JP2016518442A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016518442A5 JP2016518442A5 JP2016513482A JP2016513482A JP2016518442A5 JP 2016518442 A5 JP2016518442 A5 JP 2016518442A5 JP 2016513482 A JP2016513482 A JP 2016513482A JP 2016513482 A JP2016513482 A JP 2016513482A JP 2016518442 A5 JP2016518442 A5 JP 2016518442A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- mucopolysaccharide
- chitosan
- botulinum neurotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 20
- 108030001720 Bontoxilysin Proteins 0.000 claims 8
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 6
- 231100001103 botulinum neurotoxin Toxicity 0.000 claims 6
- 229920001661 Chitosan Polymers 0.000 claims 5
- 229940053031 botulinum toxin Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 claims 1
- GRTOGORTSDXSFK-XJTZBENFSA-N ajmalicine Chemical compound C1=CC=C2C(CCN3C[C@@H]4[C@H](C)OC=C([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 GRTOGORTSDXSFK-XJTZBENFSA-N 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000037849 arterial hypertension Diseases 0.000 claims 1
- 229940094657 botulinum toxin type a Drugs 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960000899 nadroparin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013122509 | 2013-05-15 | ||
| RU2013122509/15A RU2535115C1 (ru) | 2013-05-15 | 2013-05-15 | Фармацевтический состав, содержащий нейротоксин ботулина |
| PCT/IB2014/061417 WO2014184746A1 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518442A JP2016518442A (ja) | 2016-06-23 |
| JP2016518442A5 true JP2016518442A5 (https=) | 2017-04-27 |
| JP6440691B2 JP6440691B2 (ja) | 2018-12-19 |
Family
ID=50841919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513482A Expired - Fee Related JP6440691B2 (ja) | 2013-05-15 | 2014-05-14 | ボツリヌス神経毒を含む医薬組成物およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10258673B2 (https=) |
| EP (2) | EP3750525A1 (https=) |
| JP (1) | JP6440691B2 (https=) |
| CN (1) | CN105209014B (https=) |
| CA (1) | CA2911046C (https=) |
| DK (1) | DK2996674T3 (https=) |
| ES (1) | ES2829614T3 (https=) |
| HK (1) | HK1217173A1 (https=) |
| RU (1) | RU2535115C1 (https=) |
| WO (1) | WO2014184746A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015253045B2 (en) * | 2014-04-30 | 2020-07-16 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
| DK3174523T3 (da) * | 2014-07-31 | 2020-09-28 | Allergan Inc | Formuleringer af biologiske stoffer til intravesikal instillation |
| RU2577296C1 (ru) * | 2014-12-24 | 2016-03-10 | Евгения Николаевна Анисимова | Способ выбора эффективного и безопасного местного обезболивания у пациентов с артериальной гипертензией на амбулаторном стоматологическом приеме |
| RU2651044C2 (ru) * | 2016-08-22 | 2018-04-18 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Способ лечения желудочковых нарушений ритма сердца (варианты) |
| BR112019004935A2 (pt) | 2016-09-13 | 2019-06-04 | Allergan, Inc. | composições de toxina clostridial não proteíca estabilizada |
| JP2020525416A (ja) * | 2017-06-29 | 2020-08-27 | アドヴァイテ エルエルシー． | 眼表面障害の治療及び診断 |
| WO2019241296A1 (en) * | 2018-06-13 | 2019-12-19 | Dermata Therapeutics, Llc | Compositions for the treatment of skin conditions |
| AU2019337656A1 (en) * | 2018-09-13 | 2021-05-06 | Allergan, Inc. | Methods for treatment of masseter muscle hypertrophy |
| KR102520631B1 (ko) | 2019-10-18 | 2023-04-12 | 펜랜드 파운데이션 | 치료에 사용하기 위한 보톨리늄 독소 |
| US10960061B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of amyotrophic lateral sclerosis using botulinum toxin |
| US10987411B1 (en) | 2019-10-18 | 2021-04-27 | Penland Foundation | Treatment of chronic obstructive pulmonary disease using botulinum toxin |
| WO2021231666A1 (en) | 2020-05-15 | 2021-11-18 | Penland Foundation | Treatment of asthma using botulinum toxin |
| US10967052B1 (en) | 2019-10-18 | 2021-04-06 | Penland Foundation | Treatment of dyslexia using botulinum toxin |
| US11241479B2 (en) | 2019-10-18 | 2022-02-08 | Penland Foundation | Treatment methods using botulinum toxins |
| US10960060B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of cardiac arrhythmia using botulinum toxin |
| US11090371B1 (en) | 2019-10-18 | 2021-08-17 | Penland Foundation | Treatment of cirrhosis using botulinum toxin |
| US11925677B2 (en) | 2021-07-12 | 2024-03-12 | Penland Foundation | Treatment of diabetes and chronic pancreatitis using botulinum toxin |
| US10973873B1 (en) | 2019-10-18 | 2021-04-13 | Penland Foundation | Treatment of asthma using botulinum toxin |
| WO2023287729A1 (en) | 2021-07-12 | 2023-01-19 | Penland Foundation | Treatment of acute and chronic kidney disease |
| US20250295741A1 (en) * | 2022-11-07 | 2025-09-25 | Allergan, Inc. | Prevention of post-operative atrial fibrillation with a botulinum toxin |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2884358A (en) | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
| JPH06192296A (ja) * | 1992-10-28 | 1994-07-12 | Chiba Pref Gov | 治療用医薬品としての結晶ａ型ボツリヌス毒素の製造法。 |
| US6967088B1 (en) | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| US20120238504A1 (en) * | 1998-09-11 | 2012-09-20 | Solstice Neurosciences, Llc | Stable Formulations of Botulinum Toxin in Hydrogels |
| US6977080B1 (en) * | 1999-08-10 | 2005-12-20 | Allergan, Inc. | Intrapericardial botulinum toxin treatment for bradycardia |
| JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| US8073538B2 (en) * | 2003-11-13 | 2011-12-06 | Cardio Polymers, Inc. | Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart |
| WO2005049111A2 (en) * | 2003-11-13 | 2005-06-02 | Symphony Medical, Inc. | Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart |
| US20060228404A1 (en) * | 2004-03-04 | 2006-10-12 | Anderson Daniel G | Compositions and methods for treatment of hypertrophic tissues |
| JP2005306746A (ja) * | 2004-04-19 | 2005-11-04 | Jiyugaoka Clinic | 顔面用シワ治療剤 |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| US20060073208A1 (en) | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| GB2419817A (en) * | 2004-10-29 | 2006-05-10 | Ipsen Ltd | Treatment of cardiac fibrillation disorders |
| WO2007019554A2 (en) * | 2005-08-08 | 2007-02-15 | Momenta Pharmaceuticals, Inc. | Polysaccharides for delivery of active agents |
| AU2007249682B2 (en) * | 2006-05-15 | 2013-05-16 | Cardiopolymers, Inc. | Post-operative control of cardiac arrhythmia by modification of neuronal signaling |
| AR061669A1 (es) | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| US8821928B2 (en) * | 2007-06-04 | 2014-09-02 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
| US9044477B2 (en) * | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
| JP4999008B2 (ja) | 2008-07-15 | 2012-08-15 | 楽天株式会社 | 情報送信装置、情報送信方法、情報送信処理プログラム及び情報送信システム |
| AU2009332947C1 (en) | 2008-12-31 | 2019-01-03 | Revance Therapeutics, Inc. | Injectable botulinum toxin formulations |
| AU2015253045B2 (en) * | 2014-04-30 | 2020-07-16 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
-
2013
- 2013-05-15 RU RU2013122509/15A patent/RU2535115C1/ru active
-
2014
- 2014-05-14 US US14/888,511 patent/US10258673B2/en not_active Expired - Fee Related
- 2014-05-14 HK HK16105183.8A patent/HK1217173A1/zh unknown
- 2014-05-14 CN CN201480027168.XA patent/CN105209014B/zh not_active Expired - Fee Related
- 2014-05-14 DK DK14727073.0T patent/DK2996674T3/da active
- 2014-05-14 CA CA2911046A patent/CA2911046C/en not_active Expired - Fee Related
- 2014-05-14 ES ES14727073T patent/ES2829614T3/es active Active
- 2014-05-14 JP JP2016513482A patent/JP6440691B2/ja not_active Expired - Fee Related
- 2014-05-14 WO PCT/IB2014/061417 patent/WO2014184746A1/en not_active Ceased
- 2014-05-14 EP EP20190163.4A patent/EP3750525A1/en not_active Withdrawn
- 2014-05-14 EP EP14727073.0A patent/EP2996674B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016518442A5 (https=) | ||
| JP2014221205A5 (https=) | ||
| JP2016530321A5 (ja) | イオン性液体を含有する注射用液状タンパク質製剤およびその使用 | |
| JP2012012418A5 (https=) | ||
| JP2019069238A5 (https=) | ||
| CA2782122A1 (en) | Compositions and methods for stabilized polysaccharide formulations | |
| JP2013532139A5 (https=) | ||
| JP2014240439A5 (https=) | ||
| WO2016042163A3 (en) | Ophthalmic drug compositions | |
| AR110986A2 (es) | Composiciones de ecteinascidina, formulaciones liofilizadas, método de preparación y uso | |
| WO2016134223A3 (en) | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof | |
| US20180344896A1 (en) | Hyaluronic acid composition and preparation method therefor | |
| JP2015535243A5 (https=) | ||
| WO2017100700A3 (en) | Peptides for renal therapy | |
| JP2015531344A5 (https=) | ||
| AU2015287920A8 (en) | Micronized Wharton's Jelly | |
| JP2011522879A5 (https=) | ||
| JP2013507445A5 (https=) | ||
| JP2014525449A5 (https=) | ||
| RU2018102693A (ru) | Офтальмологические композиции, содержащие кооперативные комплексы низко- и высокомолекулярной гиалуроновой кислоты | |
| JP2019526532A5 (https=) | ||
| WO2016100949A3 (en) | Method and compositions for dissolving or solubilizing therapeutic agents | |
| CN105131348A (zh) | 一种无菌可注射材料 | |
| NZ720863A (en) | Anti-viral properties of aloe vera and acquired immune deficiency syndrome (aids) treatment | |
| JP2020520917A5 (https=) |