JP2016520077A5 - - Google Patents
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- Publication number
- JP2016520077A5 JP2016520077A5 JP2016513459A JP2016513459A JP2016520077A5 JP 2016520077 A5 JP2016520077 A5 JP 2016520077A5 JP 2016513459 A JP2016513459 A JP 2016513459A JP 2016513459 A JP2016513459 A JP 2016513459A JP 2016520077 A5 JP2016520077 A5 JP 2016520077A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- hcv
- hcv genotype
- genotype
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000711549 Hepacivirus C Species 0.000 claims description 320
- 229920001184 polypeptide Polymers 0.000 claims description 294
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 294
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 294
- 239000000203 mixture Substances 0.000 claims description 103
- 108700008783 Hepatitis C virus E1 Proteins 0.000 claims description 26
- 230000001939 inductive effect Effects 0.000 claims description 22
- 230000028993 immune response Effects 0.000 claims description 21
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 10
- 235000001014 amino acid Nutrition 0.000 claims description 10
- 235000009582 asparagine Nutrition 0.000 claims description 10
- 229960001230 asparagine Drugs 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 10
- 230000002163 immunogen Effects 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 150000001508 asparagines Chemical class 0.000 claims description 6
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 6
- 230000003472 neutralizing effect Effects 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 238000006386 neutralization reaction Methods 0.000 claims description 5
- 108091034117 Oligonucleotide Proteins 0.000 claims description 4
- 229940037003 alum Drugs 0.000 claims description 4
- 239000000833 heterodimer Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 22
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823712P | 2013-05-15 | 2013-05-15 | |
| US61/823,712 | 2013-05-15 | ||
| US201361887229P | 2013-10-04 | 2013-10-04 | |
| US61/887,229 | 2013-10-04 | ||
| PCT/IB2014/001972 WO2015132619A1 (en) | 2013-05-15 | 2014-05-15 | E1e2 hcv vaccines and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087976A Division JP2019142962A (ja) | 2013-05-15 | 2019-05-08 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520077A JP2016520077A (ja) | 2016-07-11 |
| JP2016520077A5 true JP2016520077A5 (enExample) | 2017-06-22 |
Family
ID=54054625
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513459A Withdrawn JP2016520077A (ja) | 2013-05-15 | 2014-05-15 | Ｅ１ｅ２ｈｃｖワクチン及び使用方法 |
| JP2019087976A Withdrawn JP2019142962A (ja) | 2013-05-15 | 2019-05-08 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2021001926A Pending JP2021059596A (ja) | 2013-05-15 | 2021-01-08 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2022137454A Pending JP2022172244A (ja) | 2013-05-15 | 2022-08-31 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2024130501A Pending JP2024156917A (ja) | 2013-05-15 | 2024-08-07 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087976A Withdrawn JP2019142962A (ja) | 2013-05-15 | 2019-05-08 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2021001926A Pending JP2021059596A (ja) | 2013-05-15 | 2021-01-08 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2022137454A Pending JP2022172244A (ja) | 2013-05-15 | 2022-08-31 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
| JP2024130501A Pending JP2024156917A (ja) | 2013-05-15 | 2024-08-07 | Ｅ１ｅ２ ｈｃｖワクチン及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20210145963A9 (enExample) |
| EP (2) | EP2996718B1 (enExample) |
| JP (5) | JP2016520077A (enExample) |
| CN (2) | CN105263517B (enExample) |
| AU (3) | AU2014385320B2 (enExample) |
| CA (1) | CA2909586C (enExample) |
| CL (1) | CL2015003333A1 (enExample) |
| WO (1) | WO2015132619A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117229414A (zh) * | 2015-10-08 | 2023-12-15 | 艾伯塔大学理事会 | 丙型肝炎病毒e1/e2异二聚体及其生产方法 |
| NZ751943A (en) * | 2016-09-21 | 2025-08-29 | Univ Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
| AU2017341735B2 (en) | 2016-10-11 | 2022-01-13 | Helmholtz Center for Infection Research | Hepatitis C virus immunogenic compositions comprising as an adjuvant a cyclic dinucleotide or an archaeosome and methods of use thereof |
| CN112601548A (zh) * | 2018-03-16 | 2021-04-02 | 艾伯塔大学理事会 | 丙型肝炎病毒肽组合物及其使用方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| DE69327599T2 (de) | 1992-06-25 | 2000-08-10 | Smithkline Beecham Biolog | Adjuvantien enthaltende Impfstoffzusammensetzung |
| WO1994021292A1 (en) | 1993-03-23 | 1994-09-29 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167378B1 (en) | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| AU3241095A (en) | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| AU4992197A (en) | 1996-10-11 | 1998-05-11 | Regents Of The University Of California, The | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| AU738513B2 (en) | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
| AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DE69841015D1 (de) | 1997-05-06 | 2009-09-10 | Novartis Vaccines & Diagnostic | Intrazelluläre herstellung von verkürztem hepatitis c-polypeptid e2 |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| JP4101888B2 (ja) | 1997-06-06 | 2008-06-18 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激オリゴヌクレオチド、その組成物およびその使用方法 |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| AU1145699A (en) | 1997-09-05 | 1999-03-22 | Smithkline Beecham Biologicals (Sa) | Oil in water emulsions containing saponins |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| AU746163B2 (en) | 1998-04-09 | 2002-04-18 | Smithkline Beecham Biologicals (Sa) | Adjuvant compositions |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| BRPI9915545B8 (pt) | 1998-10-16 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição de vacina, processo para preparação da mesma e kit compreendendo dois recipientes. |
| DE60043930D1 (de) | 1999-03-19 | 2010-04-15 | Glaxosmithkline Biolog Sa | Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae |
| DE60014076T2 (de) | 1999-04-19 | 2005-10-13 | Glaxosmithkline Biologicals S.A. | Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid |
| BR0014285A (pt) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico |
| TR200200774T2 (tr) | 1999-09-24 | 2002-08-21 | Smithkline Beecham Biologicals S.A. | Aşılar. |
| CZ20033515A3 (cs) * | 2001-06-29 | 2005-01-12 | Chiron Corporation | Kompozice vakcíny HCV E1E2 |
| US7348011B2 (en) * | 2005-06-10 | 2008-03-25 | Sudershan Biotech Ltd. | Hepatitis C virus vaccine |
| WO2007041432A2 (en) * | 2005-09-30 | 2007-04-12 | Novartis Vaccines And Diagnostics, Inc. | Cross-neutralization of hcv with recombinant proteins |
| US8603468B2 (en) * | 2007-11-06 | 2013-12-10 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Neutralization of HCV |
| WO2014060851A2 (en) * | 2012-10-05 | 2014-04-24 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
-
2014
- 2014-05-15 AU AU2014385320A patent/AU2014385320B2/en active Active
- 2014-05-15 JP JP2016513459A patent/JP2016520077A/ja not_active Withdrawn
- 2014-05-15 WO PCT/IB2014/001972 patent/WO2015132619A1/en not_active Ceased
- 2014-05-15 EP EP14884476.4A patent/EP2996718B1/en active Active
- 2014-05-15 EP EP19215826.9A patent/EP3689375A1/en not_active Withdrawn
- 2014-05-15 CA CA2909586A patent/CA2909586C/en active Active
- 2014-05-15 CN CN201480027001.3A patent/CN105263517B/zh active Active
- 2014-05-15 CN CN202110252076.3A patent/CN112999344A/zh active Pending
- 2014-05-15 US US14/783,699 patent/US20210145963A9/en not_active Abandoned
-
2015
- 2015-11-13 CL CL2015003333A patent/CL2015003333A1/es unknown
-
2019
- 2019-05-08 JP JP2019087976A patent/JP2019142962A/ja not_active Withdrawn
-
2020
- 2020-01-10 AU AU2020200216A patent/AU2020200216A1/en not_active Abandoned
-
2021
- 2021-01-08 JP JP2021001926A patent/JP2021059596A/ja active Pending
-
2022
- 2022-02-04 AU AU2022200747A patent/AU2022200747A1/en not_active Abandoned
- 2022-03-23 US US17/702,231 patent/US20230098265A1/en not_active Abandoned
- 2022-08-31 JP JP2022137454A patent/JP2022172244A/ja active Pending
-
2023
- 2023-11-27 US US18/520,057 patent/US20240316186A1/en active Pending
-
2024
- 2024-08-07 JP JP2024130501A patent/JP2024156917A/ja active Pending
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