AU2014232894B2 - Site 2 insulin analogues - Google Patents

Site 2 insulin analogues Download PDF

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Publication number
AU2014232894B2
AU2014232894B2 AU2014232894A AU2014232894A AU2014232894B2 AU 2014232894 B2 AU2014232894 B2 AU 2014232894B2 AU 2014232894 A AU2014232894 A AU 2014232894A AU 2014232894 A AU2014232894 A AU 2014232894A AU 2014232894 B2 AU2014232894 B2 AU 2014232894B2
Authority
AU
Australia
Prior art keywords
insulin
chain
pct
glu
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014232894A
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English (en)
Other versions
AU2014232894A1 (en
Inventor
Michael A. Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of AU2014232894A1 publication Critical patent/AU2014232894A1/en
Application granted granted Critical
Publication of AU2014232894B2 publication Critical patent/AU2014232894B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2014232894A 2013-03-15 2014-03-17 Site 2 insulin analogues Ceased AU2014232894B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798165P 2013-03-15 2013-03-15
US61/798,165 2013-03-15
PCT/US2014/030387 WO2014145593A2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Publications (2)

Publication Number Publication Date
AU2014232894A1 AU2014232894A1 (en) 2015-11-05
AU2014232894B2 true AU2014232894B2 (en) 2018-02-08

Family

ID=51538504

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014232894A Ceased AU2014232894B2 (en) 2013-03-15 2014-03-17 Site 2 insulin analogues

Country Status (10)

Country Link
US (1) US20160083448A1 (https=)
EP (1) EP2968473A4 (https=)
JP (1) JP2016516728A (https=)
KR (1) KR20150138251A (https=)
CN (1) CN105228643A (https=)
AU (1) AU2014232894B2 (https=)
BR (1) BR112015023672A2 (https=)
CA (1) CA2942524A1 (https=)
IL (1) IL241357B (https=)
WO (1) WO2014145593A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
CN107428814A (zh) * 2015-01-20 2017-12-01 卡斯西部储备大学 具有选择性信号传导特性和降低的促有丝分裂性的胰岛素类似物
CR20190096A (es) 2016-07-22 2019-09-16 Walter & Eliza Hall Inst Medical Res Análogos de insulina
MA46568A (fr) * 2016-10-24 2019-08-28 Novo Nordisk As Dosage biologique de formulations d'insuline
MY200047A (en) 2016-11-21 2023-12-06 Univ Case Western Reserve Rapid-acting insulin analogues of enhanced stability
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (https=) * 1991-02-27 1991-02-27 Novo Nordisk As
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
RU2010147076A (ru) * 2008-04-22 2012-05-27 Кейз Вестерн Ризев Юнивесити (Us) Аналоги инсулина специфичные к изоформам
CA2732439A1 (en) * 2008-07-31 2010-02-04 Case Western Reserve University Halogen-stabilized insulin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRISTENSEN ET AL., "Alanine Scanning Mutagenesis of Insulin", J BIOLOGICAL CHEMISTRY, 1997, vol. 272, no. 20, pages 12978 - 12983 *

Also Published As

Publication number Publication date
BR112015023672A2 (pt) 2017-07-18
US20160083448A1 (en) 2016-03-24
JP2016516728A (ja) 2016-06-09
EP2968473A2 (en) 2016-01-20
WO2014145593A3 (en) 2015-01-08
AU2014232894A1 (en) 2015-11-05
KR20150138251A (ko) 2015-12-09
CA2942524A1 (en) 2014-09-18
WO2014145593A2 (en) 2014-09-18
EP2968473A4 (en) 2016-11-23
IL241357A0 (en) 2015-11-30
IL241357B (en) 2021-08-31
CN105228643A (zh) 2016-01-06

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired