JP2016517418A5 - - Google Patents
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- Publication number
- JP2016517418A5 JP2016517418A5 JP2016502103A JP2016502103A JP2016517418A5 JP 2016517418 A5 JP2016517418 A5 JP 2016517418A5 JP 2016502103 A JP2016502103 A JP 2016502103A JP 2016502103 A JP2016502103 A JP 2016502103A JP 2016517418 A5 JP2016517418 A5 JP 2016517418A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cyclodextrin
- excipients
- particles
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 229920000858 Cyclodextrin Polymers 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 229920002988 biodegradable polymer Polymers 0.000 description 2
- 239000004621 biodegradable polymer Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N dilactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 description 1
Description
一実施形態において、物質の組成物は、粒子を含み、前記粒子は、タンパク質、生分解性ポリマー、及び１つ以上の賦形剤を含む。粒子は２ヶ月以上の期間に渡ってタンパク質を送達するように構成されることができる。いくつかの実施形態では、生分解性ポリマーは、０．１ｄＬ／ｇ〜１．０ｄＬ／ｇの範囲の固有粘度を有するポリ（ｄ，ｌ−ラクチド−コ−グリコリド）、ポリ（ｄ，ｌ−ラクチド）及び／またはポリエチレングリコールコポリマーを含む。いくつかの実施形態によれば、タンパク質は１０ｋＤａ〜１５０ｋＤａの範囲の分子量を有する。一実施形態では、１つ以上の賦形剤は、シクロデキストリン、トレハロース、アルギニン、またはそれらの組合せを含む。一実施形態によれば、シクロデキストリンは、スルホブチルエーテル−β−シクロデキストリンである。
別の実施形態において、水性製剤は、タンパク質、緩衝剤、並びにシクロデキストリン、トレハロース、及びアルギニンから成る群から選択される１つ以上の賦形剤を含む。１つ以上の賦形剤は、タンパク質のモル濃度に対して、１０／１〜２００／１の範囲のモル比で水性製剤中に存在することができる。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786035P | 2013-03-14 | 2013-03-14 | |
| US61/786,035 | 2013-03-14 | ||
| PCT/US2014/026320 WO2014151725A1 (en) | 2013-03-14 | 2014-03-13 | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019217753A Division JP2020029466A (ja) | 2013-03-14 | 2019-12-02 | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517418A JP2016517418A (ja) | 2016-06-16 |
| JP2016517418A5 true JP2016517418A5 (ja) | 2018-08-02 |
| JP6649246B2 JP6649246B2 (ja) | 2020-02-19 |
Family
ID=50483567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502103A Active JP6649246B2 (ja) | 2013-03-14 | 2014-03-13 | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
| JP2019217753A Pending JP2020029466A (ja) | 2013-03-14 | 2019-12-02 | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019217753A Pending JP2020029466A (ja) | 2013-03-14 | 2019-12-02 | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140274873A1 (ja) |
| EP (2) | EP2968574A1 (ja) |
| JP (2) | JP6649246B2 (ja) |
| KR (1) | KR20150128857A (ja) |
| CN (1) | CN105188759A (ja) |
| AU (2) | AU2014236938B2 (ja) |
| BR (1) | BR112015021000A2 (ja) |
| CA (1) | CA2902547A1 (ja) |
| RU (1) | RU2720412C2 (ja) |
| WO (1) | WO2014151725A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106076214B (zh) * | 2016-07-15 | 2019-12-17 | 沈阳化工大学 | 一种具有核壳结构的海藻酸钙微球制备方法 |
| GB201906835D0 (en) * | 2019-05-15 | 2019-06-26 | Ucb Biopharma Sprl | Dry microparticles |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US6448077B1 (en) | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
| DK0814778T3 (da) * | 1995-03-10 | 2001-09-17 | Roche Diagnostics Gmbh | Polypeptidholdige farmaceutiske administrationsformer i form af mikropartikler og fremgangsmåde til fremstilling deraf |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| CA2369451C (en) * | 1999-04-08 | 2009-09-22 | Genentech, Inc. | Composition based on oppositely-charged polypeptides |
| ATE355849T1 (de) * | 2000-12-21 | 2007-03-15 | Nektar Therapeutics | Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor |
| JP2005512962A (ja) | 2001-09-20 | 2005-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｐｄｇｆ抗体および設計抗体の産生方法 |
| US7265084B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US9415102B2 (en) * | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
| WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| US8591885B2 (en) * | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| US7993634B2 (en) * | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| EP1838290A2 (en) * | 2005-01-21 | 2007-10-03 | Alza Corporation | Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion |
| JP2008539260A (ja) * | 2005-04-25 | 2008-11-13 | アムジエン・インコーポレーテツド | ポロゲンを含む生分解性プチド徐放性組成物 |
| JP5074750B2 (ja) * | 2005-12-07 | 2012-11-14 | 一般財団法人化学及血清療法研究所 | シクロデキストリン類を含有する液状フィブリノゲン製剤 |
| US8642067B2 (en) * | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| KR101225233B1 (ko) * | 2007-09-05 | 2013-01-22 | 화이자 리미티드 | Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염 |
| JP5406049B2 (ja) * | 2008-02-05 | 2014-02-05 | 協和発酵バイオ株式会社 | グルタチオンの保存安定性向上方法 |
| WO2010060748A1 (en) * | 2008-11-03 | 2010-06-03 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
| EP2482804A1 (en) | 2009-10-01 | 2012-08-08 | Evonik Degussa Corporation | Microparticle compositions and methods for treating age-related macular degeneration |
| US9668915B2 (en) * | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
-
2014
- 2014-03-13 BR BR112015021000A patent/BR112015021000A2/pt not_active IP Right Cessation
- 2014-03-13 US US14/209,683 patent/US20140274873A1/en not_active Abandoned
- 2014-03-13 EP EP14717337.1A patent/EP2968574A1/en not_active Withdrawn
- 2014-03-13 KR KR1020157027832A patent/KR20150128857A/ko not_active Application Discontinuation
- 2014-03-13 RU RU2015135147A patent/RU2720412C2/ru active
- 2014-03-13 AU AU2014236938A patent/AU2014236938B2/en active Active
- 2014-03-13 CN CN201480015377.2A patent/CN105188759A/zh active Pending
- 2014-03-13 EP EP20167724.2A patent/EP3693021A1/en not_active Withdrawn
- 2014-03-13 WO PCT/US2014/026320 patent/WO2014151725A1/en active Application Filing
- 2014-03-13 JP JP2016502103A patent/JP6649246B2/ja active Active
- 2014-03-13 CA CA2902547A patent/CA2902547A1/en not_active Abandoned
-
2019
- 2019-03-19 AU AU2019201884A patent/AU2019201884B2/en active Active
- 2019-12-02 JP JP2019217753A patent/JP2020029466A/ja active Pending
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