JP2012503668A5 - - Google Patents
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- Publication number
- JP2012503668A5 JP2012503668A5 JP2011529222A JP2011529222A JP2012503668A5 JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5 JP 2011529222 A JP2011529222 A JP 2011529222A JP 2011529222 A JP2011529222 A JP 2011529222A JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- lung
- droplets
- microns
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- 238000009472 formulation Methods 0.000 claims 11
- 210000004072 lung Anatomy 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 208000002815 pulmonary hypertension Diseases 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960005032 treprostinil Drugs 0.000 claims 2
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960001726 treprostinil sodium Drugs 0.000 claims 1
- IQKAWAUTOKVMLE-ZSESPEEFSA-M treprostinil sodium Chemical compound [Na+].C1=CC=C(OCC([O-])=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 IQKAWAUTOKVMLE-ZSESPEEFSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10001708P | 2008-09-25 | 2008-09-25 | |
| US61/100,017 | 2008-09-25 | ||
| PCT/US2009/058217 WO2010036798A1 (en) | 2008-09-25 | 2009-09-24 | Deep lung pulmonary delivery of treprostinil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Division JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503668A JP2012503668A (ja) | 2012-02-09 |
| JP2012503668A5 true JP2012503668A5 (cg-RX-API-DMAC7.html) | 2012-11-08 |
Family
ID=42060085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529222A Pending JP2012503668A (ja) | 2008-09-25 | 2009-09-24 | 肺深部へのトレプロスチニルの肺送達 |
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120177693A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2330893A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2012503668A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110081204A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102164487A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2737350A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010036798A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200449A1 (en) | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| DE102009031274A1 (de) * | 2009-06-30 | 2011-01-13 | Justus-Liebig-Universität Giessen | Liposomen zur pulmonalen Applikation |
| EP2338520A1 (de) * | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| US8609728B2 (en) | 2010-03-15 | 2013-12-17 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| EP2663313B1 (en) | 2011-01-13 | 2018-08-08 | SciPharm S.à r.l. | Method for enhancing engraftment of haematopoetic stem cells |
| ES2754388T3 (es) | 2013-03-15 | 2020-04-17 | Mannkind Corp | Composiciones y métodos de dicetopiperazina microcristalina |
| AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| MX382833B (es) | 2013-10-25 | 2025-03-13 | Insmed Inc | Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
| IL260823B2 (en) * | 2016-01-29 | 2024-08-01 | Mannkind Corp | Dry powder inhaler |
| IL310250B2 (en) | 2016-05-05 | 2025-09-01 | Liquidia Tech Inc | Terpostinil in dry powder form for the treatment of pulmonary hypertension |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| BR112020020127A2 (pt) * | 2018-05-07 | 2021-01-05 | Pharmosa Biopharm Inc. | Composição farmacêutica, método de tratamento de uma doença respiratória e método para reduzir o efeito colateral de um treprostinil inalado na via respiratória superior |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| WO2021013861A1 (en) | 2019-07-22 | 2021-01-28 | Nanomi, B.V. | Sustained release trepostinil-compound microparticle compositions |
| CN115916212A (zh) | 2020-04-17 | 2023-04-04 | 联合治疗公司 | 曲前列尼尔用于治疗间质性肺病 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| BRPI0513866A (pt) * | 2004-07-26 | 2008-05-20 | Cotherix Inc | composição, micropartìculas, método para o tratamento da hipertensão pulmonar, e dispositivo de inalação |
| US20080200449A1 (en) * | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
-
2009
- 2009-09-24 WO PCT/US2009/058217 patent/WO2010036798A1/en not_active Ceased
- 2009-09-24 KR KR1020117008976A patent/KR20110081204A/ko not_active Ceased
- 2009-09-24 JP JP2011529222A patent/JP2012503668A/ja active Pending
- 2009-09-24 CA CA2737350A patent/CA2737350A1/en not_active Abandoned
- 2009-09-24 EP EP09816849A patent/EP2330893A4/en not_active Withdrawn
- 2009-09-24 US US13/120,015 patent/US20120177693A1/en not_active Abandoned
- 2009-09-24 CN CN2009801379417A patent/CN102164487A/zh active Pending
-
2015
- 2015-03-06 JP JP2015044671A patent/JP2015129177A/ja active Pending
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