BR112015021000A2 - composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricação - Google Patents
composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricaçãoInfo
- Publication number
- BR112015021000A2 BR112015021000A2 BR112015021000A BR112015021000A BR112015021000A2 BR 112015021000 A2 BR112015021000 A2 BR 112015021000A2 BR 112015021000 A BR112015021000 A BR 112015021000A BR 112015021000 A BR112015021000 A BR 112015021000A BR 112015021000 A2 BR112015021000 A2 BR 112015021000A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- manufacturing process
- proteins during
- protein
- prolonged release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
resumo composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricação tal como aqui descrita, a administração controlada e prolongada de um agente terapêutico, tal como uma proteína através da administração de uma ou mais micropartículas, pode melhorar o tratamento de condições, tais como condições oculares indesejáveis. as microesferas podem ser formuladas para proporcionar uma liberação prolongada de uma proteína, enquanto reduz o número de agregados proteicos, atingindo perfis desejáveis de liberação e aumentando a estabilidade da proteína dentro das formulações de microesferas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786035P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026320 WO2014151725A1 (en) | 2013-03-14 | 2014-03-13 | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015021000A2 true BR112015021000A2 (pt) | 2017-07-18 |
Family
ID=50483567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021000A BR112015021000A2 (pt) | 2013-03-14 | 2014-03-13 | composição de uma distribuição liberação prolongada e método de estabilizar proteínas durante o processo de fabricação |
Country Status (10)
Country | Link |
---|---|
US (1) | US20140274873A1 (pt) |
EP (2) | EP2968574A1 (pt) |
JP (2) | JP6649246B2 (pt) |
KR (1) | KR20150128857A (pt) |
CN (1) | CN105188759A (pt) |
AU (2) | AU2014236938B2 (pt) |
BR (1) | BR112015021000A2 (pt) |
CA (1) | CA2902547A1 (pt) |
RU (1) | RU2720412C2 (pt) |
WO (1) | WO2014151725A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106076214B (zh) * | 2016-07-15 | 2019-12-17 | 沈阳化工大学 | 一种具有核壳结构的海藻酸钙微球制备方法 |
GB201906835D0 (en) * | 2019-05-15 | 2019-06-26 | Ucb Biopharma Sprl | Dry microparticles |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US6448077B1 (en) | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
PT814778E (pt) * | 1995-03-10 | 2001-11-30 | Roche Diagnostics Gmbh | Formas de administracao farmaceuticas contendo polipeptidos sob a forma de microparticulas e processo para a sua preparacao |
GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
CA2369451C (en) * | 1999-04-08 | 2009-09-22 | Genentech, Inc. | Composition based on oppositely-charged polypeptides |
US6896906B2 (en) * | 2000-12-21 | 2005-05-24 | Nektar Therapeutics | Storage stable powder compositions of interleukin-4 receptor |
EP1436329A4 (en) | 2001-09-20 | 2005-04-27 | Alexion Pharma Inc | ANTI-PDGF ANTIBODIES AND METHODS FOR PRODUCING FOCUSED ANTIBODIES |
US7265084B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US9415102B2 (en) * | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
US7993634B2 (en) * | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US8591885B2 (en) * | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
EP1838290A2 (en) * | 2005-01-21 | 2007-10-03 | Alza Corporation | Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion |
US20080095849A1 (en) * | 2005-04-25 | 2008-04-24 | Amgen Inc. | Peptide sustained release compositions and uses thereof |
JP5074750B2 (ja) * | 2005-12-07 | 2012-11-14 | 一般財団法人化学及血清療法研究所 | シクロデキストリン類を含有する液状フィブリノゲン製剤 |
US8642067B2 (en) * | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
WO2009031011A2 (en) * | 2007-09-05 | 2009-03-12 | Pfizer Limited | Xinafoate salt of n4-(2, 2-difluoro-4h-benz0 [1,4] 0xazin-3-one) -6-yl] -5-fluoro-n2- [3- (methylaminocar bonylmethyleneoxy) phenyl] 2, 4-pyrimidinediamine |
JP5406049B2 (ja) * | 2008-02-05 | 2014-02-05 | 協和発酵バイオ株式会社 | グルタチオンの保存安定性向上方法 |
EP2358746B1 (en) * | 2008-11-03 | 2020-09-16 | Molecular Partners AG | Binding proteins inhibiting the vegf-a receptor interaction |
WO2011041642A1 (en) | 2009-10-01 | 2011-04-07 | Surmodics Pharmaceuticals, Inc. | Microparticle compositions and methods for treating age-related macular degeneration |
US9668915B2 (en) * | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
-
2014
- 2014-03-13 EP EP14717337.1A patent/EP2968574A1/en not_active Withdrawn
- 2014-03-13 EP EP20167724.2A patent/EP3693021A1/en not_active Withdrawn
- 2014-03-13 AU AU2014236938A patent/AU2014236938B2/en active Active
- 2014-03-13 US US14/209,683 patent/US20140274873A1/en not_active Abandoned
- 2014-03-13 CN CN201480015377.2A patent/CN105188759A/zh active Pending
- 2014-03-13 RU RU2015135147A patent/RU2720412C2/ru active
- 2014-03-13 JP JP2016502103A patent/JP6649246B2/ja active Active
- 2014-03-13 KR KR1020157027832A patent/KR20150128857A/ko not_active Application Discontinuation
- 2014-03-13 WO PCT/US2014/026320 patent/WO2014151725A1/en active Application Filing
- 2014-03-13 CA CA2902547A patent/CA2902547A1/en not_active Abandoned
- 2014-03-13 BR BR112015021000A patent/BR112015021000A2/pt not_active IP Right Cessation
-
2019
- 2019-03-19 AU AU2019201884A patent/AU2019201884B2/en active Active
- 2019-12-02 JP JP2019217753A patent/JP2020029466A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3693021A1 (en) | 2020-08-12 |
AU2019201884A1 (en) | 2019-04-11 |
WO2014151725A1 (en) | 2014-09-25 |
RU2720412C2 (ru) | 2020-04-29 |
KR20150128857A (ko) | 2015-11-18 |
AU2014236938B2 (en) | 2018-12-20 |
CN105188759A (zh) | 2015-12-23 |
US20140274873A1 (en) | 2014-09-18 |
JP2016517418A (ja) | 2016-06-16 |
JP6649246B2 (ja) | 2020-02-19 |
JP2020029466A (ja) | 2020-02-27 |
AU2019201884B2 (en) | 2020-08-27 |
EP2968574A1 (en) | 2016-01-20 |
CA2902547A1 (en) | 2014-09-25 |
RU2015135147A (ru) | 2017-04-18 |
AU2014236938A1 (en) | 2015-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/18 (2006.01), A61K 38/00 (2006.01), A61K 4 |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2662 DE 11-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |