississippi State University Influenza virus vaccine and method of making
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
JP7783047B2 (ja) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
US20230174586A1 (en) * 2018-11-14 2023-06-08 Tokyo Metropolitan Institute Of Medical Science Strain dis-derived recombinant vaccinia virus having novel influenza virus-derived hemagglutinin protein gene
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
MX2021014848A (es) * 2019-06-07 2022-05-03 Flugen Inc Columna vertebral del virus de la influenza.
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
CN110551187B (zh) * 2019-09-23 2022-09-16 新乡学院 化学合成的h7n9禽流感病毒na蛋白胞外区抗原片段及制备方法和应用
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたｎａを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
MX2023000881A (es) * 2020-07-21 2023-02-22 Flugen Inc Estructura genomica del virus de la influenza.

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071618A (en) 1974-09-03 1978-01-31 Research Foundation For Microbial Diseases Of Osaka University Process for preparing virus disease live vaccines
JPS57136528A (en) 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
NZ219515A (en) 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5166057A (en) 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5854037A (en) 1989-08-28 1998-12-29 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
PT702085E (pt) 1994-07-18 2004-04-30 Karl Klaus Conzelmann Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
WO1996010400A1 (en) 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
WO1996010631A1 (en) 1994-09-30 1996-04-11 St. Jude Children's Research Hospital Nucleic acid encoding mutant matrix proteins useful for attenuation or enhancement of influenza a virus
ATE181112T1 (de) 1995-08-09 1999-06-15 Schweiz Serum & Impfinst Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
US5994526A (en) 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
EP2112220A3 (en) 1996-07-15 2010-01-06 The Government of the United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
TW570803B (en) 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
BR9809456B1 (pt) 1997-05-23 2011-06-28 molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica.
ES2255181T3 (es) 1997-08-05 2006-06-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Antigeno inmunoprotector contra la gripe y su uso en vacunacion.
US6169175B1 (en) 1997-08-06 2001-01-02 Centers For Disease Control And Prevention Preparation and use of recombinant influenza A virus M2 construct vaccines
KR100281676B1 (ko) 1997-11-29 2001-04-02 신동권 신규한독감생백신바이러스
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
EP2345716B1 (en) 1999-04-06 2015-01-14 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6686168B1 (en) 1999-11-04 2004-02-03 Zymogenetics, Inc. Cell surface display of proteins by recombinant host cells
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
DE60142506D1 (de) 2000-03-03 2010-08-19 Chemo Sero Therapeut Res Inst In serumfreier kultur verwendbare zelle, kultursuspension und verfahren zur virusproduktion als impfstoff unter verwendung der zelle
AU5533601A (en) 2000-04-14 2001-10-30 Wisconsin Alumni Res Found Viruses comprising mutation ion channel protein
DE60137345D1 (de) 2000-04-28 2009-02-26 St Jude Childrens Res Hospital Dna-transfektionssystem zur erzeugung von infektiösen negativsträngigen rna virus
EP1201760A1 (en) 2000-10-30 2002-05-02 ARTEMIS Pharmaceuticals GmbH Influenza virus vector for human dendritic cells
EP1233059A1 (en) * 2001-02-09 2002-08-21 ARTEMIS Pharmaceuticals GmbH Influenza viruses with enhanced transcriptional and replicational capacities
WO2002068632A2 (en) 2001-02-23 2002-09-06 Wisconsin Alumni Research Foundation Methods to identify mutant cells with altered sialic acid
DE10144906B4 (de) 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
HUE050222T2 (hu) 2002-02-13 2020-11-30 Wisconsin Alumni Res Found Szignál influenzavírus-vektorok pakolására
WO2003076462A1 (en) 2002-03-08 2003-09-18 Crucell Holland B.V. Use of recombinant trypsin for vaccine production
CN103540613A (zh) 2002-04-26 2014-01-29 米迪缪尼有限公司 制备流感病毒的多质粒系统
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
US20050158342A1 (en) 2003-12-23 2005-07-21 Medimmune, Inc. Multi plasmid system for the production of influenza virus
PT2287288E (pt) 2002-07-09 2012-12-10 Baxter Int Meio isento de proteína animal para cultura de células
CA2522081C (en) 2003-04-23 2013-01-29 Wisconsin Alumni Research Foundation Recombinant influenza viruses holding a mutation in a transmembrane protein gene
JP2006525815A (ja) 2003-05-28 2006-11-16 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション Ｐｏｌｉｉプロモーターおよびリボザイムを有する組換えインフルエンザベクター
JP5215561B2 (ja) 2003-05-28 2013-06-19 ウィスコンシン アルムニ リサーチ ファンデイション ワクチン及び遺伝子治療のための高力価組換えインフルエンザ・ウイルス
CA2816222A1 (en) 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US7037707B2 (en) 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
JP2005245302A (ja) 2004-03-04 2005-09-15 Kanazawa Univ Tlo Inc 組換えインフルエンザウイルスおよびそれを用いたワクチン
NZ551640A (en) 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
EP2578229B1 (en) 2004-09-09 2013-07-10 Novartis Vaccines and Diagnostics GmbH Decreasing potential iatrogenic risks associated with vaccine antigens
JP2008520248A (ja) 2004-11-19 2008-06-19 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション タンデム転写ユニットを有する組換えインフルエンザベクター
CN101189326B (zh) 2004-12-23 2013-06-12 米迪缪尼有限公司 用于病毒增殖的非致瘤性mdck细胞系
AU2005318087B2 (en) 2004-12-24 2011-04-21 Abbott Biologicals B.V. Rescue of influenza virus
ES2527503T3 (es) 2005-03-08 2015-01-26 Medimmune, Llc Virus influenza reordenantes
EP1945778B1 (en) 2005-10-17 2012-12-26 MedImmune, LLC Methods of increasing influenza virus replication
HUE049580T2 (hu) 2006-01-27 2020-09-28 Seqirus Uk Ltd Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
AU2012204138B2 (en) 2006-03-31 2014-02-06 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
AU2014202470B2 (en) 2006-03-31 2016-08-04 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
EP2022849A4 (en) 2006-05-11 2010-10-06 Chemo Sero Therapeut Res Inst METHOD FOR PROLIFERATION OF INFLUENZA VIRUS
US7507411B2 (en) 2006-06-23 2009-03-24 University Of Saskatchewan Attenuated influenza NS1 variants
JP2010500034A (ja) 2006-08-09 2010-01-07 メッドイミューン バクシーンズ，インコーポレイティド インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
EP2069480B1 (en) 2006-09-15 2014-03-19 MedImmune, LLC Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
PL2121011T3 (pl) 2006-12-06 2014-10-31 Novartis Ag Szczepionki zawierające antygeny czterech szczepów wirusa grypy
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
JP5666905B2 (ja) 2007-06-18 2015-02-12 メディミューン，エルエルシー ヘマグルチニンポリペプチド中に変化を有するインフルエンザｂウイルス
CN101784283A (zh) 2007-06-27 2010-07-21 诺华有限公司 低添加流感疫苗
BRPI0915487A2 (pt) 2008-07-11 2017-06-27 Medimmune Inc hemaglutina de nfluenza e variantes de neuraminidase
JP5845178B2 (ja) 2009-07-16 2016-01-20 クルセル ホランド ベー ヴェー ワクチン生産のためのポリオウイルスの高力価での生産
WO2011056591A1 (en) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
GB0919117D0 (en) 2009-10-30 2009-12-16 Glaxosmithkline Biolog Sa Process
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
GB201011502D0 (en) 2010-07-08 2010-08-25 Glaxosmithkline Biolog Sa Novel process
WO2012033236A1 (ko) 2010-09-06 2012-03-15 에스케이케미칼 주식회사 무혈청 배양 및 부유 배양에 적응된 ｍｄｃｋ 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법
US9284533B2 (en) 2011-06-24 2016-03-15 Flugen, Inc. Influenza virus mutants and uses therefor
CN102304495A (zh) 2011-09-08 2012-01-04 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
BR112015030582A2 (pt) 2013-06-06 2017-08-29 Novartis Ag Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
WO2017143236A1 (en) 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development

Similar Documents

Publication Publication Date Title
JP2016524915A5 (enExample)
Ping et al. Development of high-yield influenza A virus vaccine viruses
Liu et al. Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic
Rolling et al. Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice
Stech et al. A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin
Cotter et al. A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity
CN102802666B (zh) 猪流感血凝素变异体
JP4980896B2 (ja) インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
US6573079B1 (en) Methods and interferon deficient substrates for the propagation of viruses
Zhong et al. Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens
JP2015119730A5 (enExample)
Nao et al. A single amino acid in the M1 protein responsible for the different pathogenic potentials of H5N1 highly pathogenic avian influenza virus strains
Nogales et al. Interplay of PA-X and NS1 proteins in replication and pathogenesis of a temperature-sensitive 2009 pandemic H1N1 influenza A virus
Chen et al. The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response
JP2014158487A (ja) インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
JP2014506785A5 (enExample)
JP2015180641A (ja) インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
JP2016509864A5 (enExample)
Neumann et al. Identification of amino acid changes that may have been critical for the genesis of A (H7N9) influenza viruses
JP2016501020A5 (enExample)
Kuznetsova et al. Adaptive mutation in nuclear export protein allows stable transgene expression in a chimaeric influenza A virus vector
Wang et al. Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice
Suzuki et al. Amino acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens
Sun et al. Evolution of the PB1 gene of human influenza A (H3N2) viruses circulating between 1968 and 2019
Suphaphiphat et al. Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs