JP2016517446A5 - - Google Patents
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- Publication number
- JP2016517446A5 JP2016517446A5 JP2016503417A JP2016503417A JP2016517446A5 JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5 JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- patient
- mucus
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 102000002933 Thioredoxin Human genes 0.000 claims 13
- 108060008226 thioredoxin Proteins 0.000 claims 13
- 235000018417 cysteine Nutrition 0.000 claims 11
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 11
- 210000003097 mucus Anatomy 0.000 claims 9
- 235000018102 proteins Nutrition 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 206010036790 Productive cough Diseases 0.000 claims 8
- 210000003802 sputum Anatomy 0.000 claims 8
- 208000024794 sputum Diseases 0.000 claims 8
- 229940094937 thioredoxin Drugs 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000006199 nebulizer Substances 0.000 claims 3
- 239000000443 aerosol Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792198P | 2013-03-15 | 2013-03-15 | |
| US61/792,198 | 2013-03-15 | ||
| PCT/US2014/030545 WO2014145735A2 (en) | 2013-03-15 | 2014-03-17 | Product and process for mucus viscosity normalization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517446A JP2016517446A (ja) | 2016-06-16 |
| JP2016517446A5 true JP2016517446A5 (cg-RX-API-DMAC7.html) | 2017-04-20 |
| JP6672139B2 JP6672139B2 (ja) | 2020-03-25 |
Family
ID=51527945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503417A Active JP6672139B2 (ja) | 2013-03-15 | 2014-03-17 | 粘液の粘性の正常化のための組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9168290B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2968481B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6672139B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20210068606A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105188738B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014232520B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2906868A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL241320B (cg-RX-API-DMAC7.html) |
| MX (1) | MX377653B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2750211C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145735A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2635581C (en) | 2005-12-28 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| MX377653B (es) * | 2013-03-15 | 2025-03-11 | Orpro Therapeutics Inc | Producto y uso para normalización de la viscoelasticidad del moco. |
| JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| CN106868090B (zh) * | 2017-03-28 | 2020-09-29 | 王绪友 | 一种医学检验用痰液处理方法 |
| CN107630065A (zh) * | 2017-11-02 | 2018-01-26 | 蔡慧娜 | 一种在支原体液体培养时使标本均匀分散的方法 |
| US20210213134A1 (en) * | 2018-05-17 | 2021-07-15 | Orpro Therapeutics, Inc. | Thiol-based multivalent drug delivery compositions |
| CA3163157A1 (en) * | 2020-01-03 | 2021-07-08 | Orpro Therapeutics, Inc. | Compositions having thioredoxin activity and related methods |
| CN115200954B (zh) * | 2022-06-28 | 2025-05-06 | 珠海大略科技有限公司 | 一种降低唾液粘度的方法及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3091569A (en) | 1960-08-26 | 1963-05-28 | Mead Johnson & Co | Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus |
| US3502779A (en) | 1966-08-18 | 1970-03-24 | Calbiochem | Process of mucolysis |
| US3683069A (en) * | 1970-02-19 | 1972-08-08 | Michel Hooreman | Enzymatic products which optimize the viscosity of mucuses and their applications |
| US4738841A (en) * | 1985-08-28 | 1988-04-19 | Repligen Corporation | Use of thioredoxin, thioredoxin-derived, or thioredoxin-like dithiol peptides in hair care preparations |
| US4771036A (en) | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| SE8903003D0 (sv) | 1989-09-12 | 1989-09-12 | Astra Ab | Novel medical use |
| US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5908611A (en) | 1995-05-05 | 1999-06-01 | The Scripps Research Institute | Treatment of viscous mucous-associated diseases |
| WO1998000160A1 (en) | 1996-06-28 | 1998-01-08 | Nat Jewish Ct Immun & Respirat | USE OF THIOREDOXIN-LIKE MOLECULES FOR INDUCTION OF MnSOD TO TREAT OXIDATIVE DAMAGE |
| JPH10191977A (ja) | 1997-01-14 | 1998-07-28 | Oriental Yeast Co Ltd | チオレドキシン改変体及び該改変体を含むａｐ−１の転写活性能を増強する因子 |
| DE19711052C2 (de) | 1997-03-03 | 1999-09-23 | Hans Rommelspacher | Verwendung von 2-Methyl-thiazolidin-2,4-dicarbonsäure als Mukolytikum |
| US7585645B2 (en) | 1997-05-27 | 2009-09-08 | Sembiosys Genetics Inc. | Thioredoxin and thioredoxin reductase containing oil body based products |
| US5925334A (en) | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| PT1379224E (pt) | 2001-03-29 | 2009-10-22 | Synergy Pharmaceuticals Inc | Agonistas do receptor da guanilato ciclase para o tratamento de inflamação de tecidos e carcinogénese |
| JP2005505250A (ja) | 2001-05-04 | 2005-02-24 | ゼンコー | 核酸およびチオレドキシンレダクターゼ活性を有するタンパク質 |
| US20030194798A1 (en) | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| WO2004013283A2 (en) | 2002-08-02 | 2004-02-12 | University Of Rochester | Thioredoxin mutants and uses thereof |
| CN1694726A (zh) * | 2002-09-10 | 2005-11-09 | 国家杰威什医疗及研究中心 | 用于液化粘液或痰液的产品和方法 |
| CA2498581C (en) * | 2002-09-10 | 2019-03-19 | National Jewish Medical And Research Center | Thioredoxin composition and uses thereof for liquefaction of mucus or sputum |
| JP4273234B2 (ja) | 2003-03-31 | 2009-06-03 | 独立行政法人産業技術総合研究所 | チオレドキシン改変体 |
| RU2253484C1 (ru) * | 2003-09-30 | 2005-06-10 | Российский научный центр восстановительной медицины и курортологии Министерства здравоохранения Российской Федерации | Способ лечения хронического бронхолегочного процесса при врожденных пороках развития легких у детей |
| WO2005094269A2 (en) | 2004-03-24 | 2005-10-13 | National Jewish Medical And Research Center | Mucolytic and anti-elastase compounds and methods of use thereof |
| WO2005121328A2 (en) | 2004-06-11 | 2005-12-22 | Syngenta Limited | Method for ameliorating an inflammatory skin condition |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| GB0503640D0 (en) | 2005-02-22 | 2005-03-30 | Syngenta Ltd | Improvements in or relating to organic compounds |
| MX377653B (es) | 2013-03-15 | 2025-03-11 | Orpro Therapeutics Inc | Producto y uso para normalización de la viscoelasticidad del moco. |
| US20210213134A1 (en) | 2018-05-17 | 2021-07-15 | Orpro Therapeutics, Inc. | Thiol-based multivalent drug delivery compositions |
| CA3163157A1 (en) | 2020-01-03 | 2021-07-08 | Orpro Therapeutics, Inc. | Compositions having thioredoxin activity and related methods |
-
2014
- 2014-03-17 MX MX2015013040A patent/MX377653B/es active IP Right Grant
- 2014-03-17 EP EP14762649.3A patent/EP2968481B1/en active Active
- 2014-03-17 KR KR1020217016634A patent/KR20210068606A/ko not_active Withdrawn
- 2014-03-17 CN CN201480024877.2A patent/CN105188738B/zh active Active
- 2014-03-17 JP JP2016503417A patent/JP6672139B2/ja active Active
- 2014-03-17 WO PCT/US2014/030545 patent/WO2014145735A2/en not_active Ceased
- 2014-03-17 RU RU2015143953A patent/RU2750211C2/ru active
- 2014-03-17 KR KR1020157028723A patent/KR20160007496A/ko not_active Ceased
- 2014-03-17 CA CA2906868A patent/CA2906868A1/en active Pending
- 2014-03-17 AU AU2014232520A patent/AU2014232520B2/en active Active
- 2014-03-17 US US14/216,568 patent/US9168290B2/en active Active
-
2015
- 2015-09-08 IL IL241320A patent/IL241320B/en unknown
- 2015-09-11 US US14/852,113 patent/US20160230149A1/en not_active Abandoned
-
2020
- 2020-11-23 US US17/101,588 patent/US12390511B2/en active Active
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