JP2016520193A5 - - Google Patents
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- Publication number
- JP2016520193A5 JP2016520193A5 JP2016514046A JP2016514046A JP2016520193A5 JP 2016520193 A5 JP2016520193 A5 JP 2016520193A5 JP 2016514046 A JP2016514046 A JP 2016514046A JP 2016514046 A JP2016514046 A JP 2016514046A JP 2016520193 A5 JP2016520193 A5 JP 2016520193A5
- Authority
- JP
- Japan
- Prior art keywords
- stimulating hormone
- hormone receptor
- motomeko
- thyroid
- chelating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 21
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- 239000002738 chelating agent Substances 0.000 claims 12
- 102000005962 receptors Human genes 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 239000006193 liquid solution Substances 0.000 claims 7
- 229920005862 polyol Polymers 0.000 claims 7
- 150000003077 polyols Chemical class 0.000 claims 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 4
- BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical group CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 claims 3
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 3
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004386 Erythritol Substances 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000012911 assay medium Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- 235000019414 erythritol Nutrition 0.000 claims 2
- 229940009714 erythritol Drugs 0.000 claims 2
- 229940093476 ethylene glycol Drugs 0.000 claims 2
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- 229960004063 propylene glycol Drugs 0.000 claims 2
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 238000004917 polyol method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823116P | 2013-05-14 | 2013-05-14 | |
| US61/823,116 | 2013-05-14 | ||
| PCT/US2014/037909 WO2014186402A1 (en) | 2013-05-14 | 2014-05-13 | Stabilized liquid formulations containing receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520193A JP2016520193A (ja) | 2016-07-11 |
| JP2016520193A5 true JP2016520193A5 (enExample) | 2017-06-22 |
| JP6472789B2 JP6472789B2 (ja) | 2019-02-20 |
Family
ID=51898832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514046A Active JP6472789B2 (ja) | 2013-05-14 | 2014-05-13 | 受容体含有安定化液剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10203338B2 (enExample) |
| EP (1) | EP2997039B1 (enExample) |
| JP (1) | JP6472789B2 (enExample) |
| CN (1) | CN105209486B (enExample) |
| ES (1) | ES2747634T3 (enExample) |
| WO (1) | WO2014186402A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112189139B (zh) * | 2018-09-26 | 2024-10-29 | 北卡罗来纳-查佩尔山大学 | 用于改进测定的化合物、组合物和方法 |
| JP7269906B2 (ja) * | 2019-10-29 | 2023-05-09 | 三洋化成工業株式会社 | 免疫測定用試薬、免疫測定用キット及び免疫測定方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| DE3414508A1 (de) | 1984-04-13 | 1985-10-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen |
| US4711856A (en) | 1984-09-19 | 1987-12-08 | Mayo Medical Resources | Nuclear binding assay for steroid receptor functionality in cancerous cells |
| US5089390A (en) | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5508178A (en) | 1989-01-19 | 1996-04-16 | Rose; Samuel | Nucleic acid amplification using single primer |
| US5340716A (en) | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| CA2258720A1 (en) * | 1996-06-05 | 1997-12-11 | Basil Rapoport | Human thyrotropin receptor compositions and use thereof |
| WO2002077174A2 (en) | 2001-03-27 | 2002-10-03 | Zymogenetics, Inc. | Human cytokine receptor |
| DE50306067D1 (de) | 2002-11-26 | 2007-02-01 | Brahms Ag | Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern |
| JP5405111B2 (ja) * | 2005-09-26 | 2014-02-05 | ウルリヒ ルース | Ｔｓｈ受容体及び新規ｔｓｈ受容体キメラに対する自己免疫抗体検出方法 |
| US20080305098A1 (en) | 2005-11-21 | 2008-12-11 | Dr. Fenning Biomed Gmbh | Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor |
| JP5832723B2 (ja) | 2009-03-06 | 2015-12-16 | 協和メデックス株式会社 | 可溶性インターロイキン−２受容体定量用標準品 |
| JP2011136911A (ja) | 2009-12-25 | 2011-07-14 | Tosoh Corp | 甲状腺刺激ホルモンレセプターの安定化方法 |
-
2014
- 2014-05-13 JP JP2016514046A patent/JP6472789B2/ja active Active
- 2014-05-13 EP EP14797839.9A patent/EP2997039B1/en active Active
- 2014-05-13 US US14/891,269 patent/US10203338B2/en active Active
- 2014-05-13 WO PCT/US2014/037909 patent/WO2014186402A1/en not_active Ceased
- 2014-05-13 CN CN201480028189.3A patent/CN105209486B/zh active Active
- 2014-05-13 ES ES14797839T patent/ES2747634T3/es active Active
-
2018
- 2018-08-13 US US16/102,720 patent/US11119108B2/en active Active
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