JP2016516728A - 第２部位インスリン類似体 - Google Patents

第２部位インスリン類似体 Download PDF

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Publication number
JP2016516728A
JP2016516728A JP2016503388A JP2016503388A JP2016516728A JP 2016516728 A JP2016516728 A JP 2016516728A JP 2016503388 A JP2016503388 A JP 2016503388A JP 2016503388 A JP2016503388 A JP 2016503388A JP 2016516728 A JP2016516728 A JP 2016516728A
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JP
Japan
Prior art keywords
insulin
xaa
glu
tyr
gln
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Pending
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JP2016503388A
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English (en)
Japanese (ja)
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JP2016516728A5 (https=
Inventor
エー． ワイス、マイケル
エー． ワイス、マイケル
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Case Western Reserve University
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Case Western Reserve University
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Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of JP2016516728A publication Critical patent/JP2016516728A/ja
Publication of JP2016516728A5 publication Critical patent/JP2016516728A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2016503388A 2013-03-15 2014-03-17 第２部位インスリン類似体 Pending JP2016516728A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798165P 2013-03-15 2013-03-15
US61/798,165 2013-03-15
PCT/US2014/030387 WO2014145593A2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Publications (2)

Publication Number Publication Date
JP2016516728A true JP2016516728A (ja) 2016-06-09
JP2016516728A5 JP2016516728A5 (https=) 2017-03-30

Family

ID=51538504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016503388A Pending JP2016516728A (ja) 2013-03-15 2014-03-17 第２部位インスリン類似体

Country Status (10)

Country Link
US (1) US20160083448A1 (https=)
EP (1) EP2968473A4 (https=)
JP (1) JP2016516728A (https=)
KR (1) KR20150138251A (https=)
CN (1) CN105228643A (https=)
AU (1) AU2014232894B2 (https=)
BR (1) BR112015023672A2 (https=)
CA (1) CA2942524A1 (https=)
IL (1) IL241357B (https=)
WO (1) WO2014145593A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019535733A (ja) * 2016-11-21 2019-12-12 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 安定性が増強された速効性インスリン類似体
JP2020502489A (ja) * 2016-10-24 2020-01-23 ノヴォ ノルディスク アー／エス インスリン製剤のためのバイオアッセイ

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
CN107428814A (zh) * 2015-01-20 2017-12-01 卡斯西部储备大学 具有选择性信号传导特性和降低的促有丝分裂性的胰岛素类似物
CR20190096A (es) 2016-07-22 2019-09-16 Walter & Eliza Hall Inst Medical Res Análogos de insulina
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000322A1 (en) * 1990-07-02 1992-01-09 Novo Nordisk A/S Insulin analogues with organ preferential action
WO1992012999A1 (en) * 1991-01-22 1992-08-06 Novo Nordisk A/S Novel insulin analogs
WO1992015611A1 (en) * 1991-02-27 1992-09-17 Novo Nordisk A/S Novel insulin derivatives
JP2011521621A (ja) * 2008-04-22 2011-07-28 ケイス、ウエスタン、リザーブ、ユニバーシティ アイソフォーム特異的インスリン類似体
JP2011529692A (ja) * 2008-07-31 2011-12-15 ケイス、ウエスタン、リザーブ、ユニバーシティ ハロゲン安定化インスリン

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000322A1 (en) * 1990-07-02 1992-01-09 Novo Nordisk A/S Insulin analogues with organ preferential action
WO1992012999A1 (en) * 1991-01-22 1992-08-06 Novo Nordisk A/S Novel insulin analogs
WO1992015611A1 (en) * 1991-02-27 1992-09-17 Novo Nordisk A/S Novel insulin derivatives
JP2011521621A (ja) * 2008-04-22 2011-07-28 ケイス、ウエスタン、リザーブ、ユニバーシティ アイソフォーム特異的インスリン類似体
JP2011529692A (ja) * 2008-07-31 2011-12-15 ケイス、ウエスタン、リザーブ、ユニバーシティ ハロゲン安定化インスリン

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. BIOLOGICAL CHEMISTRY, vol. 272, no. 20, JPN6018000503, 1997, pages 12978 - 12983, ISSN: 0003940862 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020502489A (ja) * 2016-10-24 2020-01-23 ノヴォ ノルディスク アー／エス インスリン製剤のためのバイオアッセイ
JP7022746B2 (ja) 2016-10-24 2022-02-18 ノヴォ ノルディスク アー／エス インスリン製剤のためのバイオアッセイ
JP2019535733A (ja) * 2016-11-21 2019-12-12 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 安定性が増強された速効性インスリン類似体
JP7286160B2 (ja) 2016-11-21 2023-06-05 ケース ウェスタン リザーブ ユニバーシティ 安定性が増強された速効性インスリン類似体

Also Published As

Publication number Publication date
BR112015023672A2 (pt) 2017-07-18
US20160083448A1 (en) 2016-03-24
EP2968473A2 (en) 2016-01-20
WO2014145593A3 (en) 2015-01-08
AU2014232894A1 (en) 2015-11-05
KR20150138251A (ko) 2015-12-09
CA2942524A1 (en) 2014-09-18
WO2014145593A2 (en) 2014-09-18
EP2968473A4 (en) 2016-11-23
AU2014232894B2 (en) 2018-02-08
IL241357A0 (en) 2015-11-30
IL241357B (en) 2021-08-31
CN105228643A (zh) 2016-01-06

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