JP2016517877A5 - - Google Patents
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- Publication number
- JP2016517877A5 JP2016517877A5 JP2016511150A JP2016511150A JP2016517877A5 JP 2016517877 A5 JP2016517877 A5 JP 2016517877A5 JP 2016511150 A JP2016511150 A JP 2016511150A JP 2016511150 A JP2016511150 A JP 2016511150A JP 2016517877 A5 JP2016517877 A5 JP 2016517877A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- methyl
- tetrahydrofuran
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- -1 methoxy, chloro, fluoro, 2-fluoroethoxy Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- CLIUTCNDBPIRQJ-CYBMUJFWSA-N 2-cyclopropyl-5-[7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl]-6,7-dihydro-4h-[1,3]oxazolo[5,4-c]pyridine Chemical compound C=12C(N3CC=4OC(=NC=4CC3)C3CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 CLIUTCNDBPIRQJ-CYBMUJFWSA-N 0.000 claims 2
- QBCXBKWIHPOTLC-CYBMUJFWSA-N 7-methyl-4-(1-methyl-5,7-dihydro-4h-pyrazolo[3,4-c]pyridin-6-yl)-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC=4N(C)N=CC=4CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 QBCXBKWIHPOTLC-CYBMUJFWSA-N 0.000 claims 2
- IWNMKIFAVMHTRY-MRXNPFEDSA-N 8-(2-fluoroethoxy)-7-methoxy-2-[7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl]-3,4-dihydro-1h-isoquinoline Chemical compound C1C2=C(OCCF)C(OC)=CC=C2CCN1C(C=12)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 IWNMKIFAVMHTRY-MRXNPFEDSA-N 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- CSBFPVUKXZXDGC-UHFFFAOYSA-N 2-cyclopropyl-6-[5-(2-fluorophenyl)-7-methylimidazo[5,1-f][1,2,4]triazin-4-yl]-7,8-dihydro-5h-pyrido[4,3-d]pyrimidine Chemical compound C=12C(N3CC4=CN=C(N=C4CC3)C3CC3)=NC=NN2C(C)=NC=1C1=CC=CC=C1F CSBFPVUKXZXDGC-UHFFFAOYSA-N 0.000 claims 1
- DPACQUUZKODHSM-CYBMUJFWSA-N 3-cyclopropyl-5-[7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl]-6,7-dihydro-4h-[1,2]oxazolo[4,3-c]pyridine Chemical compound C=12C(N3CC4=C(C5CC5)ON=C4CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 DPACQUUZKODHSM-CYBMUJFWSA-N 0.000 claims 1
- MOSXRSPLTNEPBR-CQSZACIVSA-N 4-(1-cyclopropyl-5,7-dihydro-4h-pyrazolo[3,4-c]pyridin-6-yl)-7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC=4N(C5CC5)N=CC=4CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 MOSXRSPLTNEPBR-CQSZACIVSA-N 0.000 claims 1
- VVBFRGXLQGJWRX-CYBMUJFWSA-N 4-(2-cyclopropyl-6,7-dihydro-4h-pyrazolo[4,3-c]pyridin-5-yl)-7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC4=CN(N=C4CC3)C3CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 VVBFRGXLQGJWRX-CYBMUJFWSA-N 0.000 claims 1
- WNKHBWGVHGBSCB-CQSZACIVSA-N 4-(3-cyclopropyl-1-methyl-6,7-dihydro-4h-pyrazolo[4,3-c]pyridin-5-yl)-7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC4=C(N(N=C4C4CC4)C)CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 WNKHBWGVHGBSCB-CQSZACIVSA-N 0.000 claims 1
- JYRWHVPLBWTVEW-UHFFFAOYSA-N 5-(2-fluorophenyl)-7-methyl-4-(1-methyl-5,7-dihydro-4h-pyrazolo[3,4-c]pyridin-6-yl)imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC=4N(C)N=CC=4CC3)=NC=NN2C(C)=NC=1C1=CC=CC=C1F JYRWHVPLBWTVEW-UHFFFAOYSA-N 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- DPZWYCQPJKWHLL-CQSZACIVSA-N 7-[7-methyl-5-[(3s)-oxolan-3-yl]imidazo[5,1-f][1,2,4]triazin-4-yl]-6,8-dihydro-5h-1,7-naphthyridine Chemical compound C=12C(N3CC4=NC=CC=C4CC3)=NC=NN2C(C)=NC=1[C@@H]1CCOC1 DPZWYCQPJKWHLL-CQSZACIVSA-N 0.000 claims 1
- VHJUKVHEYVODQD-CQSZACIVSA-N 7-methyl-4-(1-methyl-5,7-dihydro-4h-pyrazolo[3,4-c]pyridin-6-yl)-5-[(2r)-oxolan-2-yl]imidazo[5,1-f][1,2,4]triazine Chemical compound C=12C(N3CC=4N(C)N=CC=4CC3)=NC=NN2C(C)=NC=1[C@H]1CCCO1 VHJUKVHEYVODQD-CQSZACIVSA-N 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003918 triazines Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361818650P | 2013-05-02 | 2013-05-02 | |
| US61/818,650 | 2013-05-02 | ||
| PCT/IB2014/060945 WO2014177977A1 (en) | 2013-05-02 | 2014-04-23 | Imidazo-triazine derivatives as pde10 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517877A JP2016517877A (ja) | 2016-06-20 |
| JP2016517877A5 true JP2016517877A5 (cg-RX-API-DMAC7.html) | 2017-04-13 |
| JP6263606B2 JP6263606B2 (ja) | 2018-01-17 |
Family
ID=50841902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016511150A Expired - Fee Related JP6263606B2 (ja) | 2013-05-02 | 2014-04-23 | Ｐｄｅ１０阻害剤としてのイミダゾ−トリアジン誘導体 |
Country Status (33)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA111696C2 (uk) * | 2013-05-02 | 2016-05-25 | Пфайзер Інк. | Похідні імідазотриазину як інгібітори рde10 |
| HRP20220144T1 (hr) | 2016-09-09 | 2022-04-15 | Novartis Ag | Spojevi i pripravci kao inhibitori endosomskih toll-u sličnih receptora |
| EP3801499B1 (en) | 2018-06-07 | 2024-02-28 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| BR112022007491A2 (pt) * | 2019-10-21 | 2022-07-12 | Sk Biopharmaceuticals Co Ltd | Medicamento, composição farmacêutica e método para prevenção, alívio ou tratamento de distúrbio cognitivo, e, uso de um composto de imidazopirimidina ou imidazotriazina |
| AU2023214467A1 (en) * | 2022-02-02 | 2024-07-11 | Katholieke Universiteit Leuven | Tetrahydropyridopyrimidines and related analogs for inhibiting yap/taz-tead |
| CN117486878A (zh) * | 2023-10-27 | 2024-02-02 | 扬州市普林斯医药科技有限公司 | 一种恩那司他的制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010007867A1 (en) | 1999-12-13 | 2001-07-12 | Yuhpyng L. Chen | Substituted 6,5-hetero-bicyclic derivatives |
| DE10130167A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Imidazotriazine |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| DE10230604A1 (de) | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| JP2007508241A (ja) | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｐｄｅ１０ａ阻害剤を用いる糖尿病および関連障害の処置方法 |
| JP4559749B2 (ja) * | 2004-02-16 | 2010-10-13 | あすか製薬株式会社 | ピペラジニルピリジン誘導体 |
| EP1595881A1 (en) | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands |
| US20070167426A1 (en) | 2004-06-02 | 2007-07-19 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| TW200716102A (en) | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| US20080051419A1 (en) | 2006-07-26 | 2008-02-28 | Pfizer Inc. | Amine derivatives useful as anticancer agents |
| US8207370B2 (en) | 2006-09-26 | 2012-06-26 | Kaneka Corporation | Process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid ester |
| WO2008057402A2 (en) | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| EP2203171A2 (en) | 2007-08-21 | 2010-07-07 | Merck Sharp & Dohme Corp. | Cb2 receptor ligands for the treatment of pain |
| DE102007059723A1 (de) | 2007-12-12 | 2009-06-18 | Siemens Medical Instruments Pte. Ltd. | Hörvorrichtung mit Batterieklappenmodul |
| TWI431010B (zh) | 2007-12-19 | 2014-03-21 | Lilly Co Eli | 礦皮質素受體拮抗劑及使用方法 |
| JP2011515401A (ja) | 2008-03-20 | 2011-05-19 | アムジエン・インコーポレーテツド | オーロラキナーゼモジュレーターおよび使用方法 |
| KR101774035B1 (ko) | 2009-10-30 | 2017-09-01 | 얀센 파마슈티카 엔.브이. | 이미다조［１，２―ｂ］피리다진 유도체 및 ＰＤＥ１０ 저해제로서의 그의 용도 |
| EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| WO2011141713A1 (en) | 2010-05-13 | 2011-11-17 | Centro Nacional De Investigaciones Oncologicas (Cnio) | New bicyclic compounds as pi3-k and mtor inhibitors |
| US20130071415A1 (en) | 2010-05-28 | 2013-03-21 | Biocryst Pharmaceuticals, Inc. | Heterocyclic Compounds as Janus Kinase Inhibitors |
| WO2011157793A1 (en) | 2010-06-17 | 2011-12-22 | Novartis Ag | Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives |
| AU2012221828C1 (en) * | 2011-02-23 | 2015-10-01 | Pfizer Inc. | Imidazo[5,1-f][1,2,4]triazines for treatment of neurological disorders |
| UA111696C2 (uk) * | 2013-05-02 | 2016-05-25 | Пфайзер Інк. | Похідні імідазотриазину як інгібітори рde10 |
-
2014
- 2014-04-23 UA UAA201510060A patent/UA111696C2/uk unknown
- 2014-04-23 BR BR112015027760A patent/BR112015027760A8/pt not_active Application Discontinuation
- 2014-04-23 AU AU2014261070A patent/AU2014261070A1/en not_active Abandoned
- 2014-04-23 GE GEAP201413979A patent/GEP201706675B/en unknown
- 2014-04-23 TN TN2015000490A patent/TN2015000490A1/fr unknown
- 2014-04-23 NZ NZ712949A patent/NZ712949A/en not_active IP Right Cessation
- 2014-04-23 JP JP2016511150A patent/JP6263606B2/ja not_active Expired - Fee Related
- 2014-04-23 KR KR1020157034216A patent/KR101770905B1/ko not_active Expired - Fee Related
- 2014-04-23 WO PCT/IB2014/060945 patent/WO2014177977A1/en not_active Ceased
- 2014-04-23 AP AP2015008843A patent/AP2015008843A0/xx unknown
- 2014-04-23 MA MA38559A patent/MA38559B1/fr unknown
- 2014-04-23 EP EP14727054.0A patent/EP2991989B1/en active Active
- 2014-04-23 CN CN201480024798.1A patent/CN105164134B/zh not_active Expired - Fee Related
- 2014-04-23 DK DK14727054.0T patent/DK2991989T3/en active
- 2014-04-23 CA CA2910759A patent/CA2910759C/en not_active Expired - Fee Related
- 2014-04-23 SG SG11201508201VA patent/SG11201508201VA/en unknown
- 2014-04-23 MX MX2015015163A patent/MX2015015163A/es unknown
- 2014-04-23 ES ES14727054.0T patent/ES2637816T3/es active Active
- 2014-04-23 EA EA201591819A patent/EA027936B1/ru not_active IP Right Cessation
- 2014-04-23 MD MDA20150103A patent/MD20150103A2/ro not_active Application Discontinuation
- 2014-04-23 PE PE2015002303A patent/PE20151940A1/es not_active Application Discontinuation
- 2014-04-29 TW TW103115365A patent/TWI508966B/zh not_active IP Right Cessation
- 2014-04-30 US US14/265,458 patent/US8933224B2/en not_active Expired - Fee Related
- 2014-04-30 UY UY0001035547A patent/UY35547A/es not_active Application Discontinuation
- 2014-04-30 AR ARP140101792A patent/AR096161A1/es unknown
- 2014-11-21 US US14/549,871 patent/US9145427B2/en not_active Expired - Fee Related
-
2015
- 2015-08-19 US US14/829,842 patent/US9296761B2/en not_active Expired - Fee Related
- 2015-10-13 CL CL2015003037A patent/CL2015003037A1/es unknown
- 2015-10-19 CU CUP2015000144A patent/CU20150144A7/es unknown
- 2015-10-23 PH PH12015502462A patent/PH12015502462A1/en unknown
- 2015-10-27 CR CR20150591A patent/CR20150591A/es unknown
- 2015-10-30 NI NI201500157A patent/NI201500157A/es unknown
- 2015-11-02 DO DO2015000271A patent/DOP2015000271A/es unknown
- 2015-11-30 EC ECIEPI201550110A patent/ECSP15050110A/es unknown
- 2015-12-01 ZA ZA2015/08968A patent/ZA201508968B/en unknown
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