JP2016519933A5 - - Google Patents
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- JP2016519933A5 JP2016519933A5 JP2016513129A JP2016513129A JP2016519933A5 JP 2016519933 A5 JP2016519933 A5 JP 2016519933A5 JP 2016513129 A JP2016513129 A JP 2016513129A JP 2016513129 A JP2016513129 A JP 2016513129A JP 2016519933 A5 JP2016519933 A5 JP 2016519933A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically engineered
- blood cell
- enucleated blood
- engineered enucleated
- erythrocyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000601 blood cell Anatomy 0.000 claims 19
- 210000003743 erythrocyte Anatomy 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 108091005703 transmembrane proteins Proteins 0.000 claims 7
- 102000035160 transmembrane proteins Human genes 0.000 claims 7
- 108010052285 Membrane Proteins Proteins 0.000 claims 6
- 102000018697 Membrane Proteins Human genes 0.000 claims 6
- 210000003617 erythrocyte membrane Anatomy 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102100035716 Glycophorin-A Human genes 0.000 claims 2
- 108091005250 Glycophorins Proteins 0.000 claims 2
- 108091005956 Type II transmembrane proteins Proteins 0.000 claims 2
- 230000015271 coagulation Effects 0.000 claims 2
- 238000005345 coagulation Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019182854A JP6960177B2 (ja) | 2013-05-10 | 2019-10-03 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822071P | 2013-05-10 | 2013-05-10 | |
| US61/822,071 | 2013-05-10 | ||
| PCT/US2014/037554 WO2014183071A2 (en) | 2013-05-10 | 2014-05-09 | In vitro production of red blood cells with sortaggable proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182854A Division JP6960177B2 (ja) | 2013-05-10 | 2019-10-03 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519933A JP2016519933A (ja) | 2016-07-11 |
| JP2016519933A5 true JP2016519933A5 (enExample) | 2017-06-22 |
| JP6599848B2 JP6599848B2 (ja) | 2019-10-30 |
Family
ID=51867887
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513129A Expired - Fee Related JP6599848B2 (ja) | 2013-05-10 | 2014-05-09 | ソルタギング可能なタンパク質を有する赤血球のｉｎｖｉｔｒｏ生成 |
| JP2019182854A Expired - Fee Related JP6960177B2 (ja) | 2013-05-10 | 2019-10-03 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
| JP2021163272A Pending JP2022001063A (ja) | 2013-05-10 | 2021-10-04 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182854A Expired - Fee Related JP6960177B2 (ja) | 2013-05-10 | 2019-10-03 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
| JP2021163272A Pending JP2022001063A (ja) | 2013-05-10 | 2021-10-04 | ソルタギング可能なタンパク質を有する赤血球のｉｎ ｖｉｔｒｏ生成 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10471099B2 (enExample) |
| EP (4) | EP3693398A1 (enExample) |
| JP (3) | JP6599848B2 (enExample) |
| AU (2) | AU2014262474B2 (enExample) |
| ES (1) | ES2901383T3 (enExample) |
| HK (1) | HK1222662A1 (enExample) |
| WO (1) | WO2014183071A2 (enExample) |
Families Citing this family (86)
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| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
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| WO2012142659A1 (en) | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
| EP2726494B1 (en) * | 2011-06-28 | 2017-01-04 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| CN102559600A (zh) | 2011-12-29 | 2012-07-11 | 上海交通大学医学院 | 一种人工抗原递呈细胞及其在nk细胞扩增中的应用 |
| WO2013132317A1 (en) | 2012-03-07 | 2013-09-12 | Aurigene Discovery Technologies Limited | Peptidomimetic compounds as immunomodulators |
| CA2870485A1 (en) | 2012-04-13 | 2013-10-17 | Whitehead Institute For Biomedical Research | Sortase-modified vhh domains and uses thereof |
| US20140030697A1 (en) | 2012-06-14 | 2014-01-30 | Massachusetts Institute Of Technology | Sortase-mediated modification of viral surface proteins |
| US9267127B2 (en) | 2012-06-21 | 2016-02-23 | President And Fellows Of Harvard College | Evolution of bond-forming enzymes |
| US9511350B2 (en) | 2013-05-10 | 2016-12-06 | Clean Diesel Technologies, Inc. (Cdti) | ZPGM Diesel Oxidation Catalysts and methods of making and using same |
| EP3693398A1 (en) | 2013-05-10 | 2020-08-12 | Whitehead Institute for Biomedical Research | In vitro production of red blood cells with sortaggable proteins |
| US10260038B2 (en) | 2013-05-10 | 2019-04-16 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| CN111876387A (zh) | 2013-05-15 | 2020-11-03 | 罗切斯特大学 | 人广泛自我更新型成红细胞(esre) |
| WO2015051188A1 (en) | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| US9878045B2 (en) | 2013-10-15 | 2018-01-30 | Regents Of The University Of Minnesota | Triorthogonal reagents for dual protein conjugation |
| US10556024B2 (en) | 2013-11-13 | 2020-02-11 | Whitehead Institute For Biomedical Research | 18F labeling of proteins using sortases |
| US10053683B2 (en) | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| WO2016183482A1 (en) | 2015-05-13 | 2016-11-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
| US12048753B2 (en) | 2015-10-01 | 2024-07-30 | Whitehead Institute For Biomedical Research | Labeling of antibodies |
| US20200206269A1 (en) | 2017-08-23 | 2020-07-02 | Whitehead Institute For Biomedical Research | Production of enucleated red blood cells and uses thereof |
| WO2020243006A1 (en) * | 2019-05-24 | 2020-12-03 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
-
2014
- 2014-05-09 EP EP19219550.1A patent/EP3693398A1/en not_active Withdrawn
- 2014-05-09 HK HK16110752.9A patent/HK1222662A1/zh unknown
- 2014-05-09 US US14/890,241 patent/US10471099B2/en active Active - Reinstated
- 2014-05-09 EP EP14795167.7A patent/EP2994491A4/en not_active Withdrawn
- 2014-05-09 AU AU2014262474A patent/AU2014262474B2/en not_active Ceased
- 2014-05-09 JP JP2016513129A patent/JP6599848B2/ja not_active Expired - Fee Related
- 2014-05-09 ES ES19171188T patent/ES2901383T3/es active Active
- 2014-05-09 EP EP19171188.6A patent/EP3546484B1/en not_active Not-in-force
- 2014-05-09 EP EP19171190.2A patent/EP3546485A1/en not_active Withdrawn
- 2014-05-09 WO PCT/US2014/037554 patent/WO2014183071A2/en not_active Ceased
-
2018
- 2018-03-23 US US15/934,177 patent/US11266695B2/en active Active
-
2019
- 2019-09-16 US US16/572,425 patent/US11992505B2/en active Active
- 2019-10-03 JP JP2019182854A patent/JP6960177B2/ja not_active Expired - Fee Related
- 2019-12-16 AU AU2019283766A patent/AU2019283766B2/en not_active Ceased
-
2021
- 2021-10-04 JP JP2021163272A patent/JP2022001063A/ja active Pending
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