RU2535115C1 - Фармацевтический состав, содержащий нейротоксин ботулина - Google Patents
Фармацевтический состав, содержащий нейротоксин ботулина Download PDFInfo
- Publication number
- RU2535115C1 RU2535115C1 RU2013122509/15A RU2013122509A RU2535115C1 RU 2535115 C1 RU2535115 C1 RU 2535115C1 RU 2013122509/15 A RU2013122509/15 A RU 2013122509/15A RU 2013122509 A RU2013122509 A RU 2013122509A RU 2535115 C1 RU2535115 C1 RU 2535115C1
- Authority
- RU
- Russia
- Prior art keywords
- botulinum toxin
- pharmaceutical composition
- toxin type
- chitosan
- heparin
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title claims abstract description 57
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 53
- 231100001103 botulinum neurotoxin Toxicity 0.000 title claims description 15
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 50
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013122509/15A RU2535115C1 (ru) | 2013-05-15 | 2013-05-15 | Фармацевтический состав, содержащий нейротоксин ботулина |
| HK16105183.8A HK1217173A1 (zh) | 2013-05-15 | 2014-05-14 | 含有肉毒杆菌神经毒素的药物组合物及其应用 |
| CA2911046A CA2911046C (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
| EP20190163.4A EP3750525A1 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
| JP2016513482A JP6440691B2 (ja) | 2013-05-15 | 2014-05-14 | ボツリヌス神経毒を含む医薬組成物およびその使用 |
| ES14727073T ES2829614T3 (es) | 2013-05-15 | 2014-05-14 | Composición farmacéutica que comprende una neurotoxina botulínica y usos de la misma |
| PCT/IB2014/061417 WO2014184746A1 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
| CN201480027168.XA CN105209014B (zh) | 2013-05-15 | 2014-05-14 | 含有肉毒杆菌神经毒素的药物组合物及其应用 |
| US14/888,511 US10258673B2 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
| DK14727073.0T DK2996674T3 (da) | 2013-05-15 | 2014-05-14 | Farmaceutisk sammensætning omfattende et botulinum-neurotoxin og anvendelser deraf |
| EP14727073.0A EP2996674B1 (en) | 2013-05-15 | 2014-05-14 | Pharmaceutical composition comprising a botulinum neurotoxin and uses thereof |
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| RU2013122509/15A RU2535115C1 (ru) | 2013-05-15 | 2013-05-15 | Фармацевтический состав, содержащий нейротоксин ботулина |
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| RU2535115C1 true RU2535115C1 (ru) | 2014-12-10 |
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| US (1) | US10258673B2 (https=) |
| EP (2) | EP3750525A1 (https=) |
| JP (1) | JP6440691B2 (https=) |
| CN (1) | CN105209014B (https=) |
| CA (1) | CA2911046C (https=) |
| DK (1) | DK2996674T3 (https=) |
| ES (1) | ES2829614T3 (https=) |
| HK (1) | HK1217173A1 (https=) |
| RU (1) | RU2535115C1 (https=) |
| WO (1) | WO2014184746A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2651044C2 (ru) * | 2016-08-22 | 2018-04-18 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Способ лечения желудочковых нарушений ритма сердца (варианты) |
| US12144847B2 (en) | 2016-09-13 | 2024-11-19 | Allergan, Inc. | Non-protein clostridial toxin compositions |
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| AU2015253045B2 (en) * | 2014-04-30 | 2020-07-16 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
| DK3174523T3 (da) * | 2014-07-31 | 2020-09-28 | Allergan Inc | Formuleringer af biologiske stoffer til intravesikal instillation |
| RU2577296C1 (ru) * | 2014-12-24 | 2016-03-10 | Евгения Николаевна Анисимова | Способ выбора эффективного и безопасного местного обезболивания у пациентов с артериальной гипертензией на амбулаторном стоматологическом приеме |
| JP2020525416A (ja) * | 2017-06-29 | 2020-08-27 | アドヴァイテ エルエルシー． | 眼表面障害の治療及び診断 |
| WO2019241296A1 (en) * | 2018-06-13 | 2019-12-19 | Dermata Therapeutics, Llc | Compositions for the treatment of skin conditions |
| AU2019337656A1 (en) * | 2018-09-13 | 2021-05-06 | Allergan, Inc. | Methods for treatment of masseter muscle hypertrophy |
| KR102520631B1 (ko) | 2019-10-18 | 2023-04-12 | 펜랜드 파운데이션 | 치료에 사용하기 위한 보톨리늄 독소 |
| US10960061B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of amyotrophic lateral sclerosis using botulinum toxin |
| US10987411B1 (en) | 2019-10-18 | 2021-04-27 | Penland Foundation | Treatment of chronic obstructive pulmonary disease using botulinum toxin |
| WO2021231666A1 (en) | 2020-05-15 | 2021-11-18 | Penland Foundation | Treatment of asthma using botulinum toxin |
| US10967052B1 (en) | 2019-10-18 | 2021-04-06 | Penland Foundation | Treatment of dyslexia using botulinum toxin |
| US11241479B2 (en) | 2019-10-18 | 2022-02-08 | Penland Foundation | Treatment methods using botulinum toxins |
| US10960060B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of cardiac arrhythmia using botulinum toxin |
| US11090371B1 (en) | 2019-10-18 | 2021-08-17 | Penland Foundation | Treatment of cirrhosis using botulinum toxin |
| US11925677B2 (en) | 2021-07-12 | 2024-03-12 | Penland Foundation | Treatment of diabetes and chronic pancreatitis using botulinum toxin |
| US10973873B1 (en) | 2019-10-18 | 2021-04-13 | Penland Foundation | Treatment of asthma using botulinum toxin |
| WO2023287729A1 (en) | 2021-07-12 | 2023-01-19 | Penland Foundation | Treatment of acute and chronic kidney disease |
| US20250295741A1 (en) * | 2022-11-07 | 2025-09-25 | Allergan, Inc. | Prevention of post-operative atrial fibrillation with a botulinum toxin |
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-
2014
- 2014-05-14 US US14/888,511 patent/US10258673B2/en not_active Expired - Fee Related
- 2014-05-14 HK HK16105183.8A patent/HK1217173A1/zh unknown
- 2014-05-14 CN CN201480027168.XA patent/CN105209014B/zh not_active Expired - Fee Related
- 2014-05-14 DK DK14727073.0T patent/DK2996674T3/da active
- 2014-05-14 CA CA2911046A patent/CA2911046C/en not_active Expired - Fee Related
- 2014-05-14 ES ES14727073T patent/ES2829614T3/es active Active
- 2014-05-14 JP JP2016513482A patent/JP6440691B2/ja not_active Expired - Fee Related
- 2014-05-14 WO PCT/IB2014/061417 patent/WO2014184746A1/en not_active Ceased
- 2014-05-14 EP EP20190163.4A patent/EP3750525A1/en not_active Withdrawn
- 2014-05-14 EP EP14727073.0A patent/EP2996674B1/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2651044C2 (ru) * | 2016-08-22 | 2018-04-18 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Способ лечения желудочковых нарушений ритма сердца (варианты) |
| US12144847B2 (en) | 2016-09-13 | 2024-11-19 | Allergan, Inc. | Non-protein clostridial toxin compositions |
| US12171816B2 (en) | 2016-09-13 | 2024-12-24 | Allergan, Inc. | Non-protein Clostridial toxin compositions |
| US12409211B2 (en) | 2016-09-13 | 2025-09-09 | Allergan, Inc. | Non-protein Clostridial toxin compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2829614T3 (es) | 2021-06-01 |
| JP6440691B2 (ja) | 2018-12-19 |
| HK1217173A1 (zh) | 2016-12-30 |
| JP2016518442A (ja) | 2016-06-23 |
| WO2014184746A1 (en) | 2014-11-20 |
| CA2911046A1 (en) | 2014-11-20 |
| US20160114013A1 (en) | 2016-04-28 |
| CN105209014B (zh) | 2018-05-25 |
| EP3750525A1 (en) | 2020-12-16 |
| US10258673B2 (en) | 2019-04-16 |
| CN105209014A (zh) | 2015-12-30 |
| CA2911046C (en) | 2021-08-31 |
| EP2996674A1 (en) | 2016-03-23 |
| DK2996674T3 (da) | 2020-10-26 |
| EP2996674B1 (en) | 2020-08-12 |
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