JP2016519091A5

JP2016519091A5 -

Download PDF

Info

Publication number: JP2016519091A5
Authority: JP; Japan
Prior art keywords: phenyl; piperidin; quinoline; chloro; diethylamino
Prior art date: 2014-03-13
Legal status : Pending

Application number

JP2016503776A

Other languages

English (en)

Japanese (ja)

Other versions

JP2016519091A (ja

Filing date

2014-03-13

Publication date

2017-03-09

2014-03-13 Application filed filed Critical

2014-03-13 Priority claimed from PCT/IL2014/050273 external-priority patent/WO2014147611A1/en

2016-06-30 Publication of JP2016519091A publication Critical patent/JP2016519091A/ja

2017-03-09 Publication of JP2016519091A5 publication Critical patent/JP2016519091A5/ja

Status Pending legal-status Critical Current

Links

-1 cycloalkynyl Chemical group 0.000 claims 41
SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 14
239000008194 pharmaceutical composition Substances 0.000 claims 14
150000001875 compounds Chemical class 0.000 claims 13
229910052740 iodine Inorganic materials 0.000 claims 11
239000002105 nanoparticle Substances 0.000 claims 11
229910052794 bromium Inorganic materials 0.000 claims 9
229910052801 chlorine Inorganic materials 0.000 claims 9
229910052731 fluorine Inorganic materials 0.000 claims 9
229910052736 halogen Inorganic materials 0.000 claims 9
150000002367 halogens Chemical class 0.000 claims 9
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
239000003112 inhibitor Substances 0.000 claims 9
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
229910052799 carbon Inorganic materials 0.000 claims 8
125000004093 cyano group Chemical group *C#N 0.000 claims 8
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 8
125000001424 substituent group Chemical group 0.000 claims 8
125000001072 heteroaryl group Chemical group 0.000 claims 6
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 5
125000003342 alkenyl group Chemical group 0.000 claims 5
125000000753 cycloalkyl group Chemical group 0.000 claims 5
208000032839 leukemia Diseases 0.000 claims 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 4
206010028980 Neoplasm Diseases 0.000 claims 4
239000002202 Polyethylene glycol Substances 0.000 claims 4
125000000304 alkynyl group Chemical group 0.000 claims 4
239000002246 antineoplastic agent Substances 0.000 claims 4
125000003118 aryl group Chemical group 0.000 claims 4
235000010290 biphenyl Nutrition 0.000 claims 4
229910052739 hydrogen Inorganic materials 0.000 claims 4
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 4
238000000034 method Methods 0.000 claims 4
239000000203 mixture Substances 0.000 claims 4
230000001613 neoplastic effect Effects 0.000 claims 4
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
229920001223 polyethylene glycol Polymers 0.000 claims 4
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 3
125000000217 alkyl group Chemical group 0.000 claims 3
229940034982 antineoplastic agent Drugs 0.000 claims 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
201000011510 cancer Diseases 0.000 claims 3
210000004027 cell Anatomy 0.000 claims 3
125000000392 cycloalkenyl group Chemical group 0.000 claims 3
229960000452 diethylstilbestrol Drugs 0.000 claims 3
RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims 3
201000010099 disease Diseases 0.000 claims 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
229960004679 doxorubicin Drugs 0.000 claims 3
239000001257 hydrogen Substances 0.000 claims 3
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
229960004768 irinotecan Drugs 0.000 claims 3
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 3
208000003747 lymphoid leukemia Diseases 0.000 claims 3
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims 3
229910052757 nitrogen Inorganic materials 0.000 claims 3
230000002062 proliferating effect Effects 0.000 claims 3
CYOHGALHFOKKQC-UHFFFAOYSA-N selumetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1Cl CYOHGALHFOKKQC-UHFFFAOYSA-N 0.000 claims 3
238000011282 treatment Methods 0.000 claims 3
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 2
DEUVFVHXKDYDKY-UHFFFAOYSA-N 1-N,2-N-dimethyl-1-N-(2-naphthalen-2-ylquinolin-4-yl)propane-1,2-diamine Chemical compound CC(CN(C1=CC(=NC2=CC=CC=C12)C1=CC2=CC=CC=C2C=C1)C)NC DEUVFVHXKDYDKY-UHFFFAOYSA-N 0.000 claims 2
HZSXMMARARQQSI-UHFFFAOYSA-N 1-N,3-N-dimethyl-1-N-(2-naphthalen-2-ylquinolin-4-yl)butane-1,3-diamine Chemical compound CC(CCN(C1=CC(=NC2=CC=CC=C12)C1=CC2=CC=CC=C2C=C1)C)NC HZSXMMARARQQSI-UHFFFAOYSA-N 0.000 claims 2
MAEFVZXGDJBGEJ-UHFFFAOYSA-N 1-[(7-chloro-2-phenylquinolin-4-yl)methyl]-n,n-diethylpiperidin-4-amine Chemical compound C1CC(N(CC)CC)CCN1CC1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 MAEFVZXGDJBGEJ-UHFFFAOYSA-N 0.000 claims 2
GWTCEZODBQQDEV-UHFFFAOYSA-N 1-[(7-chloro-2-phenylquinolin-4-yl)methyl]-n,n-diethylpiperidin-4-amine;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1CC1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 GWTCEZODBQQDEV-UHFFFAOYSA-N 0.000 claims 2
ZQGCQLKLWHSFDH-UHFFFAOYSA-N 1-[1-(7-chloro-2-phenylquinolin-4-yl)ethyl]-n,n-diethylpiperidin-4-amine Chemical compound C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 ZQGCQLKLWHSFDH-UHFFFAOYSA-N 0.000 claims 2
UFRAYQJVEFYWDH-UHFFFAOYSA-N 1-[1-(7-chloro-2-phenylquinolin-4-yl)ethyl]-n,n-diethylpiperidin-4-amine;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 UFRAYQJVEFYWDH-UHFFFAOYSA-N 0.000 claims 2
XJZWHTMVUSYXQL-UHFFFAOYSA-N 1-benzyl-n-[(7-chloro-2-phenylquinolin-4-yl)methyl]piperidin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1CNC(CC1)CCN1CC1=CC=CC=C1 XJZWHTMVUSYXQL-UHFFFAOYSA-N 0.000 claims 2
PRXUHVAEXBOYLL-UHFFFAOYSA-N 1-benzyl-n-[(7-chloro-2-phenylquinolin-4-yl)methyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1CNC(CC1)CCN1CC1=CC=CC=C1 PRXUHVAEXBOYLL-UHFFFAOYSA-N 0.000 claims 2
YSCXFGNNKNNFCJ-UHFFFAOYSA-N 1-benzyl-n-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)NC(CC1)CCN1CC1=CC=CC=C1 YSCXFGNNKNNFCJ-UHFFFAOYSA-N 0.000 claims 2
ZHNRZHYUYUPBLA-UHFFFAOYSA-N 1-benzyl-n-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)NC(CC1)CCN1CC1=CC=CC=C1 ZHNRZHYUYUPBLA-UHFFFAOYSA-N 0.000 claims 2
QCAMVIZCLRQXKK-UHFFFAOYSA-N 1-benzyl-n-[1-(7-chloro-2-phenylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1C(C)NC(CC1)CCN1CC1=CC=CC=C1 QCAMVIZCLRQXKK-UHFFFAOYSA-N 0.000 claims 2
UMUPCTICRQRAOS-UHFFFAOYSA-N 1-benzyl-n-[1-(7-chloro-2-phenylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1C(C)NC(CC1)CCN1CC1=CC=CC=C1 UMUPCTICRQRAOS-UHFFFAOYSA-N 0.000 claims 2
AAUCNNKWMDLMOJ-UHFFFAOYSA-N 2-N-methyl-1-N-(2-naphthalen-2-ylquinolin-4-yl)propane-1,2-diamine Chemical compound CC(CNC1=CC(=NC2=CC=CC=C12)C1=CC2=CC=CC=C2C=C1)NC AAUCNNKWMDLMOJ-UHFFFAOYSA-N 0.000 claims 2
BVJLAIOEDPVHLO-UHFFFAOYSA-N 2-phenyl-4-(4-piperidin-1-ylpiperidin-1-yl)quinoline Chemical compound C1CCCCN1C1CCN(C=2C3=CC=CC=C3N=C(C=2)C=2C=CC=CC=2)CC1 BVJLAIOEDPVHLO-UHFFFAOYSA-N 0.000 claims 2
VBQSTQVOIRGESY-UHFFFAOYSA-N 2-phenyl-4-(4-piperidin-1-ylpiperidin-1-yl)quinoline;hydrochloride Chemical compound Cl.C1CCCCN1C1CCN(C=2C3=CC=CC=C3N=C(C=2)C=2C=CC=CC=2)CC1 VBQSTQVOIRGESY-UHFFFAOYSA-N 0.000 claims 2
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 2
WJFCKDCOXFWAHH-UHFFFAOYSA-N 3-N-methyl-1-N-(2-phenylquinolin-4-yl)butane-1,3-diamine Chemical compound CC(CCNC1=CC(=NC2=CC=CC=C12)C1=CC=CC=C1)NC WJFCKDCOXFWAHH-UHFFFAOYSA-N 0.000 claims 2
QBLDHFZVONBWRF-UHFFFAOYSA-N 4-[1-(2-phenylquinolin-4-yl)piperidin-4-yl]morpholine Chemical compound C1COCCN1C1CCN(C=2C3=CC=CC=C3N=C(C=2)C=2C=CC=CC=2)CC1 QBLDHFZVONBWRF-UHFFFAOYSA-N 0.000 claims 2
UOABNAQTSXVCDE-UHFFFAOYSA-N 4-[1-(2-phenylquinolin-4-yl)piperidin-4-yl]morpholine;hydrochloride Chemical compound Cl.C1COCCN1C1CCN(C=2C3=CC=CC=C3N=C(C=2)C=2C=CC=CC=2)CC1 UOABNAQTSXVCDE-UHFFFAOYSA-N 0.000 claims 2
KWVQYBDFEQMNKU-UHFFFAOYSA-N 4-[1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-yl]morpholine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N(CC1)CCC1N1CCOCC1 KWVQYBDFEQMNKU-UHFFFAOYSA-N 0.000 claims 2
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 2
LVHWKIFRLNWIBW-UHFFFAOYSA-N 7-chloro-n-[3-(dimethylamino)propyl]-2-phenylquinoline-4-carboxamide Chemical compound N=1C2=CC(Cl)=CC=C2C(C(=O)NCCCN(C)C)=CC=1C1=CC=CC=C1 LVHWKIFRLNWIBW-UHFFFAOYSA-N 0.000 claims 2
GCPYPISCXJSLGK-UHFFFAOYSA-N 7-chloro-n-[3-(dimethylamino)propyl]-2-phenylquinoline-4-carboxamide;hydrochloride Chemical compound Cl.N=1C2=CC(Cl)=CC=C2C(C(=O)NCCCN(C)C)=CC=1C1=CC=CC=C1 GCPYPISCXJSLGK-UHFFFAOYSA-N 0.000 claims 2
DLDZHVUSHPONNC-UHFFFAOYSA-N 7-chloro-n-methyl-2-phenyl-n-[1-(1-phenylethyl)piperidin-4-yl]quinolin-4-amine Chemical compound C=1C=CC=CC=1C(C)N(CC1)CCC1N(C)C(C1=CC=C(Cl)C=C1N=1)=CC=1C1=CC=CC=C1 DLDZHVUSHPONNC-UHFFFAOYSA-N 0.000 claims 2
MMMXGNPHOUYHCU-UHFFFAOYSA-N 7-chloro-n-methyl-2-phenyl-n-[1-(1-phenylethyl)piperidin-4-yl]quinolin-4-amine;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C)N(CC1)CCC1N(C)C(C1=CC=C(Cl)C=C1N=1)=CC=1C1=CC=CC=C1 MMMXGNPHOUYHCU-UHFFFAOYSA-N 0.000 claims 2
208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 2
UUBHCFDPZRGKGI-UHFFFAOYSA-N CC(CCNC1=CC(=NC2=CC=CC=C21)C3=CC4=CC=CC=C4C=C3)NC Chemical compound CC(CCNC1=CC(=NC2=CC=CC=C21)C3=CC4=CC=CC=C4C=C3)NC UUBHCFDPZRGKGI-UHFFFAOYSA-N 0.000 claims 2
JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical compound C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 claims 2
ZNSYYBLJJBZLRP-UHFFFAOYSA-N Cl.CC(CCNC1=CC(=NC2=CC=CC=C12)C1=CC=CC=C1)NC Chemical compound Cl.CC(CCNC1=CC(=NC2=CC=CC=C12)C1=CC=CC=C1)NC ZNSYYBLJJBZLRP-UHFFFAOYSA-N 0.000 claims 2
FSRPOISQPLQUOT-UHFFFAOYSA-N Cl.CC(CNC1=CC(=NC2=CC=CC=C12)C1=CC2=CC=CC=C2C=C1)NC Chemical compound Cl.CC(CNC1=CC(=NC2=CC=CC=C12)C1=CC2=CC=CC=C2C=C1)NC FSRPOISQPLQUOT-UHFFFAOYSA-N 0.000 claims 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
108010000817 Leuprolide Proteins 0.000 claims 2
208000028018 Lymphocytic leukaemia Diseases 0.000 claims 2
241001465754 Metazoa Species 0.000 claims 2
229930012538 Paclitaxel Natural products 0.000 claims 2
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 2
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
BORGXVOPDQUTLH-UHFFFAOYSA-N [4-(diethylamino)piperidin-1-yl]-(2-phenylquinolin-4-yl)methanone Chemical compound C1CC(N(CC)CC)CCN1C(=O)C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 BORGXVOPDQUTLH-UHFFFAOYSA-N 0.000 claims 2
PJWXRHGLTFNVLL-UHFFFAOYSA-N [4-(diethylamino)piperidin-1-yl]-(2-phenylquinolin-4-yl)methanone;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1C(=O)C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 PJWXRHGLTFNVLL-UHFFFAOYSA-N 0.000 claims 2
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
229960003272 asparaginase Drugs 0.000 claims 2
229960000397 bevacizumab Drugs 0.000 claims 2
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 2
PIQCTGMSNWUMAF-UHFFFAOYSA-N chembl522892 Chemical compound C1CN(C)CCN1C1=CC=C(NC(=N2)C=3C(NC4=CC=CC(F)=C4C=3N)=O)C2=C1 PIQCTGMSNWUMAF-UHFFFAOYSA-N 0.000 claims 2
229960003901 dacarbazine Drugs 0.000 claims 2
229960000975 daunorubicin Drugs 0.000 claims 2
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 2
102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
229960001433 erlotinib Drugs 0.000 claims 2
AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
229960005167 everolimus Drugs 0.000 claims 2
229960002074 flutamide Drugs 0.000 claims 2
MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims 2
229960005277 gemcitabine Drugs 0.000 claims 2
SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 claims 2
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 2
208000014829 head and neck neoplasm Diseases 0.000 claims 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
PSXRWZBTVAZNSF-UHFFFAOYSA-N hydron;quinoline;chloride Chemical compound Cl.N1=CC=CC2=CC=CC=C21 PSXRWZBTVAZNSF-UHFFFAOYSA-N 0.000 claims 2
KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
229960005386 ipilimumab Drugs 0.000 claims 2
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 2
229960004338 leuprorelin Drugs 0.000 claims 2
OCSMOTCMPXTDND-OUAUKWLOSA-N marimastat Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO OCSMOTCMPXTDND-OUAUKWLOSA-N 0.000 claims 2
229950008959 marimastat Drugs 0.000 claims 2
229960001786 megestrol Drugs 0.000 claims 2
201000001441 melanoma Diseases 0.000 claims 2
229960001428 mercaptopurine Drugs 0.000 claims 2
229960000350 mitotane Drugs 0.000 claims 2
125000002950 monocyclic group Chemical group 0.000 claims 2
208000025113 myeloid leukemia Diseases 0.000 claims 2
KTZBRTPLQNSXQU-UHFFFAOYSA-N n,n-diethyl-1-[(2-phenylquinolin-4-yl)methyl]piperidin-4-amine Chemical compound C1CC(N(CC)CC)CCN1CC1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 KTZBRTPLQNSXQU-UHFFFAOYSA-N 0.000 claims 2
LGWIMIAIXSDKRI-UHFFFAOYSA-N n,n-diethyl-1-[(2-phenylquinolin-4-yl)methyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1CC1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 LGWIMIAIXSDKRI-UHFFFAOYSA-N 0.000 claims 2
OXWPYKSFRXENSW-UHFFFAOYSA-N n,n-diethyl-1-[1-(2-naphthalen-2-ylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=C3C=CC=CC3=CC=2)=NC2=CC=CC=C12 OXWPYKSFRXENSW-UHFFFAOYSA-N 0.000 claims 2
ADIPKUUBQCEJIH-UHFFFAOYSA-N n,n-diethyl-1-[1-(2-naphthalen-2-ylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=C3C=CC=CC3=CC=2)=NC2=CC=CC=C12 ADIPKUUBQCEJIH-UHFFFAOYSA-N 0.000 claims 2
ZDHWTCRWZQGUIN-UHFFFAOYSA-N n,n-diethyl-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 ZDHWTCRWZQGUIN-UHFFFAOYSA-N 0.000 claims 2
KPFOWBANFFNWPR-UHFFFAOYSA-N n,n-diethyl-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C1CC(N(CC)CC)CCN1C(C)C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 KPFOWBANFFNWPR-UHFFFAOYSA-N 0.000 claims 2
FSZYSHIXKGCTCA-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-2-phenylquinolin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1NC(CC1)CCN1CC1=CC=CC=C1 FSZYSHIXKGCTCA-UHFFFAOYSA-N 0.000 claims 2
JRVUOXOOBSNYPD-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-2-phenylquinolin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1NC(CC1)CCN1CC1=CC=CC=C1 JRVUOXOOBSNYPD-UHFFFAOYSA-N 0.000 claims 2
DRLJHULBHQWFFK-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-2-phenylquinoline-4-carboxamide Chemical compound N=1C2=CC(Cl)=CC=C2C(C(=O)NC2CCN(CC=3C=CC=CC=3)CC2)=CC=1C1=CC=CC=C1 DRLJHULBHQWFFK-UHFFFAOYSA-N 0.000 claims 2
QRTRUWZLUAPMOV-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-2-phenylquinoline-4-carboxamide;hydrochloride Chemical compound Cl.N=1C2=CC(Cl)=CC=C2C(C(=O)NC2CCN(CC=3C=CC=CC=3)CC2)=CC=1C1=CC=CC=C1 QRTRUWZLUAPMOV-UHFFFAOYSA-N 0.000 claims 2
HNMAKNUALZUISG-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-n-methyl-2-phenylquinolin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1N(C)C(CC1)CCN1CC1=CC=CC=C1 HNMAKNUALZUISG-UHFFFAOYSA-N 0.000 claims 2
ZABZYTAOZDAMGB-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-7-chloro-n-methyl-2-phenylquinolin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C2C=1N(C)C(CC1)CCN1CC1=CC=CC=C1 ZABZYTAOZDAMGB-UHFFFAOYSA-N 0.000 claims 2
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
ABSNKNNIGHBHHP-UHFFFAOYSA-N n-[[1-(7-chloro-2-phenylquinolin-4-yl)piperidin-4-yl]methyl]-n-ethylethanamine Chemical compound C1CC(CN(CC)CC)CCN1C1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 ABSNKNNIGHBHHP-UHFFFAOYSA-N 0.000 claims 2
YUUKMLLFNAILPC-UHFFFAOYSA-N n-[[1-(7-chloro-2-phenylquinolin-4-yl)piperidin-4-yl]methyl]-n-ethylethanamine;hydrochloride Chemical compound Cl.C1CC(CN(CC)CC)CCN1C1=CC(C=2C=CC=CC=2)=NC2=CC(Cl)=CC=C12 YUUKMLLFNAILPC-UHFFFAOYSA-N 0.000 claims 2
NVVSGLSHDLWIBU-UHFFFAOYSA-N n-benzyl-n-(2-phenylethyl)-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N(CC1)CCC1N(CC=1C=CC=CC=1)CCC1=CC=CC=C1 NVVSGLSHDLWIBU-UHFFFAOYSA-N 0.000 claims 2
JQNOXGKAPRUXOC-UHFFFAOYSA-N n-benzyl-n-(2-phenylethyl)-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N(CC1)CCC1N(CC=1C=CC=CC=1)CCC1=CC=CC=C1 JQNOXGKAPRUXOC-UHFFFAOYSA-N 0.000 claims 2
IPKSASJDFNHVKT-UHFFFAOYSA-N n-ethyl-n-[[1-(2-phenylquinolin-4-yl)piperidin-4-yl]methyl]ethanamine Chemical compound C1CC(CN(CC)CC)CCN1C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 IPKSASJDFNHVKT-UHFFFAOYSA-N 0.000 claims 2
FABQWHKSPYLJQI-UHFFFAOYSA-N n-methyl-2-phenyl-n-[1-(1-phenylethyl)piperidin-4-yl]quinolin-4-amine Chemical compound C=1C=CC=CC=1C(C)N(CC1)CCC1N(C)C(C1=CC=CC=C1N=1)=CC=1C1=CC=CC=C1 FABQWHKSPYLJQI-UHFFFAOYSA-N 0.000 claims 2
ZGRCWUPYIZTJGC-UHFFFAOYSA-N n-methyl-2-phenyl-n-[1-(1-phenylethyl)piperidin-4-yl]quinolin-4-amine;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C)N(CC1)CCC1N(C)C(C1=CC=CC=C1N=1)=CC=1C1=CC=CC=C1 ZGRCWUPYIZTJGC-UHFFFAOYSA-N 0.000 claims 2
QGJUDWUQINMMFA-UHFFFAOYSA-N n-tert-butyl-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N1CCC(NC(C)(C)C)CC1 QGJUDWUQINMMFA-UHFFFAOYSA-N 0.000 claims 2
PNRKEYAWIOBHQC-UHFFFAOYSA-N n-tert-butyl-1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-amine;hydrochloride Chemical compound Cl.C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N1CCC(NC(C)(C)C)CC1 PNRKEYAWIOBHQC-UHFFFAOYSA-N 0.000 claims 2
HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 2
XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 claims 2
229960002653 nilutamide Drugs 0.000 claims 2
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
229960001592 paclitaxel Drugs 0.000 claims 2
229960001972 panitumumab Drugs 0.000 claims 2
HQQSBEDKMRHYME-UHFFFAOYSA-N pefloxacin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 HQQSBEDKMRHYME-UHFFFAOYSA-N 0.000 claims 2
229960001373 pegfilgrastim Drugs 0.000 claims 2
108010044644 pegfilgrastim Proteins 0.000 claims 2
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
229940002612 prodrug Drugs 0.000 claims 2
239000000651 prodrug Substances 0.000 claims 2
OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 2
OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
239000012453 solvate Substances 0.000 claims 2
125000003107 substituted aryl group Chemical group 0.000 claims 2
229960000303 topotecan Drugs 0.000 claims 2
UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
229960002066 vinorelbine Drugs 0.000 claims 2
GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 2
229960000237 vorinostat Drugs 0.000 claims 2
WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 2
BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 claims 1
PFJFPBDHCFMQPN-RGJAOAFDSA-N (1s,3s,7s,10r,11s,12s,16r)-3-[(e)-1-[2-(aminomethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(CN)=N1 PFJFPBDHCFMQPN-RGJAOAFDSA-N 0.000 claims 1
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
NECZZOFFLFZNHL-XVGZVFJZSA-N (2s)-2-amino-5-[[(2r)-3-[2-[bis[bis(2-chloroethyl)amino]-oxidophosphaniumyl]oxyethylsulfonyl]-1-[[(r)-carboxy(phenyl)methyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 NECZZOFFLFZNHL-XVGZVFJZSA-N 0.000 claims 1
MHFUWOIXNMZFIW-WNQIDUERSA-N (2s)-2-hydroxypropanoic acid;n-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Chemical compound C[C@H](O)C(O)=O.C1CN(C)CCN1C1=CC(NC2=NNC(C)=C2)=NC(SC=2C=CC(NC(=O)C3CC3)=CC=2)=N1 MHFUWOIXNMZFIW-WNQIDUERSA-N 0.000 claims 1
GTXSRFUZSLTDFX-HRCADAONSA-N (2s)-n-[(2s)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-4-methyl-2-[[(2s)-2-sulfanyl-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butanoyl]amino]pentanamide Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](S)CCN1C(=O)N(C)C(C)(C)C1=O GTXSRFUZSLTDFX-HRCADAONSA-N 0.000 claims 1
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims 1
DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims 1
DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 1
FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims 1
JNKQAHJZAUFSLB-BAWYVGMJSA-N (8s,9r,11s,13s,14s,17s)-4-chloro-11-[4-[2-(diethylamino)ethoxy]phenyl]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound C1=CC(OCCN(CC)CC)=CC=C1[C@@H]1[C@@H]2C3=CC=C(O)C(Cl)=C3CC[C@H]2[C@@H]2CC[C@H](O)[C@@]2(C)C1 JNKQAHJZAUFSLB-BAWYVGMJSA-N 0.000 claims 1
LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 1
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
BWDQBBCUWLSASG-MDZDMXLPSA-N (e)-n-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1h-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CCO)CC1=CC=C(\C=C\C(=O)NO)C=C1 BWDQBBCUWLSASG-MDZDMXLPSA-N 0.000 claims 1
SPMVMDHWKHCIDT-UHFFFAOYSA-N 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC=1C=C(C)ON=1 SPMVMDHWKHCIDT-UHFFFAOYSA-N 0.000 claims 1
102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 claims 1
VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
ROZCIVXTLACYNY-UHFFFAOYSA-N 2,3,4,5,6-pentafluoro-n-(3-fluoro-4-methoxyphenyl)benzenesulfonamide Chemical compound C1=C(F)C(OC)=CC=C1NS(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F ROZCIVXTLACYNY-UHFFFAOYSA-N 0.000 claims 1
UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
GFMMXOIFOQCCGU-UHFFFAOYSA-N 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Chemical compound C=1C=C(I)C=C(Cl)C=1NC1=C(F)C(F)=CC=C1C(=O)NOCC1CC1 GFMMXOIFOQCCGU-UHFFFAOYSA-N 0.000 claims 1
JICOGKJOQXTAIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-3-methyl-1-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]indol-5-ol Chemical compound C=1C=C(OCCN2CCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 JICOGKJOQXTAIP-UHFFFAOYSA-N 0.000 claims 1
YUFAHBUWIVNVNJ-UHFFFAOYSA-N 2-[4-(1,2-diphenylbutyl)phenoxy]-n,n-dimethylethanamine Chemical compound C=1C=CC=CC=1C(CC)C(C=1C=CC(OCCN(C)C)=CC=1)C1=CC=CC=C1 YUFAHBUWIVNVNJ-UHFFFAOYSA-N 0.000 claims 1
RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 claims 1
FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 1
AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 claims 1
DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims 1
BXKWGPLNDRYPPA-UHFFFAOYSA-N 4-[1-[1-(2-phenylquinolin-4-yl)ethyl]piperidin-4-yl]morpholine Chemical compound C=1C(C=2C=CC=CC=2)=NC2=CC=CC=C2C=1C(C)N(CC1)CCC1N1CCOCC1 BXKWGPLNDRYPPA-UHFFFAOYSA-N 0.000 claims 1
SYYMNUFXRFAELA-BTQNPOSSSA-N 4-[4-[[(1r)-1-phenylethyl]amino]-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenol;hydrobromide Chemical compound Br.N([C@H](C)C=1C=CC=CC=1)C(C=1C=2)=NC=NC=1NC=2C1=CC=C(O)C=C1 SYYMNUFXRFAELA-BTQNPOSSSA-N 0.000 claims 1
MJIALGDLOLWBRQ-MRVPVSSYSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 0.000 claims 1
HHFBDROWDBDFBR-UHFFFAOYSA-N 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC1=NC=C(CN=C(C=2C3=CC=C(Cl)C=2)C=2C(=CC=CC=2F)F)C3=N1 HHFBDROWDBDFBR-UHFFFAOYSA-N 0.000 claims 1
ZHJGWYRLJUCMRT-QGZVFWFLSA-N 5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide Chemical compound O([C@H](C)C=1C(=CC=CC=1)C(F)(F)F)C(=C(S1)C(N)=O)C=C1N(C1=C2)C=NC1=CC=C2CN1CCN(C)CC1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 0.000 claims 1
IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 claims 1
XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 1
WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 1
BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 claims 1
GBJVVSCPOBPEIT-UHFFFAOYSA-N AZT-1152 Chemical compound N=1C=NC2=CC(OCCCN(CC)CCOP(O)(O)=O)=CC=C2C=1NC(=NN1)C=C1CC(=O)NC1=CC=CC(F)=C1 GBJVVSCPOBPEIT-UHFFFAOYSA-N 0.000 claims 1
208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 claims 1
208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims 1
229940126638 Akt inhibitor Drugs 0.000 claims 1
108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 1
102400000068 Angiostatin Human genes 0.000 claims 1
108010079709 Angiostatins Proteins 0.000 claims 1
BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 1
108010024976 Asparaginase Proteins 0.000 claims 1
206010003571 Astrocytoma Diseases 0.000 claims 1
229940123877 Aurora kinase inhibitor Drugs 0.000 claims 1
MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
OLCWFLWEHWLBTO-HSZRJFAPSA-N BMS-214662 Chemical compound C=1C=CSC=1S(=O)(=O)N([C@@H](C1)CC=2C=CC=CC=2)CC2=CC(C#N)=CC=C2N1CC1=CN=CN1 OLCWFLWEHWLBTO-HSZRJFAPSA-N 0.000 claims 1
108010006654 Bleomycin Proteins 0.000 claims 1
108010037003 Buserelin Proteins 0.000 claims 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
201000009030 Carcinoma Diseases 0.000 claims 1
208000017897 Carcinoma of esophagus Diseases 0.000 claims 1
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 1
102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims 1
206010009944 Colon cancer Diseases 0.000 claims 1
MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
229930105110 Cyclosporin A Natural products 0.000 claims 1
108010036949 Cyclosporine Proteins 0.000 claims 1
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 1
108010019673 Darbepoetin alfa Proteins 0.000 claims 1
ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 1
ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 claims 1
XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 claims 1
108010079505 Endostatins Proteins 0.000 claims 1
206010014958 Eosinophilic leukaemia Diseases 0.000 claims 1
HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
108010074604 Epoetin Alfa Proteins 0.000 claims 1
QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims 1
108090000394 Erythropoietin Proteins 0.000 claims 1
102000003951 Erythropoietin Human genes 0.000 claims 1
208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
KGPGFQWBCSZGEL-ZDUSSCGKSA-N GSK690693 Chemical compound C=12N(CC)C(C=3C(=NON=3)N)=NC2=C(C#CC(C)(C)O)N=CC=1OC[C@H]1CCCNC1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 0.000 claims 1
108010069236 Goserelin Proteins 0.000 claims 1
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 claims 1
206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
108010023610 IL13-PE38 Proteins 0.000 claims 1
229940127185 IL13-PE38QQR Drugs 0.000 claims 1
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 1
JJKOTMDDZAJTGQ-DQSJHHFOSA-N Idoxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN2CCCC2)=CC=1)/C1=CC=C(I)C=C1 JJKOTMDDZAJTGQ-DQSJHHFOSA-N 0.000 claims 1
102100040018 Interferon alpha-2 Human genes 0.000 claims 1
108010079944 Interferon-alpha2b Proteins 0.000 claims 1
108010050904 Interferons Proteins 0.000 claims 1
102000014150 Interferons Human genes 0.000 claims 1
102000003815 Interleukin-11 Human genes 0.000 claims 1
108090000177 Interleukin-11 Proteins 0.000 claims 1
102000013462 Interleukin-12 Human genes 0.000 claims 1
108010065805 Interleukin-12 Proteins 0.000 claims 1
108010002350 Interleukin-2 Proteins 0.000 claims 1
102000000588 Interleukin-2 Human genes 0.000 claims 1
SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 1
208000008839 Kidney Neoplasms Diseases 0.000 claims 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
239000002067 L01XE06 - Dasatinib Substances 0.000 claims 1
239000005536 L01XE08 - Nilotinib Substances 0.000 claims 1
239000003798 L01XE11 - Pazopanib Substances 0.000 claims 1
239000002118 L01XE12 - Vandetanib Substances 0.000 claims 1
UCEQXRCJXIVODC-PMACEKPBSA-N LSM-1131 Chemical compound C1CCC2=CC=CC3=C2N1C=C3[C@@H]1C(=O)NC(=O)[C@H]1C1=CNC2=CC=CC=C12 UCEQXRCJXIVODC-PMACEKPBSA-N 0.000 claims 1
206010024305 Leukaemia monocytic Diseases 0.000 claims 1
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims 1
GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims 1
206010025323 Lymphomas Diseases 0.000 claims 1
208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 1
XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 claims 1
FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 1
108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
208000014767 Myeloproliferative disease Diseases 0.000 claims 1
201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
102000002002 Neurokinin-1 Receptors Human genes 0.000 claims 1
108010040718 Neurokinin-1 Receptors Proteins 0.000 claims 1
KRWMERLEINMZFT-UHFFFAOYSA-N O6-benzylguanine Chemical compound C=12NC=NC2=NC(N)=NC=1OCC1=CC=CC=C1 KRWMERLEINMZFT-UHFFFAOYSA-N 0.000 claims 1
108010016076 Octreotide Proteins 0.000 claims 1
101100520074 Oryza sativa subsp. japonica PIK-1 gene Proteins 0.000 claims 1
206010033128 Ovarian cancer Diseases 0.000 claims 1
206010061535 Ovarian neoplasm Diseases 0.000 claims 1
239000012661 PARP inhibitor Substances 0.000 claims 1
229940116355 PI3 kinase inhibitor Drugs 0.000 claims 1
206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 1
229920006022 Poly(L-lactide-co-glycolide)-b-poly(ethylene glycol) Polymers 0.000 claims 1
208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
206010039491 Sarcoma Diseases 0.000 claims 1
UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 claims 1
UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 claims 1
208000005718 Stomach Neoplasms Diseases 0.000 claims 1
208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
108700011582 TER 286 Proteins 0.000 claims 1
NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 1
BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
208000024313 Testicular Neoplasms Diseases 0.000 claims 1
206010057644 Testis cancer Diseases 0.000 claims 1
QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 claims 1
208000024770 Thyroid neoplasm Diseases 0.000 claims 1
IVTVGDXNLFLDRM-HNNXBMFYSA-N Tomudex Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)S1 IVTVGDXNLFLDRM-HNNXBMFYSA-N 0.000 claims 1
IWEQQRMGNVVKQW-OQKDUQJOSA-N Toremifene citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 IWEQQRMGNVVKQW-OQKDUQJOSA-N 0.000 claims 1
RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims 1
229940124674 VEGF-R inhibitor Drugs 0.000 claims 1
VEPKQEUBKLEPRA-UHFFFAOYSA-N VX-745 Chemical compound FC1=CC(F)=CC=C1SC1=NN2C=NC(=O)C(C=3C(=CC=CC=3Cl)Cl)=C2C=C1 VEPKQEUBKLEPRA-UHFFFAOYSA-N 0.000 claims 1
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
VJMAITQRABEEKP-UHFFFAOYSA-N [6-(phenylmethoxymethyl)-1,4-dioxan-2-yl]methyl acetate Chemical compound O1C(COC(=O)C)COCC1COCC1=CC=CC=C1 VJMAITQRABEEKP-UHFFFAOYSA-N 0.000 claims 1
IKWTVSLWAPBBKU-UHFFFAOYSA-N a1010_sial Chemical compound O=[As]O[As]=O IKWTVSLWAPBBKU-UHFFFAOYSA-N 0.000 claims 1
229940028652 abraxane Drugs 0.000 claims 1
229960000583 acetic acid Drugs 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 1
208000036676 acute undifferentiated leukemia Diseases 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
201000006966 adult T-cell leukemia Diseases 0.000 claims 1
108010081667 aflibercept Proteins 0.000 claims 1
MLFKVJCWGUZWNV-REOHCLBHSA-N alanosine Chemical compound OC(=O)[C@@H](N)CN(O)N=O MLFKVJCWGUZWNV-REOHCLBHSA-N 0.000 claims 1
229960000548 alemtuzumab Drugs 0.000 claims 1
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims 1
229960004538 alprazolam Drugs 0.000 claims 1
229960001097 amifostine Drugs 0.000 claims 1
JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 claims 1
ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 claims 1
229960003437 aminoglutethimide Drugs 0.000 claims 1
229960002550 amrubicin Drugs 0.000 claims 1
VJZITPJGSQKZMX-XDPRQOKASA-N amrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C(O)=C21)(N)C(=O)C)[C@H]1C[C@H](O)[C@H](O)CO1 VJZITPJGSQKZMX-XDPRQOKASA-N 0.000 claims 1
229960001220 amsacrine Drugs 0.000 claims 1
XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 claims 1
229960001694 anagrelide Drugs 0.000 claims 1
OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 claims 1
229960002932 anastrozole Drugs 0.000 claims 1
YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
239000003098 androgen Substances 0.000 claims 1
ATALOFNDEOCMKK-OITMNORJSA-N aprepitant Chemical compound O([C@@H]([C@@H]1C=2C=CC(F)=CC=2)O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)CCN1CC1=NNC(=O)N1 ATALOFNDEOCMKK-OITMNORJSA-N 0.000 claims 1
229960001372 aprepitant Drugs 0.000 claims 1
229960002594 arsenic trioxide Drugs 0.000 claims 1
GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 claims 1
229950005529 arzoxifene Drugs 0.000 claims 1
MCGDSOGUHLTADD-UHFFFAOYSA-N arzoxifene Chemical compound C1=CC(OC)=CC=C1C1=C(OC=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 MCGDSOGUHLTADD-UHFFFAOYSA-N 0.000 claims 1
FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 1
239000003719 aurora kinase inhibitor Substances 0.000 claims 1
229960003005 axitinib Drugs 0.000 claims 1
229960002756 azacitidine Drugs 0.000 claims 1
VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
244000052616 bacterial pathogen Species 0.000 claims 1
210000003651 basophil Anatomy 0.000 claims 1
229950001429 batabulin Drugs 0.000 claims 1
229960000817 bazedoxifene Drugs 0.000 claims 1
UCJGJABZCDBEDK-UHFFFAOYSA-N bazedoxifene Chemical compound C=1C=C(OCCN2CCCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 UCJGJABZCDBEDK-UHFFFAOYSA-N 0.000 claims 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
229960002938 bexarotene Drugs 0.000 claims 1
229960000997 bicalutamide Drugs 0.000 claims 1
229920000249 biocompatible polymer Polymers 0.000 claims 1
229960001561 bleomycin Drugs 0.000 claims 1
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
229960002719 buserelin Drugs 0.000 claims 1
CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 1
229960002092 busulfan Drugs 0.000 claims 1
229960005084 calcitriol Drugs 0.000 claims 1
235000020964 calcitriol Nutrition 0.000 claims 1
239000011612 calcitriol Substances 0.000 claims 1
229940127093 camptothecin Drugs 0.000 claims 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
229950000772 canfosfamide Drugs 0.000 claims 1
229960004117 capecitabine Drugs 0.000 claims 1
229960004562 carboplatin Drugs 0.000 claims 1
229960005243 carmustine Drugs 0.000 claims 1
XGGTZCKQRWXCHW-WMTVXVAQSA-N casopitant Chemical compound C1([C@H]2C[C@H](CCN2C(=O)N(C)[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N2CCN(CC2)C(C)=O)=CC=C(F)C=C1C XGGTZCKQRWXCHW-WMTVXVAQSA-N 0.000 claims 1
229960003778 casopitant Drugs 0.000 claims 1
229960002412 cediranib Drugs 0.000 claims 1
201000007455 central nervous system cancer Diseases 0.000 claims 1
208000025997 central nervous system neoplasm Diseases 0.000 claims 1
229960005395 cetuximab Drugs 0.000 claims 1
ZXFCRFYULUUSDW-OWXODZSWSA-N chembl2104970 Chemical compound C([C@H]1C2)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2CC(O)=C(C(=O)N)C1=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 claims 1
UKTAZPQNNNJVKR-KJGYPYNMSA-N chembl2368925 Chemical compound C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 UKTAZPQNNNJVKR-KJGYPYNMSA-N 0.000 claims 1
JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
229960004630 chlorambucil Drugs 0.000 claims 1
229960003677 chloroquine Drugs 0.000 claims 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
208000021668 chronic eosinophilic leukemia Diseases 0.000 claims 1
229960001265 ciclosporin Drugs 0.000 claims 1
229950009003 cilengitide Drugs 0.000 claims 1
AMLYAMJWYAIXIA-VWNVYAMZSA-N cilengitide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1=CC=CC=C1 AMLYAMJWYAIXIA-VWNVYAMZSA-N 0.000 claims 1
230000001886 ciliary effect Effects 0.000 claims 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
229960004316 cisplatin Drugs 0.000 claims 1
229960002436 cladribine Drugs 0.000 claims 1
ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 1
229960002286 clodronic acid Drugs 0.000 claims 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
208000029742 colonic neoplasm Diseases 0.000 claims 1
229940035811 conjugated estrogen Drugs 0.000 claims 1
229920001577 copolymer Polymers 0.000 claims 1
229960004544 cortisone Drugs 0.000 claims 1
208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims 1
229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims 1
229930182912 cyclosporin Natural products 0.000 claims 1
DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 claims 1
229960003843 cyproterone Drugs 0.000 claims 1
229960005029 darbepoetin alfa Drugs 0.000 claims 1
229960002448 dasatinib Drugs 0.000 claims 1
229960003603 decitabine Drugs 0.000 claims 1
229960002923 denileukin diftitox Drugs 0.000 claims 1
108010017271 denileukin diftitox Proteins 0.000 claims 1
229960000605 dexrazoxane Drugs 0.000 claims 1
NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 1
230000004069 differentiation Effects 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
229960000520 diphenhydramine Drugs 0.000 claims 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
229960003668 docetaxel Drugs 0.000 claims 1
229960003413 dolasetron Drugs 0.000 claims 1
ZWAOHEXOSAUJHY-ZIYNGMLESA-N doxifluridine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ZWAOHEXOSAUJHY-ZIYNGMLESA-N 0.000 claims 1
229950004203 droloxifene Drugs 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
229960001904 epirubicin Drugs 0.000 claims 1
229960003388 epoetin alfa Drugs 0.000 claims 1
HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims 1
QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims 1
QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 claims 1
229940082789 erbitux Drugs 0.000 claims 1
229940105423 erythropoietin Drugs 0.000 claims 1
229960005309 estradiol Drugs 0.000 claims 1
229930182833 estradiol Natural products 0.000 claims 1
229960001842 estramustine Drugs 0.000 claims 1
FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims 1
229940011871 estrogen Drugs 0.000 claims 1
239000000262 estrogen Substances 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
229940009626 etidronate Drugs 0.000 claims 1
229960005420 etoposide Drugs 0.000 claims 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
229960000255 exemestane Drugs 0.000 claims 1
DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 1
229960004039 finasteride Drugs 0.000 claims 1
229960000961 floxuridine Drugs 0.000 claims 1
ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims 1
229960000390 fludarabine Drugs 0.000 claims 1
GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 claims 1
229960002011 fludrocortisone Drugs 0.000 claims 1
229960002949 fluorouracil Drugs 0.000 claims 1
229960001751 fluoxymesterone Drugs 0.000 claims 1
YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 claims 1
210000001650 focal adhesion Anatomy 0.000 claims 1
229960002258 fulvestrant Drugs 0.000 claims 1
229960002584 gefitinib Drugs 0.000 claims 1
XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
229960000578 gemtuzumab Drugs 0.000 claims 1
229940080856 gleevec Drugs 0.000 claims 1
229960002989 glutamic acid Drugs 0.000 claims 1
229960003690 goserelin acetate Drugs 0.000 claims 1
229950005277 gossypol Drugs 0.000 claims 1
229930000755 gossypol Natural products 0.000 claims 1
229960003727 granisetron Drugs 0.000 claims 1
MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims 1
229960003878 haloperidol Drugs 0.000 claims 1
210000003128 head Anatomy 0.000 claims 1
125000005842 heteroatom Chemical group 0.000 claims 1
125000000623 heterocyclic group Chemical group 0.000 claims 1
125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
229960002193 histrelin Drugs 0.000 claims 1
108700020746 histrelin Proteins 0.000 claims 1
HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 claims 1
229960000890 hydrocortisone Drugs 0.000 claims 1
229960004171 hydroxychloroquine Drugs 0.000 claims 1
XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 1
229950000801 hydroxyprogesterone caproate Drugs 0.000 claims 1
229960000930 hydroxyzine Drugs 0.000 claims 1
ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 claims 1
229960001001 ibritumomab tiuxetan Drugs 0.000 claims 1
229960000908 idarubicin Drugs 0.000 claims 1
229950002248 idoxifene Drugs 0.000 claims 1
229960001101 ifosfamide Drugs 0.000 claims 1
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
229960002411 imatinib Drugs 0.000 claims 1
230000002401 inhibitory effect Effects 0.000 claims 1
229940079322 interferon Drugs 0.000 claims 1
229940074383 interleukin-11 Drugs 0.000 claims 1
229940117681 interleukin-12 Drugs 0.000 claims 1
229960005280 isotretinoin Drugs 0.000 claims 1
229960002014 ixabepilone Drugs 0.000 claims 1
FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 claims 1
229960004125 ketoconazole Drugs 0.000 claims 1
210000003734 kidney Anatomy 0.000 claims 1
229940043355 kinase inhibitor Drugs 0.000 claims 1
BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
GXESHMAMLJKROZ-IAPPQJPRSA-N lasofoxifene Chemical compound C1([C@@H]2[C@@H](C3=CC=C(C=C3CC2)O)C=2C=CC(OCCN3CCCC3)=CC=2)=CC=CC=C1 GXESHMAMLJKROZ-IAPPQJPRSA-N 0.000 claims 1
229960002367 lasofoxifene Drugs 0.000 claims 1
229960004942 lenalidomide Drugs 0.000 claims 1
GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
229960003881 letrozole Drugs 0.000 claims 1
HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
230000000610 leukopenic effect Effects 0.000 claims 1
229960001614 levamisole Drugs 0.000 claims 1
210000004185 liver Anatomy 0.000 claims 1
208000014018 liver neoplasm Diseases 0.000 claims 1
229960002247 lomustine Drugs 0.000 claims 1
229960004391 lorazepam Drugs 0.000 claims 1
210000004072 lung Anatomy 0.000 claims 1
208000020816 lung neoplasm Diseases 0.000 claims 1
230000002132 lysosomal effect Effects 0.000 claims 1
229940124302 mTOR inhibitor Drugs 0.000 claims 1
208000026037 malignant tumor of neck Diseases 0.000 claims 1
239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
229960004961 mechlorethamine Drugs 0.000 claims 1
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
229960002985 medroxyprogesterone acetate Drugs 0.000 claims 1
229960004296 megestrol acetate Drugs 0.000 claims 1
229960001924 melphalan Drugs 0.000 claims 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
229960004635 mesna Drugs 0.000 claims 1
229960000485 methotrexate Drugs 0.000 claims 1
229960004584 methylprednisolone Drugs 0.000 claims 1
229960004503 metoclopramide Drugs 0.000 claims 1
TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims 1
CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 claims 1
229960001156 mitoxantrone Drugs 0.000 claims 1
KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
239000003607 modifier Substances 0.000 claims 1
201000006894 monocytic leukemia Diseases 0.000 claims 1
ZTFBIUXIQYRUNT-MDWZMJQESA-N mubritinib Chemical compound C1=CC(C(F)(F)F)=CC=C1\C=C\C1=NC(COC=2C=CC(CCCCN3N=NC=C3)=CC=2)=CO1 ZTFBIUXIQYRUNT-MDWZMJQESA-N 0.000 claims 1
CFZLYZOJEFWDNE-UHFFFAOYSA-N n,n-diethyl-1-[2-(2-phenylquinolin-4-yl)propan-2-yl]piperidin-4-amine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1CC(N(CC)CC)CCN1C(C)(C)C1=CC(C=2C=CC=CC=2)=NC2=CC=CC=C12 CFZLYZOJEFWDNE-UHFFFAOYSA-N 0.000 claims 1
BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 claims 1
210000001989 nasopharynx Anatomy 0.000 claims 1
210000003739 neck Anatomy 0.000 claims 1
229950008835 neratinib Drugs 0.000 claims 1
ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 claims 1
229960005163 netupitant Drugs 0.000 claims 1
WAXQNWCZJDTGBU-UHFFFAOYSA-N netupitant Chemical compound C=1N=C(N2CCN(C)CC2)C=C(C=2C(=CC=CC=2)C)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 WAXQNWCZJDTGBU-UHFFFAOYSA-N 0.000 claims 1
210000000440 neutrophil Anatomy 0.000 claims 1
229960001346 nilotinib Drugs 0.000 claims 1
229960002700 octreotide Drugs 0.000 claims 1
229960005343 ondansetron Drugs 0.000 claims 1
229950007283 oregovomab Drugs 0.000 claims 1
210000001672 ovary Anatomy 0.000 claims 1
DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
229960001756 oxaliplatin Drugs 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
229960002131 palonosetron Drugs 0.000 claims 1
CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 claims 1
WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 1
229960003978 pamidronic acid Drugs 0.000 claims 1
210000000496 pancreas Anatomy 0.000 claims 1
229960000639 pazopanib Drugs 0.000 claims 1
CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 1
WVUNYSQLFKLYNI-AATRIKPKSA-N pelitinib Chemical compound C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC1=CC=C(F)C(Cl)=C1 WVUNYSQLFKLYNI-AATRIKPKSA-N 0.000 claims 1
229960005079 pemetrexed Drugs 0.000 claims 1
QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 1
229960002340 pentostatin Drugs 0.000 claims 1
FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 claims 1
239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 1
239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
229960003171 plicamycin Drugs 0.000 claims 1
229920000642 polymer Polymers 0.000 claims 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
229960004618 prednisone Drugs 0.000 claims 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
229960000624 procarbazine Drugs 0.000 claims 1
CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 claims 1
229960003111 prochlorperazine Drugs 0.000 claims 1
238000011321 prophylaxis Methods 0.000 claims 1
210000002307 prostate Anatomy 0.000 claims 1
201000001514 prostate carcinoma Diseases 0.000 claims 1
239000003197 protein kinase B inhibitor Substances 0.000 claims 1
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
NSSKYHSLRMEFMR-UHFFFAOYSA-N quinoline;2,2,2-trifluoroacetic acid Chemical compound [O-]C(=O)C(F)(F)F.[NH+]1=CC=CC2=CC=CC=C21 NSSKYHSLRMEFMR-UHFFFAOYSA-N 0.000 claims 1
229960004622 raloxifene Drugs 0.000 claims 1
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
229960004432 raltitrexed Drugs 0.000 claims 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
BMKDZUISNHGIBY-UHFFFAOYSA-N razoxane Chemical compound C1C(=O)NC(=O)CN1C(C)CN1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-UHFFFAOYSA-N 0.000 claims 1
229960000460 razoxane Drugs 0.000 claims 1
229940044551 receptor antagonist Drugs 0.000 claims 1
239000002464 receptor antagonist Substances 0.000 claims 1
208000028466 reproductive system neoplasm Diseases 0.000 claims 1
229930002330 retinoic acid Natural products 0.000 claims 1
229960004641 rituximab Drugs 0.000 claims 1
229960003452 romidepsin Drugs 0.000 claims 1
108010091666 romidepsin Proteins 0.000 claims 1
229950003647 semaxanib Drugs 0.000 claims 1
230000011664 signaling Effects 0.000 claims 1
229960002930 sirolimus Drugs 0.000 claims 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
229960003787 sorafenib Drugs 0.000 claims 1
229960002256 spironolactone Drugs 0.000 claims 1
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 1
229950001248 squalamine Drugs 0.000 claims 1
210000000130 stem cell Anatomy 0.000 claims 1
210000002784 stomach Anatomy 0.000 claims 1
201000000498 stomach carcinoma Diseases 0.000 claims 1
229960001052 streptozocin Drugs 0.000 claims 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
229940006509 strontium-89 Drugs 0.000 claims 1
CIOAGBVUUVVLOB-OUBTZVSYSA-N strontium-89 Chemical compound [89Sr] CIOAGBVUUVVLOB-OUBTZVSYSA-N 0.000 claims 1
125000004426 substituted alkynyl group Chemical group 0.000 claims 1
229910052717 sulfur Inorganic materials 0.000 claims 1
WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
229960001603 tamoxifen Drugs 0.000 claims 1
229960004964 temozolomide Drugs 0.000 claims 1
229960000235 temsirolimus Drugs 0.000 claims 1
QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
229960001278 teniposide Drugs 0.000 claims 1
NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims 1
201000003120 testicular cancer Diseases 0.000 claims 1
229960003604 testosterone Drugs 0.000 claims 1
229960003433 thalidomide Drugs 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1
201000002510 thyroid cancer Diseases 0.000 claims 1
229960003087 tioguanine Drugs 0.000 claims 1
MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 claims 1
PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 claims 1
229950009158 tipifarnib Drugs 0.000 claims 1
229950005976 tivantinib Drugs 0.000 claims 1
229960004167 toremifene citrate Drugs 0.000 claims 1
229960005267 tositumomab Drugs 0.000 claims 1
PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 claims 1
229960000977 trabectedin Drugs 0.000 claims 1
229960000575 trastuzumab Drugs 0.000 claims 1
229960001727 tretinoin Drugs 0.000 claims 1
RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Natural products NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 claims 1
229960003688 tropisetron Drugs 0.000 claims 1
UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 claims 1
229960001055 uracil mustard Drugs 0.000 claims 1
229960005486 vaccine Drugs 0.000 claims 1
MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 1
229960000604 valproic acid Drugs 0.000 claims 1
229960000653 valrubicin Drugs 0.000 claims 1
ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 claims 1
229960000241 vandetanib Drugs 0.000 claims 1
UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims 1
LLDWLPRYLVPDTG-UHFFFAOYSA-N vatalanib succinate Chemical compound OC(=O)CCC(O)=O.C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 LLDWLPRYLVPDTG-UHFFFAOYSA-N 0.000 claims 1
229960003862 vemurafenib Drugs 0.000 claims 1
GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 1
229960003048 vinblastine Drugs 0.000 claims 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
229960004528 vincristine Drugs 0.000 claims 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 claims 1
QDLHCMPXEPAAMD-UHFFFAOYSA-N wortmannin Natural products COCC1OC(=O)C2=COC(C3=O)=C2C1(C)C1=C3C2CCC(=O)C2(C)CC1OC(C)=O QDLHCMPXEPAAMD-UHFFFAOYSA-N 0.000 claims 1
229960004276 zoledronic acid Drugs 0.000 claims 1
XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 1
229950009819 zotarolimus Drugs 0.000 claims 1
CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 1

JP2016503776A 2013-03-18 2014-03-13 新規抗がん剤としてのキノリン誘導体 Pending JP2016519091A (ja)