CN105209486B - 含有受体的经稳定的液体配制物 - Google Patents

含有受体的经稳定的液体配制物 Download PDF

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Publication number
CN105209486B
CN105209486B CN201480028189.3A CN201480028189A CN105209486B CN 105209486 B CN105209486 B CN 105209486B CN 201480028189 A CN201480028189 A CN 201480028189A CN 105209486 B CN105209486 B CN 105209486B
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acid
receptor
chelating agent
polyol
amount
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Chinese (zh)
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CN105209486A (zh
Inventor
D.基亚埃
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201480028189.3A 2013-05-14 2014-05-13 含有受体的经稳定的液体配制物 Active CN105209486B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361823116P 2013-05-14 2013-05-14
US61/823116 2013-05-14
PCT/US2014/037909 WO2014186402A1 (en) 2013-05-14 2014-05-13 Stabilized liquid formulations containing receptors

Publications (2)

Publication Number Publication Date
CN105209486A CN105209486A (zh) 2015-12-30
CN105209486B true CN105209486B (zh) 2021-04-06

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CN201480028189.3A Active CN105209486B (zh) 2013-05-14 2014-05-13 含有受体的经稳定的液体配制物

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US (2) US10203338B2 (enExample)
EP (1) EP2997039B1 (enExample)
JP (1) JP6472789B2 (enExample)
CN (1) CN105209486B (enExample)
ES (1) ES2747634T3 (enExample)
WO (1) WO2014186402A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112189139B (zh) * 2018-09-26 2024-10-29 北卡罗来纳-查佩尔山大学 用于改进测定的化合物、组合物和方法
JP7269906B2 (ja) * 2019-10-29 2023-05-09 三洋化成工業株式会社 免疫測定用試薬、免疫測定用キット及び免疫測定方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046206A2 (en) * 1996-06-05 1997-12-11 Basil Rapoport Human thyrotropin receptor compositions and use thereof
US20030099608A1 (en) * 2001-03-27 2003-05-29 Presnell Scott R. Human cytokine receptor
WO2004048415A1 (de) * 2002-11-26 2004-06-10 B.R.A.H.M.S Aktiengesellschaft Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern
CN101322033A (zh) * 2005-09-26 2008-12-10 乌尔里希·洛斯 用于检测针对tsh受体的自身免疫抗体的方法和新型tsh受体嵌合体
US20080305098A1 (en) * 2005-11-21 2008-12-11 Dr. Fenning Biomed Gmbh Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor
JP2010230660A (ja) * 2009-03-06 2010-10-14 Kyowa Medex Co Ltd 可溶性インターロイキン−２受容体定量用標準品
JP2011136911A (ja) * 2009-12-25 2011-07-14 Tosoh Corp 甲状腺刺激ホルモンレセプターの安定化方法

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US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
DE3414508A1 (de) 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
US4711856A (en) 1984-09-19 1987-12-08 Mayo Medical Resources Nuclear binding assay for steroid receptor functionality in cancerous cells
US5089390A (en) 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046206A2 (en) * 1996-06-05 1997-12-11 Basil Rapoport Human thyrotropin receptor compositions and use thereof
US20030099608A1 (en) * 2001-03-27 2003-05-29 Presnell Scott R. Human cytokine receptor
WO2004048415A1 (de) * 2002-11-26 2004-06-10 B.R.A.H.M.S Aktiengesellschaft Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern
CN101322033A (zh) * 2005-09-26 2008-12-10 乌尔里希·洛斯 用于检测针对tsh受体的自身免疫抗体的方法和新型tsh受体嵌合体
US20080305098A1 (en) * 2005-11-21 2008-12-11 Dr. Fenning Biomed Gmbh Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor
JP2010230660A (ja) * 2009-03-06 2010-10-14 Kyowa Medex Co Ltd 可溶性インターロイキン−２受容体定量用標準品
JP2011136911A (ja) * 2009-12-25 2011-07-14 Tosoh Corp 甲状腺刺激ホルモンレセプターの安定化方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Decreased expression of the thyroid-stimulating hormone receptor in poorly-differentiated carcinoma of the thyroid;HIROFUMI MATSUMOTO 等;《ONCOLOGY REPORTS》;20080630;第19卷(第6期);第1405-1411页 *
Folding-Dependent Binding of Thyrotropin (TSH) and TSH Receptor Autoantibodies to the Murine TSH Receptor Ectodomain;H. VLASE, N. MATSUOKA 等;《Endocrinology》;19970401;第138卷(第4期);第1658-1666页 *
两种促甲状腺激素受体抗体检测方法的临床应用比较;董作亮;《天津医科大学学报》;20080930;第14卷(第3期);第297-299页 *
促甲状腺激素受体抗体在Graves病中的诊断价值;伍宁玲 等;《解放军医学杂志》;20110501;第36卷(第5期);第501-504页 *

Also Published As

Publication number Publication date
JP2016520193A (ja) 2016-07-11
ES2747634T3 (es) 2020-03-11
US20180356428A1 (en) 2018-12-13
US20160084847A1 (en) 2016-03-24
US10203338B2 (en) 2019-02-12
WO2014186402A1 (en) 2014-11-20
JP6472789B2 (ja) 2019-02-20
CN105209486A (zh) 2015-12-30
EP2997039A1 (en) 2016-03-23
US11119108B2 (en) 2021-09-14
EP2997039B1 (en) 2019-06-26
EP2997039A4 (en) 2016-11-30

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