JP2016518827A5 - - Google Patents
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- JP2016518827A5 JP2016518827A5 JP2016503572A JP2016503572A JP2016518827A5 JP 2016518827 A5 JP2016518827 A5 JP 2016518827A5 JP 2016503572 A JP2016503572 A JP 2016503572A JP 2016503572 A JP2016503572 A JP 2016503572A JP 2016518827 A5 JP2016518827 A5 JP 2016518827A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- cell
- collection container
- oxyethylene
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 35
- 239000012472 biological sample Substances 0.000 claims description 25
- -1 poly (oxyethylene) Polymers 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 24
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 18
- 229940123169 Caspase inhibitor Drugs 0.000 claims description 14
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 10
- 239000003146 anticoagulant agent Substances 0.000 claims description 10
- 229940127219 anticoagulant drug Drugs 0.000 claims description 10
- 239000000523 sample Substances 0.000 claims description 10
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000000158 apoptosis inhibitor Substances 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 6
- MBHINSULENHCMF-UHFFFAOYSA-N n,n-dimethylpropanamide Chemical compound CCC(=O)N(C)C MBHINSULENHCMF-UHFFFAOYSA-N 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 238000011109 contamination Methods 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 125000003748 selenium group Chemical group *[Se]* 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 239000003440 toxic substance Substances 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- OOBJCYKITXPCNS-REWPJTCUSA-N (3s)-5-(2,6-difluorophenoxy)-3-[[(2s)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid Chemical group O=C([C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)C=1N=C2C=CC=CC2=CC=1)C(C)C)COC1=C(F)C=CC=C1F OOBJCYKITXPCNS-REWPJTCUSA-N 0.000 claims description 3
- 229940127255 pan-caspase inhibitor Drugs 0.000 claims description 3
- 206010003445 Ascites Diseases 0.000 claims description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 claims description 2
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 206010048629 Wound secretion Diseases 0.000 claims description 2
- MIFGOLAMNLSLGH-QOKNQOGYSA-N Z-Val-Ala-Asp(OMe)-CH2F Chemical compound COC(=O)C[C@@H](C(=O)CF)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 MIFGOLAMNLSLGH-QOKNQOGYSA-N 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 210000003103 bodily secretion Anatomy 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 230000006037 cell lysis Effects 0.000 claims description 2
- 210000003756 cervix mucus Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 230000029142 excretion Effects 0.000 claims description 2
- 210000003608 fece Anatomy 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 210000004880 lymph fluid Anatomy 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 229920002866 paraformaldehyde Polymers 0.000 claims description 2
- 231100000614 poison Toxicity 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 1
- 0 C**N(*)C(*C)=* Chemical compound C**N(*)C(*C)=* 0.000 description 4
- 238000005057 refrigeration Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159834 | 2013-03-18 | ||
| EP13159834.4 | 2013-03-18 | ||
| EP13180086 | 2013-08-12 | ||
| EP13180086.4 | 2013-08-12 | ||
| PCT/EP2014/000726 WO2014146782A1 (en) | 2013-03-18 | 2014-03-18 | Stabilization and isolation of extracellular nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016518827A JP2016518827A (ja) | 2016-06-30 |
| JP2016518827A5 true JP2016518827A5 (cg-RX-API-DMAC7.html) | 2017-02-16 |
Family
ID=50434155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
| JP2016503572A Pending JP2016518827A (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503570A Active JP6407248B2 (ja) | 2013-03-18 | 2014-03-18 | 細胞外核酸の安定化および単離 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20160281133A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2976425B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6407248B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105164258B (cg-RX-API-DMAC7.html) |
| WO (2) | WO2014146782A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2761000B1 (en) | 2011-09-26 | 2016-03-16 | PreAnalytiX GmbH | Stabilisation and isolation of extracellular nucleic acids |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP3401406B1 (en) | 2011-09-26 | 2023-11-29 | PreAnalytiX GmbH | Stabilisation and isolation of extracellular nucleic acids |
| US20150225712A1 (en) * | 2012-08-21 | 2015-08-13 | Qiagen Gmbh | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| CN104755628B (zh) | 2012-09-25 | 2019-03-01 | 凯杰有限公司 | 生物样品的稳定化 |
| CA2886389A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Methods for dna and rna extraction from fixed paraffin-embedded tissue samples |
| JP6381628B2 (ja) * | 2013-03-18 | 2018-08-29 | キアゲン ゲーエムベーハー | 生物試料の安定化 |
| CN105164258B (zh) | 2013-03-18 | 2021-05-18 | 凯杰有限公司 | 细胞外核酸的稳定化和分离 |
| CN106132200B (zh) | 2014-03-18 | 2020-10-30 | 凯杰有限公司 | 胞外核酸的固定和分离 |
| EP3325647B1 (en) * | 2015-07-24 | 2020-02-19 | Cepheid | Compositions and methods for dna and rna extraction from tissue samples |
| WO2017085321A1 (en) * | 2015-11-20 | 2017-05-26 | Qiagen Gmbh | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| CN109311930B (zh) * | 2016-03-31 | 2023-02-24 | 伯克利之光生命科技公司 | 核酸稳定试剂、试剂盒及其使用方法 |
| CA3025569A1 (en) | 2016-05-27 | 2017-11-30 | Norgen Biotek Corp. | Preservation of cell-free nucleic acids in biological samples |
| AU2017313138B2 (en) | 2016-08-17 | 2024-01-04 | The Regents Of The University Of California | A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free DNA (cfDNA) assay |
| US10870891B2 (en) | 2017-01-05 | 2020-12-22 | Biodesix, Inc. | Diagnostic test system for specific, sensitive and reproducible detection of circulating nucleic acids in whole blood |
| WO2019025387A1 (de) * | 2017-08-02 | 2019-02-07 | Sarstedt Ag & Co. Kg | Verfahren und zusammensetzung zur stabilisierung zellfreier nukleinsäuren und zellen |
| CN118557354A (zh) | 2019-01-04 | 2024-08-30 | 普瑞阿那利提克斯有限公司 | 尿液稳定化 |
| WO2021058692A1 (en) | 2019-09-24 | 2021-04-01 | Qiagen Gmbh | Multimodal analysis of stabilized cell-containing bodily fluid samples |
| CA3180092A1 (en) * | 2020-05-29 | 2021-12-02 | Robert B. Darnell | Method and system for rna isolation from self-collected and small volume samples |
| JP7635480B2 (ja) * | 2020-11-27 | 2025-02-26 | 大王製紙株式会社 | Ｒｆｉｄタグ、採血管、及びアンテナ |
| WO2022133159A1 (en) | 2020-12-17 | 2022-06-23 | Nephrosant, Inc. | Kits for stabilization of urine samples |
| US20250235405A1 (en) | 2021-11-19 | 2025-07-24 | Branca Bunus Limited | A composition comprising a therapeutically active agent packaged within a drug delivery vehicle |
| JP7586593B2 (ja) * | 2022-09-29 | 2024-11-19 | 積水メディカル株式会社 | 血液保存用組成物及び血液採取容器 |
| EP4356731A1 (en) | 2022-10-19 | 2024-04-24 | Olga Alekseevna Gra | Medium and device for collecting, storing and transporting biological samples, as well as their use for the stabilization of extracellular nucleic acids |
| EP4477751A1 (en) | 2023-06-16 | 2024-12-18 | QIAGEN GmbH | Body fluid stabilization and processing |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3389133A (en) * | 1966-08-10 | 1968-06-18 | Schwarz Biores Inc | Process for isolating and purifying soluble ribonucleic acid |
| US3903179A (en) | 1973-10-15 | 1975-09-02 | Gulf Research Development Co | Method for preparing nitrocyclopropane from 3-chloro-1-nitropropane |
| JPS6083581A (ja) * | 1983-10-13 | 1985-05-11 | Hideaki Yamada | シユ−ドモナス属細菌の培養法 |
| US4938961A (en) | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5459073A (en) | 1991-05-08 | 1995-10-17 | Streck Laboratories, Inc. | Method and composition for preserving antigens and process for utilizing cytological material produced by same |
| US5460797A (en) | 1991-05-08 | 1995-10-24 | Streck Laboratories, Inc. | Method for fixing tissues and cells for analysis using oxazolidine compounds |
| GB9215002D0 (en) * | 1992-07-15 | 1992-08-26 | Univ Singapore | Method of fixing biological tissue |
| EP1146049B1 (de) | 1994-02-11 | 2005-08-17 | Qiagen GmbH | Verfahren zur Trennung von Doppelstrang/Einzelstrangnukleinsäurestrukturen |
| US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| CA2208974C (en) | 1994-12-29 | 2007-03-27 | Brookfield Engineering Laboratories, Inc. | Support system with radially rigid wire suspension |
| US6673364B1 (en) | 1995-06-07 | 2004-01-06 | The University Of British Columbia | Liposome having an exchangeable component |
| US20050158699A1 (en) | 1995-06-07 | 2005-07-21 | Kadkade Prakash G. | Cryopreservation of plant cells |
| CA2233868A1 (en) * | 1995-10-06 | 1997-04-10 | E.I. Du Pont De Nemours And Company | Nucleic acid fragments encoding stereospecific nitrile hydratase and amidase enzymes and recombinant microorganisms expressing those enzymes useful for the production of chiral amides and acides |
| ATE284891T1 (de) | 1996-02-14 | 2005-01-15 | Biomerieux Bv | Isolierung von einzelsträngigen nukleinsäuren |
| US6156504A (en) | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| PT938320E (pt) | 1996-03-26 | 2010-09-22 | Michael S Kopreski | Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro |
| US6077232A (en) | 1996-12-27 | 2000-06-20 | Sherwood Services Ag | Anticoagulant composition |
| WO1998041651A1 (en) | 1997-03-18 | 1998-09-24 | Hsc Research & Development Limited Partnership | Method for preparing chromatin |
| DE19726362A1 (de) | 1997-06-21 | 1998-12-24 | Schaeffler Waelzlager Ohg | Vorrichtung zum Verändern der Steuerzeiten von Gaswechselventilen einer Brennkraftmaschine |
| US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6534262B1 (en) | 1998-05-14 | 2003-03-18 | Whitehead Institute For Biomedical Research | Solid phase technique for selectively isolating nucleic acids |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| JP2000187033A (ja) * | 1998-12-21 | 2000-07-04 | Wako Pure Chem Ind Ltd | 細胞染色液 |
| US6407107B1 (en) * | 1999-05-28 | 2002-06-18 | The Board Of Trustees Of The Unversity Of Arkansas | Derivatives of butyric acid and uses thereof |
| US6379930B1 (en) | 1999-07-30 | 2002-04-30 | Applied Gene Technologies, Inc. | Stabilization of nucleic acid amplification cocktails |
| US6492103B1 (en) | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| DE10006662A1 (de) | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| EA005977B1 (ru) | 2000-03-23 | 2005-08-25 | Клиарант, Инк. | Способы стерилизации биологических материалов |
| AU2001257117A1 (en) * | 2000-04-18 | 2001-10-30 | Tularik, Inc. | Sitosterolemia susceptibility gene (ssg): compositions and methods of use |
| DE10031236A1 (de) | 2000-06-27 | 2002-01-10 | Qiagen Gmbh | Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien |
| US6602718B1 (en) | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| CN1596265A (zh) * | 2001-08-23 | 2005-03-16 | 免疫公司 | 循环肿瘤细胞、片段和碎片的分析 |
| EP1482962A4 (en) * | 2002-02-15 | 2009-12-23 | Sloan Kettering Inst Cancer | METHOD OF TREATING THIOREDOXIN-MEDIATED DISEASES (TRX) |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| AU2002367863A1 (en) | 2002-04-10 | 2003-10-27 | Clearant, Inc. | Methods for sterilizing biological materials |
| CA2484628A1 (en) | 2002-05-07 | 2003-11-20 | Becton, Dickinson And Company | Collection assembly |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040054160A1 (en) | 2002-09-16 | 2004-03-18 | Santona Pal | Nucleic-acid ink compositions for arraying onto a solid support |
| CA2501196A1 (en) | 2002-10-10 | 2004-04-22 | Becton, Dickinson And Company | Sample collection system with caspase inhibitor |
| US20040167165A1 (en) * | 2003-01-16 | 2004-08-26 | Geetha Shankar | Methods of treating conditions associated with an Edg-7 receptor |
| US7601491B2 (en) * | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| US7250270B2 (en) | 2003-06-13 | 2007-07-31 | Ambion, Inc. | Methods and compositions for preparing tissue samples for RNA extraction |
| JP2007527412A (ja) * | 2003-10-24 | 2007-09-27 | エグゼリクシス， インコーポレイテッド | Ｔａｏキナーゼモジュレーターおよび使用方法 |
| US7270799B2 (en) | 2004-01-15 | 2007-09-18 | Nst Neurosurvival Technologies Ltd. | Perturbed membrane-binding compounds and methods of using the same |
| EP1730304B1 (en) | 2004-02-20 | 2013-01-02 | The Regents of the University of California | Methods for salivary mrna profiling. |
| RU2006134341A (ru) * | 2004-02-28 | 2008-04-10 | Чан-Нин ДжВАН Чан-Нин Дж. ВАН (US). (US) | Комплексы нуклеиновых кислот |
| US20080176209A1 (en) | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| EP1758937B1 (en) | 2004-05-24 | 2009-09-02 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
| AU2005271831A1 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| US7086126B2 (en) * | 2004-07-30 | 2006-08-08 | Speaks, Inc. | Elastic band with snap-buckles for holding garment waistband |
| FR2883003B1 (fr) * | 2005-03-14 | 2008-04-11 | Aldivia Sa | Nouveaux antioxydants a base d'especes d'anacardiacees, plus particulierement de sclerocarya birrea, leurs procedes d'obtention et leurs applications |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| AU2011253662A1 (en) | 2005-11-30 | 2011-12-22 | Massachusetts Institute Of Technology | Pathogen-detecting cell preservation systems |
| EP1804045B1 (de) | 2005-12-30 | 2014-03-12 | QIAGEN GmbH | Ein Verfahren und ein Kit zur Behandlung einer biologischen Probe |
| CA2635978A1 (en) | 2006-01-04 | 2007-07-12 | Do-Coop Technologies Ltd. | Solid-fluid composition |
| ATE492629T1 (de) | 2006-01-20 | 2011-01-15 | Reneuron Inc | Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur |
| US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| GB0626021D0 (en) | 2006-12-29 | 2007-02-07 | Insense Ltd | The stabilisation of proteins |
| US7828887B2 (en) | 2007-04-23 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Dye-based ink formulations |
| JP5311760B2 (ja) | 2007-05-25 | 2013-10-09 | 雪印メグミルク株式会社 | 美白剤 |
| DE102007025277A1 (de) | 2007-05-31 | 2008-12-04 | Qiagen Gmbh | Verfahren zur Stabilisierung einer biologischen Probe |
| EP2027922A1 (de) | 2007-08-02 | 2009-02-25 | Qiagen GmbH | Verfahren und Vorrichtung für das Fixieren/Stabilisieren einer Probe |
| US20100285468A1 (en) | 2007-09-24 | 2010-11-11 | Allelogic Biosciences Corporation | Detection and/or quantification of nucleic acids |
| EP2259798B1 (en) * | 2008-03-05 | 2013-12-11 | Baxter International Inc. | Surface-modified particles and methods for targeted drug delivery |
| US20100137575A1 (en) | 2008-12-03 | 2010-06-03 | Connolly D Michael | Universal biological sample processing |
| US11634747B2 (en) * | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| NO2398912T3 (cg-RX-API-DMAC7.html) | 2009-02-18 | 2018-02-10 | ||
| WO2010129577A2 (en) | 2009-05-04 | 2010-11-11 | Intergrated Nano-Technologies, Inc. | Method for sample preparation |
| US20150056604A1 (en) | 2009-06-15 | 2015-02-26 | Biovec Transfusion, Llc | Compositions and methods for preserving platelet function |
| US20110027771A1 (en) | 2009-07-31 | 2011-02-03 | Artemis Health, Inc. | Methods and compositions for cell stabilization |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US8039613B2 (en) * | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| CA2776723C (en) | 2009-10-29 | 2018-09-25 | Ascendis Pharma As | Sterilization of biodegradable hydrogels |
| ES2821500T3 (es) | 2009-11-06 | 2021-04-26 | Univ Leland Stanford Junior | Diagnóstico no invasivo del rechazo de injertos en pacientes con trasplante de órganos |
| CA2780536C (en) | 2009-11-09 | 2018-01-02 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
| JP5773347B2 (ja) | 2009-11-27 | 2015-09-02 | 国立大学法人 千葉大学 | 血液細胞の凍結保存剤 |
| US8093427B2 (en) * | 2010-06-09 | 2012-01-10 | National Tsing Hua University | Construction and screening of solution-phase derived library of fenbufen and ethacrynic acid |
| US20130095473A1 (en) | 2010-06-14 | 2013-04-18 | Qiagen Gmbh | Method for determination of target cells or tissue for extraction of biomolecules from fixed biological samples |
| FR2964567B1 (fr) | 2010-09-14 | 2013-03-15 | Lvmh Rech | Extrait d'orchidee |
| ES2829374T3 (es) | 2011-05-03 | 2021-05-31 | Agios Pharmaceuticals Inc | Uso de activadores de piruvato quinasa para aumentar la vida útil de los glóbulos rojos de la sangre y tratar la anemia |
| EP3401406B1 (en) * | 2011-09-26 | 2023-11-29 | PreAnalytiX GmbH | Stabilisation and isolation of extracellular nucleic acids |
| WO2013045434A1 (en) | 2011-09-26 | 2013-04-04 | Qiagen Gmbh | Methods for separating nucleic acids by size |
| EP2761001B1 (en) | 2011-09-26 | 2018-08-01 | Qiagen GmbH | Rapid method for isolating extracellular nucleic acids |
| EP2761000B1 (en) | 2011-09-26 | 2016-03-16 | PreAnalytiX GmbH | Stabilisation and isolation of extracellular nucleic acids |
| WO2013053855A1 (en) | 2011-10-11 | 2013-04-18 | Qiagen Gmbh | Sample processing method and sample processing cartridge |
| HUE044778T2 (hu) | 2011-11-14 | 2019-11-28 | Astellas Inst For Regenerative Medicine | Humán RPE sejt gyógyászati készítmények és alkalmazásaik |
| US9546358B2 (en) * | 2012-06-04 | 2017-01-17 | New England Biolabs, Inc. | Compositions and methods for reducing background DNA amplification |
| CN104755628B (zh) | 2012-09-25 | 2019-03-01 | 凯杰有限公司 | 生物样品的稳定化 |
| WO2014055936A1 (en) | 2012-10-04 | 2014-04-10 | Integenx Inc. | Preservation of biological materials in non-aqueous fluid media |
| GB201303666D0 (en) | 2013-03-01 | 2013-04-17 | Goldsborough Andrew S | Sample fixation and stabilisation |
| JP6381628B2 (ja) | 2013-03-18 | 2018-08-29 | キアゲン ゲーエムベーハー | 生物試料の安定化 |
| CN105164258B (zh) | 2013-03-18 | 2021-05-18 | 凯杰有限公司 | 细胞外核酸的稳定化和分离 |
| CN106132200B (zh) | 2014-03-18 | 2020-10-30 | 凯杰有限公司 | 胞外核酸的固定和分离 |
| JP6687601B2 (ja) | 2014-08-07 | 2020-04-22 | ザ ジェネラル ホスピタル コーポレイション | 全血サンプルの安定化 |
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2014
- 2014-03-18 CN CN201480021235.7A patent/CN105164258B/zh active Active
- 2014-03-18 CN CN201480021291.0A patent/CN105121643A/zh active Pending
- 2014-03-18 US US14/777,882 patent/US20160281133A1/en not_active Abandoned
- 2014-03-18 EP EP14714932.2A patent/EP2976425B1/en active Active
- 2014-03-18 WO PCT/EP2014/000726 patent/WO2014146782A1/en not_active Ceased
- 2014-03-18 JP JP2016503570A patent/JP6407248B2/ja active Active
- 2014-03-18 EP EP14714933.0A patent/EP2976426A1/en not_active Withdrawn
- 2014-03-18 WO PCT/EP2014/000724 patent/WO2014146780A1/en not_active Ceased
- 2014-03-18 JP JP2016503572A patent/JP2016518827A/ja active Pending
- 2014-03-18 US US14/777,878 patent/US10144952B2/en active Active
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